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Breakthrough as common drug ‘shrinks fatal and aggressive brain tumours’ – raising hopes of a cure

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Breakthrough as common drug ‘shrinks fatal and aggressive brain tumours’ - raising hopes of a cure

A CHEAP drug that’s already on the market could be effective against deadly brain tumours, scientists say.

Glioblastomas are aggressive and fast-growing brain tumours affecting around 3,200 Brits a year that currently have no cure.

A commonly described antidepressant is effective at bypassing the blood-brain barrier to reach tumours

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A commonly described antidepressant is effective at bypassing the blood-brain barrier to reach tumoursCredit: Alamy
The Wanted’s Tom Parker passed away from glioblastoma multiforme in March 2022

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The Wanted’s Tom Parker passed away from glioblastoma multiforme in March 2022Credit: AP

Patients’ life expectancy can be extended through operations, radiation or chemotherapy, but people only tend to live 12 to 18 months after being diagnosed with the cancer.

Only a fourth of glioblastoma patients survive more than a year after their diagnosis, The Brain Tumour Charity says.

The Wanted’s Tom Parker passed away from the cancer in March 2022, two years after announcing his diagnosis.

Finding drugs that can combat brain tumours effectively is difficult, as many cancer drugs often can’t cross the blood-brain barrier.

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This is tightly-locked layer of cells that line blood vessels in the brain, which filters out germs and harmful substances that could cause damage to the organ.

As a result, many drugs aren’t able to bypass this protective layer to reach the brain and eliminate tumours.

However, antidepressants can sneak through the barrier to get to the brain.

Researchers at ETH Zurich zeroed in an inexpensive antidepressant that’s already on the market, called vortioxetine.

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In the UK, it’s known by the name Brintellix or Lundbeck, as it recommended for adults in a major depressive episode that hasn’t been eased by two other antidepressants.

Scientists used a special screening platform developed at the university that tests how active substances effects living cells from human cancer tissue, with the help of imaging techniques and computer analysis.

Their study – published in Nature Medicine – focused on neuroactive substances that cross the blood-brain barrier, such as antidepressants, Parkinson’s medication and antipsychotics.

Student told smelling bacon and deju vu were ‘anxiety and drinking too much’ gets devastating diagnosis

In total, the research team tested up to 130 different drugs on tumour tissue from 40 cancer patients who had recently undergone surgery at the University Hospital Zurich.

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Some, but not all, of the antidepressants tested were unexpectedly effective against the tumour cells – and vortioxetine proved to be the most effective.

Researchers at the University Hospital Zurich also tested vortioxetine on mice with a glioblastoma.

The drug also showed “good efficacy” these trials, especially in combination with the current standard treatments for glioblastoma – which include surgery, chemotherapy, radiation.

Professor Berend Snijder, who led the study, said: “We started with this terrible tumour and found existing drugs that fight against it.

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“We show how and why they work, and soon we’ll be able to test them on patients.” 

Co-author Michael Weller, a professor and director of the Department of Neurologyat the University Hospital Zurich, said: “The advantage of vortioxetine is that it is safe and very cost-effective.

“As the drug has already been approved, it doesn’t have to undergo a complex approval procedure and could soon supplement the standard therapy for this deadly brain tumour.”

What is a glioblastoma?

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Glioblastomas are a fast-growing type of cancerous brain tumour.

Symptoms depend on where the tumour is located, but they can include:

  • Headaches
  • Personality changes
  • Memory problems
  • Trouble speaking or understanding
  • Tiredness
  • Depression
  • Difficulty thinking
  • Seizures
  • Problems with eyesight

Scientists don’t fully understand what causes glioblastomas, therefore there is no clear way to prevent the disease.

The main treatments include surgery, radiotherapy and chemotherapy.

The average survival time following a glioblastoma diagnosis is 12 to 18 months.

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Only 25 per cent of patients live beyond one year, and just five per cent survive more than five years.

Source: Cancer Research UK and the Brain Tumour Charity

He hopes that oncologists will be able to use it soon to treat cancer.

But he stressed that cancer patients and their relatives shouldn’t obtain vortioxetine themselves and take it without the supervision of their doctor – so far, its effect on cancer has only been tested on cells and mice.

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“We don’t yet know whether the drug works in humans and what dose is required to combat the tumour, which is why clinical trials are necessary,” Prof Weller said.

“Self-medicating would be an incalculable risk.”

The research team is is now preparing two new clinical trials.

In one, glioblastoma patients will be treated with vortioxetine alongside standard treatments.

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In the second, patients will receive a personalised drug selection, which the researchers will determine using the pharmacoscopy platform.

Should vortioxetine prove effective in humans, this will be the first time in recent decades that an active substance has been found to improve the treatment of glioblastoma, researchers said.

