Health & fitness

Breakthrough blood test could detect early stages of Alzheimer’s YEARS before symptoms show

Published

2 weeks ago

September 26, 2024

Breakthrough blood test could detect early stages of Alzheimer's YEARS before symptoms show

A NEW blood test could detect Alzheimer’s disease in its early stages, years before symptoms begin to show.

Tests that evaluate specific molecules in the blood could pick up early signs of Alzheimer’s-related brain decline, while being less invasive and more cost effective than current methods, scientists say.

A blood test that looks for molecules in the blood may be able to spot Alzheimer's years before symptoms show — A blood test that looks for molecules in the blood may be able to spot Alzheimer’s years before symptoms showCredit: Getty

Alzheimer’s is usually diagnosed through physical examinations, memory tests and brain scans, as there currently isn’t a simple test to pick up the disease.

Detecting the brain robbing illness early enough for treatments to be effective has been a huge focus of recent research.

“Because the deterioration of cognitive functions in Alzheimer’s disease develops slowly over time, patients are currently diagnosed at an advanced stage of neuropathologic changes,” researchers from the Boston University Chobanian & Avedisian School of Medicine said.

“Indeed, the failure to diagnose Alzheimer’s at an early stage of molecular pathology is considered the major reason why multiple treatments have failed in clinical trials.”

Recent studies have yielded innovative ways of diagnosing Alzheimer’s, with scientists claiming that a blood test which can detect the disease up to 15 years before symptoms emerge could be made free on the NHS within a year.

The test works by measuring levels of a protein in the blood called p-tau217.

It fits into a form of molecular diagnosis that looks for what Boston University researchers referred to as “A/T/N” biomarkers.

This involves measuring levels of key proteins in the blood that are characteristic of Alzheimer’s – called beta-amyloid (“A”) and tau (“T”) – as well as looking at levels of neurodegeneration (“N”) in the brain.

But the research team claimed that measuring molecules in the blood called plasma microRNAs (miRNAs) may be more effective at picking up early signs of Alzheimer’s.

Alzheimer’s disease is thought to be triggered by genetics, as well as environmental risk factors and miRNAs control the expression of genes governing brain functions that deteriorate when someone has the brain robbing disease.

Sun Health Explainer: Dementia and Alzheimer’s disease

Scientists said that evaluating miRNAs in blood can be used to diagnose mild cognitive impairment (MCI), when someone has initial problems with memory and thinking.

For some people, MCI is an early sign of a disease that will eventually cause dementia.

Boston University researchers claimed that an miRNA blood test may also be able to predict if MCI might eventually turn into dementia, due to Alzheimer’s disease.

Their findings were published in two papers in the journal Alzheimer’s and Dementia.

Senior author Prof Ivana Delalle, of Boston University, said: “Our discovery is important because, unlike the current A/T/N biomarkers, microRNAs may serve as blood molecular biomarkers years before Alzheimer’s disease manifests clinically, thus identifying the time window for effective prevention or early intervention to stop the progression of Alzheimer’s.”

The researchers examined blood samples from 803 participants across 60 medical centres in the US and Canada.

They examined miRNA expression in blood plasma samples of three groups of participants – people who were “cognitively normal”, “mildly cognitively impaired” and patients with Alzheimer’s disease patients.

Using miRNA tests in combination with neuropsychological tests, researchers were able to predict whether participants with mild cognitive decline would later develop Alzheimer’s.

What are the early symptoms of cognitive decline?

WE all notice a natural decline in memory and thinking as we age.

This will be more pronounced in some people, as they experience memory and thinking problems that are mild but still noticeable.

This is described as mild cognitive impairment (MCI). Unlike dementia sufferers, people with MCI can still get on with day-to-day life.

Research suggests that two out of 10 people over the age
of 65 have MCI, according to Alzheimer’s Research UK.

About one in 10 people who’ve received an MCI diagnosis will go on to develop dementia.

Symptoms of MCI include:

Memory – Misplacing items or having trouble
remembering recent conversations.

