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Blood tests for cancer? We’re still a way off

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Blood tests for cancer? We’re still a way off

A new kind of blood test promises to find cancer early – sometimes even before symptoms appear.

The pitch is compelling: a single sample of blood could scan the body for dozens of different cancers at once, catching disease at a stage when it is easier to treat and more likely to be curable. For people who fear cancer – which is most of us – this sounds like a medical revolution.

These tests look for tiny pieces of DNA from cancer cells that are circulating in the blood – something my research teams have spent years working on. In the lab, powerful machines analyse these DNA fragments, searching for patterns that suggest a hidden cancer somewhere in the body.

Instead of waiting for a lump, unexplained weight loss or other symptoms, you could have a blood test every six or 12 months to check if cancer is starting to grow. NHS England described the test – which they were trialling in 142,000 patients – as “the beginning of a revolution”.

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The revolution postponed

But when researchers have put these tests through their paces, the reality has fallen well short of the headlines. In one large recent UK study, the blood test missed most cancers that participants went on to develop.

A negative test may feel like a clean bill of health, but at the moment, it is nothing of the sort. This matters because people naturally change their behaviour when they are reassured. If you believe a high-tech blood test has “ruled out” cancer, you may delay seeing a doctor when symptoms appear, or dismiss nagging changes in your body as nothing to worry about.

Traditional screening tests have their own problems, but they are built on decades of evidence. Mammograms for breast cancer, colonoscopy or stool tests for bowel cancer, and cervical screening all went through long, careful trials to show they save lives overall, not just that they find more abnormalities.

Even then, they can miss cancers, and they can also pick up growths that would never have caused harm. With multi-cancer blood tests, the evidence is much thinner, and we still do not know whether using them in healthy people actually reduces deaths from cancer.

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The tests also generate false alarms. Sometimes the test can flag people as having cancer when they don’t, causing huge amounts of stress. Health systems that are already stretched risk being overwhelmed by follow-up investigations, triggered by blood test results, that may ultimately lead nowhere.

Mammograms are built on decades of evidence.
My Ocean Production/Shutterstock.com

Cost is another consideration. These tests are not cheap to develop or buy. If these tests are used widely before we know whether they work, health services could waste money and staff time on unproven technology instead of on proven measures like prompt diagnosis, smoking cessation, weight management and ensuring that existing screening programmes reach the people who need them most.

Yet it would be wrong to dismiss these tests entirely. The underlying science is sophisticated, and it is advancing quickly. In high-risk groups – for example, people with strong family histories of certain cancers, or those with inherited genetic mutations – carefully used blood tests might genuinely help to detect tumours earlier than we can today.

They are also helpful in checking if cancer is returning after treatment, or in choosing treatments that match the specific biology of a person’s cancer.

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The deeper issue is how we introduce such technology into everyday life. There is a long history of medicine being captivated by new treatments and procedures, only to discover later that the harms and compromises were greater than expected.

Early cancer blood tests are arriving at a time when trust in institutions is fragile, misinformation spreads fast, and many people understandably feel that getting to see a doctor at all is increasingly difficult. Adding another layer of complexity and uncertainty could easily widen inequality between those who can pay privately for extra tests and those who cannot.

Sensible steps you can take

While we wait for better evidence, there are still sensible steps people can take. First, if you are invited to take part in a trial of a new cancer blood test, ask what the study is trying to show and what is already known. Genuine clinical trials, run through the NHS or academic centres, are how we answer important questions about benefits and harms.

Second, if you are offered one of these tests privately, ask who will interpret the result, what support you will get afterwards, and whether it is likely to change your care in a meaningful way.

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Most importantly, do not let the idea of a “simple blood test” overshadow the basics. If you notice a new lump, unexplained bleeding, persistent cough, weight loss or a change in bowel habit that goes on for more than a few weeks, you should still contact your GP, even if a previous test was normal.

Trust your instincts about your own body and keep pushing if you feel something is wrong. Stories of delayed diagnoses repeatedly show that persistence from patients, families and doctors can make a crucial difference.

