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Major shareholder moves on Canyon

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Major shareholder moves on Canyon

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Ticket prices set to rise as Heathrow able to recover runway money

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Heathrow Airport will be allowed to charge airlines more for its services to recover money spent on the early stages of its third runway project.

The aviation regulator is permitting the airport to claw back up to £320m through higher airport charges to airlines for each passenger, which is likely to end up being added to ticket prices.

A bidder which unsuccessfully put forward a rival design involving a shorter runway, Arora Group’s Heathrow West, will also be allowed to recover £4.1m pounds in costs.

The Civil Aviation Authority (CAA) and Heathrow said safeguards would be put in place to protect consumers from unjustified costs.

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The cost of early planning and design during 2025 and 2026 will be recovered by adding to the fees the airport charges per passenger.

Heathrow airport will also be able to collect Heathrow West’s costs up to November last year by adding to its airport charges.

The CAA said allowing these costs to be recouped will result in the maximum airport charge per passenger increasing by around 15 pence in 2028, rising to an estimated 30 pence in the following years.

In November, the government announced it preferred the £33bn scheme put forward by the airport over Arora’s alternative plan.

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At the time, the Department for Transport said Heathrow’s own proposal offered the most deliverable option, and the “greatest likelihood” of getting a decision on planning approval within this parliament.

The CAA’s Director of Consumers and Markets Tim Johnson said today’s decision “strikes a balance between supporting the delivery of benefits to consumers through timely progress on Heathrow expansion, whilst also protecting them from undue increases in costs”.

The regulator said “safeguards” designed to monitor cost efficiency would include transparency and cost reporting requirements, and assurance by independent experts.

Airlines often complain that Heathrow is the world’s most most expensive hub airport, and have repeatedly voiced concern that the airport’s expansion plans will exacerbate this.

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Hamak reports maiden resource of 210,430 ounces at Akoko project

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Hamak reports maiden resource of 210,430 ounces at Akoko project

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Boeing: Let's Not Get Carried Away

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Boeing: Let's Not Get Carried Away

Boeing: Let's Not Get Carried Away

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Kiniksa Pharmaceuticals Shares Surge 21% on Strong ARCALYST Sales and Raised 2026 Guidance

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Microsoft buys Activision, in New York City

BOSTON — Shares of Kiniksa Pharmaceuticals International plc jumped more than 21% in morning trading Tuesday after the biopharmaceutical company reported second-quarter results that exceeded expectations and raised its full-year sales outlook for its flagship drug treating recurrent pericarditis.

Kiniksa stock rose $13.43, or 21.14%, to $76.97 as of 10:06 a.m. EDT on the Nasdaq. The move came after the company announced ARCALYST (rilonacept) net product revenue of $243.6 million for the quarter ended June 30, representing approximately 55% growth from the same period a year earlier. The figure surpassed analyst estimates.

The company also increased its expected 2026 ARCALYST net product revenue guidance to a range of $980 million to $995 million, up from the previous range of $930 million to $945 million. Kiniksa reported net income of $25.4 million for the quarter and ended the period with $525.9 million in cash, cash equivalents and short-term investments, and no debt.

In a statement accompanying the results, the company highlighted continued commercial momentum. Approximately 21% of the estimated 14,000 multiple-recurrence recurrent pericarditis patients in the United States were actively on ARCALYST therapy at the end of the second quarter. More than 5,000 prescribers have written prescriptions for the drug since its launch in the indication.

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“In the second quarter, Kiniksa continued to drive growth in new and repeat prescribers of ARCALYST in recurrent pericarditis,” the company said in its earnings release. The results reflect expanding adoption of the only FDA-approved therapy specifically indicated for the condition, a painful and debilitating autoinflammatory cardiovascular disease characterized by inflammation of the pericardium.

