Cancer Research UK has warned that this sign affects 65 per cent of cancer patients

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A “very common” symptom that “doesn’t go away” even with rest could be a warning sign of cancer. While this symptom typically affects 65 per cent of cancer patients, it could easily be overlooked or mistaken for something far less serious.

Feeling slightly tired in the morning is perfectly normal. Even after a good night’s sleep, you might still feel you need a bit more rest before starting your day.

It’s also typical to experience some tiredness during daytime hours, especially throughout the winter months when chilly weather and reduced daylight hours can leave you feeling lethargic. However, persistent, overwhelming fatigue could indicate something much more serious.

Cancer Research UK has warned that tiredness which “doesn’t go away” despite adequate sleep or rest is a potential cancer warning sign. This type of fatigue may result from both the disease itself and its treatment, leaving patients “feeling very tired, exhausted and lacking energy”.

On its website, the charity explained: “Cancer-related fatigue can affect you physically, emotionally, and mentally. How long it lasts, how severe it is, and how often you might have it is different from person to person.”, reports the Mirror.

If you’re experiencing cancer-related fatigue, you may notice:

• Lack of energy – you might just want to stay in bed all day
• The need for rest even after minimal or no activity
• Feeling as though you simply can’t be bothered to do much
• Sleeping issues such as insomnia or disrupted sleep
• Struggling to get up in the morning
• Feeling anxious, downcast or depressed
• Muscle pain – you may find climbing stairs or walking short distances challenging
• Feeling out of breath after completing minor tasks, like showering or making your bed
• Difficulty concentrating, even on simple activities like watching TV or chatting with a friend
• Struggling to think clearly or make decisions easily
• Loss of interest in sex
• Loss of interest in activities you usually enjoy
• Negative feelings about yourself and others

This particular symptom can make everyday life incredibly difficult. Cancer Research UK said: “Fatigue can be very frustrating. You and your relatives might underestimate how much it can affect daily life.

“Everyday life can be difficult and you might not have the energy to cook, clean, bathe or go shopping. You might not even feel up to a chat. Things that you used to find easy to do can feel like hard work.”

The charity warns that this symptom could force you to stop working entirely. Cancer Research UK added: “Some people feel like fatigue is a constant reminder of their cancer and this can be hard to accept.

“You might worry that because you feel so tired all the time your cancer could be getting worse. But it is more likely to be a side effect of treatment, or due to the fact that cancer can cause fatigue.”

When should you consult a GP?

That said, exhaustion doesn’t automatically signal cancer. It might arise from other medical conditions or lifestyle factors, including inadequate sleep, poor nutrition, and insufficient exercise.

Other health problems known for causing tiredness include:

• Anaemia
• Under or overactive thyroid
• Diabetes
• Kidney disease
• Heart disease
• Endometriosis
• Long Covid
• Mental health issues

Certain medications such as antidepressants, chemotherapy, radiation therapy, and pain relief drugs are similarly linked with fatigue. Nevertheless, if you’re experiencing persistent, unexplained tiredness that’s disrupting your daily life, you should consult your GP.

The blockbuster GLP-1 drugs that have reshaped the treatment of diabetes and obesity may help prevent multiple substance use disorders — and reduce the tragic outcomes they cause, a large new study finds.

An analysis published Wednesday in a medical journal looked at electronic health records from more than 600,000 U.S. Veterans Affairs patients with diabetes. It found that those treated with medications such as Ozempic and Mounjaro were less likely to develop addictions to alcohol, nicotine, cocaine, opioids and other substances than those treated with a different class of drugs.

In those already addicted, the GLP-1 drugs were linked to lower risks of hospitalization, overdose and death, according to the study.

The new results suggest — but don’t prove — that the weight-loss medications may be able to target the underlying source of cravings that affect the more than 48 million Americans with substance use disorders.

“They’re actually working against the root cause of all these different addictions,” said Dr. Ziyad Al-Aly, the study’s lead author and a chief researcher at the VA St. Louis Health Care System.

Here’s what you need to know about the new research published by The BMJ:

How the study was designed

Previous studies have suggested that the drugs known as GLP-1s, or glucagon-like peptide-1 receptor agonists, could reduce addictions by targeting the brain’s reward pathways. But those studies have been small and often limited to one substance.

For this study, one of the largest to date, Al-Aly and his colleagues analyzed data from the electronic records of more than 600,000 Veterans Affairs patients with diabetes over three years. They compared people who received GLP-1 drugs with those treated with medications that lower blood sugar.

