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AbCellera Stock Soars 30% After Menopause Drug ABCL635 Hits Phase 2 Success In Hot Flash Trial Results

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AbCellera Stock Soars 30% After Menopause Drug ABCL635 Hits Phase

VANCOUVER, British Columbia — Shares of AbCellera Biologics Inc. surged more than 30% Monday after the clinical-stage biotechnology company announced positive top-line results from a Phase 2 trial of its experimental menopause drug, ABCL635, sending the stock to its highest level in months.

The stock closed up 30.32% at $9.03, with volume of more than 12.7 million shares, well above its three-month average of roughly 7.2 million shares, lifting the company’s market capitalization to about $2.76 billion. The rally came after AbCellera said before the market opened that its Phase 2 study evaluating ABCL635 for moderate-to-severe vasomotor symptoms, more commonly known as hot flashes, had met its primary efficacy endpoints.

ABCL635 is an investigational antibody designed to target NK3R, a receptor found on a specific set of neurons in the hypothalamus that plays a role in regulating body temperature. The drug is being developed as a non-hormonal, long-acting, subcutaneous treatment, an approach the company has positioned as a potential alternative to existing hormone-based therapies for menopause symptoms.

The randomized, double-blind, placebo-controlled trial enrolled 92 postmenopausal women who were experiencing an average of roughly 10 moderate or severe hot flashes per day. Participants were randomly assigned to receive either a single 600-milligram subcutaneous dose of ABCL635 or a placebo. At week four, the treatment group saw hot flash frequency drop by a mean of 8.8 events per day from baseline, compared with a 3.5 event reduction in the placebo group, a placebo-adjusted difference of 5.3 events that was statistically significant. In percentage terms, ABCL635 reduced hot flash frequency by 83% on average, compared with a 33% reduction for placebo.

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The drug also showed a significant effect on symptom severity, with treated patients seeing severity scores fall by 1.4 points on average compared with 0.3 points for placebo, and meaningful improvements were observed in patient-reported sleep quality and overall impression of symptom change. AbCellera said the drug was well tolerated over the four-week treatment period, with no serious adverse events, severe adverse events, or discontinuations due to side effects. The most common adverse events among patients receiving the treatment were headache, fatigue and injection site reactions.

Dr. JoAnn V. Pinkerton, a professor of obstetrics and gynecology at the University of Virginia School of Medicine who specializes in women’s midlife health, said the four-week data set “a new efficacy benchmark for the reduction of hot flashes both in frequency and severity.” She added that if the results are validated in a larger Phase 3 trial, the drug could offer patients a more convenient dosing option with potentially less toxicity than existing treatments.

Sarah Noonberg, AbCellera’s chief medical officer, described the results as a milestone both for the company and for women’s health more broadly. She said the data show that by targeting the NK3 receptor with an antibody, the company has demonstrated “potential best-in-class vasomotor symptom relief over four weeks with a single subcutaneous dose.”

The trial results carry particular significance for AbCellera because ABCL635 represents the company’s first internally developed drug candidate to advance into Phase 2 testing, marking a shift for a company that built its early business primarily around providing antibody discovery technology and services to pharmaceutical partners rather than developing its own drugs. Vasomotor symptoms affect an estimated 80% of women during menopause, according to figures cited by the company, with the majority describing their symptoms as moderate to severe. AbCellera estimates roughly 12 million women in the United States experience moderate-to-severe hot flashes, of which more than 6 million seek treatment, underscoring the size of the potential market opportunity if the drug advances successfully through later-stage trials and regulatory review.

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Monday’s surge builds on a period of already elevated investor interest in AbCellera. The company’s shares had climbed more than 136% year-to-date heading into the results, according to recent analysis of the stock’s performance, reflecting growing attention to the company’s pipeline as it has increasingly emphasized internal drug development alongside its existing antibody discovery partnerships. AbCellera has also struck a series of collaboration deals in recent months, including a multispecific antibody partnership with Vertex Pharmaceuticals and prior agreements with Jazz Pharmaceuticals and AbbVie, deals the company has said brought in more than $110 million in upfront payments combined.

The company reported second-quarter 2026 financial results on August 5, ahead of Monday’s trial data, showing revenue of roughly $4.05 million, down sharply from the prior year, alongside a widened net loss of $55.4 million. AbCellera has said it holds approximately $567 million in cash and more than $675 million in total available liquidity, which the company has said supports at least three years of continued investment across its pipeline.