Cancer outcomes have been improving slowly over time, thanks to a combination of better treatments, earlier diagnosis and public health measures. New technology, including blood tests that scan for traces of cancer, will probably play a part in the next chapter of that story. But on their own, they are not a magic bullet against disease.

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Volume 2 explores money and kinship in the Edo underworld

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Volume 2 explores money and kinship in the Edo underworld

At high noon on a scorching summer day, retired samurai Kohei finds the fearsome Kumagoro writhing around a field in agony. The stricken man’s name translates as “demon bear”, and he’s the proprietor of a bar of the same name. Kohei finds him next to a temple famous for a tragic legend of familial loss and despair.

This setting frames the second instalment of The Samurai Detectives, written by Shōtarō Ikenami between 1972 and 1989 and newly translated by Yui Kajita. The novel is steeped in mystery, legend, and the ties and tensions of blood kin, fierce loyalty and pride.

Returning to 18th-century Edo Japan, we leave behind the complex machinations of political assassination plots of the first book. This volume explores the seedier underbelly of the city that became modern-day Tokyo, with a new cast of characters.

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A depiction of an onikuma (demon bear) by Shunsensai Takehara in the Ehon Hyaku Monogatari (1841).
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In addition to the “demon bear” bar owner, these include an upwardly mobile but corrupt samurai willing to hew down innocent passersby, an aged father-warrior seeking his missing son, a street-vendor looking to “muscle-up”, a beloved merchant’s daughter who keeps disappearing, and a kosamebo (“demon drizzle monk”) who visits in the rain.

In the centre of all this is Kohei, the protagonist samurai-detective, and his son, the upright warrior Daijiro. They’re joined by some familiar faces from their previous adventures.

Life is looking up for the two, with a bit more money and food for Daijiro. But at heart, Kohei is still the wily old samurai whose age belies his mental and physical abilities.

There are also the familiar temptations of cosmopolitan Edo: the easy sex, the allure of money and, underpinning it, the ever-present violence – all of which threaten to topple any one of the characters that succumb to it. Sex and love make for powerful motivators but it’s money that provides the lubricant for the inevitable violence.

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Family betrayals and fatherly care

Ultimately, the second Samurai Detective volume is a meditation on the ties of parent-child relationships – and what happens when they go wrong. Satelliting Kohei and Daijiro’s admirable father-son, master-pupil, warrior-comrade dynamic of respect and care are other examples that range from love to despair.

As with the last book, the tension of law verses morality forms the basis of thesde stories. In a city of complex fealty and interconnected relationships, it asks: what does doing the right thing mean?

Social, moral and natural justice all play their part in this complex society – though in a pinch, the rough justice of the warrior code will do. This is clear through the number of arms, legs and noses that go flying during the many sword fights.

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Painting of a busy street in Edo Japan.

Suruga Street by Utagawa Hiroshige (1836).
Moma

In this volume, Kohei and Daijiro unravel mysteries shaped by complicated family relationships. At the heart of these stories are contrasts between care, respect, love and loyalty – and on the other side, neglect, abandonment, betrayal and abuse.

The ensuing resolutions use revenge as their motivator. But there are underlying concerns of power, hierarchy and money that structure the intricate society of Edo.

book cover of The Samurai Detectives: Volume 2

The Samurai Detectives: Volume 2, The Killer on the Streets by Shōtarō Ikenami, translated by Yui Kajita.
Penguin

Towards the end of the book, another tragic, unresolved character from the previous volume returns: a figure of doomed, forbidden love. While portrayed as monstrous, we come to understand that worse still was the cruelty of parental abandonment that sets the chain of events in motion. Ultimately, these are also about the abandonment of the samurai code, something that underpins all the stories in this book.

Balancing all this is the fatherly care of Kohei – not only for Daijiro, who he continues to train, but for all the characters who come his way.

From the continuing concern for Mifuyu, the warrior-daughter of the most powerful lord in Edo, to the disappeared son of his own son’s former teacher, Kohei feels the pull of a collective responsibility to the younger ones. Even the lower-status merchant daughters and unagi eel sellers on the street are not below his level of concern.

