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Breakthrough Alzheimer’s drug successfully blocks both major disease ‘hotspots’ at once for the first time

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Breakthrough Alzheimer's drug successfully blocks both major disease 'hotspots' at once for the first time

RESEARCHERS have developed a drug that successfully blocks two major Alzheimer’s disease “hotspots” at once, in a “promising” breakthrough against the brain robbing disease.

The drug – called RI-AG03 – targets spots in the brain that promote the abnormal buildup of tau, a protein that forms “tangles” around cells and is a key driver in the decline of brain function.

The drug - called RI-AG03 - targets spots in the brain that promote the abnormal buildup of tau

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The drug – called RI-AG03 – targets spots in the brain that promote the abnormal buildup of tau
It was tested in lab dish studies and on fruit flies

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It was tested in lab dish studies and on fruit flies

There are two specific “hotspots” where tau protein clumping tends to happen.

Current treatments tend to single out one spot or the other, but RI-AG03 can target and block tau aggregation in both, Lancaster University scientists said.

The research team – which also included scientists from the University of Southampton, Nottingham Trent University, Tokyo Metropolitan Institute of Medical Science and the University of Texas Southwestern Medical Centre – tested out the drug in lab dish studies and on fruit flies.

It said RI-AG03 was effective at preventing the build-up of tau proteins in both.

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Lead author Dr Anthony Aggidis said: “Our research represents an important step toward creating treatments that can prevent the progression of diseases like Alzheimer’s disease.

“By targeting both of the key areas on the tau protein, this unique approach could help address the growing impact of dementia on society, providing a much-needed new option for treating these devastating diseases.”

Tau proteins play a crucial role in maintaining the structure and function of brain cells, called neurons.

But in Alzheimer’s disease, these proteins malfunction, clumping together to form long, twisting fibres that clump together to form tangles.

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These tau clumps clog the neurons, preventing them from getting the nutrients and signals they need to survive.

As more neurons die, memory, thinking, and behaviour become increasingly impaired, leading to the cognitive decline seen in Alzheimer’s.

Lacanemab is a drug shown to slow the progression of Alzheimer’s disease

Amritpal Mudher, professor of neuroscience at the University of Southampton, said: “There are two regions of the Tau protein that act like a zipper to enable it to aggregate.

“For the first time, we have a drug which is effective in inhibiting both these regions.

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“This dual-targeting mechanism is significant because it addresses both domains that stimulate tau aggregation, potentially paving the way for more effective treatments for neurodegenerative diseases like Alzheimer’s.”

To test the drug’s effectiveness in cells within a living organism, researchers at the University of Southampton gave the drug to fruit flies with tau clumps characteristic of Alzheimer’s disease.

They found the drug suppressed neurodegeneration and extended the lives of the flies by around two weeks.

This might not seem like much in human terms, but it’s significant considering that the average fruit fly tends to live for about 30 days.

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Scientists then looked into the brains of the fruit flies to understand how the drug was working.

Prof Mudher said: “When we didn’t feed the flies with the peptide inhibitor [RI-AG03], they had lots of the pathogenic fibrils, which group together to make up a tangle.

“But when we fed them with the drug, the pathogenic fibrils decreased significantly in quantity.

“The higher the dosage given, the greater the improvement we saw in the fruit fly’s lifespan.”

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To make sure the drug wasn’t only effective in fruit flies, researchers at the University of Texas Southwestern Medical Centre tested it in a biosensor cell – a type of living human cell line that’s engineered to detect tau tangle formation.

Here too, they found the drug successfully penetrated the cells and reduced the clumping of tau proteins.

Other major Alzheimer’s breakthroughs

While experts have warned that dementia diagnoses in England have reached record numbers, there have been a number of recent advances against brain robbing diseases.

From “game-changing” drugs gaining approval to blood tests that can spot the condition years before symptoms, here are other major Alzheimer’s breakthroughs.

