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‘Longest-living Benjamin Button disease sufferer’, 28, who spent his life trying to find a cure for rare condition dies

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‘Longest-living Benjamin Button disease sufferer’, 28, who spent his life trying to find a cure for rare condition dies

THE world’s longest-living survivor of ‘Benjamin Button disease’ who spent his life searching for a cure has died.

Sammy Basso, aged just 28, was diagnosed with the rare genetic disease progeria.

Sammy Basso, 28, was the longest living progeria sufferer who spent his life trying to find cure for the disease

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Sammy Basso, 28, was the longest living progeria sufferer who spent his life trying to find cure for the diseaseCredit: Jam Press
He passed way on October 5

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He passed way on October 5Credit: Jam Press
Sammy dedicated his life to raising awareness around the rare disease

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Sammy dedicated his life to raising awareness around the rare diseaseCredit: Jam Press

The condition causes sufferers to age rapidly and appear older than they are.

People with progeria generally appear healthy at birth, but symptoms such as slowed growth, loss of fat tissue, and hair loss begin to appear in their first year.

The average life expectancy for an individual with progeria is about 15 years.

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Sammy, from the northern Italian region of Veneto, is believed to be the longest-living survivor of the rare genetic disease.

He was diagnosed with the disease aged just over two years old and founded the Italian Progeria Sammy Basso Association with the help of his parents aged 10.

He dedicated his life to raising awareness about the disease, appearing in the the National Geographic documentary “Sammy’s Journey”.

He even wrote his graduate thesis on the possibility of curing progeria through genetic engineering.

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Sammy was having dinner with family and friends on the evening of October 5 when he suddenly felt unwell.

Emergency medics were dispatched to the restaurant and tried to resuscitate the young biologist, but their efforts were in vain.

Just a few weeks before his death in Asolo, north-eastern Italy, he had returned from a trip to China.

Siblings Michiel and Amber Vandeweert who have ‘Benjamin Button disease’ progeria tell of their heartbreaking battle against bullies

And the evening before his passing, he was awarded the Paolo Rizzi Journalism Prize in the “Environment and Society” category in Venice.

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The organisers cited “his willpower, spirit of sacrifice, and the courage that sustains him”.

Sammy was born in Thiene on 1 December 1995 and lived in Tezze sul Brenta.

In 2005, he founded the Italian Progeria Association to spread knowledge about his condition and to encourage research into it.

He graduated from the University of Padua with a degree in Natural Sciences in 2018.

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In 2019, he was made a Knight of the Order of Merit of the Italian Republic by President Sergio Mattarella.

He graduated again from the University of Padua in 2021 with a master’s degree in Molecular Biology.

What is progeria?

Hutchinson-Gilford Progeria is a very rare genetic disease that affects one in every 8 million people born.

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It’s caused by a mutation in one of the two copies of the LMNA gene.

The mutation causes every cell in the body to malfunction.

People with progeria undergo rapid ageing and have distinct physical characteristics, including:

  • Hair loss 
  • Prominent eyes
  • Aged, wrinkled skin
  • A thin, beaked nose
  • Disproportionately small face compared to head size
  • Loss of fat under the skin

There are currently only 130 cases of progeria recognised worldwide, of which four in Italy.

However, this number is underestimated as cases of progeria are often difficult to trace.

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Progeria is always fatal.

On average, people with the condition survive 14.5 years, although some adults with progeria will live into their early 20s.

A drug called lonafarnib has been shown to slow down the progression of the disease.

Source: Italian Progeria Sammy Basso Association, Cleveland Clinic

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His thesis explored the correlation between progeria and inflammation.

His dream was to work at CERN in Geneva, Switzerland.

Progeria is not hereditary and is instead caused by a mutation in the LMNA gene.

The mutation likely occurs in a single sperm or egg immediately before conception.

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There are about 70 children with the disorder worldwide, most of whom will die from heart problems or strokes.

Basso is survived by his parents, who said: “We are deeply grateful for the privilege of having shared part of our journey with him.

“He taught all of us that, even though life’s obstacles may sometimes seem insurmountable, it’s worth living it fully.”

