Ten minutes of hard exercise releases molecules into the bloodstream that can shut down cancer growth signals and switch on DNA repair, according to research from Newcastle University, UK.

Exercise raises the levels of several small molecules in the blood, many of which are known to reduce inflammation, support blood vessel health and improve metabolism. 

The study involved 30 volunteers, male and female, aged 50 to 78, all overweight or obese, but otherwise healthy. They completed a 10-minute intense cycling test, after which researchers collected blood samples and analysed these for 249 proteins.

Thirteen of these proteins – which help to repair the DNA of damaged cells – increased after exercise.

Exercise boosted the activity of genes that support mitochondrial energy metabolism, enabling cells to use oxygen more efficiently. At the same time, genes linked to rapid cell growth were switched off, which could reduce the aggressiveness of cancer cells and exercise-conditioned blood promoted DNA repair, activating a key repair gene called PNKP. 

Senior lecturer in clinical exercise physiology at Newcastle University, Dr Sam Orange, who led the study, said: “What’s remarkable is that exercise doesn’t just benefit healthy tissues, it sends powerful signals through the bloodstream that can directly influence thousands of genes in cancer cells.

“These results suggest that exercise doesn’t just benefit healthy tissues, it may also create a more hostile environment for cancer cells. Even a single workout can make a difference. One bout of exercise, lasting just 10 minutes, sends powerful signals to the body. It’s a reminder that every step, every session, counts when it comes to doing your best to protect your health.”

Researchers plan to test whether repeated exercise sessions produce lasting changes and explore how these effects interact with standard cancer treatments such as chemotherapy and radiotherapy.

Exercise serum promotes DNA damage repair and remodels gene expression in colon cancer cells was published in International Journal of Cancer.

The Spring Transfer Portal window is a thing of the past, and there is a rule change being discussed to make that permanent.

Player movement after Spring Practice should be obsolete.

On today’s episode of Locked On College Football, Spencer McLaughlin breaks down some of the most impactful QB transfers that will play for new teams this year.

Indiana’s Josh Hoover has to be on top of any list. Targeting rule changes are being proposed to try to lessen the penalties for players who are flagged for it.

Spencer lays out how he would issue targeting penalties in college football.

00:00 Spring Transfers Hurt College Football
03:33 NCAA Antitrust Exemption Debate
08:04 Optimizing Transfer Portal Timing
12:41 Indiana’s Incredible Football Turnaround
20:00 LSU’s Future Hinges on Leavitt
26:15 Debating Targeting Ejection Rule
27:38 “End Targeting Ejections Now” 

Teams battling for playoff positioning meet when the Los Angeles Clippers meet the Golden State Warriors in a key NBA Pacific Division matchup on Monday night. Los Angeles is coming off a 137-117 win over the New Orleans Pelicans on Sunday, while Golden State dropped a 129-101 decision to the Los Angeles Lakers on Saturday. The Clippers (28-31), who are 18-18 against conference opponents, are 13-18 on the road this season. The Warriors (31-29), who are 21-18 against Western Conference foes, are 19-12 on their home court. Darius Garland is set to make his Clippers debut after being acquired in January from the Cleveland Cavaliers. The Warriors will be without Stephen Curry (knee), Will Richard (ankle) and Kristaps Porzingis (illness).

Tipoff from Chase Center in San Francisco is set for 10 p.m. ET. The Warriors lead the all-time series 139-103, but the teams have split a pair of games so far this season. The Clippers are a 1.5-point favorite in the latest Clippers vs. Warriors odds from DraftKings Sportsbook, while the over/under for total points scored is 2165.5. Before making any Clippers vs. Warriors picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

New users can target the DraftKings promo code, which offers $200 in bonus bets if your first $5+ bet wins:

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered Week 19 on a sizzling 38-18 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Clippers vs. Warriors 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA odds and NBA betting lines for Warriors vs. Clippers:

New users can also target the latest Underdog promo code CBSSPORTS2, good for $75 in fantasy bonus entries when you play $5 in select states.

Top Clippers vs. Warriors predictions

After 10,000 simulations of Clippers vs. Warriors, SportsLine’s model is going Over on the total (215.5). The Over has hit in four of the last five Los Angeles games, and in six of the past seven Golden State games. The Clippers are 7-3 against the spread in their last 10 games. The Warriors, meanwhile, are 3-7 ATS in their last 10.

The SportsLine model is projecting the Clippers’ Kawhi Leonard to score 24.7 points on average and be one of five Los Angeles players to score 10.4 or more points. The Warriors’ De’Anthony Melton, meanwhile, is projected to have 18.8 points as seven Golden State players score 10.4 points or more. The teams are projected to combine for 228 points as the Over hits nearly 70% of the time.

How to make Warriors vs. Clippers picks

The model also says one side of the spread hits well over 60% of the time. You can head to SportsLine to see the model’s NBA picks. 

So who wins Warriors vs. Clippers, and which side of the spread hits well over 60% of the time? Visit SportsLine now to see which side of the Clippers vs. Warriors spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.

