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Breakthrough new ‘exercise pill’ mimics benefits of high-speed 10km run without ever leaving the sofa, scientists say

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Breakthrough new 'exercise pill' mimics benefits of high-speed 10km run without ever leaving the sofa, scientists say

A BREAKTHROUGH new pill could mimic the health benefits of running – but you don’t even have to leave the sofa.

Scientists at Aarhus University in Denmark developed a drug that they claim can replicate the impact of jogging at high speed for 10 kilometres.

A pill could replicated the effects of jogging for 10km on an empty stomach

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A pill could replicated the effects of jogging for 10km on an empty stomachCredit: Alamy

The pill contains a molecule called LaKe that can mimic the effect of exercise on the body’s metabolism after fasting – the practice of abstaining from food or drink for a period of time.

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Exercise and skipping meals can make your heart stronger and reduces fat levels in the blood, researchers said.

Working out helps to increase levels of lactates and ketones in the body, chemicals which our body’s cells use for fuel.

This in turn can increase the production of appetite-suppressing hormones while bringing down levels of fat in the blood.

LaKe contains a chemical fusion of of lactate and ketones.

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Prof Thomas Poulsen, from the Department of Chemistry at Aarhus University, said: “We’ve developed a molecule that can mimic the body’s natural metabolic response to strenuous exercise and fasting.

“In practice, the molecule brings the body into a metabolic state corresponding to running 10 kilometers at high speed on an empty stomach,” he explained.

“When lactate and ketone levels in the blood increase, the production of an appetite-suppressing hormone increases and the level of free fatty acids in the blood decreases.

“This has a number of health benefits, for example reducing the risk of developing metabolic syndrome.”

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According to the professor, it’s not possible to achieve the same effect through diet alone, since lactate and ketones can’t be consumed in high enough quantities without the buildup undesirable by-products such as acid and salt.

The 5-minute ‘lazy girl workout’ to tone your arms, abs and bum

This is where LaKe comes in, as the pill contains lactate and ketones without the harmful add ons.

Prof Poulsen said: “We have now created a molecule which allows us to artificially control the amounts of lactate and ketones safely.”

So far, the pill has only been tested on rats.

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But the first clinical trials in humans are now underway at Aarhus University Hospital.

According to Prof Poulsen, the trials could pave the way for the molecule to become a nutritional supplement if they’re successful.

Scientists behind the study – published in the scientific journal: Journal of Agricultural and Food Chemistry – said people who can’t follow a strict exercise and diet plan might find it helpful.

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Dr Thomas Poulsen, a chemist at Aarhus University who led the research, said: “It can be difficult to maintain motivation to run many kilometers at high speed and go without food.

“For people with physical ailments, such as a weak heart or general weakness, a nutritional supplement can be the key to better recovery.”

According to the researchers, LaKe also has potential to ease struggles with concentration and may even be used in the treatment of serious diseases such as Parkinson’s and dementia.

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These diseases are often characterised by low energy levels in the brain, which inhibit its optimal functioning, he explained.

Prof Poulsen said: “Because lactate can take over the role of glucose in the brain under stressful or traumatic conditions, there have been experiments to increase lactate levels in people with concussion.

“Patients who cannot perform strenuous exercise will benefit greatly from a drug that can boost these levels.”

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Brain-swelling ‘sloth’ fever could be caught via SEX as cases detected in Europe for first time

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Brain-swelling 'sloth' fever could be caught via SEX as cases detected in Europe for first time

DEBILITATING ‘sloth’ fever could be passed on via sex, experts fear, after the virus was detected in sperm.

The little-known disease, officially called Oropouche virus, was found in Europe this summer for the first time after it started spreading rapidly in Latin America.

'Sloth' fever could be transmitted via sex, experts have warned

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‘Sloth’ fever could be transmitted via sex, experts have warnedCredit: Getty

The bug typically circulates between primates, including sloths – hence the nickname – before it is occasionally passed to humans by midges and mosquitoes.

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Until now, experts didn’t think the virus could spread from person to person.