Sammy was having dinner with family and friends when he suddenly felt unwell

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Sammy was having dinner with family and friends when he suddenly felt unwellCredit: Jam Press
Rita Ora and Sammy Basso attend the BoF VOICES Gala Dinner and Party at Soho Farmhouse in November 2023

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Rita Ora and Sammy Basso attend the BoF VOICES Gala Dinner and Party at Soho Farmhouse in November 2023Credit: Getty

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How ‘magic mushrooms’ could transform medicine – from treating depression to gambling and addiction

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How 'magic mushrooms' could transform medicine - from treating depression to gambling and addiction

PSYCHEDELIC drugs might still invoke images of The Beatles, Woodstock and flower power – but one day they could be prescribed by a doctor.

An emerging area of science is focusing on the idea that a “magic mushroom” trip can be beneficial for people with severe mental health issues.

Magic mushrooms could transform medicine  and be used to treat everything from depression to gambling and addiction

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Magic mushrooms could transform medicine and be used to treat everything from depression to gambling and addictionCredit: Getty
Researchers at Imperial College London published findings of a study last month

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Researchers at Imperial College London published findings of a study last monthCredit: Thomas Angus/Imperial College London

Psilocybin is the active ingredient in “shrooms”, which when taken recreationally, gives people the giggles, hallucinations and a sense of awe at their surroundings.

But evidence suggests it can help us confront our deepest fears and traumas, and get the brain firing in novel ways.

Psilocybin is an illegal Class A drug, which makes it difficult and expensive for the small number of research centres in the UK to study it.

And one of the biggest barriers to the drug being taken seriously is its reputation.

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Sam Lawes of the Centre for Evidence Based Drug Policy, told Sun Health: “It’s seen as a recreational drug and a party drug for festivals, but in terms of research we should treat it like a medicine.

“If it’s not an effective medicine, studies will show that.

“But so far, studies are showing great promise.”

A quarter of Brits will experience some form of mental health problem each year.

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For many, medicines don’t work, NHS therapy is hard to access and waiting lists are growing.

Sam says: “You can see we’ve got a burning need for an alternative solution.”

Magic mushrooms could ‘cure depression’ within three years, experts say

Researchers at Imperial College London published findings of a study last month that compared two doses of psilocybin to the SSRI antidepressant escitalopram.

Both treatments were effective at reducing depression at a six-month follow-up.

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But, unlike antidepressants, psilocybin didn’t stall sex drive.

Small studies have also shown the positive impact of psilocybin on eating disorders, anxiety, addictions, PTSD and OCD.

Psychiatrist Professor David Nutt, the leading expert in psychedelic research in the UK working at the Department of Brain Sciences at Imperial College London, has seen lives transformed with psilocybin.

He tells Sun Health: “It is almost certainly the most promising development innovation in the treatment of mental illness and also some neurological illnesses for 50 years.”

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Typically, a trial participant takes a dose comparable to that taken recreationally, closes their eyes and listens to music.

Afterwards, volunteers talk things through with a therapist.

Though science is only beginning to understand this compound’s effects, MRI brain imaging has been “remarkable”, Prof Nutt says.

Scans by the team at Imperial, published in the journal Nature Medicine, have shown that psilocybin boosts connectivity in brain regions that have become rigid in those with depression.

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Essentially it cracks open unused networks of the mind in a way not seen with antidepressants and this was linked with improved depressive symptoms.

‘UNUSED NETWORKS’

Columbia University has also shown that patients with body dysmorphic disorder had increased brain activity just one day after taking a 25mg dose of psilocybin.

Those with the greatest boost in neural connectivity had the most improvement in BDD symptoms a week later.

The effects of a single dose of pure psilocybin can last weeks, research suggests.

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It is almost certainly the most promising development innovation in the treatment of mental illness and also some neurological illnesses for 50 years

Psychiatrist Professor David Nutt

A paper published in the Journal of the American Medical Association in August found 25mg of psilocybin plus psychological support had a “rapid and sustained antidepressant effect” over six weeks.

But the long-term effects, including comparison to traditional treatments, still needs studying.

