Jensen Huang walked onto the GTC stage Monday wearing his trademark leather jacket and carrying, as it turned out, the blueprints for a new kind of monopoly.

The Nvidia CEO unveiled the Agent Toolkit, an open-source platform for building autonomous AI agents, and then rattled off the names of the companies that will use it: Adobe, Salesforce, SAP, ServiceNow, Siemens, CrowdStrike, Atlassian, Cadence, Synopsys, IQVIA, Palantir, Box, Cohesity, Dassault Systèmes, Red Hat, Cisco and Amdocs. Seventeen enterprise software companies, touching virtually every industry and every Fortune 500 corporation, all agreeing to build their next generation of AI products on a shared foundation that Nvidia designed, Nvidia optimizes and Nvidia maintains.

The toolkit provides the models, the runtime, the security framework and the optimization libraries that AI agents need to operate autonomously inside organizations — resolving customer service tickets, designing semiconductors, managing clinical trials, orchestrating marketing campaigns. Each component is open source. Each is optimized for Nvidia hardware. The combination means that as AI agents proliferate across the corporate world, they will generate demand for Nvidia GPUs not because companies choose to buy them but because the software they depend on was engineered to require them.

“The enterprise software industry will evolve into specialized agentic platforms,” Huang told the crowd, “and the IT industry is on the brink of its next great expansion.” What he left unsaid is that Nvidia has just positioned itself as the tollbooth at the entrance to that expansion — open to all, owned by one.

Inside Nvidia’s Agent Toolkit: the software stack designed to power every corporate AI worker

To grasp the significance of Monday’s announcements, it helps to understand the problem Nvidia is solving.

Building an enterprise AI agent today is an exercise in frustration. A company that wants to deploy an autonomous system — one that can, say, monitor a telecommunications network and proactively resolve customer issues before anyone calls to complain — must assemble a language model, a retrieval system, a security layer, an orchestration framework and a runtime environment, typically from different vendors whose products were never designed to work together.

Nvidia’s Agent Toolkit collapses that complexity into a unified platform. It includes Nemotron, a family of open models optimized for agentic reasoning; AI-Q, an open blueprint that lets agents perceive, reason and act on enterprise knowledge; OpenShell, an open-source runtime enforcing policy-based security, network and privacy guardrails; and cuOpt, an optimization skill library. Developers can use the toolkit to create specialized AI agents that act autonomously while using and building other software to complete tasks.

The AI-Q component addresses a pain point that has dogged enterprise AI adoption: cost. Its hybrid architecture routes complex orchestration tasks to frontier models while delegating research tasks to Nemotron’s open models, which Nvidia says can cut query costs by more than 50 percent while maintaining top-tier accuracy. Nvidia used the AI-Q Blueprint to build what it claims is the top-ranking AI agent on both the DeepResearch Bench and DeepResearch Bench II leaderboards — benchmarks that, if they hold under independent validation, position the toolkit as not merely convenient but competitively necessary.

OpenShell tackles what has been the single biggest obstacle in every boardroom conversation about letting AI agents loose inside corporate systems: trust. The runtime creates isolated sandboxes that enforce strict policies around data access, network reach and privacy boundaries. Nvidia is collaborating with Cisco, CrowdStrike, Google, Microsoft Security and TrendAI to integrate OpenShell with their existing security tools — a calculated move that enlists the cybersecurity industry as a validation layer for Nvidia’s approach rather than a competing one.

The partner list that reads like the Fortune 500: who signed on and what they’re building

The breadth of Monday’s enterprise adoption announcements reveals Nvidia’s ambitions more clearly than any specification sheet could.

Adobe, in a simultaneously announced strategic partnership, will adopt Agent Toolkit software as the foundation for running hybrid, long-running creativity, productivity and marketing agents. Shantanu Narayen, Adobe’s chair and CEO, said the companies will bring together “our Firefly models, CUDA libraries into our applications, 3D digital twins for marketing, and Agent Toolkit and Nemotron to our agentic frameworks to deliver high-quality, controllable and enterprise-grade AI workflows of the future.” The partnership extends deep: Adobe will explore OpenShell and Nemotron as foundations for personalized, secure agentic loops, and will evaluate the toolkit for large-scale workflows powered by Adobe Experience Platform. Nvidia will provide engineering expertise, early access to software and targeted go-to-market support.

Salesforce’s integration may be the one enterprise IT leaders parse most carefully. The company is working with Nvidia Agent Toolkit software including Nemotron models, enabling customers to build, customize and deploy AI agents using Agentforce for service, sales and marketing. The collaboration introduces a reference architecture where employees can use Slack as the primary conversational interface and orchestration layer for Agentforce agents — powered by Nvidia infrastructure — that participate directly in business workflows and pull from data stores in both on-premises and cloud environments. For the millions of knowledge workers who already conduct their professional lives inside Slack, this turns a messaging app into the command center for corporate AI.

