Technology
MiLaboratories gets $10M for a platform play to accelerate genomic research
Advances in DNA sequencing and the vast amounts of genomic data being produced by next-generation sequencing (NGS) technology have created a startup opportunity to build software for biologists so they can more easily analyze this big data and take the next leap. It could help when it comes to developing new vaccines, cancer treatments and so on.
For the last four years, MiLaboratories, a San Francisco-based startup with an R&D facility in Bilbao, Spain, has been building a computational biology platform to make it easier for biologists to process, analyze and aggregate their data. It incorporates features like data visualization and generative AI to boost usability.
Its platform is also designed to be a marketplace for other scientists so that they can distribute more specialized computation tools in the form of apps to keep expanding the utility for the genomics research community. MiLaboratories target scientists whose skillsets span biology, computer science and math — so-called bioinformaticians.
“It’s a ‘no code’ style approach for biologists and we also release an [open source] SDK — software development kit — allowing bioinformaticians to build real applications,” CEO Stan Poslavsky tells TechCrunch.
“During my and our founders’ scientific career, we saw a huge inefficiency . . . in how modern therapies, how modern drugs, are developed,” he explains. “Because of this friction between the data — the big data, generated by the biologists, the sequencing data — and the data analysis which is not available for them.”
While there are “thousands” of software programs and tools that can do analysis of NGS data, he says most have been developed within academia, where the focus tends to be on utility rather than usability.
There’s also a need for biologists to aggregate and integrate results from multiple analyses, he says. “In a unified picture, allowing you to understand what’s going on. And that’s the place where our platform helps dramatically,” he suggests.
The startup hopes its platform will free up bioinformaticians from being called upon to deal with the grunt work of genomic data processing so these multidisciplinary scientists can apply their skillset to the more complex tasks of building algorithms that might help advance cutting-edge science.
“Bioinformaticians are actually spending a lot of time just doing a monkey job of running the software for biologists,” says Poslavsky. “To process this data, you need to have Linux machines, go over SSH, run complicated software tools to get the analysis done and get the insight from the data.”
“[A doctor] has no skills to do this on Linux, on HPC [high performance computing] cluster, because he has other things to do. And that’s what most bioinformaticians in the companies and academia are doing, actually, just this monthly job of running the tools.”
On Thursday, MiLaboratories officially took the wraps off its SDK, Platforma.bio, which lets third-party developers contribute apps — although it’s been in alpha and beta testing for several years. (Poslavsky says “around 300 labs” have been using the beta, and “around 20” apps have been made available through the platform, so far.)
“The first applications that are available in the platform are built around our biological and bioinformatic applications, which are very popular . . . [with] companies and people involved in immune therapy developments. But we already have . . . a good selection of collaborations and people willing to bring their applications on the platform, both from academia and from the industry,” he adds.
The 2021-founded startup is also announcing a $10 million Series A funding round to continue development, with a focus on investing in community building.
“The key reason for raising money is just to plug more hands into the development of our platform. We are hiring more engineers. We are hiring what is called developer advocates, who are propagating the technology around — primarily — the academic community, because most bioinformatics software is developed in academia.”
“For the upcoming year [we will] focus on the propagation of the technology around the community, and engaging community to build their apps, to wrap their existing software, to deliver them through the platform,” he adds.
MiLaboratories’ Series A is led by Madrid-based Kfund, with participation from Acrobator Ventures, EGB Capital, Courtyard Ventures, Somersault Ventures, Speedinvest and Ten13.
Commenting in a statement, Miguel Arias, general partner of Kfund, said: “Investing in platforms that bridge the gap between developers (in this case bioinformaticians) and business users (in this case biologists) is at the core of what we want to do in our fund. There is tremendous potential in democratizing access to complex data enabling the delivery of immunological insights.”
MiLaboratories offers its software for free to academics but it’s also taking revenue via a paid model for commercial users. Per Poslavsky the startup is approaching 100 paying customers at this stage.
“Many of the big pharma companies — like Moderna, Bristol-Myers Squibb — they are our customers,” he notes, adding: “We have revenue — good revenue — allowing us to not be so dependent on venture money.”
At the start of 2022, the startup raised a $2.5 million seed round. It also previously took in a small pre-seed from a few angels.
Discussing the challenges of developing the computational biology platform, Poslavsky says the staggering amount of data being generated by NGS meant startup had to pay very careful attention to ensuring processing efficiency to avoid generating “crazy costs”.
“The amount of data generated in the space are actually, well, crazy,” he emphasizes. “Big pharma companies, our customers . . . they have petabytes of genetic data generated so far. So that’s huge scale.”
MiLaboratories has developed what Poslavsky couches as a “very sophisticated” and “mathematically proven” technology which allows for many sorts of calculations to be performed in “a very optimized way.” He suggests this tech — which it has patented — enables the platform to reach 10x efficiency compared to some other types of computational workflow.