Prof Nutt and colleagues will soon start trials to explore if psilocybin could treat opioid and gambling addictions.

He explains: “These are disorders in which people get locked into ways of thinking that they can’t escape from.

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“Gamblers know they shouldn’t gamble, but they can’t stop.

“Depressed people know that they’re not worthless and guilty, but they can’t stop those thoughts.

Psychiatrist Professor David Nutt is the leading expert in psychedelic research in the UK

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Psychiatrist Professor David Nutt is the leading expert in psychedelic research in the UKCredit: PA

“These ruminations in the brain can be broken by psychedelics.

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“For most people in these studies, their lives have been ruined and they feel depressed or anxious.

“After taking the psychedelics, they can see they are not a worthless person, they can forgive themselves and that is a great release.”

The problem is that trial participants want more of what made them better.

Prof Nutt says: “Depression is deep-seated and after a few months, it creeps back and they plead to have psilocybin again.”

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Regardless, taking magic mushrooms in a hospital setting with a therapist to hand is safer than doing so in your living room.

Now, experts want psilocybin to be medicalised as cannabis was in 2018.

This would speed up research, but more importantly, allow doctors to prescribe it in the real world, they argue.

While the UK is usually a world leader in health sciences, other countries have forged ahead with psilocybin.

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Prescribing psilocybin and MDMA for treatment-resistant depression has been legalised in Australia, and Colorado and Oregon, in the US, have legalised some use of psychedelics.

The Home Office told Sun Health it is “considering advice from the Advisory Council on the Misuse of Drugs on how best to reduce barriers to research with controlled drugs, including psilocybin, while ensuring they are not misused or exploited by criminals”.

The UK is lagging behind, mired in outdated laws and stigma

Tara Austin, Psilocybin Access Rights

In 2022, it rejected a bid to reclassify psilocybin, arguing that even if an application for a product licence was made, it would be up to the Medicines and Healthcare Products Regulatory Agency to authorise it.

As psilocybin is a natural compound “it means drug companies won’t pay for the trials because they can’t reap financial reward afterwards,” says Prof Nutt.

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Meanwhile, patients get caught in the middle. Labour MP Charlotte Nichols led a Commons debate on the topic last year.

She described her own PTSD as a “living hell” and said: “It feels like institutional cruelty to condemn us to our misery when there are proven, safe, and effective treatments if the Government would only let us access them.”

Steve Rolles, analyst at the Transform Drug Policy Foundation, added: “Politicians are very wary about being seen as soft on drugs.”

Tara Austin, of Psilocybin Access Rights, said: “The UK is lagging behind, mired in outdated laws and stigma.

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“We’ve seen an alarming rise in antidepressant use in England, which is ineffective for many, with no innovative solutions in sight.

“Veterans with PTSD, and indeed all individuals facing mental health challenges, deserve better.”

While the future of magic mushrooms as medicine is uncertain, the advice for now is clear: “Don’t try this at home”.

‘Some more hazardous than others’

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PSYCHEDELICS are powerful and that comes with risks.

Dr Paul Keedwell, fellow of the Royal College of Psychiatrists, says: “The most common risk of taking psychedelics recreationally is experiencing a ‘bad trip’ which can result in overwhelming fear, paranoia and hallucinations.

“Such experiences can lead to panic attacks, accidents and lasting trauma.

“Psilocybin can trigger acute psychosis in those with a history of psychotic episodes or family history of schizophrenia.”

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Doctors in Austria reported a case last month of a man who had amputated his penis with an axe after taking magic mushrooms.

Fortunately for the man surgeons were able to perform a successful reconstruction operation.

Dr Keedwell said someone would need “a great many mushrooms to get into trouble”.

Common side effects also include dizziness, nausea, confusion, paranoia and anxiety.

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It was concerns about psychological distress and potential harm of psychedelics, including LSD, that led to their Class A classification in 1971.

Dr Keedwell says: “In reality, some drugs like LSD are much more potent and hazardous than others.

“Relatively, psilocybin is less powerful.”

