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First newborns join screening for more than 200 rare diseases

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First newborns join screening for more than 200 rare diseases
BBC  Dominika Nanus and her one-day-old daughter Emilia, who is part of the screening programmeBBC

Dominika’s one-day-old daughter Emilia is part of the screening programme

The entire genetic code of up to 100,000 newborn babies in England will be analysed by the NHS, with the aim of speeding up the diagnosis and treatment of more than 200 rare diseases.

At present, newborns are given a heelprick blood test that checks for nine serious conditions, including cystic fibrosis.

As part of this new study, led by Genomics England, blood samples will be taken from babies’ umbilical cords to help diagnose many more gene disorders, such as haemophilia and spinal muscular atrophy.

Hundreds of blood samples have already been collected from babies born at 13 hospitals in England; around 40 hospitals will eventually offer the test.

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Jemma and her newborn son, Hugo

Jemma Jordan with her two-day-old son, Hugo, who is part of the screening programme

There are approximately 7,000 single gene disorders, but the programme will look only for those disorders that develop in early childhood for which there are effective treatments.

In some cases the diseases are curable, if caught early.

Screening newborn babies for these rare diseases involves sequencing their complete DNA – or genome – using blood samples from their umbilical cord.

At Birmingham Women’s Hospital, which is already offering the screening test, Dominika Nanus, 38, told me it was a “no-brainer” to take part in the study, having seen it advertised on a poster during an antenatal appointment.

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She said her daughter Emilia, born the previous day, would “benefit directly but also contribute to wider research”.

Before she had even named her two-day-old son – now called Hugo – Jemma Jordan, 40, told me she had no hesitation in having him screened, because she would rather know if there were any health issues “from the offset”, and because it would help children in the future.

Dr Ellen Thomas, chief medical officer at NHS England, said the 200 conditions the study looks for cause “substantial health problems early in childhood”.

“The treatments and interventions which are available for all of them can have a dramatic impact on that child,” she added.

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‘Don’t hesitate’

Lucy White with her son Joshua, who is nine years old

Lucy White with her son, Joshua Curtis, 9, who has MLD and can no longer walk or talk

At present it can take years for genetic diseases to be diagnosed, and these are often picked up only once a child becomes seriously ill.

Lucy White’s son Joshua, aged nine, has a rare genetic disorder called early juvenile Metachromatic Leukodystrophy (MLD), which is part of the new screening test.

Joshua was apparently healthy at birth, but his mobility began deteriorating at about the age of four, and in the past two years he has lost the ability to walk or talk.

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Lucy, from Surrey, says it took more than two years of hospital appointments, specialist visits, scans and other procedures before they were given a diagnosis.

Had Joshua’s condition been identified at birth he might have been eligible for a clinical trial of a treatment now available on the NHS that can halt the damage done by MLD.

Lucy has given up work as Joshua needs round-the-clock care and is tube-fed. She says he may have only another 10 years to live as the genetic condition is progressive.

She urged parents to sign up for the screening test.

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“Do not hesitate. If you can save your child’s life, that is more important than anything in this world,” she said.

Joshua dancing and singing - image taken from a family video

Just two years ago, Joshua could dance and sing

When those children selected to take part in the study turn 16, they will be asked if they want to continue in the research programme, which could involve analysing other parts of their DNA for conditions that might potentially develop when they are adults.

This might include certain cancers, heart disease or dementia.

But it might also raise ethical questions about what health information is appropriate to share with individuals about their future health risks.

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Genomics England said the entire focus of the study was on treatable conditions occurring early in childhood, and no decisions had yet been made on how whole genome sequences would be used in the future.

Dr Rich Scott, chief executive officer at Genomics England, called the study “a pivotal moment”.

He said the plan was to collect evidence to determine whether genomic newborn screening should be offered to all children.

NHS England chief executive Amanda Pritchard said diagnosing rare conditions in newborn babies through genomic testing “had the potential to give thousands of children the chance to access the right treatment at the right time, giving them the best possible start to life”.

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Amazon’s record forest fires hit Brazil’s indigenous communities

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Amazon's record forest fires hit Brazil's indigenous communities
BBC Raimundinha Rodrigues Da Sousa BBC

Raimundinha Rodrigues Da Sousa says her indigenous community is at risk from inhaling so much smoke

“If these fires continue, we indigenous people will die.”

Raimundinha Rodrigues Da Sousa runs the voluntary fire service for the Caititu indigenous community in the Brazilian Amazon.

Their land is supposed to be protected under the Brazilian constitution.

But it has been on fire for more than 15 days.

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For her brigade, their fight feels personal.

“Today it is killing the plants, in a while it will be us, because we inhale so much,” she says.

“It is a very aggressive fire that kills everything that comes its way.”

Her father, Ademar, tells us the constant smoke has caused him respiratory problems.

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“I can’t sleep due to a lack of air. It wakes me up, I feel like I’m drowning,” he says.

Getty Images A fire in the Amazon rainforest Getty Images

More than 62,000 square kilometres of Amazon rainforest has been burned this year already

The Amazon has had its worst forest fires in two decades. More than 62,000 square kilometres have been burned this year already – an area bigger than countries like Sri Lanka or Costa Rica.

The world relies on the Amazon to absorb a lot of its carbon. These fires mean it is now emitting record amounts itself.

Most fires here are illegally started by humans, according to scientists, the Federal Police, and the government: loggers and miners looking to exploit land in the Amazon, or farmers turning it into pasture.

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It is much rarer for fires to occur naturally in the humid, tropical rainforest.

Many fires encroach on protected reserves or indigenous land, either by accidentally getting out of hand, or set by people as deliberate attempts to grab land.

Raimundinha says that when her brigade arrives at the scene of a fire, they often find bottles of gasoline and matches.