The patients were divided into seven parallel trials that analyzed the risk of developing addictions to multiple substances including alcohol, cannabis, cocaine, nicotine and opioids. Another trial looked at the risk of specific harms among people with existing addictions when they took the different types of medication.

What the researchers found

Al-Aly and his colleagues found that people starting the GLP-1 drugs had lower risks of developing addiction to multiple substances. Compared with the other medications, people taking the GLP-1 drugs had a reduced risk for addiction: 18% for alcohol, 14% for cannabis, 20% for both cocaine and nicotine, and 25% for opioids.

In patients who already had substance use disorders, starting the GLP-1s was linked with a 31% lower risk of emergency department visits, 26% lower risk of hospitalizations, 25% lower risk of suicidal thoughts or attempts, 39% lower risk of overdose — and 50% lower risk of death.

Overall, the study found that using GLP-1 drugs likely prevented about seven cases of substance use disorder and 12 incidents involving serious harm for every 1,000 users over three years, Al-Aly said.

The limits of the study

Among the study’s limitations: It was conducted within the VA health system, which serves a population that is mostly older, white and male, although Al-Aly said the results were consistent in more than 35,000 women. It also includes data only from people with diabetes, not the general population.

The researchers also couldn’t account for some factors, such as socioeconomic status or lifestyle choices, that could affect the results. And the analysis focuses on the effects of using GLP-1s compared with another drug, not compared with no treatment.

As an observational study, the new analysis showed that the GLP-1s are associated with reduced risk of substance use disorders and harms, not that the drugs themselves caused the reduction.

Addiction researchers see a need for new medications

The new findings are striking, said Dr. Lorenzo Leggio, a National Institute on Drug Abuse clinical director who wasn’t involved in the study.

“Even though we don’t fully understand the mechanism, somehow the GLP-1 system is tackling addiction biology and the foundational system that underlies all these disorders,” he said.

Diabetes and weight-loss trials have shown that the GLP-1 drugs target hormones in the gut and the brain that control appetite and feelings of fullness, cutting down on what’s described as “food noise,” or intrusive thoughts of food. In the same way, this study indicates the drugs may tamp down “alcohol or drug noise,” Leggio said.

Growing evidence that GLP-1s might prevent substance use disorders is exciting, said Dr. Anna Lembke, a Stanford University addiction medicine specialist.

“We haven’t really had a new tool in our toolbox from a pharmacotherapy perspective to treat addiction in a long time,” said Lembke, noting that some addiction specialists are already prescribing GLP-1s off-label, especially when other treatments have failed.

She cautioned that the GLP-1 drugs don’t work the same way for all users and that they have risks that must be weighed against potential benefits.

What comes next

The new findings do not, by themselves, justify prescribing GLP-1 drugs to prevent or treat substance use disorders, Al-Aly said. That evidence would need to come from randomized controlled clinical trials that directly compare the use of the drugs against a placebo, or dummy medication. Several such trials are pending, Leggio noted.

The goal is finding a new way to treat addictions, which are a leading cause of sickness and death around the world.

“The consequence in terms of chronic disease of these addictive drugs is actually gigantic in our society,” Leggio said.

___

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

A federal lawsuit accuses the late pop star Michael Jackson of being a “serial child predator” who “drugged, raped, and sexually assaulted” a group of siblings over the course of years.

The complaint, filed in California federal court on Friday, comes from Edward, Dominic and Aldo Cascio, along with their sister Marie-Nicole Porte. It names the Michael Jackson Company as well as various figures in the Jackson estate.

The suit claims that Jackson, who met the Cascios’ father when he worked at a hotel that Jackson frequented, “groomed and brainwashed” the children from the time they were young, plying them drugs and alcohol and showing them pornography to desensitize them to Jackson’s alleged abuses.

Staff are accused of being aware of and facilitating the abuse, according to the lawsuit, allegedly booking Jackson in hotel rooms near the children when they traveled together.

The Cascios had previously defended Jackson’s reputation in the face of allegations of child abuse, but said they were finally “deprogrammed” about their experience after the release of the bombshell 2019 HBO documentary Leaving Neverland, which aired new allegations.

open image in gallery

“Leaving Neverland deprogrammed Plaintiffs and forced them, for the first time, to become conscious of the reality: Jackson’s abuse was wrong and had severely damaged them,” the suit claims.

After the film’s release, Jackson’s estate said the documentary was filled with “falsity” and called its claims “tabloid character assassination” based “on the word of two perjurers.”

