The mother of a boy with a rare genetic disorder, known to affect around 200 people worldwide, has said doctors told her “nothing can be done” and he is “unlikely to survive past his teens”.

Amy Sheridan-Hill, 46, a former teacher living in Ware, Hertfordshire, said she was “shocked” for her son Frankie to be diagnosed with H-ABC, a rare genetic disorder which affects certain parts of the brain, in 2021, aged five.

Frankie, now 10, was born in 2015 after Amy said she had a normal pregnancy and planned C-section, noting “no issues from birth”.

As Frankie was her first child, Amy said she was “quite unaware of the proper development stages”, so when her son could not sit up like other children she saw around her, she initially thought it was “nothing to worry about”.

But by the age of two, Amy said Frankie was not walking independently, which most toddlers learn to do by 18 months, so she took him to a doctor who made a referral to a physiotherapist.

This is when Amy said she was told her son might have hypermobility, a condition of very flexible joints, but when Frankie still was not walking by four, a physiotherapist noticed “a certain way his foot went that made her think of cerebral palsy”, so he was referred to a neurologist.

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Amy said Frankie had an MRI and then genetic testing to get his diagnosis of H-ABC – a very rare form of leukodystrophy, which is a group of genetic disorders that affect the white matter of the brain – at five years old, which came as a “massive shock” and turned their world “upside down completely”.

According to H-ABC Foundation UK, as of 2019, fewer than 200 documented cases of H-ABC have been identified, the majority of which are children, but that number is on the rise as patients have access to better clinical diagnoses.

“When you go to a doctor, you expect to be told what can be done,” Amy told PA Real Life.

“So I think to be told ‘nothing can be done’ is quite a shock.

“You’re told they’re going to die essentially. I think there’s still some PTSD from the diagnosis and I think a lot of parents say that it’s quite big to be given this information and sent on your way.

“When you google leukodystrophy, it just gives you the worst-case scenario. With some types of leukodystrophy, kids die within two years, so it is not a word you want to google if you’ve just been given that diagnosis.”

By this stage, Amy said he was behind his peers developmentally, especially with his walking ability, but also his speech and reading level.

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In the aftermath of Frankie’s diagnosis, Amy said she was “googling everything” and came across a Facebook group for H-ABC that had “less than 100 worldwide members”, so she joined it.

Shortly after, Michelle Teng, a fellow mum from the group based in Oxford, got in touch and told Amy about another Cotswolds-based mum named Ali Candy-Waters, so they all jumped on a Zoom call together and eventually decided to set up a charity called H-ABC Foundation UK to raise awareness for the condition.

“I think having mums who are going through what you’re going through is just really helpful,” Amy said.

“We don’t see each other that often, but we text constantly.

“I was talking to Ali this morning about the mum guilt of when you don’t put your child in his stander every day – because he should and it’s good for him – but actually getting him in the stander is really difficult.

“We’ve all got brilliant friends and families, but people that are going through it, they know (what it’s like) when you’re having a meltdown, so you can phone one of them.”

Through fundraising initiatives such as marathons and school bake sales, Amy said the charity has helped fund research into the disease and supported in buying other families affected by the condition wheelchairs or iPads, which can help children without speech to communicate.

Alongside this, Michelle is the co-founder of an Oxford-based company called SynaptixBio, which has recently chosen its candidate drug to take forward into clinical trials to treat H-ABC.

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Amy said the timeline for these trials could be within the next year or two and it would not completely cure Frankie, but it could potentially “hold the disease to stop children losing any more skills”.

Currently, there is no known cure for the condition, but treatments such as physical therapy and certain medication may alleviate symptoms and improve quality of life.

In the meantime, Amy said her family’s goal is to keep Frankie “as strong as possible” so that there is a “better starting point” if he is selected for the trial.

To do this, Amy said Frankie regularly has physio and occupational therapy and Botox to relax the muscles in his legs.