As she speaks, she spots another plume of smoke from some trees. She is certain it was started deliberately, as they’d only just extinguished the fires there and created a natural barrier to stop it spreading, by removing any dry vegetation from the area.

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Her team go to investigate. As we get nearer, there is a distinctive smell of smoke.

The landscape on the way to the fire is like a graveyard of trees, collapsed and blackened in their entirety.

The rainforest here barely merits its name. The trees still standing are charred and warped like burnt matchsticks. The ground is coated in white powder like the remains of a barbecue.

Her team try to put out the flames with hoses they use to spray water, attached to small plastic containers they wear like backpacks. The water is limited, so they have to be selective.

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The problem is, as soon as one is put out, another starts.

The indigenous chief, Ze Bajaga, says that the majority of these fires are arson, set by people who “no longer want the wellbeing of humanity, or nature”.

He blames a lack of “humanity”.

Zé Bajaga

Zé Bajaga, an indeigenous chief, says a lot of the fires are caused by arson

In recent years, deforestation has slowed in the Amazon. But despite attempted crackdowns by state authorities, lawlessness is still rife, and the state presence feels minimal.

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Some of the Amazon is privately owned by individuals or companies. Private owners are meant to conserve 80% of the rainforest on their land by law, and can develop the remaining 20%. But this is not well policed.

Some of the land is classified as a state-owned protected reserve, or as an indigenous reserve. Some land though is undesignated entirely – meaning it is not privately owned by anyone, and has also not been protected as a reserve.

Those areas are particularly vulnerable to land-grabs. Everywhere you drive or fly over in the south of Amazonas state, mines, loggers and farms are visible.

Dorismar Luiz Baruffi, a soy farmer based in the Amazonas town of Humaitá, has owned his land for many years. He is against the fires, but can explain why farming has “exploded” in the Amazon.

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Dorismar Luiz Baruffi

Dorismar Luiz Baruffi says there is still a lot of land to be cultivated in the Amazonas

At the heart of his, and others’, argument is the belief more land should be productive, not just protected.

“Growth of the population has increased planting up here. I started here because the region is good, it rains well here,” he explains.

“I believe if you’re working within the law, there’s no problem. It is a place that provides food. It is a state that can produce a lot. I think there is still a lot of land to be cultivated here in Amazonas.”

Deforestation is bad for farmers too though. The fewer trees there are, the less water vapour is emitted to create rain for their crops – which some farmers burn their land to make room for.

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“We did poorly this year because of the drought,” he says.

Cracked land shows the extent of the drought in the area

Brazil is also currently experiencing its worst ever drought

The fires may be mostly started by humans, but they have been made worse by Brazil’s worst-ever drought, which has turned the normally damp vegetation into a dry tinderbox.

The drought has seen the level of the rivers drop to historic lows, and almost 60% of the country is under stress from the drought.

The rivers, in parts, are now completely dry and resemble a parched desert.

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João Mendonça and his community live by the river. But the dry riverbed means they can no longer travel on the water, meaning they are cut off from nearby towns and cities.

Every day, at dawn, they must now travel by foot to the nearest city to fill up tanks of water.

Here, dolphins can be spotted popping out of the river and blue macaws fly overhead.

But João and his fellow villagers must then carry it on their backs to their community, burning their feet on the cracked dry riverbed and occasionally passing dead river life like turtles.

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They make this journey several times a day in scorching heat.

“It’s the worst drought I’ve ever seen in my life,” João says. “It has brought a lot of consequences… the absence of food on the riverside dwellers’ table. The fish are gone.”

“One of the biggest difficulties is access to the city, now the river is dry. There are elderly people, people with chronic illnesses who must make this journey.”

A group walk from the river across sand with water bottles

Communities have been cut off from the river impacting their livelihoods

Sandra Gomes Vieira, who lives with a kidney disease, and her family are among those now cut off from the city.

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“Before it was easier when I was feeling sick. My husband would put me in a canoe that would arrive in the city. Now, I must walk across that sand to reach it. There are days when I can’t do anything, I need people to carry me,” she says.

One of her three daughters has had to drop out of school: “She’s not studying because she couldn’t face walking across that sand in the heat. She felt sick.”

The drought is also making it harder to make a living.

“We live off selling products we grow. Now my produce is spoiling. And there is no way to take them to the city.”

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The impact of these fires and the drought on people’s lives in Amazonas is clear, but their message for everybody else is too.

“There are people who don’t even care about this kind of thing,” says Raimundinha Rodrigues Da Sousa, who is battling the fires every day.

“They’re just doing it without thinking about tomorrow. But for you to live in nature, you must take care of it.”

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Sizewell C nuclear project hit by fresh delays as investment talks drag on

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UK ministers have made contingency arrangements to fund the Sizewell C nuclear power project in case a final agreement with potential private investors is delayed by as much as two years, officials have admitted.

A £5.5bn subsidy scheme set up in August to support the construction of Britain’s next nuclear power station at Sizewell in Suffolk envisages a scenario where there is no agreement with private sector investors until mid-2026.

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The timeline for Sizewell C is already running late.

The last Conservative government had hoped to sign off the final investment decision by July this year but the process was disrupted by the UK general election. The government then set an end-of-year target date.

“The £5.5bn budget is based on cost estimates to fund the project until the current projected FID date with a contingency in case of delays to a FID until June 2026,” the Department for Energy Security and Net Zero said in a September letter to a campaign group Stop Sizewell C.

The UK government and French state-owned energy company EDF are expected to fund about 20 per cent each of the £20bn-plus project, with the other 60 per cent needed from institutional investors. 

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Several industry and Whitehall figures said no deal is expected before spring 2025 as ministers try to nail down firm commitments from investors for the 3.2-gigawatt project, capable of powering millions of homes.

Francois Xavier Basselot, managing director for Europe and the Middle East at Egis, an engineering consultancy involved in the design of Sizewell C, said the government had told partners that there would be no formal announcement until 2025. 

