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Stanford Study Links Estrogen-Only Hormone Therapy To 35% Lower Alzheimer’s Disease Risk

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Representation. A man with dementia unable to remember things.

A large study led by Stanford Medicine researchers has found that women who used estrogen-only menopausal hormone therapy showed significantly less brain evidence of Alzheimer’s disease at autopsy, along with lower odds of receiving a dementia diagnosis during their lifetimes, offering new pathological evidence in a research area that has produced conflicting findings for decades.

The study, published August 12 in Neurology, the medical journal of the American Academy of Neurology, analyzed data from 21,462 women, drawing on two existing research datasets: the National Alzheimer’s Coordinating Center’s autopsy cohort and the Alzheimer’s Disease Neuroimaging Initiative’s living cohort. Within that population, researchers compared 258 women who reported using estrogen-only hormone therapy against roughly 2,701 women who reported no hormone therapy use.

Women who had used estrogen-only therapy showed 35% lower odds of Alzheimer’s disease pathology in their autopsied brain tissue and 39% lower odds of having ever received a clinical dementia diagnosis, according to the study’s findings. Researchers examined brain tissue directly for amyloid plaques, neurofibrillary tangles and amyloid-plaque density, three hallmark physical changes associated with Alzheimer’s disease, rather than relying solely on cognitive test scores or clinical symptom assessments used in many earlier studies on the topic.

Jennifer Bruno, the study’s lead author and an instructor in psychiatry and behavioral sciences at Stanford, said the direct examination of brain tissue set the research apart from prior work in the field. “Women who had used estrogen-only hormone therapy had 35% lower odds,” Bruno said, describing the reduced presence of the disease’s defining brain changes compared with women who had not used the therapy.

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Because estrogen-only hormone therapy is generally prescribed to women who have undergone a hysterectomy, given that estrogen alone can raise the risk of endometrial cancer in women who still have a uterus, most participants in the estrogen-only group likely fell into that category, according to the study’s authors, though the datasets used did not include confirmed hysterectomy records.

Senior author Hadi Hosseini, an associate professor of psychiatry and behavioral sciences at Stanford, said examining actual brain tissue offered a more definitive picture than symptom-based measures alone. “By looking where the actual damage is done, the brain, you can see where the Alzheimer’s-associated defining features are,” Hosseini said, describing the approach as a way to more directly locate and quantify disease-related changes rather than inferring them indirectly.

The findings arrive in an area of medical research that has produced notably inconsistent results over the years. Earlier studies, including large trials from the Women’s Health Initiative, had previously linked menopausal hormone therapy, particularly combined estrogen-progesterone regimens, to an increased risk of dementia, guidance that shaped clinical recommendations discouraging hormone therapy use specifically for memory-related concerns. The new findings run counter to that established guidance, at least with respect to estrogen-only regimens.

Researchers cautioned that the study’s observational design means it can demonstrate an association between estrogen-only therapy and reduced Alzheimer’s pathology, but cannot prove that the therapy directly causes that reduction. Hosseini told Fox News Digital that other factors could help explain the pattern, noting it remains possible that women who used hormone therapy differed from non-users in ways researchers could not fully measure, including overall baseline health or general engagement with the health care system.

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Timing also complicates how directly the findings apply to women considering hormone therapy today. Participants in the study who used hormone therapy generally began treatment around age 70, according to reporting on the study, whereas current clinical practice typically involves starting therapy in the late 40s or early 50s and discontinuing it before age 60. Because more recent research suggests menopausal hormone therapy may offer greater benefits when started during or shortly after menopause, researchers said the study’s findings, based on a group that started therapy considerably later in life, may actually understate the potential benefit of earlier initiation.

Alzheimer’s disease remains the leading cause of dementia among older adults, with women accounting for roughly two-thirds of all diagnoses. Some research has pointed to the sharp decline in estrogen levels during menopause as a possible contributing factor to increased Alzheimer’s risk among women, a hypothesis the new findings offer additional, though still preliminary, support for.

Despite the notable findings, the study’s authors were clear that the results should not be interpreted as a basis for changing current medical guidance. Bruno said the findings represent meaningful, first-of-their-kind pathological evidence in a genuinely contested area of research, but stressed they serve as a signal calling for further study rather than a reason for women to start or stop hormone therapy specifically for brain health. Both Bruno and Hosseini said the field now needs prospective, biomarker-based clinical trials following women before, during and after menopause to determine more conclusively whether menopausal hormone therapy offers a genuine protective effect against Alzheimer’s disease.