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They fuel an inquisitiveness that leads Kohei to undignified actions, such as hiding in toilets to overhear plots of intrigue – and ultimately investigate.

As a sequel, The Samurai Detectives: The Killer on the Streets does more than paint an ongoing series of mysteries in Edo Japan. It highlights the necessity of respect, love and care in the creation of a stable society.

This article features references to books that have been included for editorial reasons, and may contain links to bookshop.org. If you click on one of the links and go on to buy something from bookshop.org The Conversation UK may earn a commission.

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Scarborough allotments ‘abandoned, derelict, or unused’

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Scarborough allotments 'abandoned, derelict, or unused'

​Since its creation last year, Scarborough Town Council has been in ​“ongoing discussions” regarding the transfer of North Yorkshire Council-managed allotment sites to the parish authority.

​Following an inspection of allotments in the town, councillors have said that any transfer of the allotment sites is conditional on agreeing a “fully costed and funded remediation package” or NYC undertaking necessary remedial works prior to their transfer.

​At a full meeting of the town council on Thursday, April 2, members were told that while dozens of plots are abandoned and unused, 340 people are on waiting lists for allotments in Scarborough.

​Cllr Sarah Mason placed on record “serious concerns regarding the historic and ongoing management of allotment sites within the Scarborough area and the implications this has for any proposed transfer of responsibility from North Yorkshire Council”.

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Scarborough Allotments. Sarah Mason/Stc.

​Speaking at the full meeting, she said: “I have undertaken a recent walkabout and inspections across all five sites, and it has revealed a pattern of long-term neglect, unclear tenancy arrangements, unmanaged risks and a significant number of plots are unused or abandoned despite long waiting lists”.

​She said that one site contained “significant amounts of rubbish, including asbestos sheeting”.

​Cllr William Stuart noted that “there are some very good allotment holders in Scarborough who are really committed and they are just as frustrated as we are”.

​A motion approved at the meeting noted the financial, compliance, legal, operational, and reputational risks that the town council faced if an immediate transfer of allotments was undertaken.

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Scarborough Allotments.. Sarah Mason/Stc.

​It stated that in their current state, the sites could not be considered fully fit for transfer without substantial remedial works or a funded plan to address the highlighted issues.

​Cllr Mason told colleagues: “There is one structure of concern on a plot which is predominantly made with asbestos sheets and is on the verge of collapse, and this has been requested on numerous occasions to be removed.

​“No regular checks have been carried out, even though this is part of the contract to the plot holders.”

Scarborough Allotments,. Sarah Mason/Stc.

​She added: “Across all sites, we have observed long-term neglect of maintenance, large numbers of unused or abandoned plots and unclear boundaries between plots, poor communication with plotholders and severe lack of management regarding clear tenancy terms, boundaries, responsibilities, and implementation”.

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​Town councillors pledged to send a formal letter to North Yorkshire Council setting out the authority’s findings and concerns and requesting “full documentation and clarification of responsibilities and seeking a clear proposal for remediation and/or funding prior to transfer”.

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Crews called to ‘deliberately’ lit bonfire on Whitby beach

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Crews called to 'deliberately' lit bonfire on Whitby beach

At 8.51pm, the Whitby crew attended a fire on the beach at Tate Hill. Shovels were used to extinguish the fire.

Then at 9.41pm, the crew re-attended the fire on the beach which had been attempted to be relit, crews dismantled the bonfire using spades and sand.

A spokesperson for North Yorkshire Fire and Rescue said: “The fire was believed to have been caused deliberately.”

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Flavor Flav, a longtime supporter of women’s sports, is courtside at Final Four

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Flavor Flav, a longtime supporter of women's sports, is courtside at Final Four

Flavor Flav was among the celebrities in attendance at the women’s Final Four on Friday night, sitting courtside for the UConn-South Carolina game with former Gamecocks player Aliyah Boston.