But a new study found “live” Oropouche virus in the semen of a 42-year-old Italian man 16 days after he initially developed symptoms, sparking concerns about possible sexual transmission.

The findings, published in Emerging Infectious Diseases, could also impact sperm donation and fertility treatments.

“Pending further evidence we recommend use of barrier protection when engaging in sexual intercourse if OROV is confirmed or suspected,” the Italian researchers said.

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Most Oropouche infections are mild, with symptoms similar to Dengue, including a headache, body pains, nausea, a rash and sensitivity to light.

Some individuals may also experience gastrointestinal symptoms, like sickness and diarrhoea.

In severe cases, the virus can also attack the brain leading to meningitis or encephalitis, which can be fatal.

To make matters worse, the disease is currently incurable.

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I felt like I’d been hit by a truck and put it down to heat stroke – it was a killer holiday virus

It has been circulating in Latin America and the Caribbean for decades.

A surge in cases of the bug, which is endemic in the Amazon Rainforest, has been recorded in Brazil this year – 7,284, up from 832 in 2023.

And many infections have been recorded in areas that have not previously seen the virus, including Cuba.

Last month, Brazil reported the world’s first deaths from the bug after two women in their early twenties passed away in Bahia state in the northeast of the country, 

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The two women, aged 21 and 24, suffered severe bleeding and hypotension and were reported dead on July 25.

At least 19 cases of Oropouche were reported in Europe for the first time in June and July, according to the European Centre for Disease Prevention and Control (ECDC) –  with 12 in Spain, five in Italy and two in Germany.

But these cases were imported into Europe – 18 of the people infected had just travelled back from Cuba and one of them from Brazil.

Oropouche virus: Everything you need to know

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Oropouche fever is a disease caused by Oropouche virus

It is spread through the bites of infected midges (small flies) and mosquitoes.

Symptoms of Oropouche fever are similar to dengue and include headache, fever, muscle aches, stiff joints, nausea, vomiting, chills, or sensitivity to light.

Severe cases may result in brain diseases such as meningitis.

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Symptoms typically start 4–8 days after being bitten and last 3–6 days.

Most people recover without long-term effects.

There are no specific medications or vaccines are available.

Precautions

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Travellers heading to affected areas should take steps to avoid bug bites.

The virus is endemic in many South American countries, in both rural and urban communities.

Outbreaks are periodically reported in Brazil, Bolivia, Colombia, Ecuador, French Guiana, Panama, Peru, and Trinidad and Tobago. 

Wear tops with long sleeves and long trousers, apply insect repellent regularly, and sleep under a mosquito net if you are not in enclosed, air-conditioned accommodation.

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Source: US Centre for Disease Control and Prevention

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The 8 subtle symptoms of Lyme disease – and why so many celebrities seem to get the debilitating bacterial infection

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The 8 subtle symptoms of Lyme disease - and why so many celebrities seem to get the debilitating bacterial infection

MIRANDA Hart is the latest in a string of famous people to be diagnosed with Lyme disease.

The bug has previously struck the likes of model Bella Hadid and her mum Yolanda, singers Justin Bieber and Avril Lavigne, and actor Ben Stiller to name a few.

Miranda Hart has been fighting Lyme disease

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Miranda Hart has been fighting Lyme diseaseCredit: Getty – Contributor
The actor and comedian initially thought she had agoraphobia, an anxiety disorder

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The actor and comedian initially thought she had agoraphobia, an anxiety disorderCredit: BBC

Lyme disease is a bacterial infection carried by ticks which spreads when they bite humans.

There are around 3,000 cases in England and Wales every year.

It can cause flu-like symptoms, including fatigue, headache, swollen joints and a fever, which can last for a few weeks.

In some cases, patients can suffer from side effects for years.

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Read more on Lyme disease

This is what happened to the Call The Midwife actor, for whom it took 33 years to get a Lyme disease diagnosis, after initially mistaking her symptoms for agoraphobia, an anxiety disorder.

The comedian has now opened up about the health battle she faced behind closed doors during an appearance on Radio 4’s Today programme while discussing her new book.

