MIRANDA Hart is the latest in a string of famous people to be diagnosed with Lyme disease.

The bug has previously struck the likes of model Bella Hadid and her mum Yolanda, singers Justin Bieber and Avril Lavigne, and actor Ben Stiller to name a few.

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Lyme disease is a bacterial infection carried by ticks which spreads when they bite humans.

There are around 3,000 cases in England and Wales every year.

It can cause flu-like symptoms, including fatigue, headache, swollen joints and a fever, which can last for a few weeks.

In some cases, patients can suffer from side effects for years.

This is what happened to the Call The Midwife actor, for whom it took 33 years to get a Lyme disease diagnosis, after initially mistaking her symptoms for agoraphobia, an anxiety disorder.

The comedian has now opened up about the health battle she faced behind closed doors during an appearance on Radio 4’s Today programme while discussing her new book.

“I was basically bed-bound – and housebound,” the 51-year-old said.

“There’d be times where I’d look at a glass of water, and think, ‘I don’t know how to pick that up’.

“All anyone wants is to be heard, accepted, loved and seen… and when you’re not – particularly in a medical situation – it’s the worst.”

So why does it seem like so many famous faces are being diagnosed with it?

Professor Paul Hunter, an expert in infectious diseases from the University of East Anglia, said there could be some factors that make celebrities more vulnerable.

“But it’s more likely that we’re more interested in hearing about celebrities, so we don’t hear about normal people,” he told The Sun.

Stars’ increased leisure time and access to the wilderness where ticks live could put them at greater risk, he added.

“If there is a rich and famous or class bias in this, it’s probably because they spend more time walking around in wooded parkland, more money to go out to those areas, or have big homes with these sorts of places,” Prof Paul said.

“As you’re walking along, the ticks jump on your legs and crawl their way up, then have a blood feast and give you Lyme disease,” he previously told MailOnline.

Celebs also have access to better healthcare, so may be more likely to get a diagnosis – though it can still take some time.

When Miranda finally received her diagnosis, she was able to trace the condition back to her teenage years.

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“Probably when I was about 14 or 15, I got a tick-borne illness and that’s when my symptoms started,” she recalled.

“It was such a relief. I mean, being misunderstood and misjudged is one of the hardest things about this kind of condition. For sure.”

Most celebs who have spoken about their Lyme disease diagnosis happen to live in the US – where there are over 300,000 cases per year.

Alexis, 41, who is married to tennis legend Serena Williams, detailed his diagnosis in a series of posts on X (formally Twitter) earlier this year.

“Doing a full battery of health scans, tests, etc, and found out I have Lyme disease,” he said.

“Wild. No symptoms, thankfully, but gonna treat.”

TV star Yolanda Hadid revealed she had suffered depression amid a pileup of symptoms for the better part of a decade, which she attributed to chronic Lyme.

“I can’t begin to describe the darkness, the pain and the hell I lived through every day,” the 60-year-old socialite told British Vogue in February 2021.

“This disease brought me to my knees.”

Her daughter, Bella – now 28 – also last year described how she had undergone 100 days of treatment amid a battle with the condition.

The supermodel shared snaps of her medical records, which revealed the extent of her health problems spanning over a decade.

According to the documents, she suffered from extreme fatigue, memory disturbances, depression, sleep disorders, headaches, muscle weakness and joint aches as a teenager.

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She also experienced night sweats, heart palpitations, cold hands and feet, numbness, ADHD, ringing in her eyes and chest pain.

Singer Justin Bieber said, in January 2020, that doctors had diagnosed him with Lyme disease after receiving nasty remarks about his appearance. 

“While a lot of people kept saying, “Justin Bieber looks like s***, on meth” etc. they failed to realise I’ve been recently diagnosed with Lyme disease,” the 30-year-old artist wrote on Instagram.

“Not only that but I had a serious case of chronic mono which affected my skin, brain function, energy, and overall health,” he added.

Actor Ben Stiller told The Hollywood Reporter in 2011 that he’d been diagnosed with the bug in 2010.

“I got it in Nantucket, Massachusetts, a couple of years ago,” he said.

I had no idea a bug bite could do this – I was bedridden for five months

Avril Lavigne

“My knee became inflamed and they couldn’t figure out what it was, then they found out it was Lyme.

“I’m symptom-free now, but Lyme doesn’t ever leave your system. It’s a really tough thing.”

In September 2020, standup comedian Amy Schumer opened up about her Lyme disease diagnosis, saying she’d had it for years.

In a post on Instagram, the Trainwreck actress said: “Anyone get Lyme this summer? I got it and I’m on doxycycline.

“I have maybe had it for years. Any advice? Can you have a glass of wine or two on it?

“I know to stay out of the sun. I’m also taking these herbs from cape cod called Lyme-2.

“I also want to say that I feel good and am excited to get rid of it.”

Avril Lavigne, spoke of her own diagnosis in 2015, which she revealed in an interview with People magazine.

She said: “I had no idea a bug bite could do this – I was bedridden for five months.

“When you go through something like that, you realise how fulfilling simple things are – things I could do anymore, like being able to get up in the morning and go to the kitchen and grab a cup of coffee. 

“It taught me patience; it taught me being more present. That was a beautiful lesson.”

What are the subtle symptoms of Lyme disease?

Most people develop a distinctive red rash in the shape of a circle with a ring around it between three and 30 days after they are bitten.

The rash can vary in size significantly and can expand over the course of days or weeks.

Typically, this blemish grows to around 15cm in diameter.