“They are obviously delaying the final investment decision but they are clearly committed to seeing it through. We will wait and see in Q1 next year,” he said.

The UK government insisted an agreement with investors could still be reached this year.

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Private investors in talks with the government over Sizewell have included Centrica, Schroders Greencoat, Emirates Nuclear Energy Corporation and Amber Infrastructure Group, according to people familiar with the matter.

However the final balance between the different investors is still being discussed and some have become more wary after the troubles faced by investors in the UK’s water sector, the people said.

Nuclear power has long been an unattractive sector for many investors due to factors ranging from cost overruns to the remote risk of a nuclear accident. 

New nuclear power is seen as critical to the UK government’s plans to slash carbon emissions as it can provide a steady supply of electricity, unlike intermittent solar and wind. 

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Yet only one nuclear power station is under construction in Britain, the Hinkley Point C project in Somerset, which is running several years late with a ballooning price tag of up to £46bn.

EDF is the majority investor in Hinkley Point C, with a 66.5 per cent stake, while CGN, a Chinese state-owned company, owns a 33.5 per cent stake. 

Ministers and EDF argue Sizewell C should be cheaper and easier to build than Hinkley Point C as lessons will have been learned from that project.

The UK government has so far committed £2.5bn to help fund the early stage development of Sizewell C before a final deal with private investors.

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It also announced up to £5.5bn in further support in August, with funding to be released in tranches and subject to approval.

All but one of the UK’s ageing fleet of existing nuclear power stations, owned by EDF with Centrica, are set to close down by the end of the decade. 

An energy department spokesperson said there were no plans for any further delays at Sizewell C. “New nuclear power stations such as Sizewell C will play an important role in helping the UK achieve energy security and net zero,” they said.

“Subsidies with extended timelines are a standard contingency measure and in no way indicative of project timelines. There are no plans for a delay to Sizewell C, with discussions with potential investors ongoing, and our intention to deliver the project as quickly as possible,” they added.

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But Alison Downes from Stop Sizewell C said ministers were “shoving public money” at the project without knowing its true cost.

“If Labour ministers have started waking up to the reality that Sizewell C cannot possibly help them decarbonise by 2030 this could explain why they are taking their time to make a final investment decision,” she said.

“However it could also indicate that the enormous, still-secret, cost and financing plans are causing considerable difficulties,” Downes added.

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Sex charge tutor case reveals ‘massive safeguarding hole’

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Sex charge tutor case reveals ‘massive safeguarding hole’
Getty Images Child writing in a note padGetty Images

A man charged with sexual assault has been advertising as a private tutor for children in maths and science, a BBC investigation has found.

The man, who we’re not naming for legal reasons, left his job as a teacher last year.

Bail conditions prevent him having any contact with children and he is due to stand trial in March.

We also found another teacher who has been barred from the classroom by a disciplinary panel but is now advertising one-to-one online tutoring sessions.

It comes after the BBC reported more than 90 private tutors had been convicted of sexual crimes against children over the last 20 years.

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BBC News has continued to examine the tutoring industry, in which there is no legal obligation for private tutors to undergo any background checks or be qualified to teach.

Charities say the cases of the two private tutors highlight a lack of regulation in this area.

Online tutoring advert for man contacted by the BBC

The man charged with sexual assault only removed his tutoring ad after the BBC contacted him

Until recently the ex-teacher who is charged with sexual assault had a personal tutoring website and an online advertisement which remained active.

The ad was only removed after the BBC made contact.

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We don’t know whether the man continued giving private lessons in maths and science after he was charged, but in a phone call he claimed to have stopped.

“It’s a massive hole in safeguarding,” says Marilyn Hawes, chief executive of the child protection campaigning group Freedom from Abuse.

“It’s a huge risk. The onus is on the individual [tutor] to be honest.”

The second tutor we found is a former science teacher who was brought before a disciplinary panel after taking a pupil on an overnight trip.

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The panel heard the girl’s parents had given permission for the outing and ruled that his interest in the child had been paternal and not sexual in nature.

But it decided his conduct was unacceptable and he had failed to maintain appropriate professional boundaries.

He was banned from teaching indefinitely and cannot teach in any school, sixth form college, relevant youth accommodation or children’s home in England.

He has been given permission to appeal against the decision in two years’ time.

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Criminal checks

Anyone wanting to work with children has to apply for a DBS – or Data and Barring service – check, which looks at criminal records and other databases of individuals banned from this kind of work.

There are three types, basic, standard and the most detailed – an enhanced check.

Under current regulations the former teacher does not need a DBS check to work as a tutor.

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But in his case, if an enhanced check had been done, it would have revealed the outcome of the disciplinary panel.

We discovered the man is still offering private online tuition.

We contacted him, posing as a parent, asking about lessons for a 15-year-old girl.

He messaged back, offering GCSE support with exam techniques and a trial online lesson.

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Following our investigation in September, the Children’s Commissioner for England, Dame Rachel de Souza, called for all private tutors to be properly DBS checked.

The Tutors’ Association, an optional membership organisation that represents 50,000 tutors across the UK, already demands its members have an enhanced DBS check.

‘My daughter was put at risk’

Our original report prompted several emails to the BBC from victims of abuse. They didn’t want to give their names.

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“I had a tutor at the age of 12. He tried to touch my breasts,” wrote one anonymous contributor. “I ran away to the bathroom and locked myself in. I refused all future lessons with him.”

A mother told us that she had dismissed her daughter’s English tutor for swearing and using inappropriate language. She told the tutor’s agency but it took no action.

“I later found out the tutor had been in a news report for physical assault,” she said. “My daughter was put at risk.”

The BBC has not corroborated their stories.

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The tutor who had been charged with sexual assault had been advertising on a website called Superprof.