“I was basically bed-bound – and housebound,” the 51-year-old said.

“There’d be times where I’d look at a glass of water, and think, ‘I don’t know how to pick that up’.

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“All anyone wants is to be heard, accepted, loved and seen… and when you’re not – particularly in a medical situation – it’s the worst.”

So why does it seem like so many famous faces are being diagnosed with it?

Justin Bieber discusses his battle with Lyme disease and how it has affected him

Professor Paul Hunter, an expert in infectious diseases from the University of East Anglia, said there could be some factors that make celebrities more vulnerable.

“But it’s more likely that we’re more interested in hearing about celebrities, so we don’t hear about normal people,” he told The Sun.

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Stars’ increased leisure time and access to the wilderness where ticks live could put them at greater risk, he added.

“If there is a rich and famous or class bias in this, it’s probably because they spend more time walking around in wooded parkland, more money to go out to those areas, or have big homes with these sorts of places,” Prof Paul said.

“As you’re walking along, the ticks jump on your legs and crawl their way up, then have a blood feast and give you Lyme disease,” he previously told MailOnline.

Celebs also have access to better healthcare, so may be more likely to get a diagnosis – though it can still take some time.

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When Miranda finally received her diagnosis, she was able to trace the condition back to her teenage years.

Both Yolanda Hadid and her daughter have been diagnosed with Lyme disease

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Both Yolanda Hadid and her daughter have been diagnosed with Lyme diseaseCredit: Getty Images – FilmMagic
Bella, 28, has been suffering from the virus for 15 years

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Bella, 28, has been suffering from the virus for 15 yearsCredit: instagram
Justin Bieber was diagnosed with Lyme disease after receiving nasty remarks about his appearance

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Justin Bieber was diagnosed with Lyme disease after receiving nasty remarks about his appearanceCredit: Instagram/Justin Bieber
Ben Stiller told The Hollywood Reporter in 2011 that he caught the bug in Nantucket, Massachusetts

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Ben Stiller told The Hollywood Reporter in 2011 that he caught the bug in Nantucket, MassachusettsCredit: Getty

“Probably when I was about 14 or 15, I got a tick-borne illness and that’s when my symptoms started,” she recalled.

“It was such a relief. I mean, being misunderstood and misjudged is one of the hardest things about this kind of condition. For sure.”

Most celebs who have spoken about their Lyme disease diagnosis happen to live in the US – where there are over 300,000 cases per year.

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Alexis, 41, who is married to tennis legend Serena Williams, detailed his diagnosis in a series of posts on X (formally Twitter) earlier this year.

“Doing a full battery of health scans, tests, etc, and found out I have Lyme disease,” he said.

“Wild. No symptoms, thankfully, but gonna treat.”

Other celebs diagnosed with Lyme disease

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These stars have spoken candidly about their battle with the tick-borne disease:

  1. Yolanda Hadid
  2. Bella Hadid
  3. Anwar Hadid
  4. Riley Keough
  5. Amy Schumer
  6. Justin Bieber
  7. Avril Lavigne
  8. Shania Twain
  9. Ben Stiller
  10. Alec Baldwin
  11. Kelly Osbourne
  12. Miranda Hart

TV star Yolanda Hadid revealed she had suffered depression amid a pileup of symptoms for the better part of a decade, which she attributed to chronic Lyme.

“I can’t begin to describe the darkness, the pain and the hell I lived through every day,” the 60-year-old socialite told British Vogue in February 2021.

“This disease brought me to my knees.”

Her daughter, Bella – now 28 – also last year described how she had undergone 100 days of treatment amid a battle with the condition.

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The supermodel shared snaps of her medical records, which revealed the extent of her health problems spanning over a decade.

According to the documents, she suffered from extreme fatigue, memory disturbances, depressionsleep disorders, headaches, muscle weakness and joint aches as a teenager.

