The Detroit Pistons and San Antonio Spurs lock horns in a regular-season game at the Frost Bank Center on Thursday, with tipoff at 8 p.m. EST. It is the second matchup between the two teams this season, with the Spurs winning the first encounter 114-103.

The Pistons suffered a 113-109 loss in their previous game against the Cleveland Cavaliers on Tuesday. They no longer hold the best record in the league, but remain in first place in the Eastern Conference standings with a 45-15 record.

Meanwhile, the Spurs destroyed the Philadelphia 76ers 131-91 in their previous outing on Tuesday. San Antonio remains in second place in the Western Conference standings with a 44-17 record.

Detroit Pistons vs. San Antonio Spurs Preview, Starting Lineups Tonight, Betting Tips and Game Prediction

Detroit Pistons vs. San Antonio Spurs Betting Tips and Odds

Moneyline: Pistons (+132), Spurs (-156)

Spread: Pistons +3.5 (-111), Spurs -3.5 (-111)

Total over/under o/u: Pistons o228.5 (-111), Spurs u228.5 (-111)

Editor’s note: Odds might change closer to tipoff.

Betting Tips

• Victor Wembanyama is expected to record over 3.5 blocks.
• Cade Cunningham is expected to record under 23.5 points.
• Jalen Duren is expected to record over 11.5 rebounds.

Detroit Pistons vs. San Antonio Spurs Preview

Cade Cunningham has been hot and cold of late, which has adversely affected the Pistons. Against the Cavaliers, Cunningham scored 10 points on 16 shots, while turning the ball over five times. Detroit needs its best player to raise his level and bounce back with an MVP-level performance against the Spurs.

Jalen Duren has been the Pistons’ best player recently, averaging 25.5 points and 13.7 rebounds on 64.4% shooting. He enters this matchup after winning the Eastern Conference Player of the Week award. The Pistons need him to win his matchup against Victor Wembanyama, just like he did when the two teams met last month.

Meanwhile, the Spurs will face a much stronger challenge against the Pistons than they did against the Sixers on Tuesday. San Antonio made Philadelphia look like a G League team and shot over 55% from the field, including 40% from beyond the arc.

The starters delivered a rollicking performance as usual, and the bench contributed handsomely as well, with rookie Dylan Harper putting on a show off the bench. The young guard made eight of his 11 shots en route to 22 points. Keldon Johnson scored 12 off the bench, helping the Spurs record the most dominant win of their campaign.

Detroit Pistons vs. San Antonio Spurs Starting Lineups Tonight

Detroit Pistons starting lineup

PG: Cade Cunningham, SG: Duncan Robinson, SF: Tobias Harris, PF: Ausar Thompson, C: Jalen Duren.

San Antonio Spurs starting lineup

PG: De’Aaron Fox, SG: Stephon Castle, SF: Julian Champagnie, PF: Devin Vassell, C: Victor Wembanyama.

Detroit Pistons vs. San Antonio Spurs Prediction

The Spurs are at home and already beaten the Pistons once this season. San Antonio would be confident of getting the job done once again and we expect Wembanyama to lead his team to yet another victory.

Final score prediction: Spurs win 111-105.