“Unfortunately, it does not appear possible to fully satisfy the demand for fuel at the current moment,” the Kremlin-appointed regional head, Sergei Aksyonov, admitted on 5 June. Hundreds of buses, he said, would not be leaving depots due to shortages.

BOSTON — Shares of Tango Therapeutics Inc. skyrocketed more than 50% on Monday after the clinical-stage biotechnology company reported highly encouraging early results from a Phase 1/2 trial combining its investigational drug vopimetostat with a partner’s therapy in patients with advanced pancreatic cancer.

Tango’s stock closed at $30.93, up $10.71 or 52.97% from Friday’s close of $20.22, hitting an all-time high during the session. The surge came after the company announced initial data showing a 92% objective response rate in a small cohort of patients with MTAP-deleted, RAS-mutant metastatic pancreatic ductal adenocarcinoma treated with vopimetostat plus Revolution Medicines’ daraxonrasib.

The dramatic move reflects investor enthusiasm for potential breakthroughs in treating one of the most lethal forms of cancer. Pancreatic cancer has long frustrated drug developers due to its aggressive nature and limited treatment options, with standard chemotherapy offering modest benefits and significant toxicity.

Tango, based in Boston, focuses on precision oncology using synthetic lethality to target genetic vulnerabilities in cancer cells. Vopimetostat is an MTA-cooperative PRMT5 inhibitor designed to work selectively in tumors with MTAP deletions, which occur in about 40% of pancreatic cancers.

According to data released Monday with a cutoff of May 28, 2026, 12 patients with previously treated PDAC in the vopimetostat plus daraxonrasib arm were response-evaluable. Eleven achieved an objective response, for a 92% ORR, with nine of those confirmed. The disease control rate reached 100%, and the six-month progression-free survival rate was 90%, with median PFS not yet reached.

Results were similarly strong in a small group of non-small cell lung cancer patients, with a 100% ORR among three evaluable patients.

The combination was generally well tolerated. Most treatment-related adverse events were Grade 1 or 2, including rash, stomatitis/mucositis and diarrhea. No discontinuations due to adverse events occurred, though some dose reductions and dose-limiting toxicities were noted at higher levels.

Tango also reported data from vopimetostat combined with Revolution Medicines’ zoldonrasib in PDAC patients, showing a 52% ORR, 74% six-month PFS rate and 96% disease control rate among 27 evaluable patients.

Malte Peters, MD, Tango’s chief executive officer, highlighted the findings in a statement. “In the first reported data from the clinical combinations of our PRMT5 inhibitor vopimetostat and RAS(ON) inhibitors, we saw extremely encouraging early results, with 92% of patients with PDAC in the vopimetostat plus daraxonrasib arm achieving an objective response,” he said.

Peters added that the durability signals and tolerability support advancing the combination. “Given these data, we intend to prioritize advancement of the vopimetostat plus daraxonrasib combination into Phase 3 development in first-line, MTAP-deleted pancreatic cancer.”

Brian Wolpin, MD, of Dana-Farber Cancer Institute, commented on the potential impact. “These early combination data demonstrated the potential to meaningfully reshape how we treat this disease with a precision-guided, chemotherapy-free approach.”

Pancreatic cancer kills roughly 50,000 Americans annually and has a five-year survival rate below 15%. The disease is often diagnosed late, and options remain limited despite recent advances in targeted therapies for specific mutations.

The trial involved heavily pretreated patients, many with liver metastases and receiving the regimen as third-line therapy. Analysts and investors viewed the results as “unprecedented” for this setting, prompting upgrades from firms like Wolfe Research.

Later in the day, Tango announced a proposed $500 million public offering of common stock to strengthen its balance sheet. The company said proceeds would support pipeline advancement, including the planned Phase 3 trial. Underwriters include J.P. Morgan, Leerink Partners, Cantor and Stifel.

As of the end of the first quarter of 2026, Tango reported a strong cash position of approximately $380 million, which it expected to fund operations into 2028. The new offering would further extend its runway.

Tango’s pipeline centers on MTAP-deleted cancers. Beyond the combinations, the company plans to report additional vopimetostat data in lung cancer and initial results for TNG456 in glioblastoma later in 2026.

The broader biotechnology sector has seen renewed interest in oncology innovation, particularly in KRAS and related pathways long considered “undruggable.” Revolution Medicines’ RAS(ON) inhibitors target mutations present in over 90% of pancreatic cancers.

Wall Street reacted positively. Tango’s market capitalization approached $4.5 billion by Monday’s close. The stock had already risen substantially year-to-date before the announcement, reflecting earlier momentum in its precision medicine approach.

Experts caution that early-phase data in small cohorts require confirmation in larger randomized trials. Pancreatic cancer trials have historically faced high failure rates, but the depth of responses and durability signals here stand out.

Tango said it aims to finalize Phase 3 design in the second half of 2026 and present full data at a scientific conference later this year. The company is also exploring additional combinations.

For patients and families affected by pancreatic cancer, Monday’s news offered a rare note of optimism. While far from a cure, the potential for a targeted, better-tolerated regimen could represent meaningful progress if later trials succeed.