The study was funded by the National Institutes of Health. Researchers said the findings underscore the continued need for well-designed clinical trials capable of establishing a clearer, causal relationship between hormone therapy and long-term brain health outcomes in women.

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Travis Kelce Flashes Wedding Ring At First Chiefs Preseason Game Since Marrying Taylor Swift In July

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Prince Harry and wife Meghan Markle were involved in a "near catastrophic car chase" involving paparazzi in New York late on May 16, 2023, a spokesperson for the couple said May 17

Travis Kelce arrived at Arrowhead Stadium on Saturday for the Kansas City Chiefs’ preseason opener against the Los Angeles Rams sporting a very visible reminder of how his life has changed since last season: a gold wedding band, worn publicly for one of the clearest looks yet since he married Taylor Swift last month.

In a video the Chiefs shared on their Instagram account captioned “TK on site,” Kelce walked through the pregame tunnel wearing a black-and-tan outfit, sunglasses and black sneakers, carrying a canned Accelerator Active Energy Drink, a brand he has an investment and partnership with, in his left hand. That positioning put his thick, yellow-gold wedding band on full display, quickly drawing attention from fans in the comments, with one writing that Kelce was “now left-handed like his wife.”

Swift, notably, was not seen at the stadium. The pop star has become a familiar presence in Chiefs suites throughout her relationship with Kelce, but she was absent from Saturday’s preseason opener, having been spotted in London earlier in the week in one of her first public appearances since the couple’s wedding. The absence prompted playful commentary online suggesting Swift had “abandoned” Kelce for their first football outing as a married couple, though there is little indication of any actual tension between the two, with the far more mundane explanation being that their schedules simply didn’t align during the preseason.

Kelce and Swift married July 3 at Madison Square Garden in New York, in a ceremony Reuters reported drew roughly 1,000 guests from entertainment and the NFL. Speaking with reporters this week about the celebration for the first time, Kelce described the night in glowing terms. “Wedding was the best night of my life,” Kelce said, thanking everyone who came out to celebrate with the couple and describing the evening as a “crazy night” filled with celebration. He also reflected on the significance of getting married inside Madison Square Garden, a venue he has described as a childhood dream, and thanked the arena’s ownership for accommodating the couple’s request for a private event.

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Despite the attention his ring drew, Kelce did not actually play in Saturday’s game, with Chiefs head coach Andy Reid holding him out of the preseason opener as a precaution. Quarterback Patrick Mahomes was also unavailable, sitting out a preseason game for the first time in his career as Kansas City continues managing his recovery from a serious knee injury suffered last season. With both Kelce and Mahomes on the sideline, the Chiefs turned to Justin Fields as their starting quarterback, with rookie Garrett Nussmeier and Chris Oladokun also seeing playing time.

Kelce, 36, is entering his 14th NFL season after what he has acknowledged was one of the more difficult stretches of his career. Kansas City finished 6-11 last season and missed the playoffs for the first time since 2014, and Kelce has said he could have done more to help the team, identifying leadership specifically as an area where he wants to improve heading into this season. He has said he wants to be someone teammates can count on when adversity hits, adding that there were things he could have handled better in that regard during the difficult 2025 campaign.

Kelce has also pushed back on any suggestion that his eventful offseason, capped by his wedding to one of the most famous performers in the world, has pulled his focus away from football. He has said he feels ready for the season and wants to set the right example for his teammates as camp continues.

Not everyone has been convinced Kelce can return to his earlier level of play. NFL insider Jason La Canfora recently relayed a blunt assessment attributed to an anonymous league scout regarding Kelce’s outlook heading into the season. “Kelce is done. That’s over. What you saw last year, that’s what he is,” the scout said, according to La Canfora, reflecting the skepticism some around the league have expressed about whether Kelce can bounce back after his numbers declined over the past two seasons.

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Kelce reported to Chiefs training camp July 29 and has said his attention has fully shifted back toward football since then. He is expected to remain one of Mahomes’ top targets at tight end once the regular season begins, even as questions persist about his ability to match his earlier career production. Kelce has not formally announced whether the 2026 season will be his last in what has already been a Pro Football Hall of Fame-caliber career.