Two-time Olympic medal-winning Indian badminton star P V Sindhu, who was stranded in Dubai due to closure of airspace in the Gulf region, has returned to the country after pulling out of the All England Championships in Birmingham.

Sindhu posted on X to announce that she is back in the city.

“Back home in Bangalore and safe. The last few days have been intense and uncertain, but I’m truly grateful to be back to my house,” she posted.

“A heartfelt thank you to the incredible ground teams, Dubai authorities, airport staff, immigration, and every single person who stepped up and took such good care of us during a very difficult time. The empathy and professionalism meant more than words can say.

“For now, it’s time to rest, reset, and figure out the next steps,” she added.

The former world champion was on her way to Birmingham via Dubai, when she was stranded after the flight operations were suspended in the Gulf region following the US and Israeli bombing of Iran.

Iran subsequently retaliated, hitting Dubai as well.

“Moments like these remind you how fragile normal life really is,” she had posted on February 28 while revealing some details of her ordeal, which included an explosion near her place of stay.

She had described the experience as “extremely tense and scary moment” for her and her team, including Indonesian coach Irwansyah Adi Pratama.

Inclement weather might spice up proceedings in the Verry Elleegant Stakes, however trainer Chris Waller intends to disregard forecasts until race day.

The Bureau of Meteorology predicts a spectrum of rain amounts this week, from just 4mm to nearly 60mm.

Star mare and dominant favourite Autumn Glow has proven versatile on different surfaces, including heavy 10 going in August’s Toy Show Quality (1100m), but her effectiveness there in a Group 1 is yet to be tested.

Waller is keeping track conditions out of his mind presently.

“I’ll worry about it Saturday morning,” Waller said.

“If you worry about it before then, you start bringing things in that you have no control over and you can lose sight of other things. Yes, it’s a factor. But as long as it’s safe, she will be running.

“They’ve got the tracks in Sydney pretty good at the moment . . . There will be room for a bit of rain.”

Unbeaten in nine races, Autumn Glow has emerged as a major force, convincingly beating fellow stable runners Aeliana and Lindermann in the Apollo Stakes (1400m) on her latest outing after moving to weight-for-age.

Those two will line up against her once more in the Group 1 Verry Elleegant Stakes (1600m) over Randwick’s track on Saturday, potentially improving with the step up in trip.

“They’re a bit more comfortable at the distance,” Waller said.

“But it’s hard to quantify, Autumn Glow might be better too.”

Waller boasts a strong record with seven wins from the last 10 runnings, four achieved by Winx from 2016-2019, and public confidence is high in Autumn Glow continuing the streak at $1.30 in early betting.

Discover premier betting sites with the keenest racing odds for the Verry Elleegant Stakes.

Paul Scholes has suggested there is a perfect manager for Manchester United, while questioning whether interim boss Michael Carrick has the experience to lead the club in the long term

Paul Scholes has proposed that Manchester United consider appointing Carlo Ancelotti as their next manager this summer. Although a permanent appointment is anticipated at the season’s end, interim head coach Michael Carrick has made a strong impression since succeeding Ruben Amorim in January and could be considered for the role on a long-term basis.

Former Reds midfielder Carrick now boasts the joint-best record of any Premier League manager over their initial seven matches, with six victories and one draw. United’s 2-1 comeback against Crystal Palace solidified their position in the top five, propelling them past Aston Villa into third place.

Nonetheless, Scholes is of the opinion that Ancelotti is the perfect fit for the club. Speaking on The Good, The Bad and The Football Podcast, he stated: “The perfect one out there – I say perfect – Ancelotti is still out there. I know he is coach of Brazil.

“He is the perfect one for Manchester United where you think he will make players feel a million dollars. And he has the experience of winning stuff.

“But the question is, is he too old now? That’s the only thing. Is there anyone else of that ilk, with more experience? They need presence as a leader.”

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Ancelotti managed Real Madrid for four years before leaving the club last year, and whilst he will guide Brazil in this summer’s World Cup, he has been absent from domestic football since his departure.

Scholes, meanwhile, outlined why he thinks Carrick may lack the necessary experience to guide the Reds forward.

“The question is, has Michael got the experience?” Scholes continued. “I know it’s a big question, I know he has managed in the Championship, but this is different.

“Can we see Michael winning the Premier League? I don’t know yet, and I think the biggest thing is, what type of manager will they look for? A tactician or a man manager who looks after people? Ole Gunnar [Solskjaer] was that.”

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“But all the people who are man managers, they always have a brilliant coach next to them, which Michael has got [Steve Holland].

“The club have to decide, do they want a master tactician, which has failed. Ole Gunnar had the man management skills, but did he have the experience to go on and win a trophy? The same questions will be asked of Michael.”

United have ten fixtures remaining this season to secure their top-four position as they strive to return to European football.

Their most recent Champions League campaign was in the 2023/24 season, when they finished bottom of their group and were eliminated early. The subsequent season saw them reach the Europa League final, where they lost 1-0 to Tottenham in Bilbao.

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