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BaCta is using engineered bacteria to grow natural rubber and slash CO2 emissions

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BaCta is using engineered bacteria to grow natural rubber and slash CO2 emissions

The synthetic biology and precision fermentation space is a hotbed of entrepreneurial activity these days. But it’s not every day you come across a startup that’s using genetic engineering to produce natural rubber — a substance that’s challenging to reproduce in a lab because of how long its polymer is.

Paris-based baCta has a proof of concept up and running that uses engineered bacteria (E.coli) to yield natural rubber in vitro. The startup says its method, which relies upon a renewable feedstock — currently it’s using glucose but is aiming to diversify into acetate and carbon — is carbon neutral.

The startup has just bagged €3.3 million (around $3.6 million at current exchange rates) so it can get to work on its next challenge: figuring out how to industrialize its lab-based process and move from producing milligrams of raw material so far into the far greater quantities necessary for other companies to use its rubber to make their own products.

Natural rubber not grown on trees

Around half the world’s rubber is synthetic (i.e. derived from petroleum); the other half (natural rubber) is harvested from the latex-laden sap of Hevea trees. Neither route is great from a sustainability point of view. Though natural rubber might sound more environmentally friendly, it can lead to deforestation if land is cleared to make way for Hevea plantations.

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At the same time, with the advent of emissions reporting regulations and the like, manufacturers in Europe and elsewhere are under pressure to find ways to reduce their carbon footprints. So if a raw material’s supply can be greener, and the product is competitively priced, there should be a clear incentive to switch to a bio-engineered version of natural rubber.

BaCta CEO and founder Mathieu Nohet sounds confident that the startup, which was only founded in January 2024, will be able to scale up production of its biosynthesized natural rubber.

He also thinks the approach it’s taken — which involves “synthetic AI enzyme technology that basically lifts scientific barriers and enables polymerization of rubber inside bacteria,” as he explains it — will allow it to hit a price-point that’s competitive versus the conventional commodity, while offering major reductions in CO2 emissions.

“Having this polymerization mechanism inside the cell enables us to be much more efficient in terms of yield and, ultimately, in terms of cost per kilogram, which means that if we’re able to pull off the mixotrophic approach [i.e. feedstock diversification], we’ll actually be competitive with the commodity at the price that is today.”

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“We’re testing acetate [as a feedstock] and also trying to fix carbon directly inside the cell to increase yield, decrease cost and carbon impact. [Natural rubber] has a huge carbon impact, so we could actually remove hundreds of millions of tons of CO2 from the atmosphere if we [are] successful.”

Initially, baCta’s go-to-market strategy entails targeting the material at luxury fashion/apparel brands — so for use-cases like premium shoes, bags, etc. — which don’t need large quantities of raw material. It would then seek to expand out to more industrial-style use cases (rubber parts for vibration damping in machinery, for example) once it’s stepped up production.

“The goal is to scale it up,” he says. “First try it in a fermenter, get it out of the lab, basically, and then to a pilot scale. So, let’s say, 100 to 200 liters cultures, so that we can start delivering bigger batches to our potential customers.”

The startup is hoping to reach pilot scale in 18 months, per Nohet. “Then we would raise another round to reach pre-industrial scale,” he says.

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BaCta’s pre-seed round is led by OVNI Capital, with participation from another.vc, Kima Ventures, Sharpstone Capital, and “prominent” business angels, including Thibaud Elziere and members of the Hexa team, as well as Nicolas Morin, co-founder of Gourmey.

Since the startup’s natural rubber is produced through genetic engineering, Nohet confirms they are able to remove specific proteins in the tree sap that can trigger allergies. This means the biosynthesized natural rubber could have an added benefit in that it could be marketed as hypoallergenic.

Down the line, the startup has plans to move beyond rubber production, too: It wants to apply the approach to deliver carbon neutral production of isoprenoids — a family of chemical compounds derived from a monomer of the rubber polymer — that have many uses in areas like industrial and pharmaceutical production.

But the company is sticking with natural rubber for starters.

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“Rubber has this advantage where many, many people use it for different usage,” he notes. “So we can actually have a sequential go-to-market, where we start with a very high-end customers, and then move towards more mass market. Plus it’s a very, common, famous, understandable product. So we think it’s easier to get people behind the mission with a first product that everybody knows.”