SAP, whose software underpins the financial and operational plumbing of most Global 2000 companies, is using open Agent Toolkit software including NeMo for enabling AI agents through Joule Studio on SAP Business Technology Platform, enabling customers and partners to design agents tailored to their own business needs. ServiceNow’s Autonomous Workforce of AI Specialists leverage Agent Toolkit software, the AI-Q Blueprint and a combination of closed and open models, including Nemotron and ServiceNow’s own Apriel models — a hybrid approach that suggests the toolkit is designed not to replace existing AI investments but to become the connective tissue between them.

From chip design to clinical trials: how agentic AI is reshaping specialized industries

The partner list extends well beyond horizontal software platforms into deeply specialized verticals where autonomous agents could compress timelines measured in years.

In semiconductor design — where a single advanced chip can cost billions of dollars and take half a decade to develop — three of the four major electronic design automation companies are building agents on Nvidia’s stack. Cadence will leverage Agent Toolkit and Nemotron with its ChipStack AI SuperAgent for semiconductor design and verification. Siemens is launching its Fuse EDA AI Agent, which uses Nemotron to autonomously orchestrate workflows across its entire electronic design automation portfolio, from design conception through manufacturing sign-off. Synopsys is building a multi-agent framework powered by its AgentEngineer technology using Nemotron and Nemo Agent Toolkit.

Healthcare and life sciences present perhaps the most consequential use case. IQVIA is integrating Nemotron and other Agent Toolkit software with IQVIA.ai, a unified agentic AI platform designed to help life sciences organizations work more efficiently across clinical, commercial and real-world operations. The scale is already significant: IQVIA has deployed more than 150 agents across internal teams and client environments, including 19 of the top 20 pharmaceutical companies.

The security sector is embedding itself into the architecture from the ground floor. CrowdStrike unveiled a Secure-by-Design AI Blueprint that embeds its Falcon platform protection directly into Nvidia AI agent architectures — including agents built on AI-Q and OpenShell — and is advancing agentic managed detection and response using Nemotron reasoning models. Cisco AI Defense will provide AI security protection for OpenShell, adding controls and guardrails to govern agent actions. These are not aftermarket bolt-ons; they are foundational integrations that signal the security industry views Nvidia’s agent platform as the substrate it needs to protect.

Dassault Systèmes is exploring Agent Toolkit software and Nemotron for its role-based AI agents, called Virtual Companions, on its 3DEXPERIENCE agentic platform. Atlassian is working with the toolkit as it evolves its Rovo AI agentic strategy for Jira and Confluence. Box is using it to enable enterprise agents to securely execute long-running business processes. Palantir is developing AI agents on Nemotron that run on its sovereign AI Operating System Reference Architecture.

The open-source gambit: why giving software away is Nvidia’s most aggressive business move

There is something almost paradoxical about a company with a multi-trillion-dollar market capitalization giving away its most strategically important software. But Nvidia’s open-source approach to Agent Toolkit is less an act of generosity than a carefully constructed competitive moat.

OpenShell is open source. Nemotron models are open. AI-Q blueprints are publicly available. LangChain, the agent engineering company whose open-source frameworks have been downloaded over 1 billion times, is working with Nvidia to integrate Agent Toolkit components into the LangChain deep agent library for developing advanced, accurate enterprise AI agents at scale. When the most popular independent framework for building AI agents absorbs your toolkit, you have transcended the category of vendor and entered the category of infrastructure.

But openness in AI has a way of being strategically selective. The models are open, but they are optimized for Nvidia’s CUDA libraries — the proprietary software layer that has locked developers into Nvidia GPUs for two decades. The runtime is open, but it integrates most deeply with Nvidia’s security partners. The blueprints are open, but they perform best on Nvidia hardware. Developers can explore Agent Toolkit and OpenShell on build.nvidia.com today, running on inference providers and Nvidia Cloud Partners including Baseten, CoreWeave, DeepInfra, DigitalOcean and others — all of which run Nvidia GPUs.

The strategy has a historical analog in Google’s approach to Android: give away the operating system to ensure that the entire mobile ecosystem generates demand for your core services. Nvidia is giving away the agent operating system to ensure that the entire enterprise AI ecosystem generates demand for its core product — the GPU. Every Salesforce agent running Nemotron, every SAP workflow orchestrated through OpenShell, every Adobe creative pipeline accelerated by CUDA creates another strand of dependency on Nvidia silicon.

This also explains the Nemotron Coalition announced Monday — a global collaboration of model builders including Mistral AI, Cursor, LangChain, Perplexity, Reflection AI, Sarvam and Thinking Machines Lab, all working to advance open frontier models. The coalition’s first project will be a base model codeveloped by Mistral AI and Nvidia, trained on Nvidia DGX Cloud, that will underpin the upcoming Nemotron 4 family. By seeding the open model ecosystem with Nvidia-optimized foundations, the company ensures that even models it does not build will run best on its hardware.

What could go wrong: the risks enterprise buyers should weigh before going all-in

For all the ambition on display Monday, several realities temper the narrative.

