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Turning Cancer Research Into Real Therapies

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Turning Cancer Research Into Real Therapies

A Scientist Focused on What Helps Patients

Dr. Flavia Pichiorri has spent much of her career asking one core question: how can discoveries in the lab help patients faster?

Based in Los Angeles, she works at the intersection of translational science and clinical research, focusing on blood cancers such as multiple myeloma and acute leukemia. Her work explores therapeutic targets like CD38 and CD84, as well as radiation-based treatment strategies designed to improve patient outcomes.

But her path into cancer research did not start in a hospital or a lab. It began in the Roman countryside.

“I grew up riding horses every morning before school,” she recalls. “That environment taught me discipline and focus very early in life.”

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Those lessons would later shape the way she approaches science.

Growing Up in Rome: Discipline and Curiosity

Pichiorri was born in Rome in 1974 and grew up in a family deeply connected to analytical fields. Her mother worked in statistics and organizational science. Her father was a mechanical engineer who worked on large industrial projects across Europe and the Middle East.

The home environment valued structure and problem solving. But her childhood also included long hours outdoors.

She spent years living near the historic Appia Antica, an ancient Roman road lined with archaeological ruins. Before school, she often rode horses through the surrounding countryside. She also competed in show jumping for nearly twenty years.

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“That experience taught me resilience,” she says. “In science, just like in riding, you have to stay focused and keep moving forward even when things don’t go as planned.”

From Classical Studies to Molecular Biology

Pichiorri’s academic path began with classical literature. In high school she studied Latin and Greek, which sharpened her analytical thinking.

Later, she shifted toward science at the University of Rome Tor Vergata, where she studied molecular biology and biochemistry. She earned a master’s degree in Biochemistry and Enzymology in 1999, graduating with top honors.

Her early research focused on enzyme polymorphisms and protein interactions. She trained on advanced biochemical techniques such as circular dichroism spectroscopy, FPLC, and HPLC.

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Soon after graduating, she joined the Italian National Research Council, where she began studying growth factors that influence the growth of multiple myeloma cells.

That work introduced her to the disease that would define much of her scientific career.

“At the time, patients with multiple myeloma often survived only a short period after diagnosis,” she explains. “There was a huge need to understand the biology of the disease.”

Moving to the United States for Cancer Research

In the early 2000s, Pichiorri joined research teams in the United States. She worked at Thomas Jefferson University in Philadelphia and later at The Ohio State University, where she completed doctoral research on tumor suppressor genes and cancer biology.

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Her studies explored fragile site genes and the molecular mechanisms involved in tumor development.

During this period she helped develop a diagnostic assay based on Clusterin, a circulating biomarker for colon cancer detection.

The project led to a patented screening method and early clinical applications.

But the turning point in her career came during her postdoctoral research.

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A Breakthrough in Multiple Myeloma Research

After finishing her PhD, Pichiorri focused on understanding how multiple myeloma cells evolve and survive.

Her research revealed that the disease is influenced not only by genetic mutations but also by epigenetic changes driven by oncogenic pathways such as c-Myc.

The findings were published in the journal Proceedings of the National Academy of Sciences. The paper quickly became one of the most cited publications in its field.

“It showed that plasma cell degeneration is not just about genetic mutations,” she says. “Epigenetic regulation also plays a major role.”

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The discovery helped open new paths for therapeutic research.

Building Translational Research Programs

In 2011, Pichiorri launched her independent research career as an assistant professor in internal medicine. She received several major grants and began leading translational programs focused on new therapies for blood cancers.

Her work helped advance clinical development of AR-42 (REC-2282), an HDAC inhibitor studied for hematologic malignancies.

She also contributed to research on oncolytic viral therapy, including Pelareorep, designed to target cancer cells while sparing healthy tissue.

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“In translational research, the goal is always the same,” she says. “You move ideas from the laboratory to the clinic, and then back again to refine them.”

Advancing CD38 and CD84 Targeted Therapies

In 2016, Pichiorri joined City of Hope, where she expanded her research programs and secured multiple federal grants.

Her team developed new antibody-based therapies targeting CD38, a protein widely expressed on myeloma cells. Some of these therapies combine antibodies with radioactive isotopes to deliver targeted treatment directly to cancer cells.

The work has already led to clinical trials in multiple myeloma and acute leukemia.