Attention problems – finding it difficult to concentrate,
e.g. while watching a TV programme or carrying out
duties at work
Disorientation – confusion about time, date or place
Thinking skills – problems with planning or completing
tasks, e.g. managing money, or cooking a meal
Problems with communication and finding the right words
Mood and behaviour changes – becoming irritable, anxious,
or feeling low

These symptoms may affect someone with MCI all the
time, or they might come and go.

There are steps we can take to keep our brains as healthy as possible. These include:

Not smoking
Doing regular physical activity
Staying mentally and socially active
Eating a healthy balanced diet
Limiting the amount of alcohol we drink
Having your hearing checked regularly
Keeping blood pressure, blood sugar and cholesterol
levels in check

“Out of the 300 miRNAs reliably detected in plasma samples across individuals, we identified 15 miRNAs that were associated with Alzheimer’s disease, or helped detect early MCI and late MCI patients, or predicted their conversion to Alzheimer’s disease,” they explained.

Prof Andrew Saykin, of the IU School of Medicine who was also involved in the research, said: “These findings provide a path toward a better understanding the molecular mechanisms driving plaques, tangles and atrophy, and may provide clues for the next generation of therapeutic targets.”

While a number of new treatments for Alzheimer’s disease are being developed and rolled out, researchers said they can only work in a real-world setting if patients at risk are identified as early as possible.

This is where miRNA tests come in.

“We have laid the groundwork for further investigations into the role of microRNAs in Alzheimer’s disease pathogenesis,” study author Prof Kwangsik Nho, of the IU School of Medicine, said.

But more work needs to “refine and confirm” specific miRNA signatures that are associated with Alzheimer’s, researchers noted.

“We envision that once specific miRNA signatures are further confirmed, the analysis of blood miRNAs will be transferred to simple assay formats enabling the adoption of blood miRNAome analysis in clinical practice,” Prof Nho said.

Researchers concluded: “Integrating plasma microRNA signatures with established cognitive screening measures in primary care settings will likely enhance the accuracy and efficiency of recognising early Alzheimer’s-associated cognitive decline.”

Other major Alzheimer’s breakthroughs

While experts have warned that dementia diagnoses in England have reached record numbers, there have been a number of recent advances against brain robbing diseases.

From “game-changing” drugs gaining approval to blood tests that can spot the condition years before symptoms, here are other major Alzheimer’s breakthroughs.

A “game-changing” Alzheimer’s drug called donanemab, that slows mental decline by up to 60 per cent has been approved in the United States. A UK decision on whether the drug will become available to patients in the UK with early symptoms is expected imminently.

A blood test that detects Alzheimer’s up to 15 years before symptoms emerge is set to be made free on the NHS within a year. The new test is cheaper, easier and at least as accurate as the current diagnosis options and works by measuring levels of a protein in the blood called p-tau217.

Researchers have developed a first-of-its-kind test that could predict dementia up to nine years before a diagnosis, with 80 per cent accuracy. It involves analysing network of connections in the brain when it’s in “idle mode” to look for very early signs of the condition.

A woman who has evaded Alzheimer’s disease despite half her relatives getting it could hold the clues to how to prevent it, with scientists pinpointing a particular gene which they think could help prevent Alzheimer’s from progressing.

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Womens Workouts

😱💥most beautiful moment women.s😱flor routine#sports #video #viral #olympics #world #champions

Published

28 mins ago

October 10, 2024

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😱💥most beautiful moment women.s😱flor routine#sports #video #viral #olympics #world #champions

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Best Pregnancy Stretches | 15-Min Full-Body Daily Stretch Routine | Relieve Pregnancy Symptoms

Published

1 hour ago

October 10, 2024

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Best Pregnancy Stretches | 15-Min Full-Body Daily Stretch Routine | Relieve Pregnancy Symptoms

These are great daily pregnancy stretches (a stretch routine) to keep away pregnancy aches and pains and help pregnancy symptoms. Guide to cope with pain in labor: http://bit.ly/31MnU5Q
5-min warm-up to do before this stretch routine: https://youtu.be/bJSrELdWksM