With the preseason underway and the newlyweds continuing to balance two extraordinarily demanding careers, Saturday’s game offered a small but telling glimpse into their post-wedding routine: Kelce back at work preparing for football, wedding ring in full view, while Swift attended to her own commitments elsewhere.

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Rebel Creamery files Chapter 11 with $23.8M Van Leeuwen judgment on appeal

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Rebel Creamery files Chapter 11 with $23.8M Van Leeuwen judgment on appeal

Rebel Creamery has filed for Chapter 11 bankruptcy protection in Utah, reporting approximately $13.78 million in assets and $23.85 million in liabilities as it appeals a $23.785 million judgment awarded to rival Van Leeuwen Ice Cream in a trade-dress dispute.

Rebel ice cream is sold at Walmart, Kroger, Safeway and other grocery stores nationwide.

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Rebel Creamery LLC filed for Chapter 11 protection on Aug. 14 in the U.S. Bankruptcy Court for the District of Utah, according to court records.

Van Leeuwen is listed among Rebel’s unsecured creditors with a $23.785 million claim stemming from the federal judgment. Rebel listed the claim as disputed and noted that the judgment is under appeal.

MAJOR CARL’S JR OPERATOR REPORTEDLY SET TO SHUTTER, SELL DOZENS OF CALIFORNIA LOCATIONS

Bowl of ice cream

Rebel Creamery has filed for Chapter 11 bankruptcy protection following a multimillion-dollar judgment in a packaging dispute with rival Van Leeuwen Ice Cream. (Getty Images )

The Van Leeuwen judgment accounts for nearly all the unsecured liabilities that Rebel listed at fixed amounts in its bankruptcy schedules. The company also reported approximately $5.22 million in cash and cash equivalents, $2.59 million in accounts receivable and $5.65 million in inventory.

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Rebel’s voluntary petition estimated both its assets and liabilities at between $10 million and $50 million and said funds would be available for distribution to unsecured creditors. The filing lists Austin Archibald as the company’s manager and member and Michael Johnson of Ray Quinney & Nebeker as bankruptcy counsel.

The bankruptcy filing came less than a month after U.S. District Judge Eric Komitee ruled that Rebel had intentionally infringed and diluted Van Leeuwen’s trade dress through its ice cream packaging.

Walmart Frozen Aisle

Rebel ice cream is sold at Walmart locations. (Jeffrey Greenberg/Universal Images Group via Getty Images)

“The evidence at that trial left no doubt that Rebel infringed and diluted Van Leeuwen’s trade dress and did so intentionally,” Komitee wrote in a July 16 memorandum and order.

Van Leeuwen sued Rebel in 2021, alleging that the company’s packaging copied the distinctive appearance of its ice cream pints.

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DETROIT BANKRUPTCY CASE OFFICIALLY CLOSES MORE THAN 13 YEARS AFTER HISTORIC FILING

The court described Van Leeuwen’s trade dress as including monochromatic cardboard pints with matching lids, a primarily pastel color palette, black script lettering and an overall minimalist design.

Komitee found that Rebel’s packaging was similar and that the evidence supported findings of consumer confusion and bad faith. The judge ordered Rebel to stop selling products bearing trade dress likely to be confused with Van Leeuwen’s and required the company to redesign its packaging.

President Biden gets ice cream at Van Leeuwen in NYC

President Joe Biden, flanked by host Seth Meyers, patronized Van Leeuwen Ice Cream after taping an episode of “Late Night with Seth Meyers” in New York City on Feb. 26, 2024. (Jim Watson/AFP via Getty Images)

Van Leeuwen sought $36.4 million in Rebel’s profits, but the court reduced the award by 33%, finding that some sales were driven by demand for keto and better-for-you ice cream rather than the packaging at issue.

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The reduction left Van Leeuwen entitled to $23.785 million in Rebel’s profits from sales of ice cream pints bearing the infringing trade dress.

Court filings do not establish that the Van Leeuwen judgment was the sole cause of Rebel’s bankruptcy filing.

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Rebel’s bankruptcy paperwork lists the Van Leeuwen litigation as being on appeal.