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Her group also identified CD84 as a therapeutic target in acute myeloid leukemia, leading to the development of an antibody later licensed to a biotechnology company.

Another project involves a single-chain CD38-directed T-cell engager, a therapeutic approach designed to help immune cells recognize and destroy leukemia stem cells.

A Philosophy Centered on Scientific Rigor

Despite a long list of grants, publications, and clinical programs, Pichiorri measures success in a different way.

“I rarely dwell on success,” she says. “In science it can be fleeting.”

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Instead, she focuses on the durability of scientific findings.

“True scientific value comes when results stand the test of time,” she explains. “It takes patience and careful validation.”

She believes meaningful progress often requires challenging established thinking.

“Scientific progress relies on questioning assumptions,” she says. “That is how new knowledge is created.”

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Looking Ahead

Today, Pichiorri continues working on translational therapies targeting CD38, CD84, and radiation-based treatments for blood cancers.

Her research spans laboratory experiments, animal models, and early-phase clinical trials. The goal remains the same: bring new treatments to patients who need them.

Outside the lab, she finds balance in hiking, gardening, horseback riding, and writing about science.

During demanding periods, she keeps her priorities simple.

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“During times of change, I focus on what I value most,” she says. “Writing science and being present with my family.”

For Pichiorri, curiosity remains the driving force.

“Each day brings new questions,” she says. “Staying engaged with those questions is what keeps science moving forward.”

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Who’s attending WA Premier Roger Cook's fuel summit

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Who’s attending WA Premier Roger Cook's fuel summit

Farmers, truckers, airlines, and fuel distributors will descend on Dumas House today to iron out a plan to ease pressure on Western Australia’s fuel supply.

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Teladoc at Barclays Conference: Strategic Shifts and AI Focus

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Teladoc at Barclays Conference: Strategic Shifts and AI Focus

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US Stock Market | SoftBank’s PayPay plans to price US IPO around low end of range, sources say

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US Stock Market | SoftBank's PayPay plans to price US IPO around low end of range, sources say
The initial public offering of SoftBank‘s PayPay is likely to price around the low end of its marketing range as war in the Middle East roil markets, said ‌two people ⁠familiar ⁠with the matter.

The IPO book was covered more than five ​times, one of the people said. It has now closed and ​pricing will be finalised after U.S. market hours on Wednesday, the person said.

The Japanese payment app operator was offering 55 million American depositary ⁠shares, priced $17 ‌to $20 apiece, a filing this month showed, targeting a valuation of up to $13.4 billion.

The ⁠people declined to be identified as the ​information is not public. PayPay declined to comment.

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PayPay ​has played a central role in encouraging Japanese consumers to move away from a preference for cash by offering rebates on its payments app.


However, it has had a bumpy IPO path. Its ‌IPO roadshow was initially postponed after markets were jolted by conflict in the Middle East, ​Reuters reported ​last week.
It ⁠had already postponed the IPO last year during the U.S. government shutdown, which disrupted regulatory processes and delayed regulatory filing.

PayPay ​plans to list on the Nasdaq under the symbol “PAYP”. Reuters first reported its plans for a U.S. listing in 2023.

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E-rideable inquiry chief critical of government inaction

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E-rideable inquiry chief critical of government inaction

The chair of an inquiry into the danger of e-rideables in Western Australia has criticised the state government’s response, arguing urgent changes should be made to regulations now.

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Ford recalls over 83,000 vehicles in two separate safety actions

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Ford recalls over 83,000 vehicles in two separate safety actions

Ford is recalling more than 83,000 vehicles in two separate actions due to issues that could increase the risk of a crash, federal regulators said.

The first recall affects 35,772 model year 2025-2026 Explorer SUVs and the dynamic bending light feature, according to the notice filed with the National Highway Traffic Safety Administration.

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The affected vehicles have an incorrect headlamp control module software calibration that results in the right headlight turning in the opposite direction of a vehicle turn.

A Ford Bronco Sport outside in a forest.

A model year 2025 Ford Bronco Sport. (Ford Motor Co.)

FORD RECALLS 1.74 MILLION VEHICLES DUE TO REARVIEW CAMERA BLACKOUTS, ISSUES

“When turning the steering wheel on a left curve, the driver’s side (LHS) bending light correctly follows the turn, while the passenger side (RHS) light bends away from the curve,” the recall report said. “Conversely, when turning on a right curve, the left-hand light follows the steering wheel and bends to the right, while the right-hand light bends inward towards the left.”

