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Will I be diagnosed with Alzheimer’s like my mother?

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Will I be diagnosed with Alzheimer's like my mother?
Sally Magnusson  Sally Magnusson (left), holding red and pink flowers, with her mother Mamie who is wearing a purple blouse and green cardigan. They are looking in the same direction and their heads are touching. There are green trees behind them. Sally Magnusson

Sally Magnusson has already written a book about how her family coped with her mother’s dementia

There can’t be many people who spend years raging and grieving over the decline of a parent from dementia without wondering if it awaits them too.

I’m one.

My mother died of this vicious brain condition in 2012. And hardly a day has passed since when that question hasn’t been darting around the edge of my mind, flaring ridiculously into view every time I misplace a word, a name or a pair of glasses.

Actually it’s perfectly normal in a busy life to lose your specs or wonder what you went looking for in the cupboard.

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But tell that to those of us in the traumatised next generation, who have watched loved ones suffer in ways we can still hardly bear to think about. Is this, we ask ourselves, the start of the horror again?

Curing Alzheimer’s is within our grasp

Now, for the first time, we can find out for sure.

A simple blood test, taken as part of a research programme and backed up where necessary by a lumbar puncture and PET scan – which produce three-dimensional images of the inside of the body – can tell us if amyloid, a brain protein implicated in Alzheimer’s disease, is already present.

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I’ve made a film about what that means for individuals like me in their 50s and 60s with a family history of Alzheimer’s, the most common of the illnesses leading to dementia.

And guess what? Deciding if you want to go through with it is not so simple.

My mother, Mamie Baird, was one of the pioneering female journalists of the 1950s.

Bright, clever, quick-witted and funny, she was still writing and giving hilarious after-dinner speeches into her 60s.

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But like a million or so others in the UK, she succumbed to a disease that gnawed at her personality and cognition until it consumed her ability to function at all.

Sally Magnusson  Sally Magnusson (left) in brown trousers and a pink T-shirt with sunglasses on her head, with her mother Mamie (centre), wearing a light blue jumper with white blouse underneath, sister Margaret (right) in beige trousers and a brown T-shirt. The three woman are sitting on a red and pink striped hammock with grass around them. Sally's sister Anna is crouching down behind them and is wearing a pink long-sleeved top.Sally Magnusson

Sally’s mother Mamie (centre) was a pioneering journalist who was still writing and giving after-dinner speeches into her 60s

There was nothing to help her: Little support, and no drug to mitigate the symptoms that over time made life an agony for her and for all of us who loved her.

Dementia is not a natural part of ageing, although the risk increases with age. It’s an illness caused by one, or a combination, of a number of brain conditions.

My mother was diagnosed with both Alzheimer’s and vascular dementia, and although we had good times together in the years afterwards, many laughs and much joyfulness in the moment, the progressive incapacity and disconnection from herself were painful to her beyond words.

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Sally Magnusson  Selfie of Sally Magnusson (right) in a navy blue top next to her daughter Anna Lisa who is wearing a grey hoodie. Anna Lisa is holding her daughter Remy who has dark hair. The sun is shining on the bright green grass and trees behind them and they are all smiling at the camera.Sally Magnusson

Sally’s daughter Anna Lisa is afraid of the implications of Sally finding out if she has the brain protein
Finestripe Sally Magnusson in a pink jumper with baby granddaughter Remy on her knee. They are in a room with a TV in the background and are playing with a yellow and red baby toy. Finestripe

Sally playing with her granddaughter Remy

In 2014, I published the book Where Memories Go, a mixture of memoir and journalism, to highlight what the experience is like for families who have to struggle on without hope of improvement – and I was stunned by the reaction.

In the thousands of messages I got from across the country, it felt as if a great floodgate of pain and family loneliness was opening.

Now 10 years on, there is hope.

Testing, treatments and cure

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Scientists have shown that the build-up of amyloid in the brains of people with Alzheimer’s can be successfully cleared.