He uses leg splints, Lycra shorts, a stander and a walker, and will need to have X-rays and surgeries in the future because his spine will start curving.

If Frankie is not eligible for the trial, Amy said it might be a few more years before he can get access to what could be a drug that completely changes her son’s life.

For now, Amy said Frankie loves playing with his “protective” and “kind” younger brother Rory, eight, and he “loves” being in a mainstream school, where she commended his “amazing teachers” and the whole class who “just really look after him”.

“It’s really sweet to see,” Amy said.

“When they do assemblies, they make Frankie the centre of things and they always make sure he’s really involved in everything.

“They specialise the curriculum for him because he is delayed, so he’ll do his own work, but he just loves being part of the class.”

She added: “Frankie is a very happy child. He can read, he loves to play PlayStation, and he can use his iPad.

“If we could keep the disease static and he doesn’t decline, he’d have a great life.

“If we could get some form of treatment in the next two or three years, I think Frankie’s path would be quite different.

“We hope that other families don’t go through what we’ve been through.”

Ultimately, Amy said she wants to raise awareness of the disease because “there’s probably more cases out there”.

She said people need to know that there are charities like H-ABC Foundation UK “that have been set up to support families and there are doctors and scientists working on treatments”.

Amy said: “Now we can tell them where we are and that gives them hope, whereas when Frankie was diagnosed, there wasn’t that hope. So we’ve had to create that hope and now we can share it with other families.”

To find out more about H-ABC Foundation UK, visit its website: www.h-abcfoundation.org.

Rat infestations in UK properties have surged over the past year, a phenomenon experts attribute to a record-breaking hot summer followed by recent heavy rainfall. Rentokil Pest Control reported a 10 per cent year-on-year rise in confirmed rodent sightings, with notable increases observed across Northern Ireland and northern England.

Northern Ireland recorded the largest increase of 26%, followed by Yorkshire (20%) and north-west England (19%).

Several other regions, including the West Midlands (16%) and Scotland (14%), also had double-digit rises.

Rentokil said longer-term climate patterns could be contributing to the increase, including 2025 being the UK’s warmest year on record.

It said milder weather could increase rat reproduction by extending their breeding season and leading to larger populations.

Rentokil warned that the record-breaking wet start to 2026 across the UK could also lead to higher levels of rat activity.

Sustained heavy rain can flood burrow systems and drainage networks, displacing rats and increasing the likelihood of infestations as they seek higher, drier shelter, it said.

Paul Blackhurst, from Rentokil, said: “Rats are highly capable swimmers. They can navigate strong currents, enter exposed pipes and sewers, and swim considerable distances in open water.

“However, what they cannot tolerate is prolonged submersion. When burrow systems and sewer networks flood, rats are forced to seek higher, drier ground, increasing the risk of infestations in properties.

“With northern regions already reporting notable increases in reported activity, continued wet weather may push more rats into properties. Early prevention and professional support are key.

“Simple steps such as proofing entry points, managing waste effectively and responding quickly to early signs of activity can make a significant difference. If a problem does become unmanageable, professional pest control experts are always on hand to provide safe and effective solutions.”

After periods of heavy rain, storms and flooding, property owners are advised to take proactive steps to reduce the risk of rodent activity, including:

– Clearing debris promptly by removing fallen branches, leaves and other items that may have accumulated around the property, as these create ideal hiding and nesting spots for rats.

– Sealing potential entry points.

– Inspecting the walls and foundations of the property for gaps, as rats can squeeze through “surprisingly small” openings.

– Removing sources of food by ensuring outdoor bins are sturdy, fitted with tight lids and positioned away from building walls where possible.

MPs debate concerns as state pension age rises to 67 between April 2026 and 2028

MPs have been debating changes to state pension rules and how people could face varying retirement ages. The state pension age is set to rise from April 2026.

Currently, you can claim your state pension upon reaching 66, but the access age is increasing to 67 between April 2026 and April 2028. With this major shift approaching, the Work and Pensions Committee has been discussing with policy specialists the potential consequences.

