Health & fitness
Breakthrough as common drug ‘shrinks fatal and aggressive brain tumours’ – raising hopes of a cure
A CHEAP drug that’s already on the market could be effective against deadly brain tumours, scientists say.
Glioblastomas are aggressive and fast-growing brain tumours affecting around 3,200 Brits a year that currently have no cure.
Patients’ life expectancy can be extended through operations, radiation or chemotherapy, but people only tend to live 12 to 18 months after being diagnosed with the cancer.
Only a fourth of glioblastoma patients survive more than a year after their diagnosis, The Brain Tumour Charity says.
The Wanted’s Tom Parker passed away from the cancer in March 2022, two years after announcing his diagnosis.
Finding drugs that can combat brain tumours effectively is difficult, as many cancer drugs often can’t cross the blood-brain barrier.
Read more on brain tumours
This is tightly-locked layer of cells that line blood vessels in the brain, which filters out germs and harmful substances that could cause damage to the organ.
As a result, many drugs aren’t able to bypass this protective layer to reach the brain and eliminate tumours.
However, antidepressants can sneak through the barrier to get to the brain.
Researchers at ETH Zurich zeroed in an inexpensive antidepressant that’s already on the market, called vortioxetine.
In the UK, it’s known by the name Brintellix or Lundbeck, as it recommended for adults in a major depressive episode that hasn’t been eased by two other antidepressants.
Scientists used a special screening platform developed at the university that tests how active substances effects living cells from human cancer tissue, with the help of imaging techniques and computer analysis.
Their study – published in Nature Medicine – focused on neuroactive substances that cross the blood-brain barrier, such as antidepressants, Parkinson’s medication and antipsychotics.
In total, the research team tested up to 130 different drugs on tumour tissue from 40 cancer patients who had recently undergone surgery at the University Hospital Zurich.
Some, but not all, of the antidepressants tested were unexpectedly effective against the tumour cells – and vortioxetine proved to be the most effective.
Researchers at the University Hospital Zurich also tested vortioxetine on mice with a glioblastoma.
The drug also showed “good efficacy” these trials, especially in combination with the current standard treatments for glioblastoma – which include surgery, chemotherapy, radiation.
Professor Berend Snijder, who led the study, said: “We started with this terrible tumour and found existing drugs that fight against it.
“We show how and why they work, and soon we’ll be able to test them on patients.”
Co-author Michael Weller, a professor and director of the Department of Neurologyat the University Hospital Zurich, said: “The advantage of vortioxetine is that it is safe and very cost-effective.
“As the drug has already been approved, it doesn’t have to undergo a complex approval procedure and could soon supplement the standard therapy for this deadly brain tumour.”
What is a glioblastoma?
Glioblastomas are a fast-growing type of cancerous brain tumour.
Symptoms depend on where the tumour is located, but they can include:
- Headaches
- Personality changes
- Memory problems
- Trouble speaking or understanding
- Tiredness
- Depression
- Difficulty thinking
- Seizures
- Problems with eyesight
Scientists don’t fully understand what causes glioblastomas, therefore there is no clear way to prevent the disease.
The main treatments include surgery, radiotherapy and chemotherapy.
The average survival time following a glioblastoma diagnosis is 12 to 18 months.
Only 25 per cent of patients live beyond one year, and just five per cent survive more than five years.
Source: Cancer Research UK and the Brain Tumour Charity
He hopes that oncologists will be able to use it soon to treat cancer.
But he stressed that cancer patients and their relatives shouldn’t obtain vortioxetine themselves and take it without the supervision of their doctor – so far, its effect on cancer has only been tested on cells and mice.
“We don’t yet know whether the drug works in humans and what dose is required to combat the tumour, which is why clinical trials are necessary,” Prof Weller said.
“Self-medicating would be an incalculable risk.”
The research team is is now preparing two new clinical trials.
In one, glioblastoma patients will be treated with vortioxetine alongside standard treatments.
In the second, patients will receive a personalised drug selection, which the researchers will determine using the pharmacoscopy platform.
Should vortioxetine prove effective in humans, this will be the first time in recent decades that an active substance has been found to improve the treatment of glioblastoma, researchers said.
Womens Workouts
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Full Body HIIT Workout // With Weights
Today’s Full Body HIIT Workout is going to bring the heat!! This workout is loaded with plenty of total body compound exercises and we are adding dumbbells for resistance. Work at your own level of intensity and do YOUR best!! #HIIT #Workout #FullBodyWorkout #Fitness
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Workout Breakdown:
0:00 Intro
0:23 Warm Up
Circuit One (40s work + 20s rest x2 rounds)
3:21 Push Press + Twist
4:21 Hip Twister
5:21 Deadlift, Squat + Curl
6:21 Bear Knee Taps
7:21 Squat Jump + Jack
13:21 Rest
Circuit Two (40s work + 20s rest x2 rounds)
13:34 Lunge + Sumo Combo
14:34 Speed Skater
15:34 Plank Hop + Press
16:34 Hip Lift + Frog Crunch
17:34 Hi-Lo Swing
23:34 Rest
Circuit Three (40s work + 20s rest x2 rounds)
23:46 Lunge Pass
24:46 Station Sprints
25:46 Kickback + Jack
26:46 Down Dog Push Up
27:46 Squat + Hop
33:46 Cool Down & Stretch
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Health & fitness
Stress can double the chances of a person’s hair going grey before 30, study reveals
STRESS can more than double the chances of going grey before 30, a study says.
Anxiety and depression appear to interfere with the follicles more than other factors including smoking, diet and exercise.
Figures suggest half of us go grey by 50 but millions start the transition to silver fox, like screen idol George Clooney, years or even decades earlier.
The study says the reasons are not clear but the stress hormone cortisol or mental health medications can cause damaging scalp inflammation.
A King Saud University team in Saudi Arabia compared rates of greying among 1,193 people aged 18 to 29.
Half had found at least one grey hair in their 20s.
One in eight reckoned they had more than 100.
Anxiety increased chances 2.24 times and depression by 2.56.
Family history of it was the biggest factor.
Smoking almost doubled the risk but good diet cut it by 32 per cent.
Study author Turki Albinhar said: “Lifestyle changes such as quitting smoking, a balanced diet, and managing stress can help mitigate risk.”
Womens Workouts
let‘s grow those GLUTES ❤️🔥 #gluteworkout #workout #gymgirl #gym #gymmotivation
Womens Workouts
40 MIN YOU VS YOU HIIT WORKOUT – Full Body, No Equipment, No Repeat – (HIIT IT HARDER DAY 22)
DAY 22 HIIT IT HARDER CHALLENGE – 40 Minute Workout to get the heart pumping, burn some calories and sweat it out 💦 YOU vs YOU because you are your biggest motivation AND your biggest competition! Grab your mat, a bottle of water and let’s do it team!
▸ Muscles Worked: Arms, Abs, Legs, Chest, Back and Shoulders
▸ Time: 40 Min
▸ Equipment: No Equipment
▸ Instructions: Follow along and complete as many reps as possible in 50 Seconds. After 10 Seconds of Rest continue to the next move.
▸ The Workout:
1. Warm Up 0:00 – 05:15
2. Workout 05:15 – 35:15
3. Cool Down 35:15
Please remember that we are all different and that you can make this your own workout ♡ Take a longer break when you need to.
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Womens Workouts
Fitness Easy Exercise |weight loss exercises for women#
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