Jackson died in 2009, not long after being acquitted in 2005 on all counts in a child molestation case. In 1994, he reportedly paid millions to settle a previous child molestation claim, though Jackson maintained his innocence throughout the process.

After his death, the Jackson estate allegedly deceived the siblings into signing a settlement that released Jackson from liability and forced any future complaints into confidential arbitration, the lawsuit claims.

Martin Singer, who represents the Jackson estate, has called the suit a “desperate money grab.”

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“The family staunchly defended Michael Jackson for more than 25 years, attesting to his innocence of inappropriate conduct,” Singer said in a statement provided to various media outlets. “This new court filing is a transparent forum-shopping tactic in their scheme to obtain hundreds of millions of dollars from Michael’s estate and companies.”

In January, the Cascios were in a Beverly Hills courthouse seeking to void what they called the “purported settlement” agreement with the estate, while the Jackson estate pushed to move the dispute into arbitration.

A judge declined to issue an immediate ruling.

“We categorically dispute these claims,” Singer reportedly told the court at the time.

Aldo Cascio recently detailed the alleged abuses in an interview with The Daily Mail.

“I was just sitting on the bed with him during the day, and I was just playing my Game Boy,” he said. “And I remember he just went to me and pulled down my shorts.”

”Since middle school, it introduced me to hell and my demons,” he added. “I realized that I might want to end my life one day.”

Wegovy and Mounjaro could help to prevent and treat addiction, experts suggest

Weight-loss jabs like Wegovy and Mounjaro could prevent and treat addiction to alcohol, cigarettes and drugs, according to a large study.

Experts believe the way the medicines work on the brain’s reward pathway cuts cravings and could help to save lives from substance abuse.

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Glucagon-like peptide-1 receptor agonists (GLP-1s) help people feel fuller by mimicking the natural hormone released after eating. Common jabs include Wegovy and Mounjaro for weight loss, and Ozempic for diabetes.

Now, a large US study has found the jabs could help in the treatment of addiction to a range of substances including alcohol, cannabis, cocaine, nicotine and opioids.

The research found GLP-1s helped both prevent substance misuse in those who had no addictions and prevented overdoses and A&E visits in people already addicted.

The researchers concluded: “GLP-1 receptor agonists were associated with lower risks of incident alcohol, cannabis, cocaine, nicotine, opioid and other substance use disorders, suggesting potential preventive effects across a broad range of substances.

“In participants with pre-existing SUDs [substance use disorders], GLP-1 receptor agonists were associated with reduced risks of SUD-related emergency department visits, hospital admissions and mortality, and drug overdoses and suicidal behaviours.”

The study looked at more than 600,000 US veterans with type 2 diabetes who were monitored for up to three years. In veterans with no history of substance abuse, starting a GLP-1 drug was linked to an overall 14 per cent reduced risk of substance use disorders.

The drugs were also linked to a reduced risk of problems with alcohol (18 per cent), cannabis (14 per cent), cocaine (20 per cent), nicotine (20 per cent) and opioids (25 per cent), when compared with people on other diabetes drugs.

This meant there were between one and six fewer cases per 1,000 people over three years.

Among those with an existing substance use disorder, starting a GLP-1 was linked to 31 per cent lower risk of SUD-related emergency department visits, 50 per cent lower deaths and 39 per cent fewer overdoses.

This is about one to 10 fewer such things happening per 1,000 people over three years.

While the study, published in the British Medical Journal (BMJ), was predominantly on older men, similar results were found in women.

The Thursday letters page wonders when Pokémon Red and Blue will be remade in 3D, as one reader looks forward to Crimson Desert.

Games Inbox is a collection of our readers’ letters, comments, and opinions. To join in with the discussions yourself email gamecentral@metro.co.uk

Mercenary thoughts
I wonder why Capcom hasn’t said anything about The Mercenaries yet? Maybe they don’t want people to put off buying the game at launch but personally I’d feel a lot more confident about buying it if they did announce it.

I’m glad to see Resident Evil Requiem doing so well though and will definitely get it at some point this year. I’m also on board with a new Resident Evil 1 remake, as it’s always been inevitable. But you’ve got to wonder what Capcom is going to do after that?

Even if they remake Resident Evil 5 and 6, which I would advise against, they’re still on the verge of running out of anything to remake. We can see that they like a new Resident Evil game coming out every year, or at least two years, so what takes the place of the remakes?

I only see two obvious options: remake obscure games like the Game Boy game or Outbreak or create a new sub-series. I would’ve made this Revelations, as I liked the focus on co-op, but I’m assuming they didn’t sell that well or we’d already have more.