A significant concern is that workers may reach a point where they’re physically unable to continue working, particularly in demanding manual roles. Yet they still face years of waiting before accessing their state pension.

The committee heard from policy advocates about the challenges confronting older employees and what additional measures could be introduced to assist them. The committee asked the panel about the suggestion the Government should offer better workplace support to sectors it can “influence most directly”, such as health, social care, and education.

Jon Richards, assistant general secretary at public service union UNISON, highlighted how the rules can vary for different workers. He said: “If you compare ambulance workers to fire and police workers, they have different retirement ages. It’s very difficult for ambulance workers, even though they are manually handling all the time, all the day, more so than police and fire workers, yet they are not able to retire as early.”

Mr Richards stated that the union carried out a survey among ambulance workers to determine what would persuade them to stay in their roles, reports the Mirror. The most frequent response was a reduction in their retirement age.

Numerous NHS staff, including ambulance crews, have their retirement age linked to the state pension age, which is due to rise beyond 67, reaching 68 between April 2044 and 2046. Some workers can choose to access reduced benefits from the age of 55, which is also the age at which private pensions can be accessed.

However, this threshold is set to increase to 57 in April 2028. Research carried out by the GMB Union in 2024 revealed that 75 per cent of ambulance workers who retired in 2023 did so before the age of 60.

By comparison, the retirement age for many police and fire service personnel is 60, although early pension access may be available in certain circumstances. Mr Richards also pointed out that initiatives to improve support within the education sector frequently overlook some vital members of staff.

He told the committee: “If you look at other sectors like education, the focus is always on teachers, professional workers, yet 50 percent of people in schools is support staff, cleaners, teaching assistants.”

He referenced a previous Department for Education study examining teachers’ mental health. Researchers believed the findings could also be applicable to teaching assistants and other school staff. Mr Richards explained that they were required to inform the department that workers such as teaching assistants function “in a completely different way” to teachers.

The policy advocate was keen to dispel a further misconception, saying: “You get this idea of public sector workers with their ‘gold-plated pensions’ and other things like that. I always say this, but the local Government pension scheme average pension is just over £5,000.”

State pensioners are set to receive a welcome boost this April thanks to the triple lock mechanism. This guarantee ensures payments increase in line with whichever is the highest of three figures: 2.5 per cent, wage growth, or inflation.

Earnings growth proved the highest measure last year, meaning pension payments will rise by 4.8 per cent from April. This will see the full new state pension climb from the current £230.25 weekly to £241.30 weekly, while the full basic state pension will increase from the present £176.45 weekly to £184.90 weekly.

After Chelsea suffered yet another red card in defeat to Arsenal, captain Reece James admitted the Blues have a discipline issue.

The Gunners went five points clear at the top of the Premier League again after a 2-1 victory over the Blues at the Emirates.

William Saliba and Jurrien Timber scored the goals for the home team, either side of a Piero Hincapie own goal just before half-time.

It was a tight game with all three goals coming from corners and not a great deal of creativity from open play on either side.

Chelsea were left disappointed to leave with nothing, but only have themselves to blame as they played the last 20 minutes with 10 men, thanks to Pedro Neto’s red card.

The winger lunged in on Gabriel Martinelli to earn himself a second yellow and pick up Chelsea’s seventh red card in the Premier League this season and ninth in all competitions.

It is a really poor disciplinary record and James admits it is a problem which the Blues must solve.

‘We’ve spoken about it, it’s come up a number of times, every time it’s someone different, not the same player,’ James told Sky Sports.

‘Internally we need to review and keep improving. It’s a problem, we are playing in the toughest league in the world, you play against top or bottom 11 v 11 it’s tough, 11 v 10 is even harder no matter who you are playing.

‘I have no doubt in the team and staff, it didn’t go our way today but we need to regroup and go again.’

Blues boss Liam Rosenior was frustrated and disappointed with the result, which was his third defeat to Arsenal since taking over at Stamford Bridge in January.

