Health & fitness

World’s first ovarian cancer vaccine ‘could eliminate the deadly disease’ that kills thousands of Brits every year

Published

4 days ago

October 4, 2024

World's first ovarian cancer vaccine 'could eliminate the deadly disease' that kills thousands of Brits every year

THE WORLD’S first vaccine combating ovarian cancer that’s being developed in the UK could “wipe out” the deadly disease, researchers say.

Scientists at the University of Oxford are creating OvarianVax, a vaccine which teaches the immune system to recognise and attack the earliest stages of ovarian cancer.

Ovarian cancer is one of the most common forms of cancer affecting women in the UK - and is responsible for over 4,000 deaths a year — Ovarian cancer is one of the most common forms of cancer affecting women in the UK – and is responsible for over 4,000 deaths a yearCredit: Getty – Contributor

Ovarian cancer can cause vague symptoms like persistent bloating, stomach pain and needing to pee more oftenCredit: PA

The hope is that the jab could be given to women preventatively on the NHS with the aim of eliminating the disease.

Experts suggest it could work in a similar way to the human papillomavirus (HPV) jab, which is on track to stamp out cervical cancer.

HPV jabs are currently dished out to secondary school children and people at high risk of the virus, cutting their risk of getting conditions linked to HPV – including cervical cancer and genital warts.

Prof Ahmed Ahmed, director of the ovarian cancer cell laboratory at MRC Weatherall Institute of Molecular Medicine the University of Oxford, and his team are working to identify cellular targets for their ovarian cancer vaccine.

Read more on ovarian cancer

They will establish which proteins on the surface of early-stage ovarian cancer cells are most strongly recognised by the immune system, and how effectively the vaccine kills mini-models of ovarian cancer in the lab.

They will then move on to human clinical trials in people with BRCA gene mutations – which massively increase the risk of ovarian cancer – and healthy women in the general population to see if the disease could be prevented.

Cancer Research UK is funding the study with up to £600,000 over the next three years.

Prof Ahmed said that, if the jab is successful, he would expect to start seeing an impact within the next five years.

At present, some 4,100 Brits died of ovarian cancer every year.

Asked if ovarian cancer could be wiped out with the new vaccine, he said: “Absolutely – that would be the aim. We still have a long way to go but it is a really exciting time. I’m very optimistic myself.”

The 5 gynaecological cancers – symptoms and how to spot them

For the work, scientists will create the vaccine in the lab, with the aim of training the immune system to recognise more than 100 proteins on the surface of ovarian cancer, known as tumour-associated antigens.

They will then move to testing the vaccine in patients with the disease.

Prof Ahmed said: “The idea is, if you give the vaccine, these tiny tumours will hopefully either reduce, shrink really significantly, or disappear.

“That would give us the sign that the vaccine is working.”

The next stage would then be to include women with BRCA mutations and a wider general population of women without known disease to see whether “the vaccine would be suitable for all” in preventing ovarian cancer.

Prof Ahmed said: “Let’s imagine that it all goes well, and the vaccine really works well.

“Now, the obvious population who would benefit from this are the BRCA1 and BRCA2 mutation carriers, because they have a very high chance of getting ovarian cancer.

“If you give it to those patients and it’s effective, then you get the best health economics and the best cost-effectiveness.

What are the signs of ovarian cancer?

Ovarian cancers affects the ovaries – the organs that store the eggs needed to make babies.

It mostly affects women over the age of 50 and can sometimes run in families, according to the NHS.

Symptoms of the cancer can be vague, particularly in its early stages, Cancer Research UK SAYS.

The charity advises you speak to a GP if you have the following symptoms:

Feeling full quickly
Loss of appetite
Pain in your abdomen or lower part of your abdomen that doesn’t go away
Bloating or an increase in the size of your abdomen
Needing to wee more often
Tiredness that is unexplained
Weight loss that is unexplained
Changes in your bowel habit or symptoms of irritable bowel syndrome, especially if this starts after the age of 50

The NHS added that bleeding from the vagina after the menopause could be another possible symptom of ovarian cancer.

“The question then becomes – would it really benefit the general population? Could you offer it to everyone?”

At the moment, there is no screening test for ovarian cancer, which is often diagnosed in late stages because the symptoms – such as bloating and no appetite – can be vague.

Women with BRCA mutations, such as actress Angelina Jolie, are at high risk.

Almost 45 per cent of people with an altered BRCA1 gene and almost 20 per cent with an altered BRCA2 gene will develop ovarian cancer by the age of 80, compared with just 2 per cent in the general population.

Currently, women with BRCA1/2 alterations are recommended to have their ovaries removed by the age of 35, which means they go through early menopause and cannot have children afterwards.

Prof Ahmed said BRCA mutation carriers could benefit greatly from the new vaccine because “they wouldn’t then have to have their ovaries removed”.

However, he said his team will be trying to get the best components included in the vaccine so it “would be effective for as many people as possible”, including the wider population.

He added: “I am optimistic because we are talking about preventing the very first few cancer cells that develop – and not trying to cure or treat or prevent the tumour coming back.

“I’m hoping that, because the number of cells that we will be targeting is quite small, we will have success.

“We’ve seen success with the HPV vaccine – it’s really, really incredibly effective.”

