FTSE 100 drugs giant reports pre-tax profits of $12.4bn for 2025, driven by cancer drug sales
Pharmaceutical heavyweight AstraZeneca has recorded a 40% leap in annual profits and forecasted continued earnings growth over the coming year, banking on robust demand for its cancer medicines.
The FTSE 100 company posted pre-tax profits of 12.4 billion US dollars (£9.06 billion) for 2025, climbing from 8.69 billion dollars (£6.35 billion) in 2024, propelled by a 49% surge in the fourth quarter on a constant currency basis.
Operating profits rose 36% on a constant currency basis to 13.74 billion dollars (£10.04 billion), whilst revenues increased 8% with currency fluctuations excluded, reaching 58.74 billion dollars (£42.93 billion).
The company indicated that revenues are projected to climb by a “mid-to-high single-digit percentage” in 2026, whilst underlying earnings per share are anticipated to grow by a low double-digit percentage.
The Anglo-Swedish pharmaceutical group is wagering on sustained strong appetite for its oncology treatments, whilst simultaneously expanding further into the US and Chinese markets and investing in increasingly sought-after weight-loss therapies.
These strategic moves are intended to help cushion the blow from losing patent protection on Farxiga, its blockbuster diabetes medication.
Farxiga’s sales growth registered a modest 2% on a constant currency basis during the fourth quarter.
Chief executive Pascal Soriot reaffirmed targets of achieving 80 billion dollars (£58.47 billion) in annual sales by 2030 through new medicines and strategic investments, with the company poised to announce results from as many as 20 advanced clinical trials this year. He stated that the “momentum across our company is continuing in 2026”.
“We have more than 100 Phase 3 studies ongoing, including a substantial and growing number of trials of our transformative technologies which have the potential to revolutionise outcomes for patients and drive our growth well beyond 2030,” Mr Soriot added.
Recently, the group announced an £13.52 billion ($18.5 billion) partnership with China’s CSPC Pharmaceutical Group to accelerate the development of experimental weight loss and diabetes drugs.
This move allows AstraZeneca to increase its investment in the rapidly expanding market for weight loss and diabetes drugs, previously dominated by blockbuster brands Mounjaro, Ozempic and Wegovy.
The annual results were released after AstraZeneca began trading shares on the NYSE earlier this month, while maintaining its listings on the London Stock Exchange and Nasdaq Stockholm.
AstraZeneca, which has key UK bases in Macclesfield and Cambridge, generates nearly half of its revenues in the US and aims to further expand in the world’s largest drugs market.
Last July, the company announced plans for around £36.55 billion ($50 billion) investment in the company by 2030, while several joint ventures in China are targeting the world’s second largest economy.
Shares in AstraZeneca rose 1% in Tuesday morning trading, with the stock having increased 28% over the past six months.
Chris Beauchamp, chief market analyst at IG, commented: “The numbers this morning continue to show how AstraZeneca seems to have its house in order when it comes to its drug pipeline.”
He further added: “The outlook and recent performance more than justifies the recent surge in the share price which has finally seen it break higher after years of sideways trading.”