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  • A “game-changing” Alzheimer’s drug called donanemab, that slows mental decline by up to 60 per cent has been approved in the United States. A UK decision on whether the drug will become available to patients in the UK with early symptoms is expected imminently.
  • A blood test that detects Alzheimer’s up to 15 years before symptoms emerge is set to be made free on the NHS within a year. The new test is cheaper, easier and at least as accurate as the current diagnosis options and works by measuring levels of a protein in the blood called p-tau217.
  • Researchers have developed a first-of-its-kind test that could predict dementia up to nine years before a diagnosis, with 80 per cent accuracy. It involves analysing network of connections in the brain when it’s in “idle mode” to look for very early signs of the condition.
  • A woman who has evaded Alzheimer’s disease despite half her relatives getting it could hold the clues to how to prevent it, with scientists pinpointing a particular gene which they think could help prevent Alzheimer’s from progressing. 

Researchers claimed their peptide-inhibiting drug is also more targeted than current treatments, potentially making it safer, with fewer side effects.

Dr Aggidis said: “We know that the toxicity of the tau protein is intimately linked with its ability to aggregate, so by inhibiting aggregation we expect to see desirable effects.

“But current aggregation inhibitors have had many side effects because they can interfere with the functions of many other proteins.

“RI-AG03 is specifically designed against the tau protein, meaning it’s less likely to undesirably interact with other proteins.”

Dr Richard Oakley, Associate Director of Research and Innovation at Alzheimer’s Society, added: “This research is taking promising steps towards a new one-of-a-kind therapy which targets Tau, a damaging protein in the brains of people living with Alzheimer’s, preventing it from clumping together.

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“This drug has the potential to be more targeted than others currently being studied, and we hope it will result in fewer toxic side effects.”

But he noted that more research needs to be done on RI-AG03.

“It’s important to note that the study is in its early stages, so we don’t yet know if it will work or be safe for humans, but it’s an exciting development and we look forward to seeing where it leads,” Dr Oakley said.

The study was funded by Alzheimer’s Society UK and published in  Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.

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30 Minute Full Body Dumbbell Workout

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30 Minute Full Body Dumbbell Workout



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This 30 minute workout uses dumbbells to shape and sculpt your full body, while keeping your heart rate up in the process. Options for all fitness levels.

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New body scan phone app ‘reveals if you’re at risk of heart disease, stroke or diabetes in just 30 seconds’

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New body scan phone app ‘reveals if you’re at risk of heart disease, stroke or diabetes in just 30 seconds’

A NEW smartphone app can tell you if you’re at risk of heart disease, stroke or diabetes, experts say.

MyBVI is an at-home body scan tool that analyses your health in as little as 30 seconds.

A phone app can reveal your risk of serious health conditions using just two photos

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A phone app can reveal your risk of serious health conditions using just two photosCredit: My BVI
MyBVI, developed by Select Research, in action

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MyBVI, developed by Select Research, in actionCredit: My BVI

It uses two photos to reveal your body fat, visceral fat, waist-to-hip ratio, waist-to-height ratio and waist circumference – without the need for a tape measure.

Using artificial intelligence (AI) and taking into account your age and gender, this then produces a body volume index (BVI) figure from zero to 20, which determines your likelihood of future health problems.

Generally, the higher the number, the higher your chances of falling ill.

A BVI score below 13 is considered low risk, while figures above 13 indicate an increased risk.

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The technology is 23 per cent more accurate than body mass index (BMI) which relies on weight and height alone, scientists claim.

Inventor Richard Barnes said: “With MyBVI, users simply take two images with their smartphone or tablet from the comfort of their home, and within seconds, they receive their measurements.

“It considers where fat is distributed on the body, and how that impacts health, rather than just on total weight.

“Anyone can do it. And the images are never stored or used, ensuring complete privacy.

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“BVI is a predictive risk indicator for three of the most significant diseases in global healthcare – diabetes, cardiovascular disease (which encompasses heart disease and stroke) and high blood pressure.”