“That’s a very important thing. It’s hidden from the eyes of the biologist — because the valuable proposition for the biologist is ‘I want to click buttons and get insight’ — but it’s very important for the business owners.”
Competition wise, Poslavsky names Seqera (and its Nextflow software) as the closest rival — in terms of popularity and value proposition. There are also open source tools for NGS processing, such as Galaxy, but MiLaboratories reckons its platform offers researchers a more accessible route to data insights.
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Technology
5 underrated indie horror movies you need to stream in October 2024
Sure, A Nightmare on Elm Street, Scream, The Exorcist, and The Conjuring are all legendary horror films that earned hundreds of millions at the box office, spawned franchises, and have been immortalized by pop culture. But there are tons of fantastic horror movies out there that didn’t have big budgets and major studios behind them. Some were made by indie filmmakers who simply knew they had a good story to tell and wanted to tell it.
This October, in addition to rewatching all the classics, be sure to check out some great indie horror movies that are guaranteed to scare and excite. From the worst STI you’ve ever had to Bigfoot (yes, Bigfoot) running loose in the woods, here are five indie horror movies you need to check out this October.
We also have guides to the best movies on Netflix, the best movies on Hulu, the best movies on Amazon Prime Video, the best movies on Max, and the best movies on Disney+.
Exists (2014)
Eduardo Sanchez, the director of The Blair Witch Project, returned in 2014 with another found-footage horror movie, Exists. The film centers around a group of friends vacationing at a remote cabin in the woods. But they soon find themselves being stalked by Bigfoot. The premise sounds a bit stupid, but somehow Sanchez managed to create a genuinely scary and effective Sasquatch movie.
When you think about it, Bigfoot is the perfect slasher villain. Big, strong, and elusive like a wild animal, but able to think and plot like a human. We have tons of ghost movies and the MonsterVerse has made King Kong cool again, so why not try a Bigfoot movie?
Hatchet (2006)
The goal of Hatchet was to revive the classic ’70s and ’80s slasher flick. The movie’s tagline leaned into this by proclaiming the film to be a return to “Old school American horror.” In the film, Victor Crowley was a deformed young boy who was bullied by everyone. One night, kids from his school set his rural cabin on fire with Victor trapped inside. Desperate to save his son, Victor’s father tried to smash through the door with a hatchet… but ended up sending it straight through Victor’s skull.
The origin story was heavily inspired by Friday the 13th, and now in the present day, a full-grown, monstrous, never-dying Victor has risen from the dead, hellbent on killing anyone who comes near his cabin on the bayou (again, very much inspired by Jason Voorhees). Thanks to some great humor, tons of throwbacks to classic slasher films, and lots of genuinely scary scenes, Hatchet is both an homage to the slasher genre while also being a solid entry.
Terrifier 2 (2022)
Art the Clown is horror’s newest it boy. Originally he appeared in the 2013 anthology film All Hallow’s Eve before getting his own film Terrifier in 2016. But it was 2022’s Terrifier 2 that really introduced Art to a wider audience – and luckily for viewers, you don’t really need to watch the previous movies to enjoy it, though it is fun to see his origins.
In Terrifer 2, Art encounters his greatest enemy yet, Final Girl Sienna Shaw (Lauren LaVera). Like all proper slasher flicks, Art kills everyone around him, building the suspense before his final battle. But what really separates the Terrifier movies from other more mainstream horror films is the totally gory, gruesome, and wild kill scenes. Somehow, the film’s kills are so bombastic that it adds a perverse and sadistic dose of humor.
Behind the Mask: The Rise of Leslie Vernon (2006)
Behind the Mask is a super unique and fun slasher movie that centers around a reporter and her crew filming segments about notorious serial killer Leslie Vernon. But they’re not just talking about the infamous killer … they’re actually following him around, getting a first-hand account of his life. Immediately, the premise disarms you. You can’t tell if the film is a comedy or a proper horror movie.
But the third act changes everything and proves that Leslie had a plan of his own the entire time. No spoilers here, just know you’re in for a great surprise and one hell of a good time. It also stars two horror legends, Robert Englund (aka Freddy Krueger) and Zelda Rubinstein from Poltergeist.
Watch Behind the Mask: The Rise of Leslie Vernon on Shudder and AMC+ .
Contracted (2013)
Before It Follows was released, Contracted was the original sexually transmitted horror movie. In the film, a young woman named Samantha is raped at a party, and it turns out the man who raped her is a necrophiliac who recently had sex with a diseased corpse.
Soon, Samantha’s body starts to fall apart and her actions become erratic and violent. Eventually, she deteriorates away into a bloodthirsty zombie. Just like It Follows, the combination of sex and horror makes Contracted terrifying. But its added dose of body horror makes it a truly squirm-worthy movie that’s disgusting, vile, and will absolutely haunt your dreams.