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MDC Assembly Guide 42U Server Cabinet – SRRCS62107

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MDC Assembly Guide 42U Server Cabinet - SRRCS62107



MDC Assembly Guide 42U Server Cabinet – SRRCS62107. Short guide, easy assembly. Call for more info. .

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Agents are the future AI companies promise — and desperately need

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Agents are the future AI companies promise — and desperately need

Humans have automated tasks for centuries. Now, AI companies see a path to profit in harnessing our love of efficiency, and they’ve got a name for their solution: agents. 

AI agents are autonomous programs that perform tasks, make decisions, and interact with environments with little human input, and they’re the focus of every major company working on AI today. Microsoft has “Copilots” designed to help businesses automate things like customer service and administrative tasks. Google Cloud CEO Thomas Kurian recently outlined a pitch for six different AI productivity agents, and Google DeepMind just poached OpenAI’s co-lead on its AI video product, Sora, to work on developing a simulation for training AI agents. Anthropic released a feature for its AI chatbot, Claude, that will let anyone create their own “AI assistant.” OpenAI includes agents as level 2 in its 5-level approach to reach AGI, or human-level artificial intelligence.

Obviously, computing is full of autonomous systems. Many people have visited a website with a pop-up customer service bot, used an automated voice assistant feature like Alexa Skills, or written a humble IFTTT script. But AI companies argue “agents” — you’d better not call them bots — are different. Instead of following a simple, rote set of instructions, they believe agents will be able to interact with environments, learn from feedback, and make decisions without constant human input. They could dynamically manage tasks like making purchases, booking travel, or scheduling meetings, adapting to unforeseen circumstances and interacting with systems that could include humans and other AI tools.

Artificial intelligence companies hope that agents will provide a way to monetize powerful, expensive AI models. Venture capital is pouring into AI agent startups that promise to revolutionize how we interact with technology. Businesses envision a leap in efficiency, with agents handling everything from customer service to data analysis. For individuals, AI companies are pitching a new era of productivity where routine tasks are automated, freeing up time for creative and strategic work. The endgame for true believers is to create AI that is a true partner, not just a tool.

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“What you really want,” OpenAI CEO Sam Altman told MIT Technology Review earlier this year, “is just this thing that is off helping you.” Altman described the killer app for AI as a “super-competent colleague that knows absolutely everything about my whole life, every email, every conversation I’ve ever had, but doesn’t feel like an extension.” It can tackle simple tasks instantly, Altman added, and for more complex ones, it will attempt them but return with questions if needed. Tech companies have been trying to automate the personal assistant since at least the 1970s, and now, they promise they’re finally getting close.

At an OpenAI press event ahead of the company’s annual Dev Day, head of developer experience Romain Huet demonstrated the company’s new Realtime API with an assistant agent. Huet gave the agent a budget and some constraints for buying 400 chocolate-covered strawberries and asked it to place an order via a phone call to a fictitious shop.

The service is similar to a Google reservation-making bot called Duplex from 2018. But that bot could only handle the simplest scenarios — it turned out a quarter of its calls were actually made by humans.

While that order was placed in English, Huet told me he gave a more complex demo in Tokyo: he prompted an agent to book a hotel room for him in Japanese where it would handle the conversation in Japanese and then call him back in English to confirm it’s done. “Of course, I wouldn’t understand the Japanese part — it just handles it,” Huet said.

But Huet’s demo immediately sparked concerns in the room full of journalists. Couldn’t the AI assistant be used for spam calls? Why didn’t it identify itself as an AI system? (Huet updated the demo for the official Dev Day, an attendee says, making the agent identify itself as “Romain’s AI Assistant.”) The unease was palpable, and it wasn’t surprising — even without agents, AI tools are already being used for deception.

There was another, arguably more immediate problem: the demo didn’t work. The agent lacked enough information and incorrectly recorded dessert flavors, causing it to auto-populate flavors like vanilla and strawberry in a column, rather than saying it didn’t have that information. Agents frequently run into issues with multi-step workflows or unexpected scenarios. And they burn more energy than a conventional bot or voice assistant. Their need for significant computational power, especially when reasoning or interacting with multiple systems, makes them costly to run at scale.

AI agents offer a leap in potential, but for everyday tasks, they aren’t yet significantly better than bots, assistants, or scripts. OpenAI and other labs aim to enhance their reasoning through reinforcement learning, all while hoping Moore’s Law continues to deliver cheaper, more powerful computing.

