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NFL Week 1 odds, predictions: Picks, best bets from 10,000 computer sims

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The NFL never shies away from loading up the opening week with must-see matchups, and the Week 1 NFL schedule, which begins in just four days, is no different. From divisional battles like the primetime matchups of Chiefs vs. Broncos (+2.5) and Cowboys vs. Giants (+3) to Aaron Rodgers’ last ride in Steelers vs. Falcons (+3.5), you have a bevy of intriguing options to place Week 1 NFL bets on. Meanwhile, Dolphins vs. Raiders is a matchup that may not garner as much interest as the aforementioned, but it still carries intrigue for Week 1 NFL picks as the only opening game guaranteed to have two new starters under center. Bet NFL games at DraftKings. Claim their new user offer here:

Miami’s Malik Willis will duel with Kirk Cousins, as the veteran gets the starting nod over Fernando Mendoza. Vegas, who went 7-10 ATS last year, is a 3.5-point favorite per the latest Week 1 NFL odds. All of the updated Week 1 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 1 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.  

Now, it has turned its attention to the latest Week 1 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick

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Top Week 1 NFL predictions

We can tell you one of the model’s strongest Week 1 NFL picks for the best betting apps is that the Jaguars (-7.5, 40.5) cover at home versus Cleveland in a Sunday 1 p.m. ET kickoff. The model has the Jags prevailing versus the spread nearly 60% of the time, continuing the success they had last year with a league-best 12-5 ATS mark in the regular season. Jacksonville was even more proficient versus the line at home, covering in 78% of games, also the best record in the NFL, while Cleveland was 2-6 ATS on the road, which was the second-worst mark in the NFL. SportsLine’s model also has the Over hitting in 64% of simulations. See which other teams to pick here.

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Another one of its Week 1 NFL predictions: the Eagles (-5.5, 44.5) cover versus the Commanders on Sunday at 4:25 p.m. ET. Philadelphia has won eight of its last nine versus Washington in games that Jalen Hurts has started and finished. He should have continued production versus Washington’s defense which ranked dead last in yards allowed last year and is in transition, with up to eight new starters and moving from a 4-3 base to a 3-4. Add in that Jayden Daniels may use his legs less to avoid the injuries he suffered in 2025, and the fact that Commanders left tackle Laremy Tunsil (triceps) is out, and Philly is forecasted to cover the spread in nearly 60% of simulations in an A-rated pick. See which other teams to pick here.

How to make Week 1 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 1 NFL schedule and just revealed multiple underdogs that outright win, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.

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So what Week 1 NFL picks can you make with confidence, and which underdogs should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.

Week 1 NFL betting odds, lines, spreads, scores

Get Week 1 NFL picks at SportsLine

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Melbourne Cup winner Half Yours set for 2026 Makybe Diva Stakes return

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The esteemed Melbourne Cup winner, Half Yours, is poised to begin its championship defence in the Makybe Diva Stakes at Flemington.

The Tony and Calvin McEvoy-trained stayer is once again being targeted for this year’s Melbourne Cup (3200m), scheduled to take place at Flemington on November 3.

Jamie Melham, who achieved a historic Caulfield and Melbourne Cup double as the first female jockey to do so, will partner the stayer in its first-up run over 1600 metres at weight-for-age this Saturday.

During the previous campaign, some observers questioned Half Yours’s form. It raced first-up in Sydney before a three-race stint in Queensland, the final of which was the Q22 (2200m) at Eagle Farm in June, where the gelding finished fourth.

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Half Yours spent time spelling in Queensland before returning to the McEvoy stable at Flemington early last month to prepare for its racing comeback.

Following two jump-outs at Flemington, Half Yours is considered ready for its return. Tony McEvoy indicated that while the most recent trial, a fourth-place finish over 1000 metres, might have appeared disappointing visually, the team was pleased with the outcome.

“I was really happy with his trial,” McEvoy commented.

“If you put him in a 1000-metre race, he would get completely run off his legs and they ran it like a race.

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“It wasn’t like a normal trial and he got chasing.

“They were also trials at Flemington where they finish on a bend, so it’s very hard for horses to make ground on a bend.

“Whilst it didn’t look impressive, I thought he moved well, trialled nicely and the horse is telling us he’s going very well while his coat is coming better by the day.

“All the data that we collate on him is normal.

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“He certainly hasn’t gone backwards.”

Following its initial run on Saturday, Half Yours is expected to contest the Group 1 Turnbull Stakes (2000m) at Flemington on October 3, a race where it previously finished fourth before capturing the Caulfield Cup.

The Group 1 Cox Plate, which will be hosted at Flemington this year, will serve as the concluding race in Half Yours’s preparation for the Melbourne Cup.

Check out the best betting markets for the race from various providers.

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4 WWE Superstars who could help Oba Femi against Bron Breakker and Bronson Reed

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Oba Femi’s match against Bron Breakker at Sunday Night’s Main Event did not reach a proper conclusion, thanks to the returning Bronson Reed. The Aus-Zilla made his first appearance since February and destroyed The Ruler with multiple Tsunamis.

Femi’s night ended with him staring at the lights, writhing in pain. Reed’s return has strengthened The Vision once again, and The Ruler will need some backup to counter the numbers advantage.

Here are four WWE Superstars who could help Oba Femi against Bron Breakker and Bronson Reed.

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#4. Je’Von Evans

Je’Von Evans has a direct reason to have problems with The Vision. Logan Paul previously tried to recruit Evans into the faction. The Young OG turned down the offer, and Bron Breakker later attacked him during his match against Austin Theory.

The Street Profits came to Evans’ aid after the attack. However, that was not the end of his issues with The Vision. Breakker and Theory later defeated Evans and Dragon Lee in July.

Evans therefore knows what Breakker and The Vision are capable of. If the two try to take advantage of Femi again, Evans could step in. It would also give Evans another chance to stand against a group he has already rejected. Moreover, Evans and Femi share plenty of history from their time in NXT, which could also come into play.


#3. & #2. The Street Profits

The Street Profits could be another natural choice to help Oba Femi. Montez Ford and Angelo Dawkins have been dealing with The Vision for much of 2026. Their issues with the group have already led to several confrontations, and they eventually won the World Tag Team Championship from Breakker and Austin Theory, only to drop it back to the heel duo.

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That history gives them a clear reason to get involved. If Breakker and Bronson Reed use their numbers to overwhelm Femi, Ford and Dawkins could come out to even things up.

Moreover, helping Femi could give The Street Profits another chance to get at Breakker and Theory. Their involvement would also keep the rivalry between the two sides going.


#1. Seth Rollins could help Oba Femi

The current situation could give Seth Rollins a perfect reason to return. The Visionary has been away from television since losing to Roman Reigns at SummerSlam.

Rollins is no stranger to The Vision. The Architect picked Bron Breakker and Bronson Reed to be part of the group. However, Breakker turned on Rollins and kicked him out, and Reed stayed with The Dog.

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Rollins had a heated feud with the group and a trilogy of matches against Breakker earlier this year. However, Reed was absent during all of it. Now that the Australian powerhouse has returned, The Visionary could resume his feud with the group that he created and help Oba Femi against Breakker and Reed.