Avril Lavigne spoke of her own diagnosis in 2015

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Avril Lavigne spoke of her own diagnosis in 2015Credit: Getty
Stand-up comedian Amy Schumer took a lighthearted approach to announcing she had Lyme disease

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Stand-up comedian Amy Schumer took a lighthearted approach to announcing she had Lyme diseaseCredit: Getty – Contributor

She also experienced night sweats, heart palpitations, cold hands and feet, numbness, ADHD, ringing in her eyes and chest pain.

Singer Justin Bieber said, in January 2020, that doctors had diagnosed him with Lyme disease after receiving nasty remarks about his appearance. 

“While a lot of people kept saying, “Justin Bieber looks like s***, on meth” etc. they failed to realise I’ve been recently diagnosed with Lyme disease,” the 30-year-old artist wrote on Instagram.

“Not only that but I had a serious case of chronic mono which affected my skin, brain function, energy, and overall health,” he added.

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Actor Ben Stiller told The Hollywood Reporter in 2011 that he’d been diagnosed with the bug in 2010.

“I got it in Nantucket, Massachusetts, a couple of years ago,” he said.

I had no idea a bug bite could do this – I was bedridden for five months

Avril Lavigne

“My knee became inflamed and they couldn’t figure out what it was, then they found out it was Lyme.

“I’m symptom-free now, but Lyme doesn’t ever leave your system. It’s a really tough thing.”

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In September 2020, standup comedian Amy Schumer opened up about her Lyme disease diagnosis, saying she’d had it for years.

In a post on Instagram, the Trainwreck actress said: “Anyone get Lyme this summer? I got it and I’m on doxycycline.

“I have maybe had it for years. Any advice? Can you have a glass of wine or two on it?

“I know to stay out of the sun. I’m also taking these herbs from cape cod called Lyme-2.

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“I also want to say that I feel good and am excited to get rid of it.”

Avril Lavigne, spoke of her own diagnosis in 2015, which she revealed in an interview with People magazine.

She said: “I had no idea a bug bite could do this – I was bedridden for five months.

“When you go through something like that, you realise how fulfilling simple things are – things I could do anymore, like being able to get up in the morning and go to the kitchen and grab a cup of coffee. 

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“It taught me patience; it taught me being more present. That was a beautiful lesson.”

What are the subtle symptoms of Lyme disease?

Most people develop a distinctive red rash in the shape of a circle with a ring around it between three and 30 days after they are bitten.

The rash can vary in size significantly and can expand over the course of days or weeks.

Typically, this blemish grows to around 15cm in diameter.

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The 8 main symptoms of Lyme disease are:

  1. A rash
  2. Tiredness
  3. Muscle pain
  4. Headaches
  5. High temperature
  6. Joint pain
  7. Chills
  8. Neck stiffness

If left untreated, Lyme disease sufferers can develop much more serious symptoms including:

  • Severe joint pain
  • Nervous system pain which can lead to paralysis of facial muscles, memory problems and difficulties concentrating
  • Heart problems, such as inflammation of the heart muscle
  • Inflammation of the membranes around the brain and spinal cord as with meningitis

What to do if you get bitten

If you’ve been bitten by a tick, it will attach to your skin.

You should try to remove it as soon as possible. This helps to reduce the risk of getting a tick-borne infection, like Lyme disease.

This is a bacterial infection that causes a pink or red circular rash to develop around the area of the bite.

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You should:

  1. Use a tick removal device or fine-toothed tweezers to gently grip the tick as close to the skin as possible.
  2. Pull steadily away from the skin without crushing the tick.
  3. Wash your skin with water and soap afterwards.
  4. Apply an antiseptic cream to the skin around the bite.

Do not use a cigarette end, match head, alcohol or petroleum jelly on a tick.

Many pharmacies and outdoor stores sell tick-removal devices.

These are useful if you often spend time in areas where there are ticks.

If the tick’s mouthparts break off in the skin and can not be removed, this may cause irritation. But, they should fall out naturally in time.

