Dyne Therapeutics, Inc. (DYN) TD Cowen 46th Annual Health Care Conference March 4, 2026 11:50 AM EST
Company Participants
Erick Lucera – CFO, Principal Financial Officer & Principal Accounting Officer and Treasurer
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Conference Call Participants
John Peyton Bohnsack – TD Cowen, Research Division
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Presentation
John Peyton Bohnsack TD Cowen, Research Division
All right. I guess we can get started. My name is Peyton Bohnsack. I’m the Vice President here on the biotech equity research team at TD Cowen. We’re pleased to have here Erick Lucera, the CFO from Dyne, and we’re looking forward to hearing all the exciting progress you guys have made.
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Erick Lucera CFO, Principal Financial Officer & Principal Accounting Officer and Treasurer
Great. Thank you very much. We’ll be making some forward-looking statements. So with that, here is the disclaimer. My name is Erick Lucera. I’m the CFO of Dyne Therapeutics, and I’m very excited to be here. I’ve been a client of Cowen’s for almost 30 years now, 15 on the buy side and 15 as a CFO. I’ve been at Dyne for almost a year. And if you asked me, well, why did I come here? One is obviously to prepare for the commercial launch, and having been through a couple of other commercial launches, it’s one of the best experiences you can have in your career. But also as a former investor, I still think like an investor, and when I saw the Dyne opportunity, I thought it was one of the most compelling opportunities I’d ever seen in those 30 years. So with that, I’m going to tell you the story as we see it here at Dyne.
We think we have a real unique opportunity to build an incredible and unique company really based on what we call the FORCE platform. There
A ‘Barron’s Roundtable’ panel analyzes the Iran conflict, its impact on crude prices and shipping through the Strait of Hormuz.
As gas prices surge while the U.S. wages war against Iran, President Donald Trump suggested in a Sunday Truth Social post that the short-term rise is a “small price” for peace.
“Short term oil prices, which will drop rapidly when the destruction of the Iran nuclear threat is over, is a very small price to pay for U.S.A., and World, Safety and Peace. ONLY FOOLS WOULD THINK DIFFERENTLY!” the president declared in the post.
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Americans have been facing rising gas prices at home as the U.S. attacks the Islamic nation..
President Donald Trump monitors military operations during Operation Epic Fury against Iran on March 2, 2026. (The White House via X Account/Anadolu via Getty Images)
The AAA national average price for a gallon of regular gas is $3.478 as of Monday, significantly higher than average one week ago of $2.997.
Rep. Thomas Massie, R-Ky., highlighted rising fuel prices amid the war in a Sunday post on X, and said that “waging war costs American taxpayers about $1 billion per day,” asserting, “This isn’t America First.”
Rep. Thomas Massie questions Attorney General Pam Bondi during a House Judiciary Committee hearing in Washington, D.C., on Feb. 11, 2026. (Nathan Posner/Anadolu via Getty Images)
Trump, an outspoken critic of Massie, is backing challenger Ed Gallrein in the Republican primary in Massie’s congressional district.
Senate Minority Leader Chuck Schumer, D-N.Y., has called for the president to tap the Strategic Petroleum Reserve to help tackle the price surge.
“The Strategic Petroleum Reserve exists for moments exactly like this,” Schumer said in a statement. “When wars and global crises disrupt energy markets, the United States has the ability to act, but President Trump and his administration are refusing to do so. Trump should release oil from the SPR now to stabilize markets, bring prices down, and stop the price shock that American families are already feeling thanks to his reckless war.”
All right. Welcome to the Global Consumer and Retail Conference. Please welcome Levi Strauss and Paul, over to you.
Paul Lejuez Citigroup Inc., Research Division
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Thank you. It’s Paul Lejuez, Citigroup. Thanks, everybody, for joining. And with me, CFO of Levi, Harmit Singh. I really appreciate you being here. I know that you might want to start with just some quick opening remarks, just to make sure we get that out of the way, and then I’ll dive into some questions.
Paul, thanks for having us. Yes, my opening remarks were largely — given the fact that we are in a quiet period, we’re closing our first quarter of ’26. I’m not going to get into current trends, latest financial outlook. In my remarks, I’m essentially going to reflect what we talked about in Q4 ’25 in the results late in January, we will be reporting results early April.