Flav, a founding member of the hip-hop group Public Enemy, is also friends with Gamecocks coach Dawn Staley.

The 67-year-old Flav is a longtime supporter of women’s sports and attended various Olympic competitions this winter. He invited the U.S. women’s ice hockey team to Las Vegas after their gold medal win in February, shortly after the women turned down a trip to Washington.

___

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AP March Madness bracket: https://apnews.com/hub/ncaa-womens-bracket and coverage: https://apnews.com/hub/march-madness

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After 16 years in power, can Viktor Orban finally be unseated?

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After 16 years in power, can Viktor Orban finally be unseated?

A slight figure in neat shirts and jackets, Magyar seemed too slick and urbane to reach the hearts of the rural electorate, but has proven himself a strong challenger. Orban, 62, is a village boy who speaks village Hungarian, Magyar is a Budapest lawyer by training. Conscious that his status as a member of the metropolitan elite may make him less likely to appeal to rural voters, Magyar has toured the countryside indefatigably for the past two years, drawing large crowds. Unlike Orban, who waxes lyrical on global politics, Magyar focusses on domestic issues such as healthcare, education, transport and rural depopulation in his speeches.

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Two in hospital after ‘large disturbance’ at Liverpool DJ event in Newsham Park

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Manchester Evening News

Two men suffered head injuries at the Newsham Park Hospital venue with around 15 police cars and ambulances attending the scene

Two people have been taken to hospital following a “large disturbance” at an event on Friday evening.

Police were called to a premises at Newsham Park Hospital on Orphan Drive in Liverpool just after 9pm on Friday, April 3, Liverpool Echo reports.

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Officers confirmed two men sustained head injuries and were taken to hospital, while the venue was evacuated. Witnesses described a significant emergency response, with around 15 police cars and ambulances descending on the scene as an event was taking place inside the former asylum building.

The incident brought an abrupt end to a live set by DJ D.O.D, which had been due to continue until 10pm. Footage from inside the venue captures the moment the music was halted, as a man on stage told the crowd: “Ladies and gentlemen, unfortunately due to an incident we have to stop,” prompting boos from those in attendance.

As attendees made their way out of the venue, many reported witnessing a substantial emergency presence, with police vehicles and ambulances lining the surrounding streets.

One event-goer described the moment the night was cut short. He said: “We were all stood there and it was coming up to 9pm. We were waiting for his bangers to be played and then he just cut it short and said ‘due to an incident we need you all to get out. We won’t be playing anymore.’

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“Then we all started booing and it just went from 0 to 100 after that.” Following the incident, DJ D.O.D apologised to fans on social media, saying: “Liverpool I’m so sorry the show was cut short, there were multiple incidents in the crowd which led to the police shutting down the show.”

“This is the last thing I wanted but your safety means more to me than carrying on the show. Music is about coming together. Hope to see you all again soon.”

Officers departed the scene at around 10.30pm. Enquiries are ongoing.

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Anyone with information can contact Merseyside Police social media desk via X @MerPolCC or on Facebook ‘Merseyside Police Contact Centre with log 930 of Friday 3 April.

You can also report information via the police website: https://www.merseyside.police.uk/ro/report/ocr/af/how-to-report-a-crime/ or call 101.

Alternatively, contact the independent charity Crimestoppers anonymously on 0800 555 111, or via their website here: https://crimestoppers-uk.org/give-information/forms/give-information-anonymously. In an emergency always call 999.

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These are the changes a Zelda: Ocarina Of Time remake has to make – Reader’s Feature

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These are the changes a Zelda: Ocarina Of Time remake has to make - Reader’s Feature
How do you remake one of the best games ever? (Nintendo)

With Nintendo rumoured to be planning a remake of one of their most beloved video games, a reader suggests a number of changes for a modern version of Zelda: Ocarina Of Time.

Nintendo don’t make a lot of remakes, but it’d be wrong to say they don’t ever do them. They are usually for more minor games though, like Super Mario RPG and a few Kirby games. It’d also be wrong to say there are never leaks about their upcoming games. It’s not common, unlike with other publishers, but it does happen – with Donkey Kong Bananza having been leaked years ahead of time, even if the information was a bit vague.