It claims to be the top platform for private tutoring in the UK.

The company says it expects its tutors to have a DBS check and it encourages them to keep it updated.

There’s no suggestion that Superprof could have known about the charge against this particular tutor.

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It’s not clear when the man posted his advert, or whether he provided a clear DBS check, carried out before he was charged.

However, even an enhanced DBS only provides a snapshot of the applicant’s criminal record at the time of application.

Superprof told BBC News: “Our priority is the safety and wellbeing of everyone who uses the platform.”

The platform said tutors are asked to upload identification, education and work credentials when they sign up.

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Tutors also contacted the BBC to say they want to be able to get an enhanced DBS check to reassure clients. But these can only be applied for by an employer or an approved organisation.

One told us: “It should be a legal requirement, just like if you work in a school.”

The government says it expects tutoring agencies to follow safeguarding guidance – and that means DBS checks should be undertaken.

The Department for Education says it is now considering what further action might be appropriate.

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Ms Hawes, from Freedom from Abuse, suggests adults accompany children to tutoring sessions, adding: “If you’re taking your child to a tutor’s home, sit in the room with them, sit in the corner and read a book while they’re having their lesson.”

If you are experiencing any of the issues mentioned in this story you can visit BBC Action Line for a list of websites and helplines that can offer direct help at any time.

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Israel presses its military advantage

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This is an audio transcript of the Rachman Review podcast episode: ‘Israel presses its military advantage’

[MUSIC PLAYING]

Gideon Rachman
Hello and welcome to the Rachman Review. I’m Gideon Rachman, chief foreign affairs commentator of the Financial Times. This week’s podcast is about Iran, Israel and the risk of all-out war in the Middle East. My guest is Sanam Vakil, director of the Middle East program at Chatham House here in London. Israeli air strikes on Lebanon are continuing, and Iran has launched a major fusillade of ballistic missiles at Israel. So what are the calculations of all sides in this conflict? And can an all-out regional war still be avoided?

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Iran has launched a barrage of missiles at Israel. The weapons lit up the skies above Tel Aviv and Jerusalem, and there were frequent explosions as they were shot down by Israel’s Iron Dome missile defence system.

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Gideon Rachman
Israel has vowed to strike back after Iran’s missile attacks. Iran said that if that happens, it too will strike back. So we’re well into the cycle of escalation and counter-escalation with major questions about the future American involvement in the conflict. I began my conversation with Sanam Vakil by asking if she thinks the cycle of escalation can be broken.

Sanam Vakil
It all depends on where, when and how Israel will respond to Iran’s strike. If Israel is targeted and doesn’t hit Iran’s nuclear facilities, as many are suggesting, or if Israel is careful not to hit Iranian oil facilities or too much infrastructure, there could be a climbdown. And I think that’s really where we need to look in order to understand where we’re going. If civilian areas are targeted, if densely populated parts of the country are being considered in response to Iran hitting Tel Aviv, which was certainly incredibly risky and designed to be not just provocative, but to inflict real harm and damage on Israel, I think we are in risk of serious confrontation that will be hard to walk back from.

And that’s also because Israel . . . but I think most of the world is looking for an opportunity to weaken the Islamic republic. Iran for decades now has been a destabilising regional actor. Of course, it’s got its advanced nuclear program. It has recently sent ballistic missiles alongside drones to Russia. And so this is being perhaps pitched as a historic opportunity to humble the Islamic republic.

Gideon Rachman
OK. We’ll get to whether that opportunity really exists in the moment. But what kind of considerations do you think Iran was making and is making now as it attempted to respond to the almost dismantlement of Hizbollah in Lebanon and the assassination of the Hamas leader in Tehran? How do you think they’ve been thinking about this?

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Sanam Vakil
Well, I think it’s important to understand Iran’s position over the past year. When the horrific attacks of October 7th took place, it’s very clear now that Iran was also surprised. Iran has been a patron and a supporter of the axis of resistance groups, Hamas, Hizbollah, the Houthis, popular mobilisation forces in Iraq, as well as backing Bashar al-Assad. But it doesn’t have the command and control of all of these groups. And recently, over the past four years, since the death of the IRGC commander, Qasem Soleimani, the management and co-ordination of the axis of resistance has become much more decentralised.

So in response to the Hamas attacks on October 7th, the axis led by Hizbollah actually, decided to make this an axis issue, not just a Hamas issue. And they piled in on October 8th and began to pressure Israel with attacks that have been ongoing for the past year. And I think what became clear for Tehran is that certainly Israel has two existential issues, a Palestinian issue that it might or might not choose to resolve, but it also has an Iran issue. And the case for taking down the axis of resistance and addressing its security crisis with Iran — which is tied to the axis of resistance — has been mounting and growing for the past year.

So it comes as no surprise, I think, to key individuals in Iran that Israel is trying — and has been quite successful — in decapitating the leadership of the axis of resistance from taking out all of the, you know, rank and file and top three layers of Hizbollah’s command, also targeting Iranian facilities quite precisely in Syria, hitting the Houthis back and showcasing the breadth of Israel’s capabilities. But ultimately, what this all foreshadows is that, perhaps is an Israeli strategy designed to also send some missiles back to Tehran and make it clear that it’s not just the tentacles of the octopus that need to be cut off, but also to paraphrase the Israeli terminology, the octopus’s head.

Gideon Rachman
What is the octopus itself thinking then? Because, you know, as you say, they’ve lost key leaders, in Qasem Soleimani. Their supreme leader Khamenei is very old. There’s a relatively inexperienced new president and then there’s always this question about how much does the Iranian military make decisions on its own? Who’s making the decisions?