Following Monday’s results, AbCellera hosted an investor conference call to discuss the Phase 2 data in greater detail and outline next steps for ABCL635’s development, including plans for further validation in a larger Phase 3 trial. Analysts covering the stock had already shown signs of growing optimism ahead of the data release, with several firms raising their price targets on the shares in the days leading up to Monday’s announcement.

With ABCL635 emerging as the company’s most advanced internally developed program, Monday’s results are likely to serve as a key reference point for how investors value AbCellera’s broader pipeline going forward, particularly as the company continues to balance its established antibody discovery business against the larger financial risks and potential rewards associated with advancing its own drug candidates through clinical development.

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$87b boost to the WA economy from small business

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$87b boost to the WA economy from small business

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Global industrial SVP & CFO Thomas Clark sells $684k in shares

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Global industrial SVP & CFO Thomas Clark sells $684k in shares

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Lachlan Hunter gains mining and petroleum shadow ministries

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Lachlan Hunter gains mining and petroleum shadow ministries

Central Wheatbelt MP Lachlan Hunter will be responsible for probing the state government on almost all primary industry matters after gaining the mining, petroleum and exploration shadow portfolios.

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Zoox CEO says autonomous vehicle regulation is needed after NHTSA warning

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Zoox CEO says autonomous vehicle regulation is needed after NHTSA warning

Zoox CEO Aicha Evans agreed that autonomous vehicles should be regulated as the Amazon subsidiary’s fleet of autonomous vehicles launched its first paid service in the United States in Las Vegas Monday. 

In June, one of Zoox’s robotaxis drove into heavy smoke at an active emergency scene in Las Vegas. Zoox issued a software recall following the incident and has since updated the technology to better detect and respond to fire and smoke.

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Evans told FOX Business host Liz Claman the company believes in transparency and taking responsibility.

“These are rare edge cases,” Evans told “The Claman Countdown” on Monday. “We learn and we continue to improve our processes along the way to make them better and better.”

THIEF USES WAYMO AS A GETAWAY CAR

zoox las vegas

Zoox, an autonomous vehicle in operation in Las Vegas, Nevada, United States on April 27, 2026.  (Tayfun Coskun/Anadolu via Getty Images / Getty Images)

“Sometimes it’s software, sometimes it is firmware, sometimes it is just using simulation,” she added. “We throw the best at it, we root cause, we learn, we improve and we deploy.”

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Evans’ remarks come as federal officials press autonomous vehicle (AV) developers to improve interactions with first responders and emergency personnel, warning that failures to do so could pose a serious risk to public safety.

“To state it bluntly: an AV that cannot safely interact with first responders is a danger to the general public,” National Highway Traffic Safety Administration (NHTSA) Administrator Jonathan Morrison wrote in July.

Evans, who thanked Morrison for his partnership in advancing American innovation, said she believes autonomous vehicle regulation is necessary.

100 KODIAK DRIVERLESS TRUCKS ARE HEADED FOR PUBLIC ROADS

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Aicha Evans, chief executive officer of Zoox Inc., speaks during the Bloomberg Technology Summit in San Francisco, California, US, on Thursday, June 22, 2023.  (David Paul Morris/Bloomberg via Getty Images / Getty Images)

“I want to unequivocally say we agree with the administrator and the administration and the regulatory agency. We need to be regulated,” she said. “And EV scenes are extremely important, because it’s about saving lives all around.”

After providing free Zoox rides in Las Vegas since 2023 under a three-year pilot program, the Amazon robotaxi brand officially began charging customers for rides on Monday.

“We have essentially, so far, the same number as people who are taking free rides,” Evans told FOX Business.

Unlike competitors such as Waymo, which retrofits regular cars for driverless operations, Zoox’s vehicles are pedal-free, steering-wheel free and passenger-focused. The robotaxis feature face-to-face campfire-style seating for up to four passengers.

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SILICON VALLEY DEVELOPER ACCUSED OF MURDER AFTER INVESTIGATORS SAY TESLA REACHED 142 MPH BEFORE FATAL CRASH

zoox robotaxi

A woman steps into a Zoox fully autonomous robotaxi that was displayed at the Line Hotel during the South by Southwest Conference and Festivals on Saturday, March 14, 2026, in Austin.  (Jay Janner/The Austin American-Statesman via Getty Images / Getty Images)

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Roughly 65 Zoox are currently deployed in Las Vegas and Evans said production is “ramping up,” with the company’s California factory is doubling output to five to six vehicles per day.