Adoption announcements are not deployment announcements. Many of the partner disclosures use carefully hedged language — “exploring,” “evaluating,” “working with” — that is standard in embargoed press releases but should not be confused with production systems serving millions of users. Adobe’s own forward-looking statements note that “due to the non-binding nature of the agreement, there are no assurances that Adobe will successfully negotiate and execute definitive documentation with Nvidia on favorable terms or at all.” The gap between a GTC keynote demonstration and an enterprise-grade rollout remains substantial.

Nvidia is not the only company chasing this market. Microsoft, with its Copilot ecosystem and Azure AI infrastructure, pursues a parallel strategy with the advantage of owning the operating systems and productivity software that most enterprises already use. Google, through Gemini and its cloud platform, has its own agent vision. Amazon, via Bedrock and AWS, is building comparable primitives. The question is not whether enterprise AI agents will be built on some platform but whether the market will consolidate around one stack or fragment across several.

The security claims, while architecturally sound, remain unproven at scale. OpenShell’s policy-based guardrails are a promising design pattern, but autonomous agents operating in complex enterprise environments will inevitably encounter edge cases that no policy framework has anticipated. CrowdStrike’s Secure-by-Design AI Blueprint and Cisco AI Defense’s OpenShell integration are exactly the kind of layered defense enterprise buyers will demand — but both are newly unveiled, not battle-hardened through years of adversarial testing. Deploying agents that can autonomously access data, execute code and interact with production systems introduces a threat surface that the industry has barely begun to map.

And there is the question of whether enterprises are ready for agents at all. The technology may be available, but organizational readiness — the governance structures, the change management, the regulatory frameworks, the human trust — often lags years behind what the platforms can deliver.

Beyond agents: the full scope of what Nvidia announced at GTC 2026

Monday’s Agent Toolkit announcement did not arrive in isolation. It landed amid an avalanche of product launches that, taken together, describe a company remaking itself at every layer of the computing stack.

Nvidia unveiled the Vera Rubin platform — seven new chips in full production, including the Vera CPU purpose-built for agentic AI, the Rubin GPU, and the newly integrated Groq 3 LPU inference accelerator — designed to power every phase of AI from pretraining to real-time agentic inference. The Vera Rubin NVL72 rack integrates 72 Rubin GPUs and 36 Vera CPUs, delivering what Nvidia claims is up to 10x higher inference throughput per watt at one-tenth the cost per token compared with the Blackwell platform. Dynamo 1.0, an open-source inference operating system that Nvidia describes as the “operating system for AI factories,” entered production with adoption from AWS, Microsoft Azure, Google Cloud and Oracle Cloud Infrastructure alongside companies like Cursor, Perplexity, PayPal and Pinterest.

The BlueField-4 STX storage architecture promises up to 5x token throughput for the long-context reasoning that agents demand, with early adopters including CoreWeave, Crusoe, Lambda, Mistral AI and Nebius. BYD, Geely, Isuzu and Nissan announced Level 4 autonomous vehicle programs on Nvidia’s DRIVE Hyperion platform, and Uber disclosed plans to launch Nvidia-powered robotaxis across 28 cities and four continents by 2028, beginning with Los Angeles and San Francisco in the first half of 2027.

Roche, the pharmaceutical giant, announced it is deploying more than 3,500 Nvidia Blackwell GPUs across hybrid cloud and on-premises environments in the U.S. and Europe — what it calls the largest announced GPU footprint available to a pharmaceutical company. Nvidia also launched physical AI tools for healthcare robotics, with CMR Surgical, Johnson & Johnson MedTech and others adopting the platform, and released Open-H, the world’s largest healthcare robotics dataset with over 700 hours of surgical video. And Nvidia even announced a Space Module based on the Vera Rubin architecture, promising to bring data-center-class AI to orbital environments.

The real meaning of GTC 2026: Nvidia is no longer selling picks and shovels

Strip away the product specifications and benchmark claims and what emerges from GTC 2026 is a single, clarifying thesis: Nvidia believes the era of AI agents will be larger than the era of AI models, and it intends to own the platform layer of that transition the way it already owns the hardware layer of the current one.

The 17 enterprise software companies that signed on Monday are making a bet of their own. They are wagering that building on Nvidia’s agent infrastructure will let them move faster than building alone — and that the benefits of a shared platform outweigh the risks of shared dependency. For Salesforce, it means Agentforce agents that can draw from both cloud and on-premises data through a single Slack interface. For Adobe, it means creative AI pipelines that span image, video, 3D and document intelligence. For SAP, it means agents woven into the transactional fabric of global commerce. Each partnership is rational on its own terms. Together, they form something larger: an industry-wide endorsement of Nvidia as the default substrate for enterprise intelligence.

Huang, who opened his career designing graphics chips for video games, closed his keynote by gesturing toward a future in which AI agents do not just assist human workers but operate as autonomous colleagues — reasoning through problems, building their own tools, learning from their mistakes. He compared the moment to the birth of the personal computer, the dawn of the internet, the rise of mobile computing.

Technology executives have a professional obligation to describe every product cycle as a revolution. But here is what made Monday different: this time, 17 of the world’s most important software companies showed up to agree with him. Whether they did so out of conviction or out of a calculated fear of being left behind may be the most important question in enterprise technology — and it is one that only the next few years can answer.