Developer Select Research hopes it can help ease the burden on medical staff by allowing patients to submit images from home, eliminating the need for GP or other clinic visits.

Millions at risk of ‘silent killer’ that triggers heart attacks and stroke – as doctors warn it’s 3 times more common than feared

How to do the body scan

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  1. Get someone to hold your phone or tablet vertically and stand in front of them.
  2. Stand facing forwards, with your arms held out straight at a 45-degree angle for the first picture.
  3. For the second photo, stand exactly side-on with your feet together and your arms straight down. Don’t look at the camera.
  4. You should receive your results a few seconds later.

Those deemed high-risk can then be monitored, “enabling cost-effective preventive care and earlier diagnosis”.

It should also reduce the chances of ‘false positives’ for obesity, particularly in patients with muscular builds, ethnic minorities and women, according to the team.

Richard said: “The government now has an opportunity to fulfil its promise of creating a future-ready NHS by adopting a more accurate understanding of body composition and its impact on health.

“BVI accurately identifies more than four out of five patients who might be at risk of heart disease, stroke or type 2 diabetes – marking a 23 per cent improvement over BMI and outperforming manual measurements.

“These findings indicate that BVI is a more effective risk indicator than BMI, which was created in 1835 and is outdated and inaccurate when assessing individual health.

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“After 18 years of development, we’ve created an app that offers more comprehensive body measurements that lowers the cost of entry and could become a new medical standard.

“It offers a more comprehensive approach, with detailed data on total body fat, visceral fat, waist-to-hip ratio, waist-to-height ratio, waist circumference and BVI.

“Maintaining good health is important for everyone, so it’s crucial that people have access to accurate tools like MyBVI to make the right decisions about their health.”

It could serve as a powerful screening tool for identifying metabolic syndrome

Researchers

MyBVI is free to download but requires a £3.99-a-month subscription to unlock “premium benefits”.

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It presents data on a graph to help users understand how their body changes over time.

The app predicts someone’s metabolic syndrome risk and severity.

A study published in the European Heart Journal – Digital Health found it to be more accurate than BMI.

“The tool offers a more precise alternative to other measures of disease risk, like BMI and waist-to-hip ratio,” the researchers said.

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“It could serve as a powerful screening tool for identifying metabolic syndrome.”

Metabolic syndrome can lead to a heart attack, stroke, diabetes, liver disease, and other serious health problems.

People with metabolic syndrome typically have apple-shaped bodies, meaning they carry a lot of their weight around their middle.

The science behind body volume index

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BVI helps people understand their body composition.

Total body fat

Body fat, also known as adipose tissue, helps store energy in our bodies and is essential for our wellbeing.

But in excess, it can also lead to the development of many diseases, including heart disease, high blood pressure, and stroke.

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Visceral fat

Visceral fat, also known as intra-abdominal fat, is the fat found on the inside of your abdomen and around your organs.

Too much of it is linked to type 2 diabetes, fatty liver disease and some forms of cancer.

Waist-to-hip ratio

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Waist-to-hip ratio measures the difference between the waist circumference and the hip circumference, and determines how much fat is stored on the waist, hips and buttocks.

Waist-to-height ratio

Someone’s waist-to-height ratio is obtained by dividing their waist size by their height.

Waist and hip circumference

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The waist is measured in a horizontal line, halfway down the side of the body between the pelvic bone and the bottom of the ribcage.

The hip circumference is measured at the widest point of the buttocks.

Source: BVI

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Miranda Cohen Workout Motivation For Females #mirandacohen #fbb #femalefitness #crossfit #fitness

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Miranda Cohen Workout Motivation For Females #mirandacohen #fbb #femalefitness #crossfit #fitness



Miranda Cohen Workout Motivation For Females #mirandacohen #fbb #femalefitness #crossfit #fitness

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Do you make your partner sleep on the sofa when they have a cold? Almost 1 in 6 bunged-up Brits are banished from bed

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Do you make your partner sleep on the sofa when they have a cold? Almost 1 in 6 bunged-up Brits are banished from bed

NEARLY one in six bunged-up Brits are banished from their beds when they have a cold – spending as long as three nights in exile.