The CEO also told FOX Business where the company could expand next, beyond Las Vegas, San Francisco, Austin and Miami, where Zoox currently operates pilot programs.

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“We will be entering Atlanta and LA and… we have big ambitions,” Evans said. “We want to be everywhere where we are welcome and show and deliver these wonderful and lovable experiences to customers around the U.S.”

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Axon: Take Some Chips Off The Table (Rating Downgrade)

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Axon: Take Some Chips Off The Table (Rating Downgrade)

Axon: Take Some Chips Off The Table (Rating Downgrade)

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Legit Social Casinos and the User Experience Standard

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Legit Social Casinos and the User Experience Standard

Digital entertainment products are often judged in seconds. A platform may have strong content, polished visuals, and a large library of games, but users will leave quickly if the first experience feels confusing. Slow loading, unclear menus, hidden support, vague reward rules, and cluttered mobile screens can all weaken trust.

That is why user experience matters so much in social casino entertainment. The category combines casino-style visuals, virtual coins, rewards, mobile access, events, and account systems. These features can be engaging, but only when users understand how they work.

A polished social casino platform should not rely only on bright design or promotional language. It should make the experience clear from the beginning. Users should know where to start, how to manage their account, how rewards function, and where to find help if they need it.

For users comparing legit social casinos, the best question is not only “which platform looks exciting?” The better question is “which platform explains itself clearly and gives users control?”

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That shift matters because trust in digital entertainment is built through product quality, not surface-level design alone.

User Experience Is a Trust Signal

A strong user experience helps people feel comfortable.

When users can find games, understand rewards, view balances, manage settings, and contact support without frustration, the platform feels more reliable. When those actions are difficult, even a visually polished site can feel uncertain.

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Social casino platforms need especially clear UX because they involve multiple systems at once. A user may need to understand virtual coins, daily rewards, tournaments, events, account settings, privacy controls, and support tools.

If those systems are not organized well, the platform can feel overwhelming. That is especially true for beginners, who may not yet understand the difference between social casino games, sweepstakes-style systems, virtual currency, bonuses, and redemption-related terms.

A legit platform should reduce confusion at every step. It should not make users guess what a coin means, where a reward came from, how an event works, or where account controls are located.

Good UX is not decoration. It is a signal that the platform has been designed around the user.

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Mobile Design Comes First

Many users interact with social casino platforms from phones or tablets. That means mobile design is not a secondary feature. It is often the main experience.

A strong mobile platform should load quickly, make buttons easy to tap, display text clearly, and keep important information visible. Users should be able to find game categories, rewards, balances, terms, support, and account controls without digging through confusing menus.

IBTimes Australia’s broader mobile technology coverage reflects how central smartphones have become to everyday digital behavior, from connectivity and payments to app-based services and mobile-first platforms. That same mobile-first expectation applies to social casino platforms.

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Poor mobile design can damage trust. If the interface feels broken, crowded, or inconsistent, users may question whether the platform is well managed. Good mobile design makes the platform feel intentional.

For social casino platforms, mobile quality is especially important because many sessions are short. A user may open the platform during a break, collect a reward, check an event, or play briefly. If the mobile experience creates friction, the platform may lose the user before the session really begins.

Clear Navigation Helps Users Stay Oriented

Navigation is one of the simplest ways to judge digital product quality.

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A strong platform should make it obvious where users can find games, account settings, rewards, promotions, support, privacy information, and terms. The main menu should be easy to understand. Important pages should not be buried.

Social casino platforms can become complicated when they include multiple game types, reward systems, events, leaderboards, and virtual currency balances. Clear navigation keeps those features manageable.

Users should not feel like they are wandering through unrelated pages. A good platform should guide them naturally from one part of the experience to another.

Good navigation also helps reduce support issues. When users can find information on their own, they are less likely to become frustrated.

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Transparent Virtual Currency Rules

Virtual currency is one of the first areas users should evaluate.

Social casino platforms may use coins, credits, bonus balances, or other platform-specific terms. These currencies may be awarded through daily rewards, promotions, missions, events, or optional purchases.

A legit platform should explain how virtual currency is earned, how it is used, whether it expires, and whether any limitations apply.

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Balances should be visible. Terms should be easy to access. Users should not need to guess which currency they are using or what it means.

Confusing coin systems weaken trust. Clear coin systems make the experience easier to manage.