Pregnancy Meal Plan: https://landing.mailerlite.com/webforms/landing/w5v4m5
Pelvic Floor Guide For Birth Prep: https://landing.mailerlite.com/webforms/landing/n1q6t1
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My other pregnancy walking workouts:

Other 15 minute Pregnancy Workouts:

Natural Birth Education Playlist:

How to avoid tearing during labor: https://youtu.be/aqLO5esBo0M
_________________________________________________________________________________________________
Other pregnancy workouts you may enjoy:
Pregnancy Exercises For Easy Delivery: https://youtu.be/CRpfORhoi2A
Pregnancy Exercises Second Trimester: https://youtu.be/qJ3L-YztHog
15 Minute Pregnancy Workout: https://youtu.be/HB7rhqj9mn0
Pregnancy Cardio Workout: https://youtu.be/Aalbd7nco8I

_________________________________________________________________________________________________
*Check with your doctor before trying any of these strategies or before starting this or any new exercise routine. Only do the movements safe for you in your pregnancy. You are responsible for your own safety. Full disclaimer at the bottom.
_________________________________________________________________________________________________
More Freebies:

GESTATIONAL DIABETES MEAL PLAN BY A DIETITIAN
https://landing.mailerlite.com/webforms/landing/q5m7q8

FREE WEIGHT MANAGEMENT COURSE WITH REGISTERED DIETITIAN AND CERTIFIED DIABETES AND BARIATRIC EDUCATOR: http://bit.ly/2mjlsF5

—- “THE COMPLETE GUIDE TO HOW I HEALED MY 4-FINGER DIASTASIS RECTI GAP”
https://www.pregnancyandchildhoodnutrition.com/diastasis-recti

—- “THE BEST 4 SCIENTIFIC-BASED DIETS (LIFESTYLES) TO LOSE WEIGHT” with all 4 types of meal plans (KETO, PLANT-BASED, MEDITERRANEAN AND CALORIE COUNTING)
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—- “HOW TO LOSE WEIGHT AND INCREASE BREAST MILK SUPPLY”
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_________________________________________________________________________________________________

Disclaimer: This is general prenatal fitness only. Please check with your doctor or health care provider to see if this video is safe for you. You are responsible for your own safety. Don’t do anything that feels unsafe for you or baby. Stop if you have any pain or discomfort, bleeding, chest pain or shortness of breath, dizziness or if you feel unwell. P&P Health Inc., Pregnancy and Postpartum TV and Jessica Pumple are not liable in any way for any injury, loss, damages, costs or expenses suffered by you in relation to this video or its content.

Jessica Pumple is a certified bariatric and diabetes educator, registered dietitian, and pre & postnatal fitness instructor. She helps pregnant women stay fit, have healthy babies, and easier labors. She helps new moms with postpartum recovery, to heal and strengthen their core and lose the baby weight.

If you enjoy our content subscribe to our channel, hit the bell button, leave a comment, and share with your friends so I can make you more of the videos you enjoy!

#pregnancystretches #pregnancyyoga #prenatalstretches

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Follow us for Part 2- Tips for Training! #movewell #fitness #moveyourbody #motivation

Published

3 hours ago

October 10, 2024

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Follow us for Part 2- Tips for Training! #movewell #fitness #moveyourbody #motivation

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Womens Workouts

Day 21: 40 Min FAT BURNING WORKOUT [Full Body HIIT CARDIO] No Equipment, No Repeats // 6WS1

Published

4 hours ago

October 10, 2024

NewsAdmin

Day 21: 40 Min FAT BURNING WORKOUT [Full Body HIIT CARDIO] No Equipment, No Repeats // 6WS1

Get ready to be dripping in sweat with this explosive 40 minute NO REPEAT, NO EQUIPMENT HIIT workout! We’ll crush 40 unique exercises back-to-back, designed to elevate your heart rate, torch calories, and sculpt toned muscles – all without lifting a single weight.