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But overall, we had a very strong year in ’25. We’re entering ’26 with momentum. Our guidance reflects it. The company is transforming into more of a denim lifestyle company. And I’d say our past was denim bottoms. Our future is more denim lifestyle. I’m happy to talk about the new, what I call a very different addressable market going forward. Overall strategies are working.
Our strategy is all about first, being brand-led, Super Bowl was a good example of brand demonstrated the strength and momentum being DTC first. Our DTC margins are growing, our DTC business is
A ‘Barron’s Roundtable’ panel analyzes the Iran conflict, its impact on crude prices and shipping through the Strait of Hormuz.
The ongoing conflict in the Middle East has sent oil prices soaring and has prompted G7 leaders to consider the potential release of emergency oil reserves to provide relief to consumers facing higher gasoline prices.
Gas prices have risen in response to the rapid increase in oil prices, with the national average price of gas rising from $3 a gallon last week to $3.48 a gallon on Monday, according to AAA data. Oil futures have surged over 48% in the last month after trading in the range of $60-70 a barrel during February to over $95 on Monday, when futures prices were briefly above $115 before declining.
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French finance minister Roland Lescure on Monday told reporters after a meeting of G7 finance ministers that leaders “are not there yet” on deciding whether to conduct an emergency release, as there aren’t current supply problems in the U.S. or Europe.
“What we’ve agreed upon is to use any necessary tools if need be to stabilize the market, including the potential release of necessary stockpiles,” Lescure added.
Rising oil prices can prompt an increase in the gasoline prices paid by consumers. (Al Drago/Getty Images)
Western economies develop strategic oil reserves in response to the 1970s oil crisis, with stockpiles like the U.S. government’s Strategic Petroleum Reserve serving as a backstop to address disruptions in the energy market that would otherwise harm the economy or imperil national security.
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Phil Flynn, senior market analyst at the Price Futures Group and FOX Business contributor, said that the “mere mention” of strategic releases was enough to pull oil prices down off of their highs, as such releases of reserves “would ease markets’ concerns of tightness of supply.”
“Historically, releases from the strategic reserve, especially in coordination with other countries, have always been successful in cooling down fear in the market place,” Flynn said. “The market has to be convinced that the transportation of that oil is going to be safe, because even if you release oil from the reserve, it’s still going to take time to get to its destination, such as the refineries.”
The U.S. and its G7 partners are considering potential releases of emergency oil reserves to ease the market turmoil. (Reuters/Todd Korol)
Andy Lipow, president of Lipow Oil Associates, told FOX Business that he expects “countries in the G7 will be forced to release oil reserves to show their public that they are taking some action to mitigate the rapid rise in prices.”
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He added that he anticipates the releases will occur within the next two weeks if the conflict hasn’t reached a resolution by that time.
“Whether or not the release will have an impact will depend on if the de facto blockade of the Strait of Hormuz continues to impact oil tanker loadings and if additional oil infrastructure is damaged.”
Oil tankers have faced the threat of attack from Iran in the Strait of Hormuz, causing a decline in shipping traffic. (Reuters/Hamad I Mohammed)
How much could reserve releases impact gas prices?
The Treasury Department in 2022 analyzed the impact of SPR releases carried out by the Biden-era Energy Department in response to oil disruptions caused by Russia’s invasion of Ukraine on gas prices.
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The U.S. released 180 million barrels from the SPR over six months in 2022, while International Energy Administration partners released an additional 60 million barrels.
It found that the U.S. SPR releases alone lowered gas prices by a range of $0.13 to $0.31 per gallon, whereas the oil reserve releases done by the U.S. in tandem with IEA partners had a larger effect by reducing prices $0.17 to $0.42 per gallon.
The findings of Treasury’s analysis were similar to those from a 2017 study by Richard Newell and Brian Priest, who found that a U.S. only release would lower gas prices by $0.33 per gallon while releases by the U.S. and IEA partners would yield a larger reduction of $0.38 a gallon.
Adrian Gore Founder, Group Chief Executive & Executive Director
Good morning. It’s really a wonderful pleasure and an honor for me, as always, to present Discovery’s interim results to 31 December 2025 this morning. I appreciate your time. We should spend, I guess, about an hour on the results. I’m joined by our Group CFO, Deon Viljoen, who is with me here. David Danilowitz, who is Head of our Investor Relations and Strategy, will anchor later the Q&A session and all of our key executives are online who will take questions. So once again, thanks from all of us for your time, and I hope we give you insight into what has been a very, very good period for our group.
