New Nasal Spray Appears To Reverse Brain Ageing In ‘Weeks’

A nasal spray has been found to reverse signs of brain ageing in preclinical trials, according to a new paper published in the Journal of Extracellular Vesicles.

The spray, which tackles a process typical to ageing brains called “neuroinflammaging”, delivered benefits within weeks – and results lasted for months.

“What we’re showing is brain ageing can be reversed, to help people stay mentally sharp, socially engaged and free from age-related decline,” research author Dr Ashok K. Shetty told Texas A&M University.

He added that this may be especially important as “brain age-related diseases like dementia are a major health concern worldwide”.

The spray aims to change how carriers of genetic material called extracellular vesicles (EVs) can reach the brain. EVS contain microRNAs.

“MicroRNAs act like master regulators,” nasal spray researcher Dr Madhu Leelavathi Narayana said. “They help modulate and regulate many gene and signalling pathways in the brain.”

The aim of the new nasal spray is to break through the brain’s defences to deliver these useful bundles of genetic information straight to people’s minds.

That way, the brain absorbs more microRNAs, which help to “recharge” the brain cells of those using the spray.

In the study, that led to less brain fog, better ability to process and remember information, and less inflammation (chronic inflammation is linked to increased signs of ageing).

“We are giving neurons their spark back by reducing oxidative stress and reactivating the brain’s mitochondria,” said Dr Naryana.

And Dr Shetty added they saw the “brain’s own repair systems switch on, healing inflammation and restoring itself”.

These were promising preclinical results, but scientists will need a lot more research to develop this spray.

“This kind of work requires resources and the right people to tackle problems and develop solutions that could change lives,” said Dr Shetty.

But, he said: “As we develop and scale this therapy, a simple, two-dose nasal spray could one day replace invasive, risky procedures or maybe even months of medication.”