Get ready to sweat, push your limits, and feel the burn like never before! This high intensity workout will challenge your endurance and leave you feeling accomplished. Remember, take breaks as needed, but don’t quit! You’ve got this! Workout details below. #6WS1 #FatBurningWorkout #NoRepeats #NoEquipment

Download our FREE 6 Week Shred 1 Home Workout Program schedule: https://bit.ly/WorkoutSchedules

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💾 Shredded: 2 Week Ab Challenge: https://bit.ly/ShreddedChallenge
💾 Sculpted Core: 2 Week Ab Challenge: https://bit.ly/UnbreakableCoreChallenge

* * * *

Workout Details:
⏱️ Duration: 40 minute workout
🏋️ Equipment: A workout mat
⏱️ Intervals: 40 seconds work, 20 seconds rest between exercises

The exercises for this killer bodyweight HIIT workout are:

0:20 Prisoner Squat + Alt Knee to Elbow
1:20 Reverse Lunge + Front Kick R
2:20 Reverse Lunge + Front Kick L
3:20 Lateral Bear Walk
4:20 Blast Off Push Ups
5:20 Boxer Squats
6:20 Curtsy Lunge to Squat R
7:20 Curtsy Lunge to Squat L
8:20 Front & Back Bear Crawl
9:20 Up Down + Tuck
10:20 Crouch to Star Jump
11:20 Plyo Lunge Clap R
12:20 Plyo Lunge Clap L
13:20 Lunge Pivots
14:20 Tricep Skull-crusher Push Up
15:20 Down Dog + Knee Drive R
16:20 Down Dog + Knee Drive L
17:20 Bicycle Crunches
18:20 Russian Twists
19:20 Side Plank Dips R
20:20 Side Plank Rotation R
21:20 Narrow Push Ups
22:20 Spider Crunches
23:20 Single Leg V Up R
24:20 Single Leg V Up L
25:20 Plank Marches
26:20 Side Plank Dips L
27:20 Side Plank Rotation L
28:20 Butterfly Crunches
29:20 Superman + Lat Pull Down
30:20 Alternating Bear Rows
31:20 Pivot Squats R
32:20 Pivot Squats L
33:20 Squat Pulses
34:20 Pike Shoulder Taps
35:20 6X High Knees + Half Burpee
36:20 Split Stance Switch + Alt Drop Lunge
37:20 Plank Jack Reaches
38:20 Push Up Pulses
39:20 Air Squats

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Thanks for supporting our YouTube channel. We couldn’t do any of this without you!
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DISCLAIMER: Before starting any workout, consult your doctor to ensure it’s safe for you. Understand that participation in any exercise carries inherent risks of injury. By engaging in this video’s exercises, you acknowledge these risks and voluntarily assume full responsibility, releasing TIFF x DAN from any liability for potential harm. Some video links are affiliate links, meaning we may earn a small commission on qualifying purchases. Your decision to purchase is always your own, and your support is greatly appreciated!

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Womens Workouts

Best Exercise for Reproductive Health in Women|Kegel Exercise-DrH S Chandrika|Doctors' Circle#shorts

Published

5 hours ago

October 10, 2024

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Best Exercise for Reproductive Health in Women|Kegel Exercise-DrH S Chandrika|Doctors' Circle#shorts

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30 min Full Body Fat Loss Standing Workout (No Jumping) | Quiet Cardio, No Yoga Mat Needed ~ Emi

Published

6 hours ago

October 10, 2024

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30 min Full Body Fat Loss Standing Workout (No Jumping) | Quiet Cardio, No Yoga Mat Needed ~ Emi

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Breakthrough blood test could detect early stages of Alzheimer’s YEARS before symptoms show

What are the early symptoms of cognitive decline?

Other major Alzheimer’s breakthroughs

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Best Exercise for Reproductive Health in Women|Kegel Exercise-DrH S Chandrika|Doctors' Circle#shorts

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