Health & fitness
World’s first ovarian cancer vaccine ‘could eliminate the deadly disease’ that kills thousands of Brits every year
THE WORLD’S first vaccine combating ovarian cancer that’s being developed in the UK could “wipe out” the deadly disease, researchers say.
Scientists at the University of Oxford are creating OvarianVax, a vaccine which teaches the immune system to recognise and attack the earliest stages of ovarian cancer.
The hope is that the jab could be given to women preventatively on the NHS with the aim of eliminating the disease.
Experts suggest it could work in a similar way to the human papillomavirus (HPV) jab, which is on track to stamp out cervical cancer.
HPV jabs are currently dished out to secondary school children and people at high risk of the virus, cutting their risk of getting conditions linked to HPV – including cervical cancer and genital warts.
Prof Ahmed Ahmed, director of the ovarian cancer cell laboratory at MRC Weatherall Institute of Molecular Medicine the University of Oxford, and his team are working to identify cellular targets for their ovarian cancer vaccine.
Read more on ovarian cancer
They will establish which proteins on the surface of early-stage ovarian cancer cells are most strongly recognised by the immune system, and how effectively the vaccine kills mini-models of ovarian cancer in the lab.
They will then move on to human clinical trials in people with BRCA gene mutations – which massively increase the risk of ovarian cancer – and healthy women in the general population to see if the disease could be prevented.
Cancer Research UK is funding the study with up to £600,000 over the next three years.
Prof Ahmed said that, if the jab is successful, he would expect to start seeing an impact within the next five years.
At present, some 4,100 Brits died of ovarian cancer every year.
Asked if ovarian cancer could be wiped out with the new vaccine, he said: “Absolutely – that would be the aim. We still have a long way to go but it is a really exciting time. I’m very optimistic myself.”
For the work, scientists will create the vaccine in the lab, with the aim of training the immune system to recognise more than 100 proteins on the surface of ovarian cancer, known as tumour-associated antigens.
They will then move to testing the vaccine in patients with the disease.
Prof Ahmed said: “The idea is, if you give the vaccine, these tiny tumours will hopefully either reduce, shrink really significantly, or disappear.
“That would give us the sign that the vaccine is working.”
The next stage would then be to include women with BRCA mutations and a wider general population of women without known disease to see whether “the vaccine would be suitable for all” in preventing ovarian cancer.
Prof Ahmed said: “Let’s imagine that it all goes well, and the vaccine really works well.
“Now, the obvious population who would benefit from this are the BRCA1 and BRCA2 mutation carriers, because they have a very high chance of getting ovarian cancer.
“If you give it to those patients and it’s effective, then you get the best health economics and the best cost-effectiveness.
What are the signs of ovarian cancer?
Ovarian cancers affects the ovaries – the organs that store the eggs needed to make babies.
It mostly affects women over the age of 50 and can sometimes run in families, according to the NHS.
Symptoms of the cancer can be vague, particularly in its early stages, Cancer Research UK SAYS.
The charity advises you speak to a GP if you have the following symptoms:
- Feeling full quickly
- Loss of appetite
- Pain in your abdomen or lower part of your abdomen that doesn’t go away
- Bloating or an increase in the size of your abdomen
- Needing to wee more often
- Tiredness that is unexplained
- Weight loss that is unexplained
- Changes in your bowel habit or symptoms of irritable bowel syndrome, especially if this starts after the age of 50
The NHS added that bleeding from the vagina after the menopause could be another possible symptom of ovarian cancer.
“The question then becomes – would it really benefit the general population? Could you offer it to everyone?”
At the moment, there is no screening test for ovarian cancer, which is often diagnosed in late stages because the symptoms – such as bloating and no appetite – can be vague.
Women with BRCA mutations, such as actress Angelina Jolie, are at high risk.
Almost 45 per cent of people with an altered BRCA1 gene and almost 20 per cent with an altered BRCA2 gene will develop ovarian cancer by the age of 80, compared with just 2 per cent in the general population.
Currently, women with BRCA1/2 alterations are recommended to have their ovaries removed by the age of 35, which means they go through early menopause and cannot have children afterwards.
Prof Ahmed said BRCA mutation carriers could benefit greatly from the new vaccine because “they wouldn’t then have to have their ovaries removed”.
However, he said his team will be trying to get the best components included in the vaccine so it “would be effective for as many people as possible”, including the wider population.
He added: “I am optimistic because we are talking about preventing the very first few cancer cells that develop – and not trying to cure or treat or prevent the tumour coming back.
“I’m hoping that, because the number of cells that we will be targeting is quite small, we will have success.
“We’ve seen success with the HPV vaccine – it’s really, really incredibly effective.”
Prof Ahmed told PA that “while the full blown timeline” for a vaccine being approved “might be many years away”, the “impact that it would have, if it’s successful, would hopefully be much sooner”.