A poll of 2,000 adults found 45 per cent of these ended up seeking refuge in the spare room, while 40 per cent have been forced to flee to the sofa in the dead of night.

One in six Brits are told to sleep on the sofa when they have a cold

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One in six Brits are told to sleep on the sofa when they have a coldCredit: Getty

And 18 per cent ended up sleeping in solitude on the floor of the kid’s room.

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Dr Sara Kayat, who has partnered with nasal spray brand Stérimar, which commissioned the research, said: “Suffering from a blocked nose or congestion can make it harder to get to sleep at night.

“A blocked nose can actually feel worse at night because more blood flows to it when you lie down, which can add to the nasal inflammation and congestion.”

It also emerged for 53 per cent their snoring will get worse when they can’t breathe clearly because of a cold or blocked nose.

READ MORE ON COLDS AND FLU

These ailments will impact the quality of sleep for 70 per cent of adults, depriving them of an average of three hours each night of precious kip.

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As a result of this, 61 per cent are low on energy the next day, with 48 per cent being more irritable.

Over a third (37 per cent) of these will struggle to concentrate and 29 per cent won’t be on top form at work, the figures found.

Dr Sara Kayat added: “Having your sleep disturbed by a cold or blocked nose is bad enough.

“But the survey shows that your sleep disturbance can quickly become the source of low energy, negative mood and even relationship grumbles if you keep your loved one awake.

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“It’s important to find a solution quickly that helps you breathe more easily, and that lets those around you get good quality sleep too.”

How do you tell the difference between coronavirus or cold and flu symptoms?

The cold and flu remedies that experts say actually work

Mike Hewitson, a pharmacist from Somerset, suggests the best thing someone can buy when they have a cold or flu is standard paracetamol.

“I generally advise people to use unbranded medicines which are often as effective as the branded products, but at a fraction of the price,” he said.

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Paracetamol can help to “control the fever” which often accompanies the flu, Mike said.

Sadik Al-Hassan, a pharmacist based in Bath, added that medicines such as Lemsip Max, which contain a combination of drugs, can also be helpful at reducing symptoms.

“The paracetamol can help reduce pain, the decongestant to clear out the sinuses and vitamin C to help you fight infections faster,” he said.

Both pharmacists warned patients against Echinacea – a herbal supplement which some take to boost immunity.

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“While it probably isn’t going to do much harm to take it for most people, there isn’t much evidence to suggest it actually helps,” Mike said.

The experts stressed that prevention is better than cure and there are many effective ways at reducing your chances of getting ill in the first place.

Sadik said: “There are a lot of cold and flu prevention nasal sprays on the market which create a gel barrier which words as a physical barrier.”

Meanwhile, Mike pointed out that it isn’t too late to get a flu jab.

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“Many pharmacies will also be able to provide you with a private flu vaccination service if you don’t qualify for the free NHS jab,” he said.

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30 min STANDING FULL BODY WORKOUT | Strength + Cardio | No Jumping | With Dumbbells + Without

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30 min STANDING FULL BODY WORKOUT | Strength + Cardio | No Jumping | With Dumbbells + Without



Join me for a 30 minute STANDING FULL BODY WORKOUT to combine sculpting exercises with dumbbells and low impact cardio without dumbbells. Today I’ll be using two 10LB weights. This is a NO WRISTS workout which means no planks, pushups or burpees! I’ll also be including a quick WARMUP and COOL DOWN. So grab your equipment and get ready to feel the burn! 💞 xox Mik

EQUIPMENT:
– Medium set of dumbbells (two 10LB weights)

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‘Fit’ man suffers horrific artery TEAR triggering fatal heart emergency – after masturbating

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'Fit' man suffers horrific artery TEAR triggering fatal heart emergency - after masturbating

A MAN’S bout of self pleasure ended in a potentially deadly heart emergency, as he suffered a torn artery after masturbating.