On Chelsea’s red card issues, the manager said: ‘It is a difficult things to put your finger on. We get paid to try and win games of football.

‘If you don’t think we have tried to address that it is crazy. We are trying to address it.

‘Sometimes you have to learn from consequence and the pain.

‘I felt the consequence of the pain of losing points against Leeds and Burnley when 2-0 up would switch us on against a very good set-play team.

‘It hasn’t and that has been the most frustrating thing about this afternoon. We come off the pitch with no points.

‘I don’t want to talk about all the good things we did in the game – of which there was a lot – when we haven’t got anything from the game. It is a really frustrating one today.’

He added: ‘In the end it is a bitterly disappointing day because we came here with a game plan we felt we could execute.

‘Again we haven’t because we haven’t had good discipline and we conceded two goals from set-plays.’

Chelsea are left sixth in the Premier League on a bad day for them as Manchester United climbed to third with a win over Crystal Palace.

The Blues are now three points behind Liverpool in fifth and six behind Aston Villa in fourth.

Arsenal, in contrast, are flying high at the top of the table, five points clear again, although second-placed Manchester City have a game in hand.

MORE: Ian Wright reveals ‘worry’ for Arsenal after win over Chelsea

MORE: Mikel Arteta gives Declan Rice injury update after Arsenal beat Chelsea

MORE: Liam Rosenior makes Arsenal claim after ‘really frustrating’ Chelsea defeat

👉Listen to The World with Richard Engel and Yalda Hakim on your podcast app👈

Can you carry out regime change without boots on the ground? Will President Trump walk away now the supreme leader is dead? Does this feel like 2003 all over again?

Richard has been in Israel watching events unfold. He was in Tel Aviv when Israel and America launched strikes against Iran which ultimately led to the killing of Ayatollah Khamenei and many members of the top command.

In this special episode, Richard answers some questions about the situation and what might happen next.

He will be back with Yalda for a regular episode later in the week.

The two of them will answer listeners’ questions, so write to them at theworld@sky.uk

You can also watch the podcast on our YouTube channel here.

British TV star and restaurateur Marco Pierre White paid a visit to The Spread Eagle on Bolton Road on Saturday and is already said to be ‘making plans to come back soon’.

Joe McLoed of McLoed 9 took over the former Italian restaurant in June last year and it is already going from strength to strength.

Speaking to The Bolton News, Joe said: “I met Marco at Bolton Food and Drink Festival last year and he said that he would come along in the new year.

Marco Pierre White spent time in the kitchen with the team (Image: supplied)

“I got a call from chef Mike Harrison asking if we had space for Marco to come in for food as he was in the area.

“Marco was on fantastic form and had a chat and laugh. He gave us all the time in the world when he didn’t have to.

“We got pictures together and had a good laugh in kitchen about the industry.”

Marco Pierre White with team members at The Spread Eagle (Image: supplied)

Marco Pierre White is widely dubbed the ‘godfather of modern cooking’ and was the first British, and then the youngest, chef to earn three Michelin stars.

He headlined as a guest at the Bolton Food and Drink Festival (BFDF) last year marking his first-ever appearance at the event as it celebrated its 20th anniversary.

Joe was also invited to cook at the prestigious BFDF Gala Dinner alongside some of the UK’s best-known chefs, creating one of the courses for VIP guests.

Joe added: “When a chef of that calibre comes in, you’re nervous about it! If you don’t get it right, it could go wrong.

“Marco was very complimentary and said that he wants to come back soon.

“It was a lovely experience for the team; to attract chefs of that level is humbling,

“There is a lot of love put into the food here and Marco’s words are a nod that we’re heading in the right direction.”

“We’re so grateful that he chose to dine with us.”

Marco Pierre White also signed a menu during his visit (Image: supplied)

Joe also announced that The Spread Eagle has just launched a new lunch offer from Wednesday to Saturday, where diners can try dishes prepared with locally sourced ingredients from sustainable farms and producers for less than £33.  