Technology
Motorola secures innovative hinge patent for its foldable phones
Motorola is not a new player in the foldable smartphone segment. It was one of the first mobile brands to offer innovative foldable smartphones. The company’s Razr (review) line of clamshell series with a vertically foldable display are among the most popular products in the segment. Now, the Lenovo-owned brand seems to be planning to take the foldable device segment to a different level. According to a report by 91mobiles, Motorola has filed an innovative hinge patent for its foldable phones.
Motorola has filed an ingenious hinge patent for its next-gen foldable devices
The source has unearthed a patent for a Motorola device with a unique hinge in the database of the US Patent Application Publication. The patent is dubbed “Autonomous form factor control of a foldable mobile device”. This means that this device can automatically adjust its hinge by tracking the user’s movements and shifts. This will allow for a better viewing angle no matter the position of the user.
Notably, the report mentions this device works like Apple’s Center Stage functionality in Mac webcams. Apple’s tech is capable of tracking a user to keep them in the frame, no matter their position. Essentially, in the patent, Motorola describes the innovative hinge to automatically adjust to control the form factor.
The unique hinge uses a shape-shifting alloy pioneered by NASA
Furthermore, the patent suggests that the unique Motorola hinge utilizes special materials, which is capable of changing shape. The hinge has Shape Memory Alloys created by NASA, which was originally intended for a spacecraft. Notably, tech pioneers like Apple and Honor have already patented foldable devices that use this special alloy.
In Motorola’s case, the alloy of the hinge can change shape when heat is applied. This allows the device to automatically adjust its hinge to offer a better viewing angle to the user. Notably, the device also utilizes small motors, which “aid in the up and down motion of the hinge’s position”. The patent describes “The phone tracks the user’s movements and shifts to offer a better viewing angle”.
It also requires a powerful processor capable of tracking a user’s movement and shifting the hinge accordingly
Also, this unique foldable device requires its processor to be smart and have enough processing power to analyze the folded/unfolded state of the hinge. In addition, the processor can also track the user’s position/movements. Without having said that, the device tracks the user using various cameras.
That said, think of a foldable smartphone/tablet that you put on a table and it shifts its hinge to offer a better viewing angle whenever you move around the area. It’s worth mentioning that tech companies file patents for future technologies all the time. That doesn’t mean they all finally make it to the commercial products. However, it would be interesting to see Motorola applying this unique hinge in one of its future foldable products.
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Technology
Nintendo’s latest hardware is not the Switch 2
We’ve been waiting and waiting, and Nintendo finally did the right thing and announced an entirely new piece of hardware. Alas, it’s not a new console but a very Nintendo-looking smart alarm clock. The Alarmo has motion sensors that let you snooze it based on your movement. (There is a physical snooze button too.)
You’ll also be able to check how much you move around while you sleep, and the clock has sleeping sounds and music to drift off to.
You can set the clock’s background with scenes inspired by the likes of Super Mario Odyssey, The Legend of Zelda: Breath of the Wild, Splatoon 3, Pikmin 4 and, er, Ring Fit Adventure. The company says it plans to add more games as updates in the future. And when it’s time to wake you up, Alarmo will use music and sounds from those games.
For now, the curio is only available if you’re a Nintendo Switch Online member in the US and Canada. Other regions will have to wait, although as I finished writing today’s TMA, Nintendo’s UK site had the clock available to buy. You can order the $100 Alarmo online now, and Nintendo says it will be available at retail early next year.
— Mat Smith
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The biggest stories you might have missed
All to mark the album’s 30th anniversary.
While other classic albums often get remasters for big anniversaries, Green Day (with the help of an art studio called Brain) went in a lo-fi direction. It’s re-releasing the music on defunct and/or (very) inconvenient formats in very limited editions. As a result, you can hear what “Basket Case” sounds like through a Big Mouth “Billie” Bass, listen to “Welcome to Paradise” on a Game Boy cartridge. Other formats include an answering machine, toothbrush, animatronic stuffed animal, floppy disc, doorbell, Fisher Price record, HitClip and — this is crazy — MiniDisc.
It kicks off at 10PM ET / 7PM PT today.
If you’re intrigued by what Tesla has planned for its robotaxis, you’ll probably have to pull a late one. At the company’s long-delayed robotaxi event, we’re not expecting to see a fully finished vehicle, but investors and Tesla fans are hoping for a working prototype. The manic-jumping Tesla boss, Elon Musk, began talking about the robotaxi plan years ago. However, it took on greater importance earlier this year when Tesla reportedly shelved its plans for an entry-level EV in favor of the autonomous ridesharing project.
It’s been a tough week for the digital library.
The Internet Archive has been hit this week with a series of DDoS attacks, which have taken the service offline. The Verge noticed a popup on the site when the online database went down. The popup has since disappeared. This attack apparently came just as the Internet Archive was going to disclose a previous breach of its site that resulted in the theft of more than 31 million records. A DDoS organization known as Blackmeta claimed responsibility for the attacks with a confusing message that the platform “belongs to the USA.” The Internet Archive is headquartered in San Francisco.
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