This is especially important when a platform uses more than one type of currency. If users see different balances, each one should have a clear purpose. A good platform should explain the difference in plain language, not only in fine print.

Rewards Should Be Clear and Useful

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Rewards are central to social casino entertainment.

A platform may offer login bonuses, mission rewards, event prizes, leaderboard incentives, seasonal promotions, or daily gifts. These rewards can make short sessions feel active and engaging.

But rewards should always be understandable.

Users should know what they received, how it can be used, whether it expires, and whether any terms apply. If a reward is promoted loudly but explained poorly, the platform is not supporting a strong user experience.

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The best reward systems are transparent and easy to track. A user should be able to see reward history, current balances, available bonuses, and any relevant conditions without confusion.

Rewards should add to the experience. They should not create uncertainty.

Event Design Should Reduce Confusion

Events can help a platform feel fresh.

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Daily missions, weekend tournaments, seasonal campaigns, leaderboard races, limited-time challenges, and themed promotions can give users new goals. These features make familiar games feel more active and can encourage users to return.

But event design must be clear. Users should know how to join, when the event ends, how progress is measured, what rewards are available, and whether conditions apply.

A confusing event system creates friction. A clear event system creates momentum.

For social casino platforms, events should feel like opportunities, not puzzles. If the user needs to read several pages to understand basic participation, the event may not be designed well.

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Good event design uses simple language, visible progress, and clear deadlines.

Game Libraries Need Organization

Game variety can be a strength, but only when users can navigate it.

A platform may include slot-style games, card-inspired formats, roulette-style features, bonus games, tournaments, and themed events. That variety can appeal to different users, but it can also overwhelm beginners.

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Good organization helps. Search tools, categories, featured games, recently played sections, popular titles, and event labels make discovery easier.

A legit platform should not simply offer many games. It should help users find the right game quickly.

Organization also supports trust. When a platform’s game library feels structured, users are more likely to feel that the product has been built carefully.

A large library without clear categories can feel messy. A smaller library with better navigation may feel easier to use.

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Support Must Be Visible

Support access is one of the clearest signals of platform quality.

Users may need help with login issues, account settings, rewards, virtual currency, events, technical problems, privacy controls, or promotional terms.

A strong platform should make support easy to find. This may include an FAQ page, help center, support email, contact form, ticket system, or live chat.

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Support should not be hidden at the bottom of unrelated pages. Users should be able to locate help before they need it.

Visible support builds confidence. It tells users that questions are expected and that the platform is prepared to answer them.

The quality of support content matters too. Help pages should use clear language and answer practical questions directly.

Account Controls Matter

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A legit platform gives users control over their experience.

Account controls may include profile settings, notification preferences, privacy options, security tools, communication choices, and responsible-use features.

These controls matter because social casino platforms often use rewards, reminders, events, and promotional updates. Users should be able to manage how they interact with those features.

A platform that makes account settings easy to access feels more mature and user focused.

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Control is part of trust. Users should be able to adjust notifications, review account details, manage communication preferences, and understand privacy choices without frustration.

If basic account controls are difficult to find, the platform may not meet modern user expectations.

Privacy and Security Are Part of UX

Privacy and security should not feel separate from the user experience. They are part of it.

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Users should be able to understand what information they provide, how account access is protected, and where privacy settings can be managed. A platform should make security features visible without making the experience feel intimidating.

Good UX gives users confidence. That includes confidence that their account can be managed, their settings can be adjusted, and their information is handled according to clear policies.

For social casino platforms, privacy and security are especially important because users may create accounts, receive rewards, manage balances, and interact with promotional systems.

A platform that explains these areas clearly is easier to trust.

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Warning Signs to Watch For

Users should be cautious if a platform has uncleared coin rules, vague reward terms, hidden support, poor mobile performance, inconsistent information, or aggressive promotional language.

Another warning sign is confusing navigation. If users cannot find basic settings or terms, the platform may not be prioritizing usability.

Visual design should never be used to distract from missing information.

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A trustworthy platform explains first and promotes second. It does not rely on excitement alone. It gives users the information they need to understand the experience.

Consistency matters as well. If one page describes rewards in one way and another page uses different language, users may become uncertain.

Why Legit Platforms Stand Out

Legit social casinos stand out because they combine entertainment with clarity.

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They make virtual currency rules easy to understand. They explain rewards. They organize games well. They make mobile navigation smooth. They provide accessible support. They give users account controls.