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Prince Harry Reportedly Plans To Visit London Every Few Months After ‘Energising’ Reunion With Charles

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Prince Harry

Prince Harry is planning to make significantly more frequent trips back to the United Kingdom in the coming year, according to a report in The Times, following what a source close to the Duke of Sussex described as an “energising” reunion with King Charles III last month.

Harry last visited the UK in July, bringing his wife, Meghan Markle, and their two children, Prince Archie and Princess Lilibet, from their home in California. The trip marked the first time in more than four years that King Charles had been reunited with his grandchildren, now ages seven and four. The family met privately with Charles and Queen Camilla at Highgrove House, the King’s private residence in Gloucestershire, in a gathering that had been kept largely under wraps until after it occurred.

According to The Times, a source close to Harry said the success of that visit has convinced him to return to Britain considerably more often going forward. “The template for his visits has been working well, so the frequency of trips will increase,” the source said, adding that the pace of Harry’s trips would pick up further in the run-up to the 2027 Invictus Games in Birmingham, an event Harry founded and has said he is determined to make the best edition of the competition yet. The source said Harry has grown increasingly focused on his charitable patronages during these visits and hopes to spend less time on legal disputes going forward, while continuing to prioritize time with his family whenever he returns.

Harry’s next UK trip is expected in September, when he will attend the WellChild Awards, a charity event honoring seriously ill children and their caregivers that Harry has attended annually as the organization’s patron. That visit is expected to last roughly a week and will also include continued preparation for the Birmingham Games.

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The Highgrove reunion followed a lengthy period of estrangement between Harry and his father. The two had not met in person since February 2024, a gap of roughly 19 months, before reconnecting for a private tea at Clarence House in September 2025. Harry has spoken candidly in the past about his desire to repair the relationship, telling the BBC following a separate visit that he did not know how much longer his father had, referencing Charles’s ongoing cancer treatment, and expressing hope for reconciliation. “I would love reconciliation with my family,” Harry said at the time, adding that he saw no benefit in continuing to fight with relatives.

The relationship between Harry and the royal family has remained strained since he and Meghan stepped back from their roles as senior working royals in 2020 and relocated to California. That estrangement deepened considerably following the couple’s 2021 interview with Oprah Winfrey, their Netflix documentary series, and Harry’s 2023 memoir, “Spare,” all of which detailed private family disputes and tensions with both Charles and Prince William. A separate legal battle over Harry’s publicly funded security arrangements during UK visits further complicated the relationship, with Harry saying in 2025 that his father had stopped speaking with him specifically because of the ongoing security dispute.

During the family’s July visit, Harry, Meghan and their children also traveled to Althorp in Northamptonshire, the ancestral home of the Spencer family and the burial site of Harry’s mother, Princess Diana. Harry spent time there with his uncle, Charles Spencer, the ninth Earl Spencer, and Spencer’s wife, Norwegian archaeologist Dr. Cat Jarman. Meghan later shared photos from the visit on Instagram, including images showing Harry and Archie carrying flowers believed to have been placed at Diana’s grave, along with photos from the family’s broader summer travels, including time spent at their holiday home in Portugal.

It remains unclear whether Meghan and the couple’s children will accompany Harry on each of his more frequent planned visits going forward, or whether some of the increased travel will involve Harry returning to the UK alone to focus specifically on his charitable and Invictus-related commitments. Buckingham Palace has not issued official comment on the reported plans for more frequent visits.

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With Invictus Games preparations intensifying and Harry’s relationship with his father showing signs of continued warming following the July reunion, the coming months are likely to offer further indications of whether the reported shift toward more regular UK visits materializes as described, and whether it corresponds with any broader, sustained improvement in Harry’s relationship with the rest of the royal family beyond his father.

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Liberty Live earnings up next: Can revenue surge narrow losses?

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Liberty Live earnings up next: Can revenue surge narrow losses?

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U.S. equity inflows triple week-on-week as Wall Street hovers near record levels

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U.S. equity inflows triple week-on-week as Wall Street hovers near record levels

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Police Union President Claims Inexperienced Detectives Hampered Early Nancy Guthrie Case Investigation

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Savannah Guthrie & Nancy Guthrie

TUCSON, Ariz. — The president of the union representing Pima County sheriff’s deputies says the investigation into the disappearance of Nancy Guthrie, the mother of “Today” show co-anchor Savannah Guthrie, was hampered from its earliest days by a homicide unit left short of experienced detectives following an unrelated internal personnel dispute.