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Source: NHS 

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Wanyo Mori Dance Workout 💪 #dance #exercise #workout #viralshorts #subscribe

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Cases of incurable ‘eye-bleeding disease’ with mortality rate of 90% surge in one week – infecting 58 and killing 13

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Cases of incurable ‘eye-bleeding disease’ with mortality rate of 90% surge in one week - infecting 58 and killing 13

THIRTEEN people have died in a major outbreak of a highly contagious “eye-bleeding disease” – as cases almost doubled in the space of a week.

The sometimes fatal virus – which has a mortality rate of up to 90 per cent – has sickened 58 people as it spreads rapidly through the East African nation of Rwanda.

At least 58 people in Rwanda have been infected with Marburg virus

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At least 58 people in Rwanda have been infected with Marburg virusCredit: Getty
Thirteen people have died and many still remain in isolation

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Thirteen people have died and many still remain in isolationCredit: AP
Marburg has been named as a pandemic threat by the World Health Organisation

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Marburg has been named as a pandemic threat by the World Health Organisation

An outbreak of the bug, which is a close cousin to Ebola, was first confirmed in Rwanda at the end of last month.

As of September 30, at least 26 Marburg virus infections had been reported in the East African country.

In an update issued on October 8, Rwanda’s ministry of health warned cases had almost doubled in the space of a few days.

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A total of 58 people have been sickened by the virus and 13 have died.

Meanwhile, 33 patients remain in isolation and 12 have recovered.

Health authorities have completed a whopping 2,655 to detect people carrying the highly infectious disease.

This is the first documented outbreak of Marburg virus – which causes uncontrolled bleeding from different body parts including the eyes – in Rwanda and authorities there are racing to trace its source.

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Health authorities are also rolling out hundreds of doses of an experimental vaccine, in a bid to stop the fatal virus in its tracks.

Those most at risk – like doctors and people who’ve come in contact with Marburg patients – will be the first to receive the jabs, Health Minister Sabin Nsanzimana said.

First case of deadly Ebola-like Marburg virus with a fatality rate as high as 88pc detected in Guinea, West Africa

It comes after the detection of two suspected Marburg infections shut down a major train station in Hamburg, Germany.

Passengers were evacuated from two platforms at Hamburg Central Station in Germany as emergency personnel, dressed in full protective gear, boarded a train arriving from Frankfurt.

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Fears of the disease spreading into Europe were further sparked by reports of a person suspected of carrying the disease travelling into Belgium.

But the Belgian government health authority told The Sun that the individual feared to have potentially carried Marburg virus to Belgium was immediately put into isolation and has completed the full incubation period without developing any symptoms.

The bug was first identified in 1967 in Marburg, Germany.

It’s a “cousin” to the deadly Ebola virus, which killed more than 11,000 people during an outbreak in West Africa between 2014 and 2016.

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Virologist Adam Hume, of Boston University in Massachusetts, told the journal Nature that the death rate from Marburg has ranged from 23 per cent to 90 per cent in past outbreaks.

While there are no vaccines or treatments, supportive care can increases a person’s chances of survival.

What is Marburg virus?

Marburg is a filovirus like its more famous cousin, Ebola.

These are part of a broader group of viruses that can cause viral haemorrhagic fever, a syndrome of fever and bleeding.

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Up to 90 per cent of those infected die.

The first outbreaks occurred in 1967 in lab workers in Germany and Yugoslavia who were working with African green monkeys imported from Uganda.

The virus was identified in a lab in Marburg, Germany.

Since then, outbreaks have occurred in a handful of countries in Africa, less frequently than Ebola.

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Marburg’s natural host is a fruit bat, but it can also infect primates, pigs and other animals.

Human outbreaks start after a person has contact with an infected animal.

It’s spread between people mainly through direct contact, especially with bodily fluids, and it causes an illness like Ebola, with fever, headache and malaise, followed by vomiting, diarrhoea, and aches and pains.

The bleeding follows about five days later, and it can be fatal in up to 90 per cent of people infected.

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Early symptoms caused by the virus can be similar to those caused by other diseases, including high fever, headache and malaise.

But people with Marburg soon develop severe watery diarrhoea, nausea and vomiting.

Patients may also begin bleeding from their noses, gums or other areas of their body.