They’re convinced that if drugs already in development (and at least one, lecanemab, is now licensed for use in the UK, although not yet on the NHS) are given to people before they develop symptoms, Alzheimer’s can be stopped in its tracks.

Finestripe  Sally Magnusson (left) is sitting across a table from Prof Craig Ritchie. She is wearing glasses, a cream top and a burgundy jacket. She is holding a mug. Prof Ricthie is facing away from the camera wearing a dark top and is gesticulating with his hand. There is a mug on the table and chars behind the pair.Finestripe

Prof Craig Ritchie says thousands of people need to come forward for testing before they are conscious of symptoms

As Prof Craig Ritchie, who runs the pioneering Scottish Brain Sciences (SBS) in Edinburgh, says: “We can cure Alzheimer’s before it becomes dementia – just as we learned to stop HIV before it became AIDS.”

But to do that, scientists like him need many thousands of people to come forward for testing before they’re conscious of symptoms.

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Which means that folk like me, still gaily going about normal lives and tackling demanding jobs, have to be prepared to find out that they already have the disease process of Alzheimer’s going on in their brains.

Prof Ritchie, who I originally met through my work with the music and dementia charity Playlist for Life, suggested I join the enormous research cohort he is trying to gather at SBS.

“After all, Sally,” he said, “you might equally discover you’re not amyloid-positive. Imagine the relief that would be.”

And if it turns out that I am? If I know what cannot be unknown, what then?

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Sally Magnusson  Sally Magnusson with her family in formal wedding clothes. Sally is in the centre wearing a red dress and white jacket and her daughter Anna Lisa is on her right wearing a black dress. Sally's husband Norman is on her left in a kilt and sporran and formal wedding jacket. Also pictured are the couple's four sons Jamie, Rossie, Magnus & Siggy.Sally Magnusson

Sally and husband Norman with their daughter Anna Lisa and sons Jamie, Rossie, Magnus and Siggy

Treatments are coming, but they’re not here yet. The paradox is that only if people like me join research programmes like Craig’s can they come in time to save those of us in our 60s now.

I asked my own family about this.

My four sons think I should go ahead and do it. Find out the truth, they say, and let’s deal with it together.

But my daughter, still traumatised by seeing what happened to her grandma, burst into tears.

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She’s afraid that if we do find out that amyloid is lurking in my brain, with no immediate means of removing it, the knowing will affect our present, not just our future.

We are on the cusp of game-changing developments today, which, if scientists are right, could cure Alzheimer’s soon.

Biomarkers in the blood will allow people at risk to be identified and given the opportunity to participate in trials for new treatments.

That’s good for them and it’s good for their children and grandchildren. But if these trials can’t be run at scale with non-symptomatic volunteers, scientists won’t be able to develop this vital next stage of treatments.

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So they need people like me. What should I do? That’s what my film is about.

Sally Magnusson: Alzheimer’s, a Cure and Me will be broadcast on BBC Scotland at 21:00 on Sunday 13 October. It will also be available on the iplayer.

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Business

should Google be broken up?

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As suggested by the fact that its very name has become shorthand for online search, Google’s dominance isn’t in question: if you look at market share, it has no real rivals. In the US, nearly 90 per cent of search queries flowed through Google in 2020, and on mobile that figure was 95 per cent — the next closest, Microsoft’s Bing, accounted for just 6 per cent.

On Tuesday, the US Department of Justice proposed various remedies to break down what a judge has ruled is the search giant’s illegal monopoly. This “high-level framework” offered solutions that ranged from softer approaches, such as Google limiting payments to smartphone makers in return for exclusivity on their devices, up to the most draconian option: forcibly breaking up the company.

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A structural remedy could mean spinning off Google’s Chrome browser or Android operating system. But it’s unclear if even this would shake their dominance. We know that when European Android users select a search engine when they set up a new phone, nine out of 10 still use Google.

A hearing is set for April, and Amit Mehta, the judge who branded Google a “monopolist” at the conclusion of the trial in August, has said he will try to rule by August 2025.

