Business
Colorectal Cancer Now Leading Cause of Cancer Deaths in Americans Under 50, New Data Show
Colorectal cancer has become the leading cause of cancer-related deaths among adults under age 50 in the United States, surpassing other major malignancies as overall cancer mortality in this age group continues to decline sharply, according to recent analyses from the American Cancer Society and published research.

A study released January 22, 2026, in the Journal of the American Medical Association examined U.S. cancer death trends from 1990 through 2023 for the five leading causes in people younger than 50. Researchers found that total cancer deaths in this demographic dropped 44 percent over the period, from 25.5 per 100,000 people in 1990 to 14.2 in 2023. Declines occurred in four of the top five causes — brain cancer (0.3 percent annual drop from 2014-2023), breast cancer (1.4 percent), leukemia (2.3 percent) and lung cancer (5.7 percent) — reflecting advances in prevention, early detection and treatment.
Colorectal cancer stood alone as an outlier. Mortality rose by an average of 1.1 percent annually since 2005, propelling it from the fifth-leading cause in the early 1990s to the top spot by 2023 — seven years earlier than some projections had anticipated. The disease now ranks first overall for cancer deaths under 50, second for women (behind breast cancer) and first for men.
“Overall progress against cancer in young adults has been remarkable, but colorectal cancer is moving in the wrong direction,” said Rebecca L. Siegel, senior scientific director of surveillance research at the American Cancer Society and lead author of the JAMA research letter. “This confirms a real increase in underlying risk for generations born after about 1950.”
The American Cancer Society’s “Colorectal Cancer Statistics, 2026” report, published in March, reinforced the trend. It projected 158,850 new colorectal cancer cases and 55,230 deaths nationwide this year, with incidence rising 3 percent annually in adults aged 20-49 and 0.4 percent in those 50-64, while falling 2.5 percent in those 65 and older. Mortality has climbed 1 percent per year since 2004 in those under 50 and since 2019 in the 50-64 group.
The shift is driven largely by tumors in the distal colon and rectum. About one in five diagnoses now occurs in people under 55, up from far lower proportions decades ago. Younger patients are more likely to present with advanced-stage disease, contributing to poorer outcomes.
Experts attribute the rise to a mix of factors, though no single cause has been pinpointed. Potential contributors include changes in diet (higher processed foods, red meat and low fiber), sedentary lifestyles, obesity, diabetes, antibiotic use altering gut microbiomes and environmental exposures. Unlike older adults, where screening has driven steep declines, many under 50 lack routine checks, delaying diagnosis until symptoms like bleeding, pain or bowel changes appear — often dismissed as benign issues in younger people.
In response, major guidelines now recommend colorectal cancer screening starting at age 45 for average-risk adults, down from 50. Options include colonoscopy every 10 years, annual fecal immunochemical tests or stool DNA tests every three years. Uptake of non-invasive stool tests has risen, helping offset pandemic-related drops in colonoscopies.
The Colorectal Cancer Alliance called the findings a wake-up call, urging greater awareness, symptom education and involvement in research initiatives like Project Cure CRC to accelerate treatments.
Despite the alarming trend in young adults, overall U.S. colorectal cancer mortality has fallen 56 percent since 1970 due to screening, reduced smoking and better therapies. Yet progress has slowed recently, with rates stable from 2020-2023 after earlier annual declines of about 2 percent.
Advocates stress that many deaths could be prevented through earlier detection. Symptoms in younger people — persistent abdominal pain, unexplained weight loss, changes in bowel habits or rectal bleeding — warrant prompt medical attention, even if uncommon for the age group.
Ongoing research explores why incidence surges in post-1950 birth cohorts, with calls for more etiologic studies into modern lifestyle and environmental factors. As these generations age, the burden may grow without intervention.
Health organizations emphasize equity: screening gaps persist in underserved communities, where stool-based tests show promise for accessibility and cost.
The data highlight a paradox — broad success against cancer in young adults overshadowed by one disease’s relentless rise. Experts urge clinicians to consider colorectal cancer in symptomatic patients under 50 and public campaigns to normalize screening discussions.
With March designated Colorectal Cancer Awareness Month, groups promote blue-ribbon campaigns to boost awareness and early action.
As the trend persists into 2026, the message remains clear: colorectal cancer is no longer just an older person’s disease. Vigilance, lifestyle changes and timely screening offer the best defense against what has become the top cancer killer for Americans in their prime working and family years.
Business
Form 144 CONOCOPHILLIPS For: 13 March

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Mach Natural Resources LP 2025 Q4 – Results – Earnings Call Presentation (NYSE:MNR) 2026-03-13
Q4: 2026-03-12 Earnings Summary
EPS of $0.50 beats by $0.23
| Revenue of $387.54M (64.95% Y/Y) beats by $28.00M
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Business
Tower Semiconductor: The Hidden AI Photonics Winner (NASDAQ:TSEM)
Hi, I’m Yiannis. Spotting winners before they break out is what I do best.Experience: Previously worked at Deloitte and KPMG in external/internal auditing and consulting. Education: Chartered Certified Accountant, Fellow Member of ACCA Global, with BSc and MSc degrees from U.K. business schools. Investment Style: Spotting high-potential winners before they break out, focusing on asymmetric opportunities (with at least upside potential of 3-5X outweighing the downside risk). By leveraging market inefficiencies and contrarian insights, we seek to maximize long-term compounding while protecting against capital impairment.Risk management is paramount—we seek a strong margin of safety to protect against capital impairment while maximizing long-term compounding. Our 2-3 year investment horizon allows us to ride out volatility, ensuring that patience, discipline, and intelligent capital allocation drive outsized returns over time.
Analyst’s Disclosure: I/we have a beneficial long position in the shares of TSEM, AAOI, NVDA either through stock ownership, options, or other derivatives. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.
Seeking Alpha’s Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.
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Factbox-How many people have been killed in the US-Israeli war on Iran?

