Scientists Have Found A Way To Stop Ageing ‘Zombie Cells’

As we age, our bodies lose some resilience, which can lead to less movement throughout the day and an increased risk of facing multiple chronic diseases at once (multimorbidity).

This happens partly because senescent cells, sometimes called “zombie” cells, stop dividing and build up. They secrete “proinflammatory molecules that contribute to chronic inflammation and ageing-related diseases”.

A process called senolysis usually clears these away, but as we get older, that cleaning system becomes less efficient.

But scientists from the University of Kyoto think they’ve found a way to slow or stop the production of these “zombie cells”.

Though we knew that “zombie cells” seemed to create inflammation that affected nearby cells, scientists weren’t sure about how this went on to affect someone’s body.

These researchers looked closer at the senescent cells themselves and found they heavily relied on glycolysis (using sugar for energy), a process which is also involved in the spreading of cancer cells.

Using bioluminescence to help see what was going on in the cell better, scientists found that two enzymes were crucial to glycolysis in “zombie cells”. Their binding was increased in sensecent cells.

So, when they were able to interrupt that key interaction, researchers could selectively “delete” zombie cells.

In mice, the change was linked to reduced lung fibrosis.

They also found that when this activity was diminished, a protein that triggers cell death was suppressed too.

The study authors hope this might help to maintain resilience in older age.

That way, it’s hoped, the risk of multimorbidity might go down.

This study’s corresponding author, Hiroshi Kondoh, said: “Our findings in glycolytic regulation suggest that impaired metabolic resilience in ageing is one of the targets for senotherapy, to aid in preservation of resilience in ageing.”