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30 MIN KILLER HIIT Workout – No Equipment – No repeats, Full Body Cardio Home Workout

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30 MIN KILLER HIIT Workout - No Equipment - No repeats, Full Body Cardio Home Workout



Bring on another KILLER Workout – Are you ready Team?! 30 min Killer HIIT with No Equipment that will make your body SWEAT! Burn fat, improve your cardio fitness, and sweat it out! It’s the best way to work your full body in just 30 minutes, that’s all you need! Let’s do it ❤️

♡ Sign up to my Grow with Anna APP: https://growwithanna.page.link/GetGrowNow

▸ Muscles Worked: Full Body
▸ Time: 30 Min + cool down
▸ Equipment: No Equipment, Bodyweight Only

Workout:
▸ Warm Up 30 sec on, no rest
▸ Workout 50 sec on, 10 sec off
▸ Final Challenge 🔥 60 sec on, no rest
▸ Cool Down 30 sec on, 10 sec off

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Please remember that we are all different and that you can make this your own workout ♡ Take a longer break when you need to.

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D I S C L A I M E R

If you are a newbie start with a simple and easy exercise before attempting all advanced exercises. Performing exercises out of your capability might strain your muscles and you may get injured.

This channel offers health, fitness and nutritional information. You should not rely on this information as a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment. By performing any fitness exercises without supervision like with this video, you are performing them at your own risk. See a fitness professional to give you advice on your exercise form. Growingannanas will not be responsible or liable for any injury or harm you sustain as a result of this video.

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🤣🤣Josey Dêh 😂😂C'est pas BBL Naturel qui est làaa🤣 #sports #bienêtre #lifestyle #viralshort #josey

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Womens Workouts

30 MIN Full Body HIIT Workout

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30 MIN Full Body HIIT Workout



Today’s 30 minute full body HIIT Workout is quick, intense and super sweaty! Using dumbbells for added resistance combined with body-weight exercises for a total body HIIT session that will have you feeling strong and energized. Let’s do it!!! #HIITWorkout #HomeWorkout #HR12WEEK

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Workout Breakdown:
0:00 Intro
0:23 Warm Up
2:43 HIIT Circuit One (40s work + 20s rest x2 rounds)
Push Press + Twist
Lunge + Curl
Deadlift Jack
Side Lunges
High Knees

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12:56 HIIT Circuit Two (40s work + 20s rest x2 rounds)
T-Push Ups
Tricep Extension
Lunge + Press (R)
Lunge + Press (L)
Pivot Hops

23:08 HIIT Circuit Three (40s work + 20s rest x2 rounds)
Front + Sumo Squats
Walking Plank
Front Swing
Curtsey + Raise
Jump Squat + Pulse

33:08 Cool Down & Stretch

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This is my own personal workout and may not be suited for you. It is strongly recommended that you consult with your physician before beginning any exercise program. By engaging in this exercise or exercise program, you agree that you do so at your own risk.

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Women´s Training vs Men´s Training

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Are you a narcissist? Take the 28-question ‘Dark Tetrad’ personality test to find out

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Are you a narcissist? Take the 28-question 'Dark Tetrad' personality test to find out

THE TERM ‘narcissist’ is often thrown around to describe people who seem self-absorbed or have a large ego.

Have you ever wondered if it applies to you or a particularly annoying friend or colleague?

Narcissism is defined as an egotistical preoccupation with self

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Narcissism is defined as an egotistical preoccupation with selfCredit: Getty
A 28-question quiz can tell you where you fall on the scale of narcissism

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A 28-question quiz can tell you where you fall on the scale of narcissismCredit: Psychological Testing
It also assesses psychopathy, Machiavellianism, and sadism

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It also assesses psychopathy, Machiavellianism, and sadismCredit: Psychological Testing
You'll be scored on how the four personality traits making up the 'Dark Tetrad'

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You’ll be scored on how the four personality traits making up the ‘Dark Tetrad’Credit: Psychological Testing

Now, a 28-minute test can tell you where you fall on the score of narcissism – as well as three other “negative” personality types.

The five-minute quiz, published on the website Psychological Testing Online, is an online version of the Short Dark Tetrad test, by personality psychology researcher and professor Delroy Paulhus.