The latest leak didn’t really have any information though, beyond the fact that a remake of Zelda: Ocarina Of Time is coming. There’s no hint of who’s making it or how far it’ll go in changing things. Will it be a Resident Evil 2 style deal or something closer to the 3DS version of Ocarina Of Time, which was really just a remaster.

I have no idea, but naturally I’m hoping it’s as big budget an effort as possible, which seems likely if it’s supposed to be their key Christmas game. If it is that kind of effort though that implies changes – just like the Resident Evil remakes – and I have some ideas for what they could be.

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I will say from the start, that I’m hoping the changes will be relatively minimal. I don’t think there’s any need to change the combat or (with one exception) the dungeon designs, but there is a lot of fine tuning that would be useful. However, another thing I don’t want them to change is the creepiness and weirdness of the game, which is more extreme than most of the modern ones – so it’ll need actually scary ReDeads and keeping the Forest Temple as it is.

The first change I’d make is simple: voice-acting. The most recent games have been slowly adding more but while I absolutely agree that Link shouldn’t talk everyone else should. It just spoils the immersion when they don’t, and I don’t believe they have it that way for any reason other than Nintendo don’t like spending money on actors.

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Another big decision is the art style. It’s hard to tell whether the original was meant to be photorealistic or not, given the limited tech, but while it’s close I’d say it was stylised a bit and it should stay that way. Looking at character faces in particular, you can see a subtle cartoonish effect and I’d like them to keep that.

Some basic changes would be making Hyrule Field bigger and/or filled with more things and generally ensuring that the whole game is just one big open world, just with the same design as the original. That should be no problem given the last two games.

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One of the biggest problems I can foresee is that Ocarina Of Time is a lot more complicated than a modern game, especially in terms of dungeon puzzles. It wasn’t considered particularly hard at the time but nowadays people aren’t going to be used to the lack of hand-holding.

The infamous Water Temple is going to flummox any younger gamer, so I think that either has to be changed or, and this would be my preference, they have alternative versions of the dungeons and maybe the game as a whole, with a lite mode that’s easier and simpler and the full fat version.

There’s a lot of other stuff that could be added, like new side quests (the original doesn’t actually have many), more monsters everywhere (again, there’s not many, which is probably because of the limitations of the N64), and maybe even a new dungeon (a lot of fans think there should’ve been a Light Temple).

On a story note, I’d also like some clarification on what happens to Navi at the end, hopefully leading into a tease about a Majora’s Mask remake. I never liked that her fate was never revealed.

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Considering how beloved the game is and how many later ones copied it, especially Twilight Princess, I don’t envy whoever gets the job of doing the remake but I can definitely say that I will be there day one.

By reader Onibee

The Legend Of Zelda: Ocarina Of Time artwork of Link and main characters
Would a remake look more like the original’s artwork? (Nintendo)

The reader’s features do not necessarily represent the views of GameCentral or Metro.

You can submit your own 500 to 600-word reader feature at any time, which if used will be published in the next appropriate weekend slot.

Just contact us at gamecentral@metro.co.uk or use our Submit Stuff page and you won’t need to send an email.

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Faced with new energy shock, Europe asks if reviving nuclear is the answer

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Faced with new energy shock, Europe asks if reviving nuclear is the answer

In 1990, Europe produced around a third of its electricity from nuclear power. That has now fallen to an average of 15%, leaving the continent “completely dependent on expensive and volatile imports” of fossil fuels, she said, putting Europe at a disadvantage compared with other regions of the world.

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Price vs Pineiro: Date, fight time, undercard, prediction, how to watch, ring walks and latest odds

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Price vs Pineiro: Date, fight time, undercard, prediction, how to watch, ring walks and latest odds

She now faces WBA mandatory challenger Pineiro, the undefeated Puerto Rican southpaw with a perfect 10-fight pro record who has been the WBA’s interim champion since stopping Marie Pier Houle last year and then defeating Anahi Ester Sanchez.