He said that, through the clinical trials, he would hope to start seeing the impact of the vaccine “in four or five years on the healthy population”.
There are around 7,500 new ovarian cancer cases every year in the UK, with BRCA mutations accounting for around 5-15 per cent of these cases.
Michelle Mitchell, chief executive of Cancer Research UK, said: “Projects like OvarianVax are a really important step forward into an exciting future, where cancer is much more preventable.
“This funding will power crucial discoveries in the lab which will realise our ambitions to improve ovarian cancer survival.
“OvarianVax builds on the exciting developments in vaccine technology during the pandemic.
“This is one of many projects which we hope will give women longer, better lives, free from the fear of cancer.”
Womens Workouts
Tried Hulahoop for the first time🥰 #hulahoop #shorts #workout #coreworkout
Womens Workouts
30 Minute Full Body Beginner Dumbbell Workout [With Modifications]
Tap in with us for a 30 minute dumbbell strength workout—especially if you’re a beginner who needs guidance with weight training! Throughout this workout we will show you what muscles are working, how to do each exercise, and give you audio cues to make sure your form is correct. We designed this workout to include intermediate level exercises so that you have a level to work up to. However, if you struggle with certain exercises, we’ve included modifications for those intermediate exercises. Even if you’re a bit more advanced, you can always come back to this workout for a form check and guidance.
If you have any questions, drop them in the comments and we well get back to you as soon as we can!
Check out our other dumbbell workouts:
45 Minute Full Body Dumbbell Workout: https://youtu.be/qs9wyBQrNYA
30 Minute Full Body Dumbbell AMRAP: https://youtu.be/rEEZB68GTs0
30 Minute Full Body Dumbbell Workout https://youtu.be/4sUGg9mcMGU
20 Minute Full Body Dumbbell Workout: https://youtu.be/mf1xQS_Zlkc
20 Minute Light Dumbbell Workout: https://youtu.be/PFGeohvbNq8
15 Minute Full Body Dumbbell Workout: https://youtu.be/xqVBoyKXbsA
10 Minute Light Dumbbell Workout: https://youtu.be/mnzaEyTm-MA
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Womens Workouts
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Womens Workouts
FUEL Series 30 Min NO REPEAT Full Body Workout | Day 29
No repeat but as always, this doesn’t mean random movements ‘thrown together’… these exercises are programmed to provide intensity to a group of muscles but rest to that area at other times… even though no repeat, it will consist of repetitional reps towards those muscles!
For this workout, you will need some dumbbells, your mat, a chair for Bulgarian lunges and a stepper/yoga block/wedge for heel elevated squats. I also use 2 yoga blocks for deeper push ups but you can absolutely perform regular push ups or use push-up bars to deepen the range if you like!
The dumbbells I am using for your reference are 2 x 10kg!
The timer will be on for a majority of the work 45 seconds of work with 15 seconds of rest! However, when we are on the mat for the abs specific, the timer will be 60 seconds per exercise with no specific rest in between!
PRESS
SQUAT TO PRESS
CLEAN TO SQUAT TO PRESS
CLEAN TO SQUAT
SQUAT
WALL SIT MARCH
DIAMOND PRESS
FLYES
PALMS FACING PRESS
ABS (60 seconds, no rest)
LEG LOWER
ALTERNATING LEG LOWER
SMALL TUCK
CRUNCH
STRAIGHT LEG REVERSE CRUNCH
TUCK TO EXTENSION
BULGARIAN LUNGE x2 DUMBBELLS
SWITCH SIDE!
DECLINE PUSH UPS
FWD LEAN BULGARIAN LUNGE x1 DB
SWITCH SIDE!
DIPS
BULGARIAN LUNGE BODYWEIGHT
SWITCH SIDE!
DEEP PUSH UPS
SUPINE ROW
ELEVATE HEEL SQUATS
WALL SIT x1 DB
BODYWEIGHT ONLY ELEVATE SQUAT
CALF RAISE WALL SIT
ELEVATE SQUAT
WALL SIT
FINISHER!
45/15/45/15/60
HOVER TO DOWN DOG
PLANK TO TUCK
TRICEP PUSH UPS
PLANK TO TUCK
SPRAWLS!
The finisher really highlighted just how hard we worked our ENTIRE body!!
No repeat… No let up!