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Sanam Vakil
Well, Iranian decision-making, particularly on security and foreign policy issues, takes place in an institution known as the Supreme National Security Council, which is composed of the new incoming president and members of his cabinet, alongside IRGC and military leaders, representatives from the Office of the Supreme Leader. Effectively, you have the heads of the formal and informal parts of government, and they put forward recommendations that are then taken forward by the supreme leader, approved or disapproved. Over the past few months since the killing of Ismail Haniyeh — the Hamas leader in Tehran — there has been a growing debate in these circles in Iran as to whether the regime should pursue strategic patience and play the long game or push back and stop what looks like a haemorrhaging and targeting of Iranian assets and personnel across the region. And for the past few months, effectively, those in favour of patience were prevailing. But it looks like the hardliners have won over the debate.

Gideon Rachman
So the hardliners have won, but presumably even they are aware of the risks to Iran. Do you think Iran has a game plan for what happens if, I think seems likely, Israel hits back? I mean, there’s a question of how and when. But let’s say Israel goes for a fairly maximalist response. How much does Iran have left in terms of escalation?

Sanam Vakil
Iran is in a very difficult and defensive position. It doesn’t have the military capacity and conventional capabilities to fight back against Israel that has a quantitative military edge across the entire Middle East. And we should remember that Israel has the full backing and support of the United States that has also mobilised additional forces into the region. So if there is a strategy, it’s very hard to see Iran hit back, I think, deliberately to save its reputation, to also show the axis that it does have skin in the game and try and reassert some red lines. It did say immediately after the attack was finished last night that that’s it for Tehran. But it’s very clear that this is not where it ends. Israel is certainly going to respond and make it clear that if Iran counter-responds to an Israeli attack, that this is gonna get very ugly.

Gideon Rachman
We talked about Iran’s weakness and obviously, Israel’s feeling confident and militant at the moment. But there must be risks for Israel as well. I mean, so far have knocked all these rockets down and the Iron Dome was working well. But these are ballistic missiles, hundreds of them coming at Israel. And the likelihood of one of them striking central Tel Aviv at some point must be fairly high.

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Sanam Vakil
Certainly. And Iran provided very little warning. And these ballistic missiles move extremely fast. It takes about 12 minutes, I’ve heard, for them to move from Tehran to Tel Aviv. So this was not like the attack that we saw in April where Iran telegraphed and telephoned everyone and sent very slow-moving surface-to-surface and cruise missiles and drones into Israel. They didn’t give too much warning and time for Centcom to create a joint command structure where other Arab states could also participate. I think we’re in a very difficult moment. And clearly Iran has decided that while maybe there is no strategic off-ramp, by responding, perhaps there is an avenue where there can be greater momentum and push for a ceasefire in some of the other frontiers. Perhaps Arab states can play a diplomatic role?

Gideon Rachman
Arab states? But they have terrible relations with the Arab states.

Sanam Vakil
They don’t have good relations with their neighbours. I think that’s very fair to say. But Iran today is less isolated than it was a number of years ago. It has restored diplomatic ties with almost all regional countries, and so there are now more interlocutors that can prevail upon Tehran, but also pass messages back and forth to bring down the temperature.

Gideon Rachman
And we mentioned obviously, the US plays an absolutely critical role in all this. And, you know, over the years there’s been speculation not just that Israel might attack Iran’s nuclear facilities, but that America might. But, you know, I’m sure we’ve talked to many of the same people over the last year. It’s been pretty clear to me that the Biden administration does not want a major escalation in the Middle East, was urging Israel not to go full force after Hizbollah, but now we are where we are. Biden has come out saying they’re fully behind Israel. How do you think the Americans are seeing it? May they be coming around to the Israeli point of view that this actually is a unique opportunity to take out the axis of resistance, to strike a real blow at the Islamic republic?

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Sanam Vakil
I think this is a really concerning moment, not just for the limited US engagement and the metastasising conflicts in the region, but also for regional states as well, who are deeply concerned that the US seems relatively absent, preoccupied obviously with its own election and domestic problems. And President Biden has taken an approach which has been very clear to defend Israel’s security and clearly will not put any further handcuffs on Israel in advance of this US election. The war in Gaza has already caused enough upheaval on US campuses, and clearly Middle East politics have become very partisan in the US on both sides. And so they don’t want this conflict to be a cause for Kamala Harris to lose this election, for example.

But I think we’re in a real existential moment, because if Israel does decide to hit some nuclear facilities, this is where the war will get out of hand, I would imagine, and Iran will escalate. And Iran has made it very clear that if certain infrastructure, from its oil refineries, let alone its nuclear program, are targeted, Iran will export the conflict beyond Iran and not just hit US bases, I would imagine, in Syria and Iraq, but also target its neighbours, Gulf Arab infrastructure as a way of pressuring the US as well as other countries.

Gideon Rachman
Wouldn’t that kind of be signing their own death warrant? If they attack the US directly or they attack the Saudis, then all these countries will say, well, now we have carte blanche to go after the Islamic republic.

Sanam Vakil
I’m with you. It is a death warrant. And that’s why we’re in this dangerous cycle and it doesn’t seem we have any off-ramps. There is a lot of talk taking place on social media, in the media by political leaders also, that seem to be indulging this war footing from Israel without thinking about the consequences.

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Gideon Rachman
So what are the consequences? Because I guess, you know, if I were an Israeli, I’ll say, well, the consequence we’re talking about is the overthrow of this regime that none of us like anyway. So that’s good, isn’t it?

Sanam Vakil
I wish it was so simple, Gideon. The last time the international community supported the overthrow of a regime, it didn’t work very well. And 21 years on, from that war, the US is in a very different place. It’s diminished. It has domestic demands and priorities. I think it’s unrealistic for us to get behind this notion of regime change. I can’t imagine western states supporting this in today’s climate. I also can’t imagine regional states supporting this in this climate. So I think we have to have the courage to say that regime change is not on offer. What is on offer? If there’s going to be a cycle of escalation, it has to lead to a cycle of de-escalation. And that’s gonna require clear red lines, deterrence and negotiation, not regime change. Regime change for what? For whom? By whom? It seems really lofty and unrealistic.