So what do you think: should Google be broken up? Tell us your view by voting in our poll or commenting below the line.

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Money

Business owners fast-tracking exit plans over CGT concerns

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Premier Miton hires ex-Quilter director as COO

UK business owners have fast-tracked their exit plans over the past 12 months, according to new research from Evelyn Partners.

Nearly one in three (29%) have accelerated business exits in the past year, amid rumours CGT rates could take centre stage in the upcoming Budget.

This is an uplift on the 23% who said 18 months ago that they had brought forward business exits over the previous year.

The research found nearly a quarter (23%) of the 500 business owners with turnovers of upwards of £5m surveyed by Evelyn Partners who had fast-tracked their exits in the last year had done so because of worries about an increase in CGT.

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In addition, 20% brought forward business exits over the past 12 months because of fears of potential cuts in IHT reliefs.

The government has ruled out increasing the main rate of corporation tax above 25% and has pledged to freeze headline rates of VAT, income tax and National Insurance in the Budget.

However, the Treasury has remained tight-lipped on the outlook for CGT rates and IHT reliefs, as well as the tax rules around workplace pensions.

Other factors are also at play, with 25% of business owners who had fast-tracked business exits saying they had done so because of personal finance challenges resulting in a need to access the capital tied up in their business.

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In addition, 24% brought forward plans due to increased costs of accessing capital as a result of rising interest rates.

Laura Hayward, tax partner at Evelyn Partners, said: “As the countdown to the Budget on 30 October ticks away, we have been contacted by an increasing number of business owners worried about what the chancellor will do to CGT and IHT.

“The prime minister’s statement that the upcoming Budget would be ‘painful’ has put owner-managed businesses on edge and this has prompted many to want to exit as quickly as possible.

“The business environment for many owners has already been tough enough in recent years as they have worked hard to rebuild their businesses after the pandemic, against a backdrop of cost-of-living pressures and high inflation.

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“Add to that the potential for unfavourable tax changes in the upcoming Budget and it’s completely understandable that some are hoping to realise the gains of their successes sooner rather than later.

Of those owners who are currently working towards a business exit, family succession (22%) is the most popular strategy followed by establishing an employee ownership trust (16%).

Hayward added: “Whatever strategy is used, exiting a business is a really big decision for business owners and it’s important that they put in place a plan that is appropriate for them and their business.

They need to carefully consider a range of factors, with possible changes to the tax regime being just one aspect.

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“Holistic advice considering both the business and personal implications of a sale will help make the exit – which can be fast-tracked if need be – as successful as possible.”

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State pensioners earning £1,068 warned they owe HMRC tax

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State pensioners earning £1,068 warned they owe HMRC tax


Pensioners are just as liable to pay income tax as anyone else

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Travel

TUMI Unveils New Turin Collection with Lando Norris

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TUMI Unveils New Turin Collection with Lando Norris

Alongside Turin, the campaign highlights TUMI’s iconic Alpha X and 19 Degree Titanium collections, as well as silhouettes from the TUMI | McLaren range.

Continue reading TUMI Unveils New Turin Collection with Lando Norris at Business Traveller.

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Business

BP warns of hit to earnings from weak refining margins and lower output

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BP said its third-quarter earnings would be lower than expected when it reports at the end of October, on weak margins at its refineries, lower output from its oilfields and higher exploration write-offs.

Giacomo Romeo, an analyst at Jefferies, said he expected consensus earnings would now be about 10 per cent lower than the $2.3bn previously forecast.

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BP said it had taken hits of up to $1.1bn across its businesses and that net debt would be higher than expected, partly because some of its divestment proceeds would fall into the subsequent quarter.

The oil major’s share price has lagged behind its peers and is down more than 12 per cent in the year to date.

This is a developing story

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Money

Warning for 335,000 taxpayers ahead of key HMRC deadline including Vinted and eBay sellers – do you need to act?

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Warning for 335,000 taxpayers ahead of key HMRC deadline including Vinted and eBay sellers - do you need to act?