The developments underscore the accelerating pace of innovation in oncology, where genetic insights and combination strategies are opening new avenues against historically intractable diseases. Tango’s rapid stock reaction illustrates how clinical data can swiftly reshape valuations in the biotech space.

Analysts will closely watch regulatory feedback and the details of the Phase 3 plan. Success in front-line pancreatic cancer could position vopimetostat as a cornerstone therapy in this high-unmet-need indication.

Tango Therapeutics continues to execute on its strategy of leveraging synthetic lethality for precision cancer medicines. Monday’s results mark a significant milestone, though the path to approval remains ahead.

In an exchange filing released on Monday, Brigade Enterprises announced that its shareholders approved the issue of bonus shares through postal ballot by way of e-voting on June 7. Only those shareholders who own shares of the real estate company in their demat accounts as on the record date will be eligible to receive the bonus shares.

Earlier in May, Brigade Enterprises announced its first bonus issue in around seven years, coinciding with the release of its Q4 results. It had said that its board has approved the plan to issue one bonus share with a face value of Rs 10 each for every three shares held in the company as on the record date.

The company approved the plan to increase its share capital from Rs 250 crore, divided into 25 crore shares, to Rs 400 crore, divided into 40 crore shares.

Also read: Brigade Enterprises set to reward 1.5 lakh retail shareholders, check details

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A bonus issue consists of free shares distributed by a company from its reserves and is often seen as a sign of strong financial health and growth prospects. While the issue of bonus shares increases the total number of outstanding shares, it does not change the company’s market capitalisation. However, it can improve liquidity and affordability, allowing more investors to add shares of the company to their portfolio.

Brigade Enterprises share price

Brigade Enterprises shares gained nearly 1% on Tuesday morning to trade at Rs 647.50 apiece on NSE. The shares have fallen nearly 15% in one month and are down around 28% in 2026 so far.
In the longer term, the shares of the company gained 18% in three years and 140% in five years. The company currently has a market capitalisation of more than Rs 15,862 crore.At the end of the financial year 2026, promoters and promoter group held 41% stake in the company, while the remaining 59% stake was held by the public and institutions. Out of this, nearly 1.5 lakh retail investors held around 4% stake in the company, according to NSE’s data on the company’s shareholding pattern as on March 31, 2026.

Brigade Enterprises in May reported a consolidated net profit of Rs 190 crore for the fourth quarter of the financial year 2025-26, compared to Rs 249 crore a year ago. Its revenue meanwhile declined to Rs 1,523 crore from Rs 1,532 crore a year earlier.

Along with the Q4 results and bonus issue, Brigade Enterprises also announced a final dividend of Rs 2 per equity share for the financial year 2026.

Also read: Infosys dividend alert! Last date to buy IT giant’s shares to secure Rs 25/sh payout

(Disclaimer: Recommendations, suggestions, views and opinions given by the experts are their own. These do not represent the views of The Economic Times)

The company rolled out the next-generation Apple Intelligence features, AI-powered photo editing tools, enhanced child-safety capabilities and software updates across iPhone, iPad, Mac, Apple Watch and Vision Pro.

Redington has been a key Apple distribution partner since 2007, handling the logistics, warehousing and distribution of Apple products to retailers and resellers across India, the Middle East, Turkey, Africa and South Asia.

Redington shares sharply surged to an intraday high of Rs 241 apiece on NSE on Tuesday morning, snapping a two-session losing streak. Notably, Apple shares meanwhile closed around 2% lower after its annual conference.

In what was Tim Cook’s last WWDC as the Apple CEO, the company on Monday unveiled a much-awaited overhaul of Siri, introducing a more conversational, context-aware version of its digital assistant as the company seeks to catch up with AI rivals including ChatGPT, Gemini and Claude.

The new model called ‘Siri AI’ will now come with a dedicated app, a redesigned interface and improved conversational abilities. According to Apple, it can understand a user’s personal context, access broad world knowledge and even understand what is currently on a user’s screen.

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Also read: Siri gets an AI makeover, its biggest upgrade since 2011 debut
Apple also unveiled the next generation of Apple Intelligence, built on updated Apple Foundation Models that power Siri, image generation, writing assistance and reasoning capabilities. It also significantly expanded its Visual Intelligence, bringing image understanding capabilities to more devices. On the iPhone, Siri can now analyse what users see through the Camera app and answer questions about objects, locations and food. The assistant can also perform actions such as splitting restaurant bills using Apple Cash.

Redington has a long-standing partnership with Apple, dating back to a 2007 distribution agreement for Apple products in India. Redington manages logistics, warehousing, and distribution to resellers and retailers across India, the Middle East, Turkey, Africa, and South Asia. It is one of Apple’s key official national distributors and supply-chain partners in India.
Redington in May reported a consolidated net profit of Rs 391 crore for the January-March quarter of FY26. This is over 41% lower than the Rs 666 crore net profit reported in the corresponding quarter of the previous financial year. The firm’s revenue from operations, meanwhile, increased nearly 26% YoY to Rs 33,213 crore during the quarter under review.