Beyond the commercial performance, Kiniksa provided an update on its pipeline. An interval analysis from the Phase 2 dose-focusing portion of the KPL-387 Phase 2/3 trial in recurrent pericarditis showed rapid and sustained reductions in pain and inflammation at the 300 mg subcutaneous once-monthly dose selected for Phase 3. Time to treatment response was a median of 4.0 days, and time to C-reactive protein normalization was a median of 8.0 days. Efficacy was durable throughout the monthly dosing interval, and the drug was generally well-tolerated, consistent with the known safety profile of interleukin-1 pathway inhibition.

The company has initiated and is dosing patients in PASTORALE, the pivotal Phase 3 randomized withdrawal trial evaluating KPL-387 300 mg subcutaneous once-monthly in a liquid formulation. Kiniksa targets potential commercialization of KPL-387 in the 2028-2029 timeframe. It also remains on track to initiate a Phase 1 first-in-human trial for KPL-1161, an Fc-modified IL-1 antagonist designed for once-quarterly dosing, by the end of 2026.

Sanj K. Patel, Kiniksa’s chief executive officer, commented on the dual progress in commercialization and clinical development. “In our clinical portfolio, KPL-387 Phase 2 data supported initiation of the pivotal Phase 3 trial, PASTORALE, which is now enrolling and dosing patients. We are excited to advance KPL-387 with its target product profile of once-monthly subcutaneous dosing in a liquid formulation. We expect to bring this potential additional treatment option to patients in the 2028/2029 timeframe. Additionally, we continue to develop KPL-1161 with a target profile of once-quarterly dosing and are on track to initiate a Phase 1 trial by the end of this year.”

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The strong quarterly performance builds on earlier 2026 momentum. In the first quarter, ARCALYST revenue had already shown robust growth, prompting a previous upward revision to guidance. The further increase announced Tuesday signals confidence that underlying demand remains solid and that market penetration has room to expand. Recurrent pericarditis affects an estimated larger patient population beyond the multiple-recurrence segment currently being captured, and earlier treatment approaches could further broaden the addressable market over time.

Kiniksa focuses on developing and commercializing therapies for diseases with unmet need, with particular emphasis on cardiovascular indications. ARCALYST, an interleukin-1 alpha and beta cytokine trap, received FDA approval for recurrent pericarditis and has become the cornerstone of the company’s revenue. The pipeline assets KPL-387 and KPL-1161 aim to offer differentiated dosing convenience while targeting the same validated IL-1 pathway.

Analysts had anticipated solid results given the trajectory of ARCALYST prescriptions and the limited competition in the recurrent pericarditis space. The combination of a clear revenue beat, a meaningful guidance raise, positive mid-stage data and Phase 3 initiation provided multiple catalysts that investors rewarded with a sharp revaluation of the shares. The stock had already risen substantially year-to-date prior to the report, reflecting growing recognition of the commercial potential of ARCALYST and the strategic value of the IL-1 franchise.

The company expects its current operating plan to remain cash-flow positive on an annual basis. With a strengthened balance sheet and no debt, Kiniksa is positioned to fund ongoing commercial efforts and clinical development without near-term financing needs. Management is scheduled to discuss the results further on a conference call and webcast.

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Investors will continue to monitor prescription trends, the pace of new prescriber adoption and any updates from the PASTORALE trial. Success with KPL-387 could eventually provide a next-generation option with less frequent dosing than ARCALYST’s weekly regimen, potentially expanding the franchise. For now, the second-quarter numbers and raised outlook underscore that the existing product continues to gain traction in a market that remains underpenetrated.

The rapid share-price reaction underscores the market’s sensitivity to execution in rare-disease commercialization and clear clinical progress. Kiniksa’s results arrive amid a broader biotech environment in which companies demonstrating both commercial traction and pipeline advancement have often been rewarded. The day’s gains place the stock near the upper end of its 52-week range as the company advances its dual commercial and development strategy in cardiovascular inflammation.

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Rescuers in Japan haul survivors from collapsed mall as earthquake toll rises to 13

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Rescuers in Japan haul survivors from collapsed mall as earthquake toll rises to 13

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Liontown Limited (LINRF) Q4 2026 Earnings Call Transcript

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OneWater Marine Inc. (ONEW) Q1 2026 Earnings Call Transcript