Morsels and Measures is a “McLeod 9 interpretation of bar food” with a selection of Joe’s favourite snippets inspired by the restaurants tasting menu.

 The Spread Eagle, 10 Bolton Rd, Edgworth, BL7 0DS

It is an image that will haunt very many people across Israel. A corner of Beit Shemesh, flattened by an Iranian missile; a synagogue destroyed; people killed while they sought refuge in a bomb shelter.

If you wanted proof that war, even this war, is not just about aerial defences and surgical strikes, this was it. A ghastly vista of sudden death.

Live updates on strikes

When we arrived on the scene, we were told, repeatedly, that this was just a place where people lived, prayed and got taught. No military base, no hardware, not even a government office.

“Why would this be a target,” said one person. “There is no excuse.”

What we saw when we arrived was a chaotic aftermath. What we heard was a horror story.

Dozens of residents had gone to the bomb shelter after receiving an alert on their phone and then hearing an air raid siren. It is the sort of behaviour that is, at once, disconcerting and also normal.

Thanks to previous conflicts, including the 12-day war just eight months ago, Israelis are accustomed to getting such warnings.

The shelter was supposed to be their sanctuary. Instead, it became a tomb in a matter of moments.

The missile somehow evaded Israel‘s formidable air defences.

“Nothing can be one hundred percent effective,” said one Israeli military official to me. “We cannot stop every single missile. We can try, but we know that eventually one will get through.”

And so it did, devastatingly. We watched as huge diggers were brought in to try to clear the rubble, and as search and rescue teams worked out how to look for survivors. There were soldiers, emergency workers, local residents, police and politicians.

We spoke to one of them, Amichai Eliyahu, Israel’s outspoken culture minister. He was surveying the destruction, his head shaking. This, he said, was an embodiment of why Israel needed to fight Iran.

“What did these people here ever do to them? What did these babies do to harm them?” he said to me.

“They have never done anything bad to Iran, we don’t even share a border with Iran. This was done for no reason at all, except pure hatred for the sake of hatred. So I’m asking all those who defend them in the world, who are you defending? Monsters, Monsters want to kill us.”

Read more:
What we know so far about the strikes
Which Iranian officials are dead?
Attacks close Middle East airports

Lieutenant Colonel Yochay Manoff was more sanguine, when we spoke on a ridge overlooking the scene. He is a company commander in Israel’s National Rescue Unit, accustomed to difficult situations and traumatic problems.

But, for him, this one was difficult to accept.

“Just for reference, this is one missile that hit and affected so many buildings and so many lives,” he told me. “Think about the amount of missiles that were on the way from Iran to Israel over the last two days. The damage could be immense.”

Could be, but hasn’t been. Israel puts so much store by its aerial defence systems that sometimes its citizens can appear complacent, so confident are they in the military technology.

But this was proof that nothing works perfectly, all of the time.

Every now and then a missile will get through the array of defence systems that guard Israel’s airspace, and sometimes they strike with horrific impact. This corner of Beit Shemesh offered grim evidence of that.

Sir Keir Starmer said the UK will allow the US to use British bases after Britain, France and Germany together said they would help ‘destroy Iran’s capability to fire missiles and drones at their source’

The UK has agreed to a US request to use British military bases to strike Iranian missile sites, Sir Keir Starmer has confirmed.

But the UK Prime Minister said the UK “will not join offensive action” in Iran, adding: “We all remember the mistakes of Iraq and we have learned those lessons.”

It comes as Iran continues its assault on the Middle East in revenge attacks for the joint US-Israeli operation yesterday which saw missiles rain down on Tehran, Mirror reports.

A joint statement between UK, France and Germany said: “We will take steps to defend our interests and those of our allies in the region, potentially through enabling necessary and proportionate defensive action to destroy Iran’s capability to fire missiles and drones at their source.

“We have agreed to work together with the US and allies in the region on this matter.”