So let me begin by just showing the numbers. I think they are hopefully self-evident. It has been an excellent, strong and robust period for our group. You can see normalized operating profit up 24%, normalized headline earnings up 27%, new business up 12%, and I’ll take you through obviously a lot of that through the presentation.
I thought, obviously, to provide some context, it’s almost axiomatic to say that we live in a complex and changing and volatile environment. But certainly, 2 dramatic forces are shaping virtually everything we do and to an extent, how things play out going forward will be determined by these 2 very substantial
Inside Social Casino Games: The Tech and Design Behind Slots, Cards, and Live Events
Social casino games look simple: spin, tap, win virtual coins, repeat. But the strongest titles are built like modern mobile games. Under the hood, they rely on live-service tooling, data pipelines, and carefully tuned virtual economies.
The sector’s growth is one reason the design conversation keeps widening beyond “gameplay.” As the audience expands, players pay more attention to how systems work: event pacing, fairness cues, security, and user controls.
social casino games
What makes a game a “social casino game”?
Most products combine three layers:
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1) Casino-style core games Slots, roulette-style formats, poker variants, blackjack/table games, plus hybrids.
2) Free-to-play economy Virtual currency, daily bonuses, and optional purchases.
3) Social + live systems Events, tournaments, clubs, gifting, chat, and seasonal challenges.
The casino theme is the surface. The “live” layer is what drives repeat play.
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The virtual economy: pacing is the product
A social casino economy must answer basic questions:
How many coins does a player earn per session?
How fast do they spend them?
How do rewards scale with level?
How do events change the pace?
That balancing is typically managed with analytics and experimentation. Teams run A/B tests, adjust event reward tables, and segment players (new vs. veteran, casual vs. competitive) to keep the experience stable. If the economy is confusing, or feels suddenly “tighter”, players notice fast.
RNG, balancing, and the perception of “fairness”
Players often ask whether outcomes are random. In social casino games, results are usually driven by RNG combined with balancing parameters. But perceived fairness depends on communication as much as math:
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Clear rules for bonuses and event scoring
Consistent behavior over time
Transparent progression (what it takes to unlock, level, or qualify)
Even a technically sound system can feel unfair if it’s opaque.
LiveOps: the operational layer most players never see
LiveOps (live operations) is what turns a static app into a weekly routine. In practice, it includes:
Daily missions
Weekend events
Limited-time tournaments
Season-style progression tracks
Club competitions and cooperative milestones
This requires internal tooling: scheduling dashboards, event configuration, reward systems, and real-time monitoring. The better the tooling, the more varied, and stable, the event calendar becomes.
Personalization and segmentation
Most mature products personalize the experience:
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Segmentation by skill, spend, and engagement
Offers tuned to behavior
Recommendations for rooms and modes
Dynamic pacing to reduce churn
This is where social casino gamesintersect with broader mobile technology: instrumentation, data reliability, and rapid experimentation.
UX is a fairness feature
UX isn’t just aesthetics. It affects whether a system feels understandable:
Onboarding that explains coins and bonuses
Clear navigation between rooms and events
Progress indicators that match real outcomes
Notifications that inform rather than overwhelm
Accessible settings for privacy and account controls
If players can’t understand what happened, or why they lost momentum, trust erodes.
Security, integrity, and anti-cheat
As products scale, abuse attempts increase: bots, event manipulation, account takeovers, and payment fraud. Strong platforms invest in:
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Bot detection and anti-cheat
Fraud monitoring
Rate limiting and exploit prevention
Secure authentication and recovery
Moderation for chat and clubs
These systems rarely make headlines. But they decide whether competition and community remain credible.
Social Casino Games in the U.S.: What Comes Next
In the United States, social casino games are increasingly shaped by the same forces driving mainstream mobile entertainment: live events, personalization, and fast iteration based on player behavior. As the category expands, the most successful experiences are likely to be those that pair engaging game loops with clearer transparency, stronger account protections, and more accessible user controls.
For players, that shift should translate into products that feel easier to understand, safer to navigate, and more sustainably enjoyable over time, while still delivering the quick, familiar fun that made the genre popular in the first place.
Disclosure: Social casino games are typically free-to-play and use virtual currency; they do not offer real-money gambling or cash winnings. This content is for informational purposes only, always review a platform’s terms, privacy policy, and responsible play options before participating.