Sgt. Aaron Cross, president of the Pima County Deputies Organization, detailed his account of the staffing issues in an interview published August 15 by TMZ. According to Cross, two of the department’s most senior homicide detectives had been investigating a separate homicide case and were building probable cause against a suspect when a commander pressured them to make an arrest before they believed the case was ready. “What happened is two most senior detectives in the Homicide unit had been transferred out,” Cross said, adding that when the detectives declined to arrest the suspect prematurely, they were reassigned out of the Homicide Unit and into the Cold Case Unit.

Cross said that reassignment, which predated Nancy Guthrie’s disappearance and was unrelated to her case, ultimately left the Homicide Unit short-staffed and inexperienced by the time she vanished from her Tucson home in the early hours of February 1. According to Cross, the sergeant placed in charge of the Guthrie investigation had been promoted to that rank only in 2023 and had no prior homicide experience before rapidly moving from patrol duty into the unit. Cross said the detectives assigned to assist likewise had limited experience, generally three years or less, which he described as an unusual staffing decision for a case that quickly drew intense local and national scrutiny.

Cross’s account of the commander who ordered the earlier reassignment, whom he described as one of Sheriff Chris Nanos’s “favoured sons,” has not been independently confirmed. Cross has a documented history of political friction with Nanos. According to Fox News, Nanos placed Cross on administrative leave in the weeks before the sheriff’s contested 2024 re-election, which he won by just 481 votes, after Cross had publicly opposed him and allegedly collaborated with one of his election opponents. That history should be weighed alongside Cross’s latest allegations, which reflect his own characterization of internal department dynamics rather than an independently verified account.

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Cross’s criticism echoes concerns raised earlier this year by separate sources. Fox News Digital reported in April, citing two sources with knowledge of the department, that only one detective assigned to the Homicide Unit at the time of Guthrie’s disappearance had more than three years of experience, while five others had less than two years, and that the sergeant supervising the unit had roughly six months of experience in that role and had never personally worked a homicide case before being placed in charge.

Sheriff Nanos has pushed back against ongoing criticism of the investigation’s handling. Addressing scrutiny of the case earlier this year, Nanos said internal or political commentary distracts from the active investigation, and that his department’s focus remains on pursuing justice and transparency for the Guthrie family. Nanos has also maintained publicly that the case remains active and has not become a cold case, despite the extended timeline.

Cross’s comments were not limited to detective experience levels. He also raised concerns about the department’s decision to allow Nancy Guthrie’s family control over the crime scene relatively early in the investigation, according to reporting from The Daily Beast, and pointed to broader coordination problems between local and federal investigators. A separate Wall Street Journal examination of the investigation reported additional concerns involving coordination between local and federal authorities and the handling of evidence during the case, adding to the broader scrutiny surrounding the department’s response.

Nancy Guthrie, 84, was last seen by family on January 31 at her home in Tucson’s Catalina Foothills neighborhood and was reported missing the following day. The FBI has said an armed individual appeared to tamper with her doorbell camera around the time of her disappearance, and blood found at her home has been confirmed to belong to her. The case is being investigated as a kidnapping, with two ransom notes tied to the disappearance made public in late July. No suspect has been publicly named, and Guthrie has not been found more than six and a half months after she vanished.

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Cross was careful to frame his criticism around staffing and process decisions rather than claiming that different personnel choices would necessarily have solved the case. His allegations, however, add to a broader pattern of scrutiny surrounding the Pima County Sheriff’s Department’s handling of one of the most closely watched missing-person investigations in the country, at a moment when the Guthrie family continues to wait for answers about Nancy’s whereabouts.

Neither the Pima County Sheriff’s Department nor Sheriff Nanos has issued a detailed, on-the-record response specifically addressing Cross’s claims regarding the earlier detective transfers or the characterization of the commander involved in that decision.

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Paysign CEO Mark Newcomer sells $1.78m in common stock

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Paysign CEO Mark Newcomer sells $1.78m in common stock

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Nicole Kidman Reveals Her Pre-Scene Line-Running Ritual With Morgan Freeman On Lioness Season Three Set

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Taylor Sheridan's 'Lioness' Season 3 Set for August 2 Premiere

Nicole Kidman says she and her “Lioness” castmates, including Morgan Freeman, have developed a demanding pre-scene ritual to keep up with the density of the scripts Taylor Sheridan writes for the CIA thriller, running through their lines together and quizzing each other on the meaning of nearly every word before cameras start rolling.