THOUSANDS of taxpayers have been warned not to miss a fast-approaching HMRC deadline or they could face fines of £100.

There are just three weeks left to submit a paper self-assessment tax return with the final cut-off point on October 31.

The deadline to submit a paper self-assessment tax return is approaching fast.

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The deadline to submit a paper self-assessment tax return is approaching fast.

The assessment is used by the government body to collect income tax.

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This tax is usually deducted automatically from people’s wages, pensions and savings.

However, people and businesses with extra income must report it in a tax return.

Many people choose to complete this process online through the HMRC website as the online deadline is not until January 31, 2025.

But if you want to submit your tax return via the post you must complete it by October 31.

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In some instances submitting a physical tax return is your only option, especially if you need to fill in the foreign income and gains, or the trust and estate pages.

This is because these forms are not available online.

If you sell clothes or other items on websites such as eBay or Vinted you might want to make note of the date.

That is because since the beginning of 2024, firms like Vinted have to pass on customer data to HMRC if a user sells 30 or more items, or earns over £1,700, in a year.

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While the reporting rules have changed, this is not a new tax.

I’ve made £1.5k on Vinted – the mistake that affects the algorithm and the EXACT number of pictures to take to make cash

Those who earn more than £1,000 outside their regular employment were already required to file a Self Assessment tax form with HMRC.

It is worth bearing in mind that HMRC will fine you for failing to file your return by the deadline.

Then, a £10 daily fine applies every day you don’t submit your tax return.

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Alastair Douglas, chief executive of TotallyMoney said it is important people do not get “caught out”.

The financial professional said people struggling with learning difficulties such as autism or dyslexia should contact HMRC’s extra support team for assistance. 

He explained: “They’re specially trained, and can guide you through the process with a video appointment or phone call — you’ll just need to mention your situation when contacting the HMRC helpline or webchat.”

Do I have to pay tax on my second-hand sales?

Sellers on apps such as eBay and Vinted my be required to pay tax.

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If you have made 30 sales or £1,700 this year you will be contacted by Vinted and asked to submit the seller report form on the app.

This year, the company said it will only approach new sellers who registered in 2024.

If you do not hear from Vinted then you don’t need to do anything, though you may need to file a tax return for other reasons separately.

Users who meet the criteria will be asked to add their National Insurance Number to a pre-filled form and check the details are correct before submitting it.

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This will be done on the Vinted app.

You don’t need to calculate or count anything yourself.

A Vinted spokesperson said: “Reporting members’ details to the authorities does not necessarily lead to taxation.

“Taxation is a separate matter that doesn’t depend on HMRC reporting.”

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They added: “HMRC requires Vinted to collect information from members who meet the criteria mentioned above, regardless of whether or not their earnings are taxable.”

Vinted said that it will be getting in contact with users who need to fill out these forms towards the end of the year.

What that means in practice is that money you make may be reported to the taxman if it’s over the amounts above.

Whether or not you have to pay tax will depend on your wider circumstances.

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The majority of people pay income tax automatically through employment via what’s known as PAYE.

How do I file a tax return?

TO file a self assessment tax retun, you’ll need to register with HMRC first, which will then issue you with a Unique Taxpayer Reference (UTR).

You must register for self assessment by October 5 if you have to file a tax return and you have not sent one before.

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You can do so by visiting www.gov.uk/register-for-self-assessment.

If you’ve previously registered and already have a UTR, you don’t need to go through this step again.

Once you’ve got your UTR, you can sign in via the “Self Assessment tax return” section of HMRC’s website by visiting www.gov.uk/log-in-file-self-assessment-tax-return.

You can then file your self assessment tax return online.

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The deadline for sending a return online is January 31 every year.

If you need a paper copy of the main Self Assessment tax return, call HMRC on 03000 200 3610 and request an SA100 form.

The deadline for sending a return using a paper form is October 31 every year.

You need to pay the tax you owe by midnight on January 31 each year.

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HMRC accepts your payment on the date you make it, not the date it reaches its account.

File late and HMRC will issue you with a fine.

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