Desperate England slump to first-ever defeat by Italy to pile pressure on Borthwick

Italy have made three changes to their starting XV from their defeat to France. Ignacio Brex is back in the centres having missed the last two games due to personal reasons. Alessandro Garbisi comes in at scrum-half to make it a double whammy of Garbisis at half-back. With Ange Capuozzo out with a shoulder injury, Lorenzo Pani is in at full-back.

Italy starting XV: 15 Lorenzo Pani, 14 Louis Lynagh, 13 Juan Ignacio Brex, 12 Tommaso Menoncello, 11 Monty Ioane, 10 Paolo Garbisi, 9 Alessandro Garbisi; 1 Danilo Fischetti, 2 Giacomo Nicotera, 3 Simone Ferrari, 4 Niccolo Cannone, 5 Andrea Zambonin, 6 Michele Lamaro, 7 Manuel Zuliani, 8 Lorenzo Cannone.

Replacements: 16 Tommaso Di Bartolomeo, 17 Mirco Pagnolo, 18 Muhamed Hasa, 19 Federico Ruzza, 20 Riccardo Favretto, 21 Alessandro Fusco, 22 Leonardo Marin, 23 Tommaso Allan.

Steve Borthwick has decided to make wholesale changes following England’s loss to Ireland, making nine personnel changes and three positional switches. The backline looks very different, with Elliot Daly, Fin Smith, Ben Spencer, Tom Roebuck, Seb Atkinson and Cadan Murley coming into the team. George Ford, Fraser Dingwall and Henry Arundell are all out of the matchday squad, with Alex Mitchell and Ollie Lawrence both injured.

England starting XV: 15 Elliot Daly; 14 Tom Roebuck, 13 Tommy Freeman, 12 Seb Atkinson, 11 Cadan Murley; 10 Fin Smith, 9 Ben Spencer; 1 Ellis Genge, 2 Jamie George, 3 Joe Heyes, 4 Maro Itoje (captain), 5 Alex Coles, 6 Guy Pepper, 7 Tom Curry, 8 Ben Earl.

Replacements: 16 Luke Cowan-Dickie, 17 Bevan Rodd, 18 Trevor Davison, 19 Ollie Chessum, 20 Sam Underhill, 21 Henry Pollock, 22 Jack van Poortvliet, 23 Marcus Smith.