Speaking at Paramount+’s “The Icons of Taylor Sheridan’s Universe” event in April, Kidman described the sheer level of preparation required to make Sheridan’s dialogue feel natural on screen. “We have to understand every single thing we’re saying,” Kidman said, describing the scripts as dense and the process of fully absorbing them as a significant undertaking each episode.

Kidman said that before filming key scenes, she, Freeman and co-star Michael Kelly regularly run their lines together, then work through the material further to make sure every term and reference actually makes sense to them. She described the process as needing to become second nature, saying dialogue has to come across as though it’s language the actors would naturally use every day, even though much of the show’s specialized CIA and military terminology is far from their normal vocabulary. Kidman said she and her castmates work through that material by repeatedly asking each other to define and clarify terms until the meaning is fully locked in.

Beyond the line-running sessions with her co-stars, Kidman has said she works with a dedicated research team to help her understand every specific term she uses on screen, supplementing the fact-checking work Sheridan does himself as the show’s creator and primary writer. Kidman has previously compared the overall experience of preparing for the role to writing a thesis on the CIA, given the depth of research required to keep up with the show’s rapidly evolving, topical storylines. She said the show’s third season in particular has felt especially urgent and relevant, describing the experience of filming it as constantly navigating difficult, high-stakes subject matter that requires the cast to stay sharp scene to scene.

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Freeman, 89, has offered his own praise for Sheridan’s writing style in a separate interview with The New York Times, crediting the creator’s ability to center the human experience within high-stakes, geopolitically charged storylines. Sheridan’s work, Freeman said, “has to do more with the human experience, what people are actually going through,” pointing to the emotional realism he says has defined Sheridan’s writing across multiple projects, including “Yellowstone.” Freeman specifically highlighted the character arc of Zoe Saldaña’s Joe McNamara within “Lioness,” noting the personal stakes involved for a woman balancing a dangerous covert career with a husband and children at home, and praising Sheridan for having what he called the courage to write honestly about those kinds of difficult, high-pressure personal decisions.

“Lioness,” which returned for its third season August 2 on Paramount+, follows Joe as she leads the CIA’s Lioness undercover program while navigating threats that increasingly bleed into her personal life. According to the show’s official logline, unseen forces circle Joe’s world throughout the new season as patterns emerge, names vanish and paths rearrange, forcing her to confront enemies operating in the shadows while managing a growing conflict between her professional duty and her home life. Kidman plays CIA supervisor Kaitlyn Meade, Kelly plays CIA Deputy Director of Operations Byron Westfield, and Freeman plays Secretary of State Edwin Mullins, rounding out the trio of senior officials who guide Joe’s missions from Washington.

Season three consists of eight episodes, released weekly on Sundays, following the same episode-count structure as the show’s first two seasons. The series, created by Sheridan and based loosely on a real CIA program, launched in 2023 and has grown into one of several Sheridan-created shows currently airing across Paramount+, alongside projects including “Yellowstone,” “Landman,” “Mayor of Kingstown” and “Tulsa King.”

Both Kidman and Saldaña serve as executive producers on the series in addition to their on-screen roles, giving them a hand in shaping the show’s direction behind the scenes as well. The extensive preparation Kidman has described, running lines, defining unfamiliar terminology and consulting outside research, reflects the broader approach the cast has taken toward capturing the technical authenticity that has become a hallmark of Sheridan’s high-profile television projects.

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With new episodes continuing to release weekly through late September, “Lioness” remains one of the most closely watched entries in Sheridan’s expanding television universe, with Kidman, Freeman and the rest of the ensemble cast continuing to lean on their behind-the-scenes preparation routine to keep pace with the show’s dense, fast-moving scripts.

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With Fed mum on next move, investors look to earnings to keep stocks afloat

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TTM Technologies: Upgrading To Buy, Shares Look Cheap

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TTM Technologies: Upgrading To Buy, Shares Look Cheap

TTM Technologies: Upgrading To Buy, Shares Look Cheap

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