Prof Ahmed told PA that “while the full blown timeline” for a vaccine being approved “might be many years away”, the “impact that it would have, if it’s successful, would hopefully be much sooner”.

He said that, through the clinical trials, he would hope to start seeing the impact of the vaccine “in four or five years on the healthy population”.

There are around 7,500 new ovarian cancer cases every year in the UK, with BRCA mutations accounting for around 5-15 per cent of these cases.

Michelle Mitchell, chief executive of Cancer Research UK, said: “Projects like OvarianVax are a really important step forward into an exciting future, where cancer is much more preventable.

All the ovarian cancer symptoms you need to know, plus little known symptoms of other gynaecological cancers

“This funding will power crucial discoveries in the lab which will realise our ambitions to improve ovarian cancer survival.

“OvarianVax builds on the exciting developments in vaccine technology during the pandemic.

“This is one of many projects which we hope will give women longer, better lives, free from the fear of cancer.”

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Womens Workouts

Day 27 – 30 MIN HIIT IT HARD Surprise Workout – Full Body, No Equipment, No Repeat

Published

29 mins ago

October 8, 2024

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Day 27 - 30 MIN HIIT IT HARD Surprise Workout - Full Body, No Equipment, No Repeat

Today we will HIIT IT HARD with 30 mins of full-body, calorie-burning, no-repeat exercises! We’re all in this together! From Day 1 to 28, you have all been encouraging and motivating each other – we’re an unstoppable team who love to get SUPER SWEATY… who agrees with me??
Get on your mat, let’s do it!!

WORKOUT DETAILS

👉🏼 Duration: 30 MIN (Plus 5 mins of cool-down stretches)
👉🏼 Intensity: Super Sweaty 💧💧💧
👉🏼 No Equipment
👉🏼 50 Sec Work, 10 Sec Rest
👉🏼 No Repeat

Please remember that we are all different and that you can make this your OWN workout… take a longer break when you need to.

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D I S C L A I M E R

If you are a newbie start with a simple and easy exercise before attempting all advanced exercises. Performing exercises out of your capability might strain your muscles and you may get injured.

This channel offers health, fitness and nutritional information. You should not rely on this information as a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment. By performing any fitness exercises without supervision like with this video, you are performing them at your own risk. See a fitness professional to give you advice on your exercise form. Growingannanas will not be responsible or liable for any injury or harm you sustain as a result of this video.

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Womens Workouts

😱💥most beutiful momentwomen.s😱 floor routine#shorts #video #viral #olympics #world #champions

Published

2 hours ago

October 8, 2024

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😱💥most beutiful momentwomen.s😱 floor routine#shorts #video #viral #olympics #world #champions
your question.
What is floor routine?
What are the rules of floor routine?
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Womens Workouts

25 MIN FULL BODY WORKOUT || Energising Mat Pilates

Published

3 hours ago

October 8, 2024

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25 MIN FULL BODY WORKOUT || Energising Mat Pilates

This Full Body Pilates Workout is perfect for when you are short on time and will leave you feeling strong and energised! 😊

🌸 Wearing Gymshark http://gym.sh/Shop-Nicole

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🎥 Videography by Bodie Rex
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—
DISCLAIMER:
Please consult your doctor or health care professional before starting this workout. If you experience pain or discomfort at any time during this workout, you should stop immediately. By performing these exercises, you do so at your own risk. By using this video, you understand and agree that Move With Nicole Pty Ltd will not be held responsible or liable for any injury or loss you may suffer as a result of this workout video.

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Womens Workouts

Tried Hulahoop for the first time🥰 #hulahoop #shorts #workout #coreworkout

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4 hours ago

October 8, 2024

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Tried Hulahoop for the first time🥰 #hulahoop #shorts #workout #coreworkout

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Womens Workouts

30 Minute Full Body Beginner Dumbbell Workout [With Modifications]

Published

5 hours ago

October 8, 2024

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30 Minute Full Body Beginner Dumbbell Workout [With Modifications]

Tap in with us for a 30 minute dumbbell strength workout—especially if you’re a beginner who needs guidance with weight training! Throughout this workout we will show you what muscles are working, how to do each exercise, and give you audio cues to make sure your form is correct. We designed this workout to include intermediate level exercises so that you have a level to work up to. However, if you struggle with certain exercises, we’ve included modifications for those intermediate exercises. Even if you’re a bit more advanced, you can always come back to this workout for a form check and guidance.

If you have any questions, drop them in the comments and we well get back to you as soon as we can!

Check out our other dumbbell workouts:
45 Minute Full Body Dumbbell Workout: https://youtu.be/qs9wyBQrNYA
30 Minute Full Body Dumbbell AMRAP: https://youtu.be/rEEZB68GTs0
30 Minute Full Body Dumbbell Workout https://youtu.be/4sUGg9mcMGU
20 Minute Full Body Dumbbell Workout: https://youtu.be/mf1xQS_Zlkc
20 Minute Light Dumbbell Workout: https://youtu.be/PFGeohvbNq8
15 Minute Full Body Dumbbell Workout: https://youtu.be/xqVBoyKXbsA
10 Minute Light Dumbbell Workout: https://youtu.be/mnzaEyTm-MA

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