Maybe a series of prequels? If the main cast are getting old then maybe some stories of them as younger people? I don’t really understand what anyone in S.T.A.R.S. did before the zombie outbreak, so maybe they could explore that. Why did an ordinary city police force have such a highly trained team of special forces soldiers? Were they just giving out parking tickets before Resident Evil 1 happened?
Cranston

Simple explanation
I wonder how many cheering the death of Highguard (and all the job losses at the developer) have actually played the game? I played it and I thought it was good. Not mind-blowing or anything but something I enjoyed and which did have some good ideas.

Personally, I don’t think it failed for any reason than it looked and sounded kinda of generic. I really don’t think it was any more complicated than that. People getting upset about it being the mic drop at The Game Awards are the usual loud minority and I don’t think that affected anything.

It just took a bit of time and effort to get to know and appreciate, and I can totally understand that people don’t have much of the first to spare nowadays.
Bernie

Second thoughts
I completely support Sony’s idea not to release single-player games on the PC. Why they ever thought it would be a good idea I don’t know but, as most people have been saying all along, exclusives sell consoles. It’s why Nintendo is still in business, it’s why Xbox barely is, and it’s why everyone loved the PlayStation 4.

I’m genuinely surprised that they did a U-turn but I’m very glad that they’ve admitted the mistake. Assuming the rumours are true, I suppose, but I guess we’ll see.

It makes me wonder what else Sony might be having second thoughts on though. I imagine they took special note of Highguard’s failure but I wonder what the poor response to God Of War: Sons Of Sparta made them think? More first party games and less stuff farmed out to nobody developers?

I’d be feeling quite optimistic now, if it wasn’t for shutting down Bluepoint, which seems even more stupid given what we’re hearing now.
Goldface

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Whatever annoucement
I’ve got to say you are not exaggerating when you say companies are not putting an effort in anymore. Between Sony tweeting out Wolverine’s release date and whatever that Assassin’s Creed blog was supposed to be, things are being announced with all the enthusiasm of a bored office worker at 4.55pm on a Friday.

We’ve been hearing rumours about a Black Flag remake for years and all we get is a single picture that we’re not even sure is supposed to be there? And it’s not even a good picture, is what makes me laugh!

It’s pointless asking for E3 to come back but please, for pity’s sake, could publishers put some effort into pretending they want to be in the games making business? And by that I do not mean a super slick video were developers are reading things they’d never say in real-life off a board.
Scooter

The remake dimension
I have no problem with Pokémon FireRed and LeafGreen being re-released on Switch, although personally I haven’t bought them. I’m curious, though, as to when the inevitable will happen and Nintendo will remake one of the older games in 3D (no I Choose You, Pikachu! doesn’t count).

I imagine the only reason it hasn’t happened so far is that they’ve been mocked for their bad graphics and bugs. But at some point Red and Blue is going to be remade to look like Winds and Waves, or one of the Legends games. It worked for Resident Evil, after all.
MonsterB

Unsatisfied customer
RE: Gambon and buying a PlayStation 5. I think it depends, as most of the best games on PlayStation 5 were cross-gen. If you have played the likes of God Of War, The Last Of Us, and Spider-Man 2 already on the PlayStation 4, and really don’t want to play them again, then it would seem a little pointless.

Resident Evil Requiem may run fine on Switch 2 but the PlayStation 5 is going to be a superior experience. Price wise, if you look at second-hand, you could probably get a PlayStation 5 and a PlayStation Portal for the same price as the Switch 2.

Then there is the game prices. For a tenner(-ish) a month you’d have a huge library of games on PlayStation whereas Nintendo you’ll be coughing up £60 a time to play something new. I have to admit I’ve been very disappointed with my Switch 2 so far and I couldn’t recommend it at it’s current price with the games that have been released.

Hated Donkey Kong Bananza (sorry) and I’m surprised Nintendo would release a game with such frequent frame rate and camera issues. Zelda was well worth playing again but not for the £500+ I’ve spent on it so far.
P B

Catch up
In response to Gambon asking about buying a Switch 2, I’d say that it’s an easy choice to make if you’ve never owned a Switch.

You’ll have instant access to an incredible library of games like Super Mario Odyssey, Zelda: Breath Of The Wild and Tears Of The Kingdom, and a host of amazing indie titles like Into The Breach, Hades etc. that are great for playing handheld.
drlowdon

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Better than fine
Nice pick up on the Switch 2 version of Resident Evil Requiem. I’m sure it’s something that a lot of buyers were looking at. I remember the ‘impossible ports’ of the OG Switch, like The Witcher 3 and Doom (Eternal) and despite them being amazing technical achievements… well, they were pretty dire compared to their PlayStation 4/Xbox One counterparts.