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Business
FedEx Corporation: Its Valuation Has Already Traveled Quite Too Far
FedEx Corporation: Its Valuation Has Already Traveled Quite Too Far
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Savills buys Eastdil Secured in $1bn deal to expand US real estate investment banking
Savills has agreed a deal worth close to $1 billion to acquire US property investment bank Eastdil Secured, marking a significant strategic move aimed at strengthening the British real estate group’s presence in the lucrative American market.
The London-listed property adviser will pay approximately $921 million for the business in a transaction combining both cash and shares. Around $553 million will be paid in cash, while roughly $369 million will be settled in Savills shares issued to existing Eastdil investors, including Singapore’s sovereign wealth fund Temasek, Guggenheim Partners and a group of senior staff shareholders.
The acquisition represents the first major deal under Savills’ new chief executive Simon Shaw, who took over from Mark Ridley at the start of 2026. Shaw described the combination as a “marriage made in heaven”, highlighting the longstanding relationship between the two companies in global real estate transactions.
Eastdil Secured is widely regarded as one of the most influential advisers in the global property capital markets sector. The firm specialises in advising major landlords, developers and institutional investors on high-value property sales, financing arrangements and complex investment transactions. Its client base includes some of the largest global real estate investors and private equity firms.
By bringing Eastdil into the group, Savills aims to significantly deepen its foothold in the United States, the world’s largest property investment market, where the company has historically had a more limited presence compared with Europe and Asia.
Shaw said the acquisition fills a strategic gap in Savills’ global platform. While the firm enjoys strong market positions across many international property markets, the US had remained the most significant region where its capabilities were comparatively underdeveloped.
He said: “We’ve got great market share in many parts of the world, but the one hole in our network has been the US. Eastdil is the leading capital markets operator in the largest real estate investment market in the world and provides direct access to the deepest pools of capital.”
Savills believes the combined organisation will enable it to compete more aggressively for high-value real estate advisory mandates, including mergers and acquisitions involving property portfolios, large-scale financing deals and global investment transactions.
The acquisition was announced alongside Savills’ latest financial results, which showed the company continuing to grow despite a challenging global economic environment marked by geopolitical tensions, tariffs and macroeconomic uncertainty.
For the year ending December 2025, Savills reported revenue of £2.55 billion, up from £2.40 billion the previous year, representing growth of 6 per cent.
Pre-tax profits rose by 14 per cent to £101 million, compared with £88.3 million in 2024. The company attributed the increase partly to stronger demand for its non-transactional services, including investment management, consultancy and property management.
These divisions now account for the majority of Savills’ earnings, reflecting a broader industry shift away from reliance solely on property transactions toward advisory and asset-management services that provide more stable revenue streams.
Income from these less transactional activities increased by 8 per cent over the year, while revenues linked directly to property transactions rose by 4 per cent.
Savills said the middle part of 2025 had been particularly challenging for deal activity as investors delayed decisions amid global tariff disputes and uncertainty surrounding fiscal policy ahead of the UK government’s autumn budget.
However, the company experienced a sharp rebound in activity toward the end of the year. Shaw described December as “astonishing”, suggesting that many investors returned to the market once political uncertainty had eased and the budget had been delivered.
He said investors were increasingly adjusting to a world characterised by geopolitical tension and economic volatility.
“Both occupiers and investors have started to accept that geopolitical change is now a constant,” Shaw said. “There comes a moment where you simply have to continue investing and doing business despite that backdrop.”
Savills also reported that the stronger momentum seen late in 2025 had continued into the opening months of 2026. Although the firm acknowledged that it remains difficult to assess the full impact of the ongoing conflict in the Middle East, it said there had been little immediate disruption to global property investment activity.
According to Shaw, London could potentially benefit from increased investor interest if global instability persists, as capital historically flows toward markets perceived as stable and secure.
“I think there is a likelihood that capital will tilt slightly towards traditional safe havens,” he said. “It would be logical that investors feel more comfortable placing money in markets where legal systems and institutions are well established.”
Savills’ board has also approved a higher shareholder payout following the improved financial performance. The company increased its final dividend by 8 per cent to 15.7p per share, payable in May, while also announcing a supplemental dividend of 10.7p per share.
Despite the strategic rationale for the Eastdil acquisition, investors initially reacted cautiously to the announcement. Savills shares fell 7.2 per cent, closing down 72p at 930p on the day the deal was unveiled.
Founded in 1855 by surveyor Alfred Savill, the company has evolved from a traditional land agency serving wealthy landowners into one of the world’s largest property advisory groups.
Although widely recognised by the public as a residential estate agent, the residential business accounts for only about a tenth of Savills’ overall operations. The majority of its income now comes from commercial real estate services such as advising investors, leasing office space, managing buildings and providing consultancy to institutional clients.
Savills has expanded internationally through a series of acquisitions over the past three decades, establishing operations across Europe, Asia, the Middle East and Australia. However, the United States has remained the final major real estate market where its presence lagged behind competitors.
The purchase of Eastdil Secured is therefore expected to play a central role in Savills’ long-term strategy of building a truly global real estate advisory platform capable of competing with the largest property consultancies and investment banks in the sector.
Business
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