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Cute😍Girl gym Attitude WhatsApp Status💯Girl,s workout Motivation😈Fitness lover,s

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Cute😍Girl gym Attitude WhatsApp Status💯Girl,s workout Motivation😈Fitness lover,s



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Full Body HIIT Workout // With Weights

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Full Body HIIT Workout // With Weights



Today’s Full Body HIIT Workout is going to bring the heat!! This workout is loaded with plenty of total body compound exercises and we are adding dumbbells for resistance. Work at your own level of intensity and do YOUR best!! #HIIT #Workout #FullBodyWorkout #Fitness

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Workout Breakdown:
0:00 Intro
0:23 Warm Up

Circuit One (40s work + 20s rest x2 rounds)
3:21 Push Press + Twist
4:21 Hip Twister
5:21 Deadlift, Squat + Curl
6:21 Bear Knee Taps
7:21 Squat Jump + Jack

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13:21 Rest

Circuit Two (40s work + 20s rest x2 rounds)
13:34 Lunge + Sumo Combo
14:34 Speed Skater
15:34 Plank Hop + Press
16:34 Hip Lift + Frog Crunch
17:34 Hi-Lo Swing

23:34 Rest

Circuit Three (40s work + 20s rest x2 rounds)
23:46 Lunge Pass
24:46 Station Sprints
25:46 Kickback + Jack
26:46 Down Dog Push Up
27:46 Squat + Hop

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33:46 Cool Down & Stretch

Equipment Needed:
Dumbbells: I used a set of 10lbs each
Exercise mat: https://lululemon.prf.hn/l/Kj00Lb1

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This is my own personal workout and may not be suited for you. It is strongly recommended that you consult with your physician before beginning any exercise program. By engaging in this exercise or exercise program, you agree that you do so at your own risk.

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Stress can double the chances of a person’s hair going grey before 30, study reveals

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Stress can double the chances of a person’s hair going grey before 30, study reveals

STRESS can more than double the chances of going grey before 30, a study says.

Anxiety and depression appear to interfere with the follicles more than other factors including smoking, diet and exercise.

A study has found stress can more than double the chances of going grey before 30, pictured silver fox George Clooney

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A study has found stress can more than double the chances of going grey before 30, pictured silver fox George ClooneyCredit: Getty

Figures suggest half of us go grey by 50 but millions start the transition to silver fox, like screen idol George Clooney, years or even decades earlier.

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The study says the reasons are not clear but the stress hormone cortisol or mental health medications can cause damaging scalp inflammation.

A King Saud University team in Saudi Arabia compared rates of greying among 1,193 people aged 18 to 29.

Half had found at least one grey hair in their 20s.

One in eight reckoned they had more than 100.

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Anxiety increased chances 2.24 times and depression by 2.56.

Family history of it was the biggest factor.

Smoking almost doubled the risk but good diet cut it by 32 per cent.

Study author Turki Albinhar said: “Lifestyle changes such as quitting smoking, a balanced diet, and managing stress can help mitigate risk.”     

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Woman issues urgent warning to check the codes on hair dye bottles, after a shop swap left her with grey locks

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let‘s grow those GLUTES ❤️‍🔥 #gluteworkout #workout #gymgirl #gym #gymmotivation

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let‘s grow those GLUTES ❤️‍🔥 #gluteworkout #workout #gymgirl #gym #gymmotivation

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40 MIN YOU VS YOU HIIT WORKOUT – Full Body, No Equipment, No Repeat – (HIIT IT HARDER DAY 22)

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40 MIN YOU VS YOU HIIT WORKOUT - Full Body, No Equipment, No Repeat - (HIIT IT HARDER DAY 22)



DAY 22 HIIT IT HARDER CHALLENGE – 40 Minute Workout to get the heart pumping, burn some calories and sweat it out 💦 YOU vs YOU because you are your biggest motivation AND your biggest competition! Grab your mat, a bottle of water and let’s do it team!

▸ Muscles Worked: Arms, Abs, Legs, Chest, Back and Shoulders
▸ Time: 40 Min
▸ Equipment: No Equipment

▸ Instructions: Follow along and complete as many reps as possible in 50 Seconds. After 10 Seconds of Rest continue to the next move.

▸ The Workout:
1. Warm Up 0:00 – 05:15
2. Workout 05:15 – 35:15
3. Cool Down 35:15

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Please remember that we are all different and that you can make this your own workout ♡ Take a longer break when you need to.

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#growingannanas #growwithanna #homeworkouts #hiitworkout #workoutchallenge

D I S C L A I M E R

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If you are a newbie start with a simple and easy exercise before attempting all advanced exercises. Performing exercises out of your capability might strain your muscles and you may get injured.

This channel offers health, fitness and nutritional information. You should not rely on this information as a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment. By performing any fitness exercises without supervision like with this video, you are performing them at your own risk. See a fitness professional to give you advice on your exercise form. Growingannanas will not be responsible or liable for any injury or harm you sustain as a result of this video.

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Fitness Easy Exercise |weight loss exercises for women#

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Fitness Easy Exercise |weight loss exercises for women#

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