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What Can We Expect from Digital Healthcare in 2021?

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What Can We Expect from Digital Healthcare in 2021?

by Gonzalo Wangüemert Villalba

4 September 2025

Introduction The open-source AI ecosystem reached a turning point in August 2025 when Elon Musk’s company xAI released Grok 2.5 and, almost simultaneously, OpenAI launched two new models under the names GPT-OSS-20B and GPT-OSS-120B. While both announcements signalled a commitment to transparency and broader accessibility, the details of these releases highlight strikingly different approaches to what open AI should mean. This article explores the architecture, accessibility, performance benchmarks, regulatory compliance and wider industry impact of these three models. The aim is to clarify whether xAI’s Grok or OpenAI’s GPT-OSS family currently offers more value for developers, businesses and regulators in Europe and beyond. What Was Released Grok 2.5, described by xAI as a 270 billion parameter model, was made available through the release of its weights and tokenizer. These files amount to roughly half a terabyte and were published on Hugging Face. Yet the release lacks critical elements such as training code, detailed architectural notes or dataset documentation. Most importantly, Grok 2.5 comes with a bespoke licence drafted by xAI that has not yet been clearly scrutinised by legal or open-source communities. Analysts have noted that its terms could be revocable or carry restrictions that prevent the model from being considered genuinely open source. Elon Musk promised on social media that Grok 3 would be published in the same manner within six months, suggesting this is just the beginning of a broader strategy by xAI to join the open-source race. By contrast, OpenAI unveiled GPT-OSS-20B and GPT-OSS-120B on 5 August 2025 with a far more comprehensive package. The models were released under the widely recognised Apache 2.0 licence, which is permissive, business-friendly and in line with requirements of the European Union’s AI Act. OpenAI did not only share the weights but also architectural details, training methodology, evaluation benchmarks, code samples and usage guidelines. This represents one of the most transparent releases ever made by the company, which historically faced criticism for keeping its frontier models proprietary. Architectural Approach The architectural differences between these models reveal much about their intended use. Grok 2.5 is a dense transformer with all 270 billion parameters engaged in computation. Without detailed documentation, it is unclear how efficiently it handles scaling or what kinds of attention mechanisms are employed. Meanwhile, GPT-OSS-20B and GPT-OSS-120B make use of a Mixture-of-Experts design. In practice this means that although the models contain 21 and 117 billion parameters respectively, only a small subset of those parameters are activated for each token. GPT-OSS-20B activates 3.6 billion and GPT-OSS-120B activates just over 5 billion. This architecture leads to far greater efficiency, allowing the smaller of the two to run comfortably on devices with only 16 gigabytes of memory, including Snapdragon laptops and consumer-grade graphics cards. The larger model requires 80 gigabytes of GPU memory, placing it in the range of high-end professional hardware, yet still far more efficient than a dense model of similar size. This is a deliberate choice by OpenAI to ensure that open-weight models are not only theoretically available but practically usable. Documentation and Transparency The difference in documentation further separates the two releases. OpenAI’s GPT-OSS models include explanations of their sparse attention layers, grouped multi-query attention, and support for extended context lengths up to 128,000 tokens. These details allow independent researchers to understand, test and even modify the architecture. By contrast, Grok 2.5 offers little more than its weight files and tokenizer, making it effectively a black box. From a developer’s perspective this is crucial: having access to weights without knowing how the system was trained or structured limits reproducibility and hinders adaptation. Transparency also affects regulatory compliance and community trust, making OpenAI’s approach significantly more robust. Performance and Benchmarks Benchmark performance is another area where GPT-OSS models shine. According to OpenAI’s technical documentation and independent testing, GPT-OSS-120B rivals or exceeds the reasoning ability of the company’s o4-mini model, while GPT-OSS-20B achieves parity with the o3-mini. On benchmarks such as MMLU, Codeforces, HealthBench and the AIME mathematics tests from 2024 and 2025, the models perform strongly, especially considering their efficient architecture. GPT-OSS-20B in particular impressed researchers by outperforming much larger competitors such as Qwen3-32B on certain coding and reasoning tasks, despite using less energy and memory. Academic studies published on arXiv in August 2025 highlighted that the model achieved nearly 32 per cent higher throughput and more than 25 per cent lower energy consumption per 1,000 tokens than rival models. Interestingly, one paper noted that GPT-OSS-20B outperformed its larger sibling GPT-OSS-120B on some human evaluation benchmarks, suggesting that sparse scaling does not always correlate linearly with capability. In terms of safety and robustness, the GPT-OSS models again appear carefully designed. They perform comparably to o4-mini on jailbreak resistance and bias testing, though they display higher hallucination rates in simple factual question-answering tasks. This transparency allows researchers to target weaknesses directly, which is part of the value of an open-weight release. Grok 2.5, however, lacks publicly available benchmarks altogether. Without independent testing, its actual capabilities remain uncertain, leaving the community with only Musk’s promotional statements to go by. Regulatory Compliance Regulatory compliance is a particularly important issue for organisations in Europe under the EU AI Act. The legislation requires general-purpose AI models to be released under genuinely open licences, accompanied by detailed technical documentation, information on training and testing datasets, and usage reporting. For models that exceed systemic risk thresholds, such as those trained with more than 10²⁵ floating point operations, further obligations apply, including risk assessment and registration. Grok 2.5, by virtue of its vague licence and lack of documentation, appears non-compliant on several counts. Unless xAI publishes more details or adapts its licensing, European businesses may find it difficult or legally risky to adopt Grok in their workflows. GPT-OSS-20B and 120B, by contrast, seem carefully aligned with the requirements of the AI Act. Their Apache 2.0 licence is recognised under the Act, their documentation meets transparency demands, and OpenAI has signalled a commitment to provide usage reporting. From a regulatory standpoint, OpenAI’s releases are safer bets for integration within the UK and EU. Community Reception The reception from the AI community reflects these differences. Developers welcomed OpenAI’s move as a long-awaited recognition of the open-source movement, especially after years of criticism that the company had become overly protective of its models. Some users, however, expressed frustration with the mixture-of-experts design, reporting that it can lead to repetitive tool-calling behaviours and less engaging conversational output. Yet most acknowledged that for tasks requiring structured reasoning, coding or mathematical precision, the GPT-OSS family performs exceptionally well. Grok 2.5’s release was greeted with more scepticism. While some praised Musk for at least releasing weights, others argued that without a proper licence or documentation it was little more than a symbolic gesture designed to signal openness while avoiding true transparency. Strategic Implications The strategic motivations behind these releases are also worth considering. For xAI, releasing Grok 2.5 may be less about immediate usability and more about positioning in the competitive AI landscape, particularly against Chinese developers and American rivals. For OpenAI, the move appears to be a balancing act: maintaining leadership in proprietary frontier models like GPT-5 while offering credible open-weight alternatives that address regulatory scrutiny and community pressure. This dual strategy could prove effective, enabling the company to dominate both commercial and open-source markets. Conclusion Ultimately, the comparison between Grok 2.5 and GPT-OSS-20B and 120B is not merely technical but philosophical. xAI’s release demonstrates a willingness to participate in the open-source movement but stops short of true openness. OpenAI, on the other hand, has set a new standard for what open-weight releases should look like in 2025: efficient architectures, extensive documentation, clear licensing, strong benchmark performance and regulatory compliance. For European businesses and policymakers evaluating open-source AI options, GPT-OSS currently represents the more practical, compliant and capable choice.  In conclusion, while both xAI and OpenAI contributed to the momentum of open-source AI in August 2025, the details reveal that not all openness is created equal. Grok 2.5 stands as an important symbolic release, but OpenAI’s GPT-OSS family sets the benchmark for practical usability, compliance with the EU AI Act, and genuine transparency.