Price is confident of continuing that winning streak and retaining her titles on home soil as she looks to secure a blockbuster showdown at middleweight with American superstar Claressa Shields, having grown tired of chasing an undisputed fight with WBO welterweight champion Mikaela Mayer.

Price vs Pineiro fight date and venue

Price vs Pineiro takes place on Saturday April 4, 2026 at Utilita Arena Cardiff in Cardiff, Wales.

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Price vs Pineiro fight time and ring walks

Price and Pineiro are expected to be in the ring for Saturday’s main event at approximately 9pm BST, which is 4pm ET and 1pm PT in the United States.

The undercard is expected to get underway around 5pm BST (12pm ET and 10am PT).

Rhys Edwards and Gully Powar compete for the vacant British featherweight title in Cardiff

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Getty Images

How to watch Price vs Pineiro

TV channel: In the UK, Price vs Pineiro is being shown live and free to air on BBC Two as part of promotional company Boxxer’s landmark broadcasting deal with the BBC, with coverage beginning at 8pm BST.

Live stream: The event is also available to watch online via the BBC Sport website and BBC iPlayer, where coverage gets underway at 5pm BST.

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Price vs Pineiro undercard

Chief support on Saturday comes from Wales’ Rhys Edwards and Gully Powar of Wolverhampton, who battle for the vacant British featherweight title.

Lauren Price vs Stephanie Pineiro – for the WBA, WBC, IBF, IBO and The Ring women’s welterweight titles

Rhys Edwards vs Gully Powar – for the vacant British featherweight title

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Kane Shepherd vs Teo Alin

Lewys Parfitt vs Morgan McIntosh

Kyran Jones vs Connor Goulding

Jacob Robinson vs Caine Singh

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Mikey O’Sullivan vs Jose Manuel Perez

Yuvraj Karia vs Jake Pollard

Price is expected to face American superstar Claressa Shields later in 2026

Getty Images

Price vs Pineiro prediction

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Price is a big favourite here for a reason. She has hardly skipped a beat in her impressive pro career so far and was far too good for the legendary Jonas last summer.

It’s important that she doesn’t overlook a tough opponent in Pineiro, but we see this as another straightforward stepping stone en route to the very biggest fights for Price – including that enormous clash with undisputed heavyweight champion Shields.

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When is FA Cup draw? Start time, ball numbers, TV channel, live stream for semi-finals

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When is FA Cup draw? Start time, ball numbers, TV channel, live stream for semi-finals

The FA Cup semi-final draw takes place this weekend after all four quarter-final ties have been played.

At least one giant will fall as Manchester City host Liverpool in the standout tie, which kicks off the weekend.

Arsenal and Chelsea will hope for a smooth passage into the last four by beating Southampton and Port Vale, respectively.

West Ham are gunning for their first semi-final berth in 20 years, but face a tricky test against Leeds ahead of the draw.

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When is the FA Cup semi-final draw?

The FA Cup semi-final draw will take place on Sunday April 5, 2026, after West Ham vs Leeds at the London Stadium.

The game kicks off at 4.30pm BST, so the earliest the draw can be held is around 6.45pm. Extra time and penalties would see the draw begin at around 7.15pm or 7.30pm.

Becky Ives will present the draw, which will be made by Ally McCoist.

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TNT Sports presenter Ally McCoist will conduct the quarter-final draw

The FA via Getty Images

Where to watch FA Cup semi-final draw

TV channel: In the UK, coverage of the draw will be broadcast live on TNT Sports 1.

Live stream: You can also follow along online via the HBO Max app and website with a subscription, as well as on the TNT Sports YouTube channel.

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Live blog: Follow the FA Cup quarter-final draw as it happens tonight with Standard Sport’s dedicated live blog.

FA Cup semi-final draw ball numbers

1. Southampton or Arsenal

When will FA Cup semi-final ties take place?

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FA Cup semi-final matches are scheduled to be held across the weekend of April 25/26, 2026.

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