I haven’t seen the latest Resident Evil running on Switch 2, but my young cousin has Cyberpunk 2077 on his and I have compared it to my playthrough on my PlayStation 5. It’s worth remembering that two things can be true with these ports; If you’re not a big gamer they are good enough and remarkable for a handheld, however they are downgrades across the board on the PlayStation 5 versions.

Even to untrained eyes they are noticeable and whether you can put up with that is only something the individual can answer. I’m reminded of PlayStation 2 ports of Xbox or GameCube titles back in the mid-2000s (Max Payne anyone?), they’re fine as long as someone doesn’t show you the other version, after which it’s tough to go back.

I guess the biggest question was always not whether the Switch 2 could run these games… but whether the consoles primary gamers would actually buy enough third party titles to make the efforts worthwhile? The legacy of the OG Switch is that Nintendo taught its users not to expect good third party ports, so those gamers probably picked up other formats in the intervening years leaving just those who played Nintendo exclusively ready to upgrade to the new machine.

Turning that around will be a slow process and news that third party titles are continuing to sell below publisher expectations is a worry.
Marc

GC: Resident Evil Requiem on the Switch 2 seems to have sold well. It’s just difficult to tell, because a lot of people bought the trilogy bundle instead.

Inbox also-rans
Will you be reviewing Crimson Desert?
LoRd SiNn

GC: Yes. We’re also interested in reviewing crimson dessert. Red velvet cake is delish.

It is so weird to me to see people talk about having a pre-order and then worrying whether the game will be good or not. Why are you pre-ordering it then?
Fome

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The small print
New Inbox updates appear every weekday morning, with special Hot Topic Inboxes at the weekend. Readers’ letters are used on merit and may be edited for length and content.

You can also submit your own 500 to 600-word Reader’s Feature at any time via email or our Submit Stuff page, which if used will be shown in the next available weekend slot.

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MORE: Games Inbox: Is it worth buying a PS5 in 2026?

MORE: Games Inbox: When will the next Legend Of Zelda game be announced?

MORE: Games Inbox: Does Resident Evil Requiem live up to the hype?

But results never tell the whole story.

Four games ago at West Ham, Manchester United were “stodgy’” by Carrick’s own admission. It took an injury-time Benjamin Sesko goal to salvage a point.

At Everton, Sesko finished off the only notable passage of play from either side. On Sunday, Manchester United‘s response to going behind early to Crystal Palace was muted until Matheus Cunha won the penalty that also brought the red card that turned the game on its head.

Carrick’s team have been getting results. However, their most-recent performances have not matched those that beat Manchester City, Arsenal and Fulham at the start of his time at the helm.

Cunha and Bryan Mbeumo have not been a goal threat; Kobbie Mainoo’s performance levels have dipped, while penetration from full-back areas has reduced.

It is a basic reality that they do not have limitless numbers of top-quality players. By the final whistle at St James’ Park, Matthijs de Ligt, Mason Mount, Lisandro Martinez, Noussair Mazraoui and Patrick Dorgu were all absent because of injury. Casemiro and Luke Shaw were off the pitch feeling the effects of two hard games in four days. Carrick does not have the squad depth to cover those losses and still keep standards high.

So, embarrassingly, Manchester United lost against 10 men for the second time in just over three months. The damage was done by William Osula – a player who, as an 11-year-old, appeared on the pitch at Old Trafford to collect a Soccer Schools World Skills final victory prize.

His goal came after he got the better of Tyrell Malacia, who was making only his second appearance of a season he started as a member of Amorim’s ‘bomb squad’. The previous one was against Newcastle too.

The damage is not too bad though. Liverpool lost 24 hours earlier against the league’s bottom club before Aston Villa suffered a heavy home loss to Chelsea on Wednesday.

Manchester United remain third. They remain, out of the sides scrapping it out for three Champions League places in addition to the ones Arsenal and Manchester City will claim, the ones with no European or domestic cup distractions.

“We need to learn from this,” said Carrick.

“There is no sense in not learning lessons and understanding how tonight happened.

“We can’t lose sight of the bigger picture though – we have put ourselves into a position that can be really exciting.

“We’ve got to be positive going into the next game and look forward to it because there is a lot to play for.”

Carrick is right about that.

He needs to make sure his team’s response to this defeat is just as sure footed.