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So, if AI agents aren’t yet very useful, why is the idea so popular? In short: market pressures. These companies are sitting on powerful but expensive technology and are desperate to find practical use cases that they can also charge users for. The gap between promise and reality also creates a compelling hype cycle that fuels funding, and it just so happens that OpenAI raised $6.6 billion right as it started hyping agents.

AI agent startups have secured $8.2 billion in investor funding over the last 12 months

Big tech companies have been rushing to integrate all kinds of “AI” into their products, but they hope AI assistants in particular could be the key to unlocking revenue. Huet’s AI calling demo outpaces what models can currently do at scale, but he told me he expects features like it to appear more commonly as soon as next year, as OpenAI refines its “reasoning” o1 model.

For now, the concept seems to be mostly siloed in enterprise software stacks, not products for consumers. Salesforce, which provides customer relationship management (CRM) software, spun up an “agent” feature to great fanfare a few weeks ahead of its annual Dreamforce conference. The feature lets customers use natural language to essentially build a customer service chatbot in a few minutes through Slack, instead of spending a lot of time coding one. The chatbots have access to a company’s CRM data and can process natural language easier than a bot not based on large language models, potentially making them better at limited tasks like asking questions about orders and returns.

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AI agent startups (still an admittedly nebulous term) are already becoming quite a buzzy investment. They’ve secured $8.2 billion in investor funding over the last 12 months, spread over 156 deals, an increase of 81.4 percent year over year, according to PitchBook data. One of the better-known projects is Sierra, a customer service agent similar to Salesforce’s latest project and launched by former Salesforce co-CEO Bret Taylor. There’s also Harvey, which offers AI agents for lawyers, and TaxGPT, an AI agent to handle your taxes.

Despite all the enthusiasm for agents, these high-stakes uses raise a clear question: can they actually be trusted with something as serious as law or taxes? AI hallucinations, which have frequently tripped up users of ChatGPT, currently have no remedy in sight. More fundamentally, as IBM presciently stated in 1979, “a computer can never be held accountable” — and as a corollary, “a computer must never make a management decision.” Rather than autonomous decision-makers, AI assistants are best viewed as what they truly are: powerful but imperfect tools for low-stakes tasks. Is that worth the big bucks AI companies hope people will pay?

For now, market pressures prevail, and AI companies are racing to monetize. “I think 2025 is going to be the year that agentic systems finally hit the mainstream,” OpenAI’s new chief product officer, Kevin Weil, said at the press event. “And if we do it right, it takes us to a world where we actually get to spend more time on the human things that matter, and a little less time staring at our phones.”

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Nintendo to hold playtest for a new, unannounced Switch Online feature

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Nintendo Switch

Nintendo has announced that it will perform a playtest this month for a mysterious, new Nintendo Switch Online feature.

The Nintendo Switch Online: Playtest Program is scheduled to begin on October 24 and will run through November 6.

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A quick look at Supermicro’s X13 generation of GPU servers

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A quick look at Supermicro’s X13 generation of GPU servers



Get a quick look at Supermicro’s X13 generation GPU system. Supermicro’s X13 portfolio features more than 15 system families optimized for tomorrow’s data center workloads. Join ServeTheHome’s Patrick Kennedy as he takes a deep dive into the X13 range to find out how Supermicro is able to deliver the highest-performing, most energy-efficient rack-scale server solutions available today!

Learn more: https://www.supermicro.com/en/products/x13

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Do the 2024 Nobel prizes show that AI is the future of science?

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Do the 2024 Nobel prizes show that AI is the future of science?

AI may increasingly contribute to scientific discoveries

Yuichiro Chino/Getty Images

It is a common refrain that artificial intelligence is coming to take all our jobs, and now it seems that Nobel prizewinners are no exception. Two of the awards this year, for physics and chemistry, have been claimed by people working in the field of AI – much to the chagrin of some researchers in areas more traditionally recognised by these categories. What does the rise of the AI Nobel mean for the future of science?

“These prizes reflect two different ways of reckoning with the relationship between AI and science:…

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CARA PASANG WALLMOUNT RACK SERVER 9U CISCOM

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CARA PASANG WALLMOUNT RACK SERVER 9U CISCOM



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