These features may not be as flashy as game graphics or promotional banners, but they matter more over time.

Users return to platforms that feel understandable and reliable. A platform that is easy to use the first time is more likely to earn repeat visits.

The best platforms do not force users to choose between excitement and clarity. They offer both.

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The Product Design Takeaway

Social casino entertainment is not only about games. It is about the complete digital product.

A legit platform should make every part of the experience easier to understand virtual currency, rewards, events, mobile navigation, support, privacy, account settings, and user controls.

The best social casinos are visually engaging. They are organized, transparent, responsive, and designed around user confidence.

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In a crowded digital entertainment market, trust is not created by branding alone. It is created by clear product decisions that make users feel informed and in control.

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Berkshire Hathaway Is Getting Aggressive, Reiterate Buy

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Berkshire Hathaway Is Getting Aggressive, Reiterate Buy

Berkshire Hathaway Is Getting Aggressive, Reiterate Buy

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Positive Breakout: These 9 stocks cross above their 200 DMAs

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The Economic Times

In the Nifty500 pack, nine stocks’ closing prices crossed above their 200 DMA (Daily Moving Averages) on August 10, 2026, according to stockedge.com’s technical scan data. Traders use the 200-day daily moving average (DMA) as a key indicator to determine the overall trend in a particular stock. As long as the stock is priced above the 200-day SMA on the daily timeframe, it is generally considered to be in an overall uptrend. Take a look:​

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Imported Argentina beef recalled in Florida and Texas over reinspection lapse

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Beef prices up 50% since 2021 as Trump demands action

Nearly 30,000 pounds of imported raw beef from South America have been recalled in two states over the failure to reinspect the product after arriving in the U.S., according to the U.S. Department of Agriculture’s Food Safety and Inspection Service (FSIS).

Florida-based Corte Argentino USA LLC is recalling about 29,628 pounds of raw beef products that were imported from Argentina “without the benefit of import reinspection into the United States,” which checks documentation, labeling, packaging, the product’s general condition and sometimes samples for contaminants, FSIS announced on Friday.

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After incoming shipments meet U.S. Customs and Border Protection and Animal and Plant Health Inspection Service requirements, they must be reinspected by FSIS.

MORE THAN 3,200 POUNDS OF PASTRAMI, CORNED BEEF RECALLED OVER POSSIBLE LISTERIA CONTAMINATION

Recalled raw beef

Florida-based Corte Argentino USA LLC is recalling about 29,628 pounds of raw beef products that were imported from Argentina. (U.S. Department of Agriculture’s Food Safety and Inspection Service)

The products were distributed to distributors and retailers in Florida and Texas.

The affected products were produced between May 15 and May 20. They have use or freeze-by dates between September 15 and September 20.

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The recall includes various weight cardboard boxes containing “FrigorIfico Gorina SAIC” boneless beef “Top Sirloin Butt” (“Cuadril Sin Tapa”), “FrigorIfico Gorina SAIC” boneless beef “Eye Round” (“Peceto”), “FrigorIfico Gorina SAIC” boneless beef “Topside Cap Off” (“Nalga AD S/Tapa”), “FrigorIfico Gorina SAIC” boneless beef “Flat” (“Carnaza Cuadrada”) and “FrigorIfico Gorina SAIC” boneless beef “Knuckle” (“Bola de Lomo”).

Outside of the USDA building.

There have been no confirmed reports of illness or injury in connection with the consumption of the recalled products. (J. David Ake/Getty Images / Getty Images)

The affected products feature Argentinian establishment number “EST. N° OF. 2025” and shipping mark “26644-AA.”

The issue was discovered during routine FSIS inspection activities.

There have been no confirmed reports of illness or injury in connection with the consumption of the recalled products, FSIS said. Anyone concerned about an illness or injury is urged to contact a healthcare provider.

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CLIMBING ROPES RECALLED OVER RISK OF DEATH FROM FALLING, REGULATORS SAY

Packaged U.S. beef in grocery store.

The products were distributed to distributors and retailers in Florida and Texas. (John Gress/Corbis / Getty Images)

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FSIS said it is concerned that some affected products may be in consumers’ refrigerators and freezers.

Consumers who have purchased these products are instructed not to consume them and to either throw them away or return them to the place of purchase.

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Spyre Therapeutics director Albers sells $2.4m in stock

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Spyre Therapeutics director Albers sells $2.4m in stock

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