The deadly bug Marburg virus jumps to humans from fruit bats.

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It’s then spread from person to person through very close contact with the blood, bodily fluids or secretions from an infected patient, the UK Health Security Agency (UKHSA) notes.

This can be from direct contact or from touching a surface that’s got blood or bodily fluids on it.

EFFORTS TO CONTAIN VIRUS

In Rwanda, some of the first people later found to be infected with Marburg initially tested positive for malaria.

But health-care workers knew something wasn’t right when the usual treatment wasn’t working.

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By the time the workers realised they had a Marburg outbreak on their hands, a number of them had already become infected, Mr Nsanzimana said in a press conference last week.

Rwanda this began trialling an experimental vaccine in the hopes of containing the virus.

The east African country has received 700 doses of the vaccine from the Sabin Vaccine Institute, a US-based non-profit organisation.

The Marburg vaccine has only been tested in adults aged 18 and older, with no current plans to conduct trials in children.

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According to the BBC, Rwanda’s health minister said there were plans to order more doses of the jab.

Most of the recorded Marburg cases so far have involved healthcare staff treating infected patients in and around Kigali, the country’s capital.

Kigali is home to 1.2million people and has a well-connected airport, raising fears of international spread.

FEARS OF GLOBAL SPREAD

Paul Hunter, a professor of medicine at the University of East Anglia, told The Sun this outbreak of Marburg could “crop up in any country globally”.

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“The incubation period is between five and 15 days, plenty long enough for someone to get on a plane and fly anywhere in the world,” he explained.

The incubation period of a virus is the time between exposure to the virus and the onset of symptoms.

“Airport screening wouldn’t eliminate that risk due to the long incubation period,” Prof Paul said, as people could be travelling without showing any symptoms.

Should we be worried?

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By Professor Paul Hunter, from the Univeristy of East Anglia

Even if the Marburg was brought over to Europe or the UK, the chance of it spreading like wildfire is small.

The disease spreads easily in hospitals in Africa because they don’t have the infection prevention resources we have in the West.

Once a diagnosis has been made in the UK the patient would be transferred to one of the High Level Isolation Units either at the Royal Free, London or Newcastle.

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Once there the staff are very well trained in how to protect themselves.

The risk to healthcare workers would likely be early in the illness when, fortunately, patients are not as infectious.

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Low Impact 30 minute cardio workout- Beginner/intermediate

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Low Impact 30 minute cardio workout- Beginner/intermediate



https://teambodyproject.com

Transform your body in just 10 weeks and take part in the entire Body Project system. Start your Body Project TODAY!

Or simply come and join the conversation at http://www.facebook.com/bodyprojectso…

In this 30 minute cardio workout, I (Daniel) take you through a number of interval drills to raise your heart rate, burn calories and release those feel good hormones.

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Comment below to let us know how you get on!

This low impact cardio workout includes a warm up and a cool down before and after the exercise routine, we advise you follow both for safety and best practise.

This beginner routine is in our cardio range – we also provide Personal Training (resistance), Pilates and Yoga workouts.

Enjoy the workout!

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Exercise disclaimer –

As with any physical activity, before beginning any fitness regime, you must consult with your health care professional to ensure that you are mindful of your current health and any restrictions that are appropriate for you.

You should seek medical attention immediately if there are any unanticipated changes to your physical condition at any time.

None of the information contained within this Website or on our videos is intended to be used as medical advice and the Website is not intended to be used to diagnose, treat, cure or prevent any medical condition (including any mental health conditions) or for any therapeutic purposes.

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Before relying on the information on this Website, it is your responsibility to carefully evaluate the accuracy and relevance of the information for their purposes and obtain appropriate professional medical advice.

Always consult a qualified medical professional if you have any questions concerning your medical condition or injury.

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#malaikaarora 's post workout glow is making us feel like hitting the gym soon! 😉 #shorts

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#malaikaarora 's post workout glow is making us feel like hitting the gym soon! 😉 #shorts



#malaikaarora ‘s post workout glow is making us feel like hitting the gym soon! 😉 #shorts

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