Also read: Siri AI, Apple Intelligence, child safety tools and more — Biggest announcements from Apple

Redington share price

Redington shares have gained over 6% in one month but declined around 14% in 2026 so far. The stock is down 17% in one year. In the longer term, the shares of the tech company jumped 28% in three years and more than 74% in five years.

The company currently has a market capitalisation of more than Rs 18,537 crore.

(Disclaimer: Recommendations, suggestions, views and opinions given by the experts are their own. These do not represent the views of The Economic Times)

This article was written by

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NEW YORK — Verizon Communications Inc. customers reported connectivity issues with wireless services Tuesday, prompting the telecommunications giant to monitor the situation as isolated complaints surfaced online.

The reports emerged around early morning Eastern Time, with users noting difficulties making calls, sending texts or accessing mobile data in various locations. A monitoring account on X, formerly Twitter, highlighted the complaints, directing users to a community forum for discussion.

According to the DesignTAXI community post linked in social media alerts, issues began surfacing around 12:27 a.m. ET based on tracking data. Subscribers shared experiences of network disruptions, though the scale appeared limited compared to previous widespread outages.

Downdetector, a site that aggregates user reports, showed no major spike indicating a nationwide outage as of Tuesday afternoon, with current data reflecting normal operations for most services. Verizon’s own network status tools also did not flag broad problems.

Verizon, one of the largest U.S. wireless carriers serving millions of customers, has not issued a public statement specifically addressing Tuesday’s reports. The company typically investigates such complaints through its engineering teams and provides updates via its website or official social channels when disruptions affect a significant number of users.

This latest episode comes amid ongoing scrutiny of telecom reliability following several notable service interruptions earlier in 2026. In January, Verizon experienced a major nationwide outage lasting nearly 10 hours that disrupted voice, text and data services for hundreds of thousands of customers across the country. Reports peaked at over 175,000 on Downdetector, with many phones displaying “SOS” mode instead of regular signal bars.

That January disruption, which began shortly after noon ET on Jan. 14, impacted major metropolitan areas from New York to Seattle. Verizon later attributed it to a software issue and confirmed it was not related to cybersecurity. The company resolved the problem by late evening and offered affected customers a $20 account credit.

” We are aware of an issue impacting wireless voice and data services for some customers. Our engineers are engaged and are working to identify and solve the issue quickly,” Verizon stated during the January event. Officials emphasized the importance of reliable connectivity and apologized for the inconvenience.

Telecom experts note that even minor service hiccups can have outsized effects in an increasingly connected world. Mobile networks support everything from emergency communications and remote work to navigation and financial transactions. Federal regulators, including the Federal Communications Commission, require carriers to maintain robust systems and report significant outages.

For customers experiencing problems Tuesday, standard troubleshooting steps recommended by Verizon and industry sources include:

• Restarting the device.
• Toggling airplane mode on and off.
• Checking for software updates.
• Ensuring the SIM card is properly seated.
• Testing with Wi-Fi calling if available.

Users in areas with potential coverage gaps may also switch to another carrier’s network temporarily via roaming, though this depends on their plan.

Verizon operates one of the most extensive 5G networks in the United States, covering a vast majority of the population. The company has invested heavily in expanding mid-band spectrum and fiber infrastructure to support growing demand for high-speed data. However, like all carriers, it faces challenges from network congestion, infrastructure maintenance and external factors such as weather or fiber cuts.

Tuesday’s reports echo smaller, localized issues that carriers handle routinely. Social media often amplifies such complaints, creating the perception of broader problems. Accounts like @status_is_down specialize in flagging these events to reassure users they are not isolated.

Industry analysts suggest that as reliance on wireless services grows, transparency from providers becomes increasingly important. Past outages have sparked discussions about backup communication methods, including satellite-based services like those offered by Starlink or emergency landlines.

Verizon customers can check for localized issues using the company’s network status page or by contacting support. The carrier also maintains apps and account portals for real-time notifications.

Broader context in the telecommunications sector shows continued consolidation and investment. Verizon reported strong financial performance in recent quarters, driven by postpaid phone additions and fixed wireless access growth. The company competes fiercely with AT&T, T-Mobile and emerging players in the 5G space.

For businesses and individuals dependent on uninterrupted service, experts recommend diversifying providers or using secondary devices. Public safety officials often advise keeping charged backup phones or satellite messengers for emergencies.

As of Tuesday afternoon, no widespread resolution announcement had been issued for the reported issues, and Downdetector indicated typical complaint volumes. Users are encouraged to report problems directly to Verizon for faster troubleshooting.

This situation underscores the critical role of mobile networks in daily life and the need for resilience against both minor glitches and major failures. Verizon, with its extensive infrastructure, remains a backbone for communications across the U.S., but incidents like these highlight ongoing challenges in maintaining perfect uptime.

Customers affected by any service disruption are typically eligible for credits or adjustments, depending on the duration and impact. Past precedents suggest Verizon will investigate Tuesday’s reports thoroughly.