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It’s designed to assess a set of four interrelated personality traits that are considered to be negative or harmful, according to Psychology Today.

These are narcissism, psychopathy, Machiavellianism, and sadism.

It’s noted on the website that the quiz is meant to be educational and entertaining – it can’t provide a diagnosis of narcissism and shouldn’t be used to diagnose a disease or condition or provide any sort of psychological advice.

To be formally diagnosed with narcissistic personality disorder – a mental health condition characterised by impulsivity, volatility, attention-seeking, and a lack of empathy – you need to be assessed by a psychologist or psychiatrist.

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Prof Paulhus defined narcissism as “an egotistical preoccupation with self”.

“Because of all their experience with maintaining their self image, people who score high for narcissism will often appear charming but their narcissism will later lead to extreme difficulty in developing close relationships,” he said

Meanwhile, Machiavellianism is described as a tendency to be manipulative and deceitful and see people as a means to achieve one’s own goals.

Psychopathy is a condition characterised by a lack of empathy and emotional response.

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“The relative lack of emotions leads results in high stress tolerance, low empathy, little guilt and leads them to seek extremely stimulating activities, resulting in impulsivity and a disposition towards interpersonal conflict,” Prof Paulhus said.

As for sadism, this means deriving pleasure the pain and humiliation of others.

Completing the 28-part questionnaire will give you an idea of whether you score low, average or high for these four personality traits.

The test first asks whether you’re male or female before presenting a series of 28 statements, to which you have to reply if you “strongly disagree”, “disagree”, “neither agree nor disagree”, “agree” or “strongly agree”.

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The quiz opens with the statement: “It’s not wise to let people know your secrets.”

It then goes on to ask whether you think others see you as a natural leader or if others describe you as “out of control”.

According to Dr Erin Buckels, an assistant professor of Psychology and Principal Investigator of the Dark Personality Research Lab at the University of Winnipeg, the Short Dark Tetrad Test assesses four personality themes.

It aims to gauge how “crafty”, “special”, “wild” or “mean” you are.

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What is narcissistic personality disorder?

The condition is one of seven types of personality disorders and is named after Narcissus from Greek mythology, who fell in love with his own reflection.

It results in the sufferer being obsessed with the fantasy of unlimited success, power, brilliance and ideal love and beauty and have an inflated sense of their importance coupled with a deep need for excessive attention.

But behind the confidence, sufferers can be extremely vulnerable to slightest criticism and have low self-esteem, the Mayo Clinic reports.

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The disorder can also cause problems in many areas of life – including work, relationships and financial affairs.

People with narcissistic personality disorder may be generally unhappy and disappointed when they’re not given the admiration they think they deserve and may find relationships unfulfilling.

According to the Mayo Clinic, sufferers can:

  • Have an exaggerated sense of self-importance
  • Have a sense of entitlement and require constant, excessive admiration
  • Expect to be recognised as superior even without achievements that warrant it
  • Exaggerate achievements and talents
  • Be preoccupied with fantasies about success, power, brilliance, beauty or the perfect mate
  • Believe they are superior and can only associate with equally special people
  • Monopolise conversations and belittle or look down on people they perceive as inferior
  • Take advantage of others to get what they want
  • Have an inability or unwillingness to recognise the needs and feelings of others
  • Be envious of others and believe others envy them
  • Behave in an arrogant or haughty manner, coming across as conceited, boastful and pretentious

Source: Mayo Clinic

“Watching a fist fight excited me,” is the fourth statement quiz-takers are asked to respond to.

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The test goes on to question whether you “have a unique talent for persuading people” or you think “group activities tend to be dull” without you.

It poses questions around how you respond to violence, whether you think manipulation is a useful to achieve what you want and how you view yourself.

“I have some exceptional qualities” is one such statement, as is “I like to show off every now and then”.

At the end of the questionnaire, you’ll be scored on the four personality types on a scale of 1 to 5.

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For narcissism, a score of above 3.71 is considered “high”.

As for Machiavellianism, above 4.03 is “high”. For psychopathy, this is 2.64 and sadism 3.14.

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