Let’s do this! 👊🏼🤩
Cx
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Don’t forget to subscribe and turn on notifications so that you don’t miss any Workouts, Community Updates or Surprises: https://youtube.com/c/carolinegirvan/?sub_confirmation=1
5 Minute Warm-Up: https://youtu.be/JOoIsy8SX4c (Always warm up before any workout)
Today’s Optional Add-on Workout: https://youtu.be/a-V4Or5xyis
20 Minute Extended Stretch and Relax: https://youtu.be/y87vSUoIMGU
FUEL Series Playlist: https://www.youtube.com/playlist?list=PLhu1QCKrfgPXD0AUCqAzmB9c5kyXP1ofQ
FUEL Series Calendar: https://carolinegirvan.com/fuel-calendar-col.pdf
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Caroline Girvan Community: https://facebook.com/groups/carolinegirvan
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Business Enquiries Email: info@carolinegirvan.com
Ab Workouts: https://www.youtube.com/playlist?list=PLhu1QCKrfgPX_3_Fir25lT1zjLvmjifl7
Cardio Workouts: https://www.youtube.com/playlist?list=PLhu1QCKrfgPVj9hpw_O3t1LoUcqUWpJio
HIIT Workouts: https://www.youtube.com/playlist?list=PLhu1QCKrfgPXHHqpj3cBJkNSRwF3P3h2k
……………………………………………………………
Disclaimer: If you are new to exercise or are planning on beginning a new fitness programme, you should consult your physician. This video may offer health, fitness or nutritional information and is meant for educational purposes only. This information is not an alternative to seeking professional medical advice or suggested treatment. Performing any exercise or programme is solely at your own risk.
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Health & fitness
Can I take Ozempic if I’m not overweight or obese? I just want to slim down before Christmas
FLU season may feel a little far off, but preparation starts now.
If you haven’t booked in your vaccine, this is your sign to do so!
Flu jabs are free on the NHS if you’re over 65, pregnant, have certain health conditions or if you’re a healthcare worker, carer or live with someone who is immunocompromised.
Two and three-year-olds can get the flu nasal spray vaccine.
Booking takes just minutes.
Use the NHS app, call your GP, or 119 free, or go online to nhs.uk/nhs- services/pharmacies/book-flu- vaccination.
Technically, flu season starts in December but infection rates start to rise this month.
Why bother getting a jab?
Well, flu is not just a bad cold, it causes a more severe illness.
While most people will recover after a week or two, for those identified as “at risk” it can be worse, fatal in some cases.
In the past two winters, both mild,18,000 deaths were associated with flu.
If you are not eligible for a free flu vaccine, one at a pharmacy costs from £12.
Here’s a selection of what readers have asked this week . . .
HOT FLUSHES 16 YEARS AFTER LAST PERIOD
Q) I HAD my last period at age 58 and at almost 74, I’m still having hot flushes.
I had been on HRT for four years previously when I was perimenopausal.
One GP told me it could go on until I’m 100 and another told me to “just live with it”.
But they’re really difficult to live with. I recently went away for a few days and the weather was lovely and warm but I was uncomfortable, to say the least.
Can you recommend what, if anything, I can do?
A) It sounds like you’re having a hard time at the moment and I’m sorry to hear that.
It’s always important to ensure that hot flushes aren’t just put down to and assumed to be the menopause.
Other things must be ruled out, especially if at the age of 74 they are new or getting worse.
There are plenty of other conditions which can cause hot flushes such as thyroid disorders, some infections and certain types of cancer as well.
So please make sure your GP investigates if necessary.
If you’re wondering about starting HRT again then there are a few things to think about.
Whatever your age, it is important to understand and be able to assess the risks versus benefit of treatment.
That equation does change as we get older, making the risks of taking HRT more significant as we age.
That’s not to say you absolutely can’t take it, but it is not commonly started in women above the age of 60, or if they are more than ten years past menopause.
It would be worth asking if there is a GP or nurse at the practice who has a special interest in menopause and if not, you may need to be referred to a menopause specialist if you do want to explore HRT further.
Of course there are non-hormonal treatments that can treat hot flushes too, including some antidepressant medications, gabapentin and, just last year, a new drug called fezolinetant was licensed in the UK for moderate to severe vasomotor symptoms – however, it is currently licensed for those up to age 65.
IS OZEMPIC SAFE FOR EVERYONE?
Q) IS it safe for people who are not overweight to use Ozempic?
A) Ozempic is not licensed as a treatment for obesity or weight loss in the UK and should only be prescribed for diabetes.
Wegovy, which contains the same drug, semaglutide, is licensed for weight loss.
Mounjaro is a slightly newer, similar drug which is also licensed for treating obesity.
These types of injectable medications work to help people lose weight, predominantly by suppressing appetite.
The causes of obesity are complex, with genetics being one of the major factors.
Our genes partly determine how much we need to eat before we feel full and play a part in how our brain responds to food cues, so a highly responsive person will feel the urge to eat more often on any given day.
With the changes to the world over the past few decades, with bigger portion sizes, calorie-dense foods and food cues everywhere we turn, it’s easy to see why some people, due to their genetics, find it difficult to remain a healthy weight more than others.
So one way to look at these drugs is that they level the playing field.
For people who are genetically predisposed to being more hungry, the medication makes their urge to eat more aligned to that of a person who finds it easy to stay slim.