Gideon Rachman
Yeah, and in fact, now we’re talking, I remember, I think correctly, that Phil Gordon — who is Harris’s national security adviser — wrote a book with the subtitle The False Promise of Regime Change in the Middle East. So there are Americans who’ve lived through the experiences of Iraq, Afghanistan, etc, and who, at least in theory, are resistant to this notion of regime change. But one sort of feels the train’s rolling a bit towards a very radical attempt to take down the Islamic republic.

Sanam Vakil
I would just say one additional point, that there is clear dissatisfaction, opposition across Iran towards its leadership. We’ve seen that through so many rounds of very fierce and powerful protests from within Iranian society that is organic. There is a legitimacy crisis and Iran’s leadership know it. But wars bring out complicated narratives and complicated emotions. And there is a scenario where Iranian people will rally around the flag in the same way that Lebanese people who are seeing their country face another war with Israel, another occupation by Israel, potentially long-term, who dislike Hizbollah, who see Hizbollah as a destructive destabilising force within the Lebanese system, are fiercely nationalistic in this moment. And that’s important to also consider.

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Gideon Rachman
One other major development in a week of incredibly dramatic developments was the death of Hassan Nasrallah, killed by the Israelis. How much can Hizbollah, do you think, function without its long-standing leader?

Sanam Vakil
The death of Hassan Nasrallah is hugely significant. I think he provided a lot of moral but also symbolic leadership for Hizbollah for a number of decades now. And he was particularly close to the Iranian leadership and particularly close to Ali Khamenei, Iran’s supreme leader. That closeness shouldn’t be underestimated because actually, after the death of Qasem Soleimani as well, Hizbollah took an even more important role for Iran’s management of the axis of resistance. Hizbollah was the partner and the co-ordinator in chief in bringing the groups together and coordinating operations around the region.

So his death is a massive blow. Certainly, I think the organisation had prepared for scenarios where he might have been killed along the way. I think the bigger challenge though is that his death comes alongside the killing of three layers of Hizbollah’s leadership. Certainly, there will be a long list of people who will fill shoes of those that have been killed, but they’re untested, they’re unknown and perhaps more ideological than Nasrallah himself. Believe it or not, he was seen to be relatively pragmatic after being the leader of Hizbollah for so long. So this is what’s dangerous about this moment.

Gideon Rachman
Yeah. Let’s finish in the moment on Lebanon. We shouldn’t forget because that’s where the actual war is currently going on, as well as Gaza. But thinking of other things that might happen in this military conflict, sort of regime change, etc. Because Iran doesn’t have great options. But one of the things they’ve discussed over the years is shutting down the oil flows from the west. And are they capable of doing that, at least for a while, because that would obviously disrupt energy markets and cause the petrol price to soar just ahead of the US presidential election?

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Sanam Vakil
I mean, there are, I think, a number of scenarios on offer and we’re going to hear a lot of them trotted out over the coming days. But attacks on ships, you know, that’s certainly been under way, led by the Houthis in the Red Sea. I think attacks on infrastructure across the region, oil refineries and the like, pipelines, desalination plants, any kind of infrastructure can be targeted by Iran, but also by the axis of resistance. And it’s important to remember that the axis of resistance is down. It’s certainly degraded, but it hasn’t been destroyed, not in Gaza, not in Lebanon and not in other parts of the Middle East just yet.

Gideon Rachman
Israel is currently at war in Lebanon and in Gaza. Looking at the Lebanese conflict, there are already, according to Lebanese government, you know, thousands of people dead, a million people displaced. Do we have any sense of how that can be put back together again? I mean, is there any possibility that this is, as the Israelis say, a limited ground incursion and that they will feel they’ve done enough damage to Hizbollah and they’ll pull out?

Sanam Vakil
I’m not terribly optimistic, unfortunately. I think there was a moment of opportunity as Israel was foreshadowing a ground invasion and Nasrallah was killed for the Lebanese government to showcase unity, elect a president — they’ve had a caretaker government for quite some time — and try and rebuild a state that hasn’t been cohesive or operational and lobby the international community for a ceasefire.

Instead, I think we’re in a bit of a rinse and repeat moment. I’m deeply worried that what Israel is trying to execute in Lebanon will look to a certain degree like what we’ve seen in Gaza. Mind you, there’s only supposedly one battalion in, but that Israel will occupy a good portion of southern Lebanon, obviously with the aim of achieving UN Security Council Resolution 1701, creating a buffer zone and making sure all threats are pushed back to the Litani river. But that would mean the long-term Israeli presence in another country, breaches of sovereignty and, of course, deep political and economic damage. Let’s not forget the huge loss of life, displacement for Lebanese citizens that nobody is really discussing.

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Gideon Rachman
Yeah. And the other thing that people have stopped discussing for a moment is Gaza, which presumably, the conflict continues there will be at a slightly lower intensity, but it’s not over yet by any means, is it?

Sanam Vakil
Absolutely. We are at the tragic one-year milestone of the Hamas attacks and the war. And nobody is talking about Gaza, which I think is really troubling and scary because there we have seen millions displaced, again, 41,000 people killed by official count, and no plan, no discussion of a ceasefire, let alone what comes next. Arab states are trying to get ahead of it, trying to reinvigorate some discussion. The Jordanian president last Friday at the UN again tried to challenge Israel to think about the future, dangling the promise of regional integration and the promise of peace in the region, if and only if they could consider the prospect of Palestinians and Palestinian statehood. Netanyahu spoke at the United Nations and didn’t mention the word Palestine once, and I think that is striking. And that in itself is the problem. Israel has not achieved security through a military conflict. And over and over again, decade after decade, it has proven its military prowess. It has quantitative military edge. But what it doesn’t have is security. And that can only be granted through negotiations, through a peace process, through investment in another way of thinking. And that still hasn’t come to light one year on.