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Glassnode flags extended sell-side pressure ahead

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OpenAI launches smart contract security evaluation system

BTC is down ~28% this month; Glassnode’s sub‑1 realized P/L ratio signals 5–6 more months of downside pressure.

Summary

  • BTC trades near ~$63k after a sharp February selloff, about 47% below its ~$126k ATH from October 2025.
  • Glassnode’s 90D realized profit/loss ratio has fallen below 1, historically preceding at least 5–6 months where realized losses dominate realized profits.
  • In prior cycles, BTC dropped ~25% over six months in 2022 and >50% over five months in 2018 after this metric flipped sub‑1, implying risk of further drawdown if patterns repeat.

Bitcoin has approached previous highs following a sharp decline in February, though blockchain analytics firm Glassnode has indicated further downward pressure may persist for several months, according to the company’s recent analysis.

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Glassnode reported that Bitcoin’s realized profit/loss ratio, measured as a 90-day moving average, has fallen below 1. The firm stated this metric suggests the decline could continue for an additional five to six months.

In a post on social media platform X, Glassnode cited historical data showing that drops in the Realized Profit/Loss Ratio below 1 have preceded decline periods lasting at least six months. The firm noted that a return above 1 generally indicates a decrease in selling pressure.

The analytics company referenced the 2022 and 2018 bear markets as comparative examples. During the 2022 bear market, Bitcoin declined 25% in value six months after its profit/loss ratio fell below 1, according to Glassnode. Under similar conditions in 2018, Bitcoin experienced a drop exceeding 50% over five months.

Glassnode stated that if historical patterns repeat, the cryptocurrency’s price could continue its downward trend for five months or longer.

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The Realized Profit/Loss Ratio measures the ratio of profits to losses realized on the Bitcoin network, providing insight into market sentiment and selling pressure among holders.

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5 red months, 74% LTH profit rapidly eroding

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5 red months, 74% LTH profit rapidly eroding

BTC is down ~50% from ATH, with 74% LTH profit shrinking as supply in loss hits 50% amid multi‑month selling.