In an update this evening, Mr Starmer said it “remains the case” that the UK is not involved with the strikes on Iran, but Britain will allow the US to use British bases to support its operation.

He said “partners in the Gulf have asked us to do more to defend them”, adding that “it’s my duty to protect British lives.”

“We have British jets in the air as part of coordinated defensive operations. Which have already successfully intercepted Iranian strikes. But the only way to stop the threat is to destroy the missiles at source. In their storage depots or the launchers which are used to fire the missiles,” Mr Starmer continued.

“The US has requested permission to use British bases for that specific and limited defensive purpose. We have taken the decision to accept this request. To prevent Iran firing missiles across the region, killing innocent civilians, putting British lives at risk and hitting countries that have not been involved.

“The basis of our decision is the collective self-defence of longstanding friends and allies, and protecting British lives.”

The PM said while the UK is “not joining these strikes”, Britain “will continue with our defensive actions in the region.”

“And we will also bring experts from Ukraine together with our own counter drone expertise, to help our Gulf partners shoot down Iranian drones attacking them.”

He concluded: “We all remember the mistakes of Iraq and we have learned those lessons. We were not involved in the initial strikes on Iran, and we will not join offensive action now.

“But Iran is pursuing a scorched earth strategy, so we are supporting the collective self-defence of our allies and our people in the region, because that is our duty to the British people.

“It is the best way to eliminate the urgent threat and prevent the situation spiralling further.

“This is the British government – protecting British interests and British lives.”

A large cordon was in place on Stockport Road

A Manchester park was taped off this evening (March 1) with a police helicopter scouring the scene following reports of a ‘serious assault’ in the area.

Greater Manchester Police attended the scene on Stockport Road in Longsight just after 5:30pm on reports of a ‘serious assault’ in the area around Crowcroft Park.

An injured man was found at the scene and was taken to hospital for treatment, the force said. Photos from the scene showed multiple police cars in attendance outside the takeaways on Stockport Road.

Click here to prioritise Manchester news in Google from the MEN

There were also several cordons in place along Stockport Road and East Road, which run to the north and west of the park. Multiple accounts on Facebook reported seeing a police helicopter in the area and over the park.

A spokesperson for GMP said: “At around 5.35pm today (1 March) officers responded to reports of a serious assault at Crowcroft Park, Stockport Road.

“A man has been taken to hospital for treatment and enquiries are currently ongoing.”

Arsenal are going to have to navigate the tension of the title race with just nine matches left in their bid to win a first league title since 2004.

And when asked by BBC Sport if they have had to go to another level with their work on set-pieces due to the work other sides are doing, Arteta agreed.

“Yes but every team is to be fair,” he said. “Look where they are in terms of the amount of goals that they score.

“We hadn’t scored set-pieces for a few weeks now, but we scored so many in open play.

“Today was an option to score from this kind of situation. We’ve done it so well and we conceded as well.”

Chelsea were starting to grow into the game before Timber’s crucial goal, while they needed goalkeeper David Raya to produce some excellent saves to deny the sixth-placed Blues a point.

“I didn’t think there was an awful lot between the two teams, but Arsenal came out on top and at this stage of the season that’s vital, isn’t it?,” added Arteta’s former Everton team-mate Osman.

“If your strengths are pacy wide men that create things all the time, you give them the ball all the time.

“If your strength is set-pieces, you try to win set-pieces and score from them and they’re very good at it, very effective.

“And ultimately that was that was the difference between the teams, but Arsenal won’t care because it’s another three points.”

According to Osman, Arsenal can be criticised for their style of play and are often compared to title winners of the past but if they win the title, that is all that matters.

“Many people watching want to see beautiful football or purists want to see open play great goals back to front.” he said.

“That’s not how football’s always played. Football is about being effective in both penalty areas, finding a way.

“I think whatever happens in between can be pleasing, can be enjoyable, can be exciting.

“But ultimately, it’s less important than what happens in both penalty areas because that’s where games are won and lost.”