Gideon Rachman
And in fact, if anything, it seems to be going the other way. I mean, the peace party in Israel or suddenly the two-state solution party is more or less collapsed, doesn’t it?

Sanam Vakil
Yes, there is no discussion. At least openly, in the public domain, about a two-state solution. There is no discussion about a solution. And that’s shocking but important to lay out there. Israel is one year on addressing its security, and Netanyahu has tried to rehabilitate himself and in fact, he has to a certain degree. And he’s brought more parties into his coalition. And he looks like he’s personally on stronger footing.

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But is Israel more secure today? I think not. That can only be achieved not through the barrel of a gun or through missiles as wars are executed today. Again, that can only happen through the hard work at a negotiating table and acknowledging that they have a domestic Palestinian security crisis that needs to be resolved. It’s worthwhile noting that there was an attack in Jaffa on Tuesday in Israel where Israeli citizens were killed. And this is not going away. You can degrade and decapitate Hizbollah. You can kill Hamas’s leadership. What you’re not doing is closing down the conflicts, addressing the structural challenges across the region that would give people hope, avenue for a better political future, economic prosperity. And that comes through self-determination, and that comes through the empowerment of people on the ground, not through a militarisation of conflict.

Gideon Rachman
Last question, though. I don’t think the US government would really disagree with what you just laid out. That more or less is their position, and yet they seem curiously powerless for the world’s sole superpower. I mean, it’s Israel that’s driving events, really, not the Biden administration.

Sanam Vakil
I think that most governments theoretically agree with this scenario. The reality is, of course, that it’s very hard to impose these solutions on your partners and allies. The US, of course, is less influential or unwilling to be more influential in this moment, as we previously discussed. But I think that political settlements are hard to achieve. Hard to achieve in four-year electoral cycles. They require strategy, they require investment, they require partnership and sustained co-operation. And that’s hard to sell, I think, in the west, in the UK, in Europe and in the United States. Everyone is looking to Washington, hoping that the next US president will take a bigger role, will take the lead in trying to solve some of these conflicts. But I don’t think that Washington alone can bear that burden. We have seen the US pull back and reprioritise, and it’s calling on its allies and partners to share the burden. And I think that the time is now for burden sharing.

[MUSIC PLAYING]

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Gideon Rachman
That was Sanam Vakil of Chatham House, ending this edition of the Rachman Review. Thanks for listening and please join me again next week.

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‘Israel vows rapid revenge’ and ‘Kate’s hug of love’

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'Israel vows rapid revenge' and 'Kate's hug of love'
 The I paper front page for 3 October

“Israel vows rapid revenge strike on Iran” says the i paper over a photo of crouching soldiers. “Netanyahu knows the US cannot restrain him now” is the paper’s analysis of how the Israeli prime minister views the conflict. In domestic British politics, the I judges that James Cleverly has been “catapulted” into Tory leader contention after delivering a “brilliant” speech to the party’s conference.
The Metro front page for 3 October

“Now Iran must pay the price”, is the headline on Metro’s front page, quoting former Israeli Prime Minister Naftali Bennett. He “urges strikes on nuclear plants to avenge” Iran’s missile attack on Israel on Tuesday.
The Financial Times front page for 3 October

“OpenAI asks investors not to back rivals” the Financial Times reports in its main headline. The ChatGPT maker is seeking to “shut out challengers to its early lead in generative artificial intelligence” after raising $6.6bn (£5bn) in funds, it says. Dominating the front page is a photo of a woman clutching a cat against a background of smoking rubble after an Israeli air strike on Beirut. “Mideast pain” reads the headline as “Israel vows to hit back at Iran”.
The Sun front page for 3 October

Catherine, Princess of Wales, embraces young cancer patient Liz Hatton on the front page of the Sun. “Kate’s hug of love” came when Liz, 16, visited her at Windsor Castle. The princess recently said she had completed chemotherapy. Making the paper’s second headline is “Keir’s swift £6k payback”, referring to news that Prime Minister Sir Keir Starmer has paid back £6,000 “in freebies – including Taylor Swift gig tickets”. “But critics said it was only a tiny percentage of the £107,145 in gifts and hospitality he has received since 2019,” the Sun adds.
The Daily Telegraph front page for 3 October

Catherine also “goes back to work with a hug” on the front of the Daily Telegraph, which carries the same photo. It was the princess’s first day back at work since completing chemotherapy. The Telegraph’s angle on the Middle East conflict is concern about the fitness of the UK’s armed forces to help defend Israel. The RAF “lacks weapons to hit Iranian missiles” and British destroyers are “ill-equipped”, it says, quoting defence experts and former Defence Secretary Sir Ben Wallace. The paper’s cartoonist Matt turns his attention to the end of the first Tory conference since the election, when the party saw its majority in Parliament crumble. “They’ve rebooked this hall for 2029,” one activist says to another as they pack up. “I asked if they’d need more seats and they said probably not.”
The Daily Express front page for 3 October

The photo of the Princess of Wales and young Liz makes the front of the Daily Express too – as does a story about the Middle East conflict. “Security chiefs fear rise in terror attacks in UK” the headline says over a photo of British police in front of pro-Israel demonstrators. The “crisis could ‘galvanise’ extremists to target British Jews”, according to the paper.
The Daily Mirror front page for 3 October

The Daily Mirror also leads on the “touching royal moment” at Windsor. On the Middle East conflict, the paper carries an appeal to British nationals still in Lebanon to “get out NOW”.
The Daily Mail front page for 3 October

The Daily Mail leads with Sir Keir coughing “up £6,000 to pay for his freebies” but “brave Kate’s hug for fellow cancer sufferer” also makes its front, with the same photo.
The Guardian front page for 3 October