The 8 main symptoms of Lyme disease are:

1. A rash
2. Tiredness
3. Muscle pain
4. Headaches
5. High temperature
6. Joint pain
7. Chills
8. Neck stiffness

If left untreated, Lyme disease sufferers can develop much more serious symptoms including:

• Severe joint pain
• Nervous system pain which can lead to paralysis of facial muscles, memory problems and difficulties concentrating
• Heart problems, such as inflammation of the heart muscle
• Inflammation of the membranes around the brain and spinal cord as with meningitis

THIRTEEN people have died in a major outbreak of a highly contagious “eye-bleeding disease” – as cases almost doubled in the space of a week.

The sometimes fatal virus – which has a mortality rate of up to 90 per cent – has sickened 58 people as it spreads rapidly through the East African nation of Rwanda.

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An outbreak of the bug, which is a close cousin to Ebola, was first confirmed in Rwanda at the end of last month.

As of September 30, at least 26 Marburg virus infections had been reported in the East African country.

In an update issued on October 8, Rwanda’s ministry of health warned cases had almost doubled in the space of a few days.

A total of 58 people have been sickened by the virus and 13 have died.

Meanwhile, 33 patients remain in isolation and 12 have recovered.

Health authorities have completed a whopping 2,655 to detect people carrying the highly infectious disease.

This is the first documented outbreak of Marburg virus – which causes uncontrolled bleeding from different body parts including the eyes – in Rwanda and authorities there are racing to trace its source.

Health authorities are also rolling out hundreds of doses of an experimental vaccine, in a bid to stop the fatal virus in its tracks.

Those most at risk – like doctors and people who’ve come in contact with Marburg patients – will be the first to receive the jabs, Health Minister Sabin Nsanzimana said.

It comes after the detection of two suspected Marburg infections shut down a major train station in Hamburg, Germany.

Passengers were evacuated from two platforms at Hamburg Central Station in Germany as emergency personnel, dressed in full protective gear, boarded a train arriving from Frankfurt.

Fears of the disease spreading into Europe were further sparked by reports of a person suspected of carrying the disease travelling into Belgium.

But the Belgian government health authority told The Sun that the individual feared to have potentially carried Marburg virus to Belgium was immediately put into isolation and has completed the full incubation period without developing any symptoms.

The bug was first identified in 1967 in Marburg, Germany.

It’s a “cousin” to the deadly Ebola virus, which killed more than 11,000 people during an outbreak in West Africa between 2014 and 2016.

Virologist Adam Hume, of Boston University in Massachusetts, told the journal Nature that the death rate from Marburg has ranged from 23 per cent to 90 per cent in past outbreaks.

While there are no vaccines or treatments, supportive care can increases a person’s chances of survival.

What is Marburg virus?

Marburg is a filovirus like its more famous cousin, Ebola.

These are part of a broader group of viruses that can cause viral haemorrhagic fever, a syndrome of fever and bleeding.

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Up to 90 per cent of those infected die.

The first outbreaks occurred in 1967 in lab workers in Germany and Yugoslavia who were working with African green monkeys imported from Uganda.

The virus was identified in a lab in Marburg, Germany.

Since then, outbreaks have occurred in a handful of countries in Africa, less frequently than Ebola.

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Marburg’s natural host is a fruit bat, but it can also infect primates, pigs and other animals.

Human outbreaks start after a person has contact with an infected animal.

It’s spread between people mainly through direct contact, especially with bodily fluids, and it causes an illness like Ebola, with fever, headache and malaise, followed by vomiting, diarrhoea, and aches and pains.

The bleeding follows about five days later, and it can be fatal in up to 90 per cent of people infected.

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Early symptoms caused by the virus can be similar to those caused by other diseases, including high fever, headache and malaise.

But people with Marburg soon develop severe watery diarrhoea, nausea and vomiting.

Patients may also begin bleeding from their noses, gums or other areas of their body.

The deadly bug Marburg virus jumps to humans from fruit bats.

It’s then spread from person to person through very close contact with the blood, bodily fluids or secretions from an infected patient, the UK Health Security Agency (UKHSA) notes.

This can be from direct contact or from touching a surface that’s got blood or bodily fluids on it.

EFFORTS TO CONTAIN VIRUS

In Rwanda, some of the first people later found to be infected with Marburg initially tested positive for malaria.

But health-care workers knew something wasn’t right when the usual treatment wasn’t working.

By the time the workers realised they had a Marburg outbreak on their hands, a number of them had already become infected, Mr Nsanzimana said in a press conference last week.

Rwanda this began trialling an experimental vaccine in the hopes of containing the virus.

The east African country has received 700 doses of the vaccine from the Sabin Vaccine Institute, a US-based non-profit organisation.

The Marburg vaccine has only been tested in adults aged 18 and older, with no current plans to conduct trials in children.

According to the BBC, Rwanda’s health minister said there were plans to order more doses of the jab.

Most of the recorded Marburg cases so far have involved healthcare staff treating infected patients in and around Kigali, the country’s capital.

Kigali is home to 1.2million people and has a well-connected airport, raising fears of international spread.

FEARS OF GLOBAL SPREAD

Paul Hunter, a professor of medicine at the University of East Anglia, told The Sun this outbreak of Marburg could “crop up in any country globally”.

“The incubation period is between five and 15 days, plenty long enough for someone to get on a plane and fly anywhere in the world,” he explained.

The incubation period of a virus is the time between exposure to the virus and the onset of symptoms.

“Airport screening wouldn’t eliminate that risk due to the long incubation period,” Prof Paul said, as people could be travelling without showing any symptoms.