In terms of safety, no medication is without any risk and the balance against benefits is different for each individual, but are more likely to lean towards being beneficial for people who have severe obesity, especially if they have related health issues.
For people of a healthy weight, or who carry excess weight but remain metabolically healthy, it’s much more likely that the risks outweigh any benefit.
Common side effects include nausea, vomiting, abdominal discomfort, gallstones and diarrhoea.
Less common, but more severe side effects include acute pancreatitis.
So in a nutshell, the simple answer to your question is no.
Tip of the week
SEASONAL affective disorder is when shorter days – and as a result, less daylight – can lead people to suffer from mood changes, fatigue, and depression.
If you have had a persistently low mood and are struggling to cope, please see your GP who can help.
Q) MY son is 17 and has got some spots on his back and shoulders and I’m not sure what it could be.
A) Thank you for the picture, below, which shows the classic signs of acne, a common skin condition.
Both blackheads and whiteheads can occur with acne and it can range from a few spots on the face, neck, back and chest, to something more problematic, with solid painful lumps under the skin which may cause scarring.
Acne usually starts during puberty but can come at any point and most of us will experience it at some point.
It’s caused by lots of different factors – sebaceous (oil-producing) glands are found near the surface of the skin and they’re affected by our hormones.
In acne, the glands are sensitive and can produce too much oil.
At the same time, dead skin cells build up and block the pores, leading to blackheads and whiteheads.
Fortunately, there are lots of treatments – your son could try going to your local pharmacist first and requesting some over-the-counter medications that don’t require a prescription such as benzoyl peroxide or azelaic acid.
Could you help him with applying this to the skin?
It could be several months before changes are seen so it’s worth persevering with whatever treatment you start with.
Often people stop using treatments after the first few days because they can cause some mild increase in redness, dryness and irritation at first.
But as long as the symptoms are mild you should continue, or use on intermittent days until the skin gets used to it.
Alongside any treatment it’s important to follow some simple lifestyle rules too – don’t wash more than twice a day or use strong soaps as this can strip the natural oils from the skin and make the sebaceous glands work even harder to produce more.
Moisturise using a fragrance-free water-based emollient and try to avoid picking spots.
If over-the-counter medications don’t work, your GP can prescribe something.
Options include antibiotic or retinoid topical treatments applied directly to the skin, oral antibiotics, or oral contraceptive pills in females.
Dermatologists can prescribe isotretinoin capsules (Roaccutane) which is highly effective but it’s important to understand the potential side effects on mental and sexual health.
OBESITY LEVELS TRIPLE
WE are wolfing down giant portions of food without even realising, experts have warned.
More than a third of us never think about how the size of a serving can affect the waistline, and regularly eat way too much pasta, rice, cheese and cereal to be healthy, research by MyFitnessPal found.
Obesity levels here have more than tripled since 1994, with an estimated 26 per cent of people now in the category, according to the British Obesity Society.
But 77 per cent say they feel uncomfortably full after meals and two-thirds are going back for seconds.
One in five eat so quickly that they don’t realise they are full, with four in ten eating in front of the TV.
Only half of those surveyed checked packets for serving size suggestions.
It all means half of us are eating double the NHS-recommended portion of pasta (75g, one handful) and rice (75g, one and a half handfuls).
Half of us fill a cereal bowl to the top at breakfast time, instead of adhering to the recommended 40g.
A third of the survey participants said they have no grasp on what the recommended portion size for a meal should be.
MyFitnessPal head of nutrition Melissa Jaeger said: “By paying more attention to portion sizes and using a nutrition tracking app, we can make more informed choices that better support our health goals.”
QUALITY OF LIFE ISSUES
THOUGH modern medicine continues to evolve rapidly, increases in life expectancy have stalled, a study suggests.
Average life expectancy almost doubled over the course of the 19th and 20th centuries, but the rate of increase has dramatically slowed in the past 30 years, according to Chicago-based research.
Life expectancy at birth in the world’s longest-living populations has increased by only an average of six and a half years since 1990, according to the analysis of the longest-living countries in the world, reported in the journal Nature Aging.
The researchers say ageing and its complications are now the main obstacle to a longer life.
But aiming to extend life by reducing age-related disease could be harmful, if those additional years aren’t healthy, they maintain.
Lead author Professor Jay Olshansky said: “Most people alive today at older ages are living on time that was manufactured by medicine.
“But these medical Band-Aids are producing fewer extra years of life even though they’re occurring at an accelerated pace, implying that the period of rapid increases in life expectancy is now over.
“We should now shift our focus to efforts that slow ageing and extend ‘healthspan’.”
Some scientists had predicted that life expectancy would continue to improve over the 21st century thanks to advances in medicine and public health.
Womens Workouts
Bored of lunges and squats…TRY THIS #fitness #legworkout #workout
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