Over a photo of mourners for an Israeli officer killed in Lebanon, the Guardian runs the headline “US warns Israel: we won’t support attacks on Iranian nuclear sites”. In domestic news, there is “alarm at rise in vaping among non-smokers” and BBC presenter Adrian Chiles reveals what he has “learned from five years of oversharing”.
The Times front page for 3 October

“Eight soldiers die in battle with Hezbollah” is the Times’ take on the latest stage of the Middle East conflict. It has a photo of an Iranian missile downed over Israel’s Negev Desert. Reporting Sir Keir’s repayment, the paper says he still has the “suits and specs”.
The Daily Star front page for 3 October

The “sarnie torment” of Line of Duty star Anna Maxwell Martin grips the Daily Star. She is, it says, “scared witless of sandwiches and fridges”. Vying for front page space along with the “bread-based comestible terror” are pieces on “Essex ghouls” and a shortage of “ugly dogs”.
AFP A firefighter works at the site of an overnight Israeli air strike in Beirut's southern suburb of Shayyah on October 2, 2024. AFP

A firefighter works at the site of an overnight Israeli air strike in Beirut on Wednesday

The Guardian leads on Washington’s attempts to contain the Middle East conflict. The paper says the White House fears that ultimately US forces could be drawn in, if the Israelis target Iran’s nuclear facilities. The Sun urges Britain and America not to be “squeamish” and back Israel all the way if, in its words, “Tel Aviv opts to cut the head off the snake”. The Daily Mirror favours persevering with diplomacy until, it says, “every avenue has been exhausted”. Gideon Rachman in the Financial Times observes that US President Joe Biden’s efforts to prevent a war in the Middle East are failing. He says that each time Israel has defied his calls for restraint, Washington has still come to its aid and, with the presidential election weeks away, this support is unlikely to weaken.

Analysis in the Daily Mail suggests targeting Iran’s nuclear centre might be the most dangerous option for Israel as Tehran could respond with dirty bombs – missiles tipped with nuclear waste. Equally bombing Iran’s oil export facility could lead to a retaliatory attack on Saudi Arabia, hitting global supplies and undermining international support. There is a suggestion in the I paper that Israel might hit Iran’s military bases or even its leadership.

Experts raise concerns in the Daily Telegraph that UK forces lack the equipment to help protect Israel. The Conservatives’ former Defence Secretary Sir Ben Wallace tells the paper the upgrade of systems on some of the Royal Navy’s anti-missile destroyers needs to be accelerated. The Daily Express reports that security chiefs fear the crisis could lead to terror attacks in the UK. The security services and the Met are said to be on “red alert”. A Jewish charity, the Community Security Trust, is mounting its biggest security operation before the anniversary of the 7 October attack by Hamas.

The Daily Mail suggests Sir Keir Starmer was “humiliated” into paying back what it calls his £6,000 worth of “freebies”. The Times points out he is keeping more than £40,000 worth of clothes, glasses and football tickets accepted in his time at Number 10. And the Sun calculates the repayment is just 5% of the £107,000 in gifts, benefits and hospitality Sir Keir has received since 2019.

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Several front pages show the first picture of the Princess of Wales at work since completing her chemotherapy. She is shown embracing a teenager with cancer, in what the Sun describes as “Kate’s hug of love”. Sixteen-year-old photographer Liz Hatton, who has a terminal diagnosis, was fulfilling a bucket list, according to the Mail when she was invited to take pictures at an investiture in Windsor Castle.

The I reports on research revealing how dolphins smile at one another to show they are ready to play. The author of the study at the University of Pisa explains that open-mouthed expressions and mimicry are often used by mammals and social carnivores to signal fun and avoid conflict.

And the Times says there is relief for the editor of Private Eye, Ian Hislop, after fears he was the target of an assassin. The police were called because of fears a gunshot had been fired into his black cab. A Met office investigation ensued and revealed a mechanical fault had caused the back window to shatter.

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Toyota delays US electric car production plans as EV sales slow

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Toyota delays US electric car production plans as EV sales slow

Toyota is pushing back the start date for electric vehicle (EV) manufacturing in the US, as global demand for battery-powered cars continues to soften.

The Japanese motor industry giant was aiming to start production in late 2025 or early 2026.

Toyota now expects to launch its US EV operation at an unspecified time in 2026, a company spokesperson told BBC News.

Several other major car makers, including Volvo and Ford, have recently scaled back their EV plans.

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“We’re still focused on our global [battery electric vehicle] target of 1.5M vehicles by 2026,” said Toyota spokesperson Scott Vazin, adding that in the next two years it plans to introduce “5 to 7 [battery electric vehicles] in the US market.”

Earlier this year, the firm announced it was investing $1.3bn (£980m) in its Kentucky factory as part of plans to build a three-row, electric sport utility vehicle (SUV) there.

The company has also announced plans to build another electric model at a plant in Indiana.

To support these goals Toyota is ramping up its lithium-ion battery production with a factory in North Carolina, which it expects will come online next year.

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Toyota’s announcement came as the global car industry continues to struggle with weakening demand for electric vehicles in some major markets.

On Wednesday, Tesla’s quarterly figures missed Wall Street expectations, putting leading EV maker at risk of its first-ever decline in annual deliveries.

Last month, Volvo abandoned its target to produce only fully electric cars by 2030, saying it now expected to be selling some hybrid vehicles by that date.

The company blamed changing market conditions for its decision to give up a target it had announced only three years ago.

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In August, Ford announced that it is shaking up its strategy for electric vehicles, scrapping plans for a large, three-row, all-electric SUV and postponing the launch of its next electric pickup truck.

Chief financial officer John Lawler said the firm was adjusting its plans in response to “pricing and margin compression”.

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