The report said a headlight that turns incorrectly could result in increased glare to other drivers and increase the risk of a crash.

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FORD IN DEEP WATER AFTER SWEEPING RECALLS HIT EVERY MODEL SINCE 2020 – WITH ONE EXCEPTION

Ford said it is not aware of any accidents or injuries related to the issue.

Updates to fix the headlight control module software will be available over the air or through dealerships at no charge. Owner notification letters are expected to be mailed March 23.

In a separate action, Ford is recalling 47,804 vehicles due to issues with the engine gas recirculation (EGR) valve that could lead to a loss of motive power, most likely at low speeds, which Ford said increases the risk of a crash.

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Ford issued two separate recalls for certain model year 2025-2026 Explorers and certain 2025 Ranger, Mustang, Maverick, Explorer, Escape, Bronco, Bronco Sport, Lincoln Nautilus and Corsair vehicles. (Jeff Kowalsky/Bloomberg via Getty Images )

FORD BUILDS ONE-OF-A-KIND EXPLORER FOR POPE LEO XIV

The recall affects certain model year 2025 Ranger, Mustang, Maverick, Explorer, Escape, Bronco, Bronco Sport, Lincoln Nautilus and Corsair vehicles with 1.5-liter, 2.0-liter or 2.3-liter engines.

Ford said it is not aware of any accidents, injuries or fires related to the condition.

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The automaker said a fix is still under development. Owners will be notified by mail once a remedy is available and will need to take their vehicles to a Ford or Lincoln dealer for a free repair.

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American Tower director Robert D. Hormats to step down after annual meeting

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American Tower director Robert D. Hormats to step down after annual meeting

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Understanding the Rise of Hybrid Working

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Hybrid working has become one of the most discussed topics in the post-pandemic world, with more and more companies shifting their focus to this flexible work arrangement.

In recent years, the way people approach their jobs has undergone a significant transformation.

Advances in technology, changing expectations from employees, and the experiences of recent years have all contributed to a shift in how organisations structure their work environments. One of the most notable developments is the growing popularity of hybrid work models, which allow employees to split their time between working remotely and spending time in a physical office.

This shift represents a broader cultural change in how businesses view productivity and flexibility. Rather than requiring employees to be present in the office every day, many organisations now recognise that different tasks and working styles benefit from different environments. As a result, companies are experimenting with new approaches that combine the advantages of both remote and office-based work.

Why Flexible Work Models Are Gaining Popularity

Many businesses have found that flexible working arrangements provide benefits for both employers and employees. From a recruitment perspective, offering flexibility has become an important way to attract skilled professionals. Job seekers increasingly value roles that allow them greater control over their working patterns, and companies that offer this flexibility often stand out in competitive industries.

Productivity is another key factor. For tasks that require focus and minimal interruption, working from home can often be more efficient. Meanwhile, the office remains a valuable environment for collaboration, brainstorming, and team discussions. A hybrid approach enables organisations to use each setting for its strengths.

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Businesses may also benefit financially. Reduced office occupancy can lead to lower operational costs, while employees save time and money by commuting less frequently. These practical advantages have made hybrid working an appealing option for many companies.

Rethinking the Modern Office

As working patterns evolve, organisations are reconsidering the role of the office itself. Instead of being a place where employees simply sit at desks for the entire workday, offices are increasingly designed as spaces for collaboration and interaction.

Modern workplaces often feature flexible layouts with shared desks, breakout areas, and meeting rooms that encourage teamwork. Social spaces and informal seating areas can also help foster creativity and connection among colleagues. This shift reflects the idea that when employees come into the office, their time should be focused on activities that benefit from face-to-face interaction.

To support these changes, many companies are also reviewing their workplace strategies. Resources such as guidance on hybrid working can help organisations understand how to balance remote and office-based work effectively while ensuring that teams remain productive and connected.

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The Role of Technology

Technology is a central component of successful hybrid workplaces. Cloud-based platforms allow employees to access files, software, and systems from almost anywhere, making it possible to collaborate even when team members are not in the same location.