The 59-year-old man called an ambulance after getting a tight jaw and tingling in his hands following his solo sesh.

A man, 59, suffered a tear to his artery after masturbating

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A man, 59, suffered a tear to his artery after masturbatingCredit: Clinic and Experimental Emergency Medicine
He experienced tingling in his hands and jaw tightness

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He experienced tingling in his hands and jaw tightnessCredit: Clinic and Experimental Emergency Medicine

Doctors were baffled by his symptoms, at first fearing he had a severe case of sepsis.

But a battery of tests revealed he had in fact suffered a tear to his aorta, the body’s largest artery that carries blood from the heart to the body.

This resulted in severe aortic regurgitation, a medical emergency where the blood flows backwards into the heart.

Aortic dissection – as a tear to the aorta is called – is a rare condition that can be life threatening if not identified and treated promptly.

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People suffering the health emergency usually experience a sharp, ripping pain in their chest or upper back, as well as shortness of breath, heavy sweating, confusion and severe stomach pain, the Cleveland Clinic states.

But unusually, the patient in question suffered no chest pain, shortness of breath, loss of consciousness or nausea as would be expected in health emergency of this type.

Only about 6.4 per cent of patients with aortic dissections don’t experience chest pain, doctors from the Department of Emergency Medicine at Mount Sinai hospital in New York – who oversaw the man’s case – wrote.

“As such, painless dissections are atypical presentations, more likely to be associated with increased mortality,” the said in a report published to the journal Clinic and Experimental Emergency Medicine.

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It’s also unusual for the man to have suffered the tear following masturbation – although he’s not the first to do so.

Another report details the case of a 60-year-old man who experienced a “ripping” pain in his chest, neck and back in the hours after indulging in a bout of masturbation.

Dr Philippa Kaye Answers Most Embarrassing Men’s Health Questions Part 2

The 59-year old patient had a past medical history of high blood pressure, which puts extra strain on the heart, blood vessels and other organs and raises the risk of experiencing heart disease, heart attacks and strokes.

He also had a rare form of chronic pancreatitis, inflammation of the pancreas caused by the immune system attacking the organ, as well as chronic renal insufficiency – a long-term condition where the kidneys don’t work as well as they should.

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But the day before he suffered his health emergency, the man had been on a 3-mile jog.

After his solo sesh, the man described experiencing “lightheadedness, a tingling sensation to both hands, and jaw tightness”, according to the report.

Feeling unwell, he decided to lie down and unintentionally wet himself.

He decided to call an ambulance after this episode of urinary incontinence.

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Test conducted at the hospital revealed he was suffering from extremely low blood pressure and a slow pulse.

Medics feared he may be suffering from sepsis – a life threatening overreaction to an infection – and gave the man a dose of antibiotics.

Other horrifying case reports involving… penises

FROM gangrene to amputations and food poisoning, here are a few bizarre and horrifying case reports involving the male member.

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Though his condition seemed to improve, the patient reported feeling dizzy when trying to walk and he underwent further monitoring and tests to his heart.

At this point, an ultrasound scan revealed that he’d suffered a e type A aortic dissection – a tear starting on the upper part of the aorta closer to the heart.

This can be immediately life-threatening and usually requires emergency open-chest surgery to repair or replace the first part of the aorta where the tear started.

The man did in fact undergo surgery for an aortic graft replacement, which involves replacing a damaged section of the aorta and aortic valve with a tube.

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He’s understood to have since recovered from his ordeal.

It remains unclear why he suffered a tear to his aorta following masturbation, though medics said his chronic pancreatitis appears to be an “important risk factor”.

Medics dwelled on the fact that the patient didn’t experience any pain from his aortic dissection, stressing that this was unusual.

“This case reinforces that aortic dissection can be present without pain, including the classic presentation of tearing chest pain or back pain,” they wrote.

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