Summary

  • Long-term BTC holders still sit on ~74% average profit, but that margin is compressing as price grinds toward the LTH cost basis near ~$39k.
  • BTC has printed almost five straight red monthly candles after a volatility spike above 150%, while weekly RSI hits one of its most oversold levels ever around the $60k-$65k zone.
  • BTC supply in loss has hit ~10m coins, roughly 50% of the 20m circulating, a capital destruction level that has historically coincided with bear market bottoms.

Bitcoin long-term holders currently hold an average profit of approximately 74%, though that margin continues to decline as the cryptocurrency’s price moves closer to their cost basis, according to CryptoQuant analyst Darkfost.

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The analyst noted that historical bear market cycles have been characterized by prices breaking below the long-term holder cost basis, triggering capitulation phases marked by realized losses of around 20%. Long-term holders are defined as investors known to be less sensitive to short-term price fluctuations, Darkfost stated.

Market recovery and bull phase entry have historically occurred only after such capitulation events, according to the analysis.

Glassnode reported that the 90-day moving average of the Realized Profit/Loss Ratio has fallen below 1, confirming a transition into an excess loss-realization regime. The blockchain analytics firm stated that these bearish conditions have historically persisted for at least six months before liquidity returns to markets.

Analyst James Check reported that Bitcoin has recorded nearly five consecutive red monthly candles following the largest volatility spike of the current cycle. Check observed that one-week realized volatility spiked above 150%, a level typically associated with capitulation events, and that weekly RSI has reached one of the most oversold readings in Bitcoin’s history. A significant amount of Bitcoin has migrated to new holders in a high price range this year, according to Check’s analysis.

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Bitcoin supply in loss reached 10 million coins, the fourth-highest reading on record, analyst James Van Straten reported. Van Straten noted that circulating supply will reach 20 million Bitcoin next week, with 50% held at a loss. Historical patterns suggest such capital destruction levels are sufficient for a bear market bottom, according to Van Straten.

Bitcoin experienced a minor price rebound during early Asian trading hours, though bearish sentiment remains dominant in the market. The price movement formed another lower high while a key support level continues to hold, according to technical analysis.

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Anchorage Digital Buys Strategy STRC as Stock Becomes Most-Shorted

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Anchorage Digital Buys Strategy STRC as Stock Becomes Most-Shorted

Crypto bank Anchorage Digital said it now holds Strategy’s perpetual preferred security STRC on its balance sheet, adding an institutional backer to Michael Saylor’s Bitcoin treasury company at a time when Wall Street traders are increasingly betting against it.

In a Wednesday post on X, Anchorage co-founder and CEO Nathan McCauley said the purchase shows alignment between two companies built around Bitcoin (BTC) infrastructure and corporate treasury adoption. “Conviction compounds. Institutions don’t just talk about Bitcoin, they structure around it,” McCauley wrote.

“When the company that operationalizes Bitcoin infrastructure puts capital alongside the company that operationalized the Bitcoin treasury strategy…that’s a signal,” he added. Anchorage did not reveal the size or timing of the position.

According to Strategy’s website, STRC is a Nasdaq-listed perpetual preferred security marketed as a short-duration, high-yield instrument. The shares pay an 11.25% annual dividend distributed monthly in cash. Capital raised through the instrument has historically financed the firm’s continued Bitcoin accumulation.

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Related: Michael Saylor says quantum threat to Bitcoin is more than 10 years away

Strategy becomes Wall Street’s most-shorted stock

Anchorage’s purchase comes as Strategy has climbed to the top of Goldman Sachs’ list of most-shorted large-cap US equities by short interest as a percentage of market capitalization. A year ago, it did not rank among the top 50. The company began rising on the list in late 2025 as its share price weakened even before Bitcoin peaked in October.

Strategy becomes the most shorted large-cap stock. Source: Goldman Sachs

Short selling involves borrowing shares and selling them with the expectation of repurchasing later at a lower price. Losses can grow if the stock rises.

Strategy functions as a leveraged public-equity proxy for Bitcoin. It issues securities and deploys the proceeds into BTC. Gains can amplify during rallies, while downturns magnify pressure on the share price.

The company currently holds 717,722 Bitcoin worth about $46.68 billion at current market prices. On Monday, it announced another purchase, acquiring 592 BTC for $39.8 million. The coins were acquired at an average cost of roughly $76,020, leaving the company sitting on an estimated $7 billion unrealized loss with Bitcoin trading near $66,000.

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Related: Michael Saylor hints at Strategy’s 100th Bitcoin buy

Strategy plans debt-to-equity shift

Last week, Strategy founder Michael Saylor said the company intends to convert roughly $6 billion in convertible bond debt into equity, replacing repayment obligations with newly issued shares. The change would lower leverage on the balance sheet by turning bondholders into shareholders, though it could dilute existing investors.