Communication tools have also become essential. Video conferencing, instant messaging, and project management platforms help teams stay connected and organised. When used effectively, these technologies ensure that remote workers remain fully involved in discussions, projects, and decision-making processes.

However, technology alone is not enough. Organisations must also develop clear communication practices so that everyone knows when and how to connect with colleagues, regardless of where they are working.

Supporting Employee Wellbeing

One of the biggest advantages of hybrid working is the potential improvement in work–life balance. Employees can often organise their schedules more effectively, allowing them to manage personal commitments while maintaining professional responsibilities.

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At the same time, businesses must be mindful of potential challenges. Remote workers can sometimes feel disconnected if communication is limited, and the absence of clear boundaries between work and home life may lead to longer working hours. Establishing clear expectations and encouraging regular check-ins can help ensure that employees feel supported and engaged.

A Long-Term Shift in Workplace Culture

Hybrid working is increasingly seen as a long-term evolution rather than a temporary adjustment. Organisations that successfully adopt this model are often those that focus on flexibility, strong communication, and thoughtful workplace design.

By recognising that productivity does not depend solely on location, businesses can create environments where employees feel trusted, motivated, and able to perform at their best. As workplace expectations continue to evolve, hybrid models are likely to remain an important part of the future of work.

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California Pizza Kitchen expanding beyond pizza

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California Pizza Kitchen expanding beyond pizza

New frozen food products will include appetizers and entrees.

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Champion to step down from Black Swan State Theatre Company

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Champion to step down from Black Swan State Theatre Company

Acclaimed artistic director Kate Champion will leave Black Swan State Theatre Company after programming five seasons.

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Federal appeals court terminates Biden SAVE student loan plan

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Federal appeals court terminates Biden SAVE student loan plan

A federal appeals court on Monday officially finalized the termination of the Saving on a Valuable Education (SAVE) plan, the Biden program that significantly lowered repayment rates for millions of student loan borrowers.

The judgment, issued by the U.S. Court of Appeals for the 8th Circuit, reverses a lower court’s February dismissal of a Republican-led legal challenge against the SAVE plan. That ruling was issued by Judge John Ross of the U.S. District Court for the Eastern District of Missouri.

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Originally introduced in 2023 under former President Joe Biden, the SAVE plan was hailed as the “most affordable repayment plan ever created” for federal student loan borrowers. The program was the first and only plan in history that prevented the balance from ever growing by subsidizing 100% of all unpaid monthly interest.

More than 7 million student loan borrowers reportedly remain enrolled in the SAVE plan as of the fourth quarter.

TRUMP ADMINISTRATION SERVES FINAL BLOW TO END BIDEN’S SAVE STUDENT LOAN PROGRAM

biden making campaign speech

President Joe Biden speaks at the Pieper-Hillside Boys & Girls Club in Milwaukee, Wisconsin on March 13, 2024. (Alex Wroblewski for The Washington Post via Getty Images) / Getty Images)

Student loan borrowers enrolled in the SAVE plan have been urged to explore switching to a new repayment program.

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Among alternative options, the Income-Based Repayment (IBR) plan sets monthly payments at 10% to 15% of discretionary income over a 20 to 25-year period.

TRUMP ADMINISTRATION AGREES TO SPEED UP STUDENT LOAN FORGIVENESS UNDER NEW COURT DEAL

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Student loan borrowers are urged to seek alternative repayment plans following Monday’s decision.  (iStock  / iStock)

Under the Big Beautiful Bill Act (OBBBA), passed last year under President Donald Trump, the Repayment Assistance Plan (RAP) will become available starting July 1, 2026. RAP uses a sliding scale of 1% to 10% of a borrower’s total Adjusted Gross Income (AGI) and requires 30 years of payments for all participants.

Borrowers pursuing Public Service Loan Forgiveness (PSLF), a federal program that cancels remaining student debt after 10 years of qualifying public service, should verify their eligibility and file an application to reclaim credit for the months when their SAVE plan progress was effectively frozen.

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Education Secretary Linda McMahon giving a speech in front of the American flag. (Darren McCollester / Getty Images)

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Monday’s decision has effectively resolved a years-long legal battle between Republican-led states and the federal government. The ruling comes after nearly 8 million borrowers paused payments under “litigation forbearance” following an earlier injunction, and it follows a brief period of confusion when a lower court attempted to dismiss the case after a settlement with the Trump administration.

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