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Acadia Pharmaceuticals: Another Bite At The Alzheimer’s Apple (NASDAQ:ACAD)

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Acadia Pharmaceuticals: Another Bite At The Alzheimer's Apple (NASDAQ:ACAD)

This article was written by

Retired history instructor. Alzheimer’s disease researcher for the past two decades.My goal is to give investors solid advice based on the mechanisms of action of Alzheimer’s drugs. This advice is informed by a background in biology (conservation, ecology, evolution, environmental science, and biochemistry) and twenty years of a very in depth review of the research on Alzheimer’s disease. I have come to the conclusion that Alzheimer’s disease is caused by oxidation and nitration. Many treatments for Alzheimer’s disease address factors that can contribute to oxidation and nitration such as misfolded amyloid and tau proteins and neuroinflammation, but very few direct scavenge compounds (such as hydrogen peroxide and peroxynitrite) that cause oxidation and nitration nor do they reverse any of the damage already present. Thus, most treatments for Alzheimer’s disease only slow down the early progression of the disease for awhile. Certain natural products such as panax ginseng and various essential oils via aromatherapy inhibit oxidation and nitration, scavenge agents that cause oxidative and nitrostative stress, and reverse part of their damage. Such treatments have the potential to stabilize Alzheimer’s disease.

Analyst’s Disclosure: I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Seeking Alpha’s Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.

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Main Street Sports sues Comcast, Charter for underpaid licensing fees

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Main Street Sports sues Comcast, Charter for underpaid licensing fees

A detailed view of a hand holding a Fanduel Sports Network branded microphone during an interview after the Detroit Pistons defeated the Boston Celtics at Little Caesars Arena on February 26, 2025 in Detroit, Michigan.

Nic Antaya | Getty Images

Main Street Sports, the now-defunct owner of a portfolio of regional sports networks, is suing cable companies Comcast and Charter Communications in separate lawsuits for what it alleges are underpaid licensing fees.

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The company that began its winddown earlier this year is alleging that Comcast and Charter — the two largest pay TV providers in the U.S. — breached their contracts and underpaid Main Street in the earlier part of 2026 when its networks were still delivering NBA and NHL games to local markets across the country, according to the lawsuits, which were seen by CNBC.

The suits were filed in Delaware Superior Court on Monday. Representatives for Comcast and Charter didn’t immediately respond to requests for comment.

Main Street, the entity that originated as Fox Sports networks, has been through a series of owners since 2019, as well as several name changes. The company emerged from bankruptcy protection in early 2025, when its channels took on the name of FanDuel Sports Network. It had about 15 channels, and at one point after its bankruptcy exit aired games for about 30 teams across Major League Baseball, the National Hockey League and the National Basketball Association.

However, despite touting subscriber growth as recently as the spring, Main Street continued to face liquidity issues when its MLB fees payments were due, CNBC previously reported. The company had long been weighed down by a heavy debt load.

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The issues led to its inevitable winddown. While it aired its final local MLB games in 2025, the company aired the entirety of the NBA regular season, as well as the NHL regular season and first round of playoffs this year.

Problems have been piling up for regional sports networks as the pay TV bundle continues to bleed subscribers.

Regional sports networks were once a lucrative business model for teams and leagues, as the channels pay high fees to air local games that trickle down to team payrolls. However the proliferation of cord cutting has led many pay TV distributors to rework their agreements with these channels.

Even the direct-to-consumer streaming offerings for these networks have been in a state of change. Last month, two of New York’s independently owned regional sports networks left their own streaming app for a deal to be distributed by streaming platform DAZN.

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Oil Price Today (August 25): Crude oil at $92 as investors digest US economic sanctions on Iran. What’s next for investors?

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Oil Price Today (August 25): Crude oil at $92 as investors digest US economic sanctions on Iran. What’s next for investors?
Oil prices gained marginally on Tuesday after falling more than 2% in the previous session, as investors weighed the impact of tougher U.S. secondary sanctions on Iran.

Brent crude futures were up 6 cents, or 0.1%, at $92.16 a barrel, while U.S. West Texas Intermediate crude was up 15 cents at $85.12. Both contracts fell more than 2% on Monday, with U.S. crude touching a one-week low as investors took profits following a rally over the previous two weeks.

U.S. Treasury Secretary Scott Bessent on Monday unveiled an expansion of sanctions aimed at cutting off Iran’s economic lifeline and forcing an end to the war between the two countries. He said countries would have to sever their business ties with Iran or risk being excluded from the dollar-based financial system.

Also read: ‘Economic D-Day’: US announces expansion of sanctions in ‘onslaught’ on Iran

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Bessent did not identify the countries that would be targeted or say when the penalties would come into effect. He said countries would instead be given time to comply with the new directive.


U.S. Defense Secretary Pete Hegseth said on Monday that Washington would not rule out using military force against Iran. However, the U.S. is also turning towards greater economic pressure, which analysts said had eased concerns over threats to Middle Eastern oil supplies from the war.
Tensions remain, however. An oil tanker was struck by an unidentified projectile and disabled on Tuesday northeast of Oman’s Ash Shishah, the United Kingdom Maritime Trade Operations said.Iran continues to insist that it should control the key Strait of Hormuz. Before the war began in February, the waterway typically carried cargoes equivalent to about 20% of global oil consumption. On Monday, Iran named 45 tankers that it said had violated its rules for crossing the strait and threatened action against them, including confiscating their cargoes.

Supply disruptions resulting from the U.S.-Israeli war on Iran, which began on February 28, have led countries to draw down their commercial and strategic reserves.

Where are prices headed?

The duration of the disruption will be a key factor for crude prices. JPMorgan estimates that each additional month of disruption could add around $7 to $8 a barrel to Brent prices. If the disruption continues for three months, the bank expects average monthly Brent prices to reach around $114 a barrel.

Read more: Iran vows to retaliate after US widens sanctions

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Goldman Sachs has also warned that Brent could climb to $120 a barrel if shipping disruptions through the Strait of Hormuz, the world’s most important oil transit route, persist.

At the same time, Goldman Sachs expects tensions in the Middle East to eventually ease under its base case. The bank forecasts Brent to average $80 a barrel in the fourth quarter and $75 a barrel next year. It said risks remained tilted to the upside, with disruptions through the Strait of Hormuz and the Red Sea potentially lasting longer than expected.

(Disclaimer: Recommendations, suggestions, views and opinions given by the experts are their own. These do not represent the views of The Economic Times)

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Why is Coles stock rising today?

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Why is Coles stock rising today?

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Host Hotels & Resorts: Valuation Still Looks Attractive

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Host Hotels & Resorts: Valuation Still Looks Attractive

Host Hotels & Resorts: Valuation Still Looks Attractive

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New 10p coin enters circulation – will you spot one?

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New 10p coin in the palm of someone's hand with one coin on the side showing an image of King Charles and dated 2026, with another coin on the reverse side showing a capercaillie.

Something new might appear in your change when you pay in cash from now on: a 10p coin featuring the portrait of King Charles and the world’s largest grouse.

Sufficient demand for the coins mean newly-minted 10p pieces are entering circulation for the first time for about four years, this time with a new design.

The Royal Mint says shoppers and collectors should discover the coins, which were minted and dated in 2023 and 2026, across the country.

The reverse side of the coin depicts an image of the capercaillie which is found in a small part of Scotland and threatened with extinction.

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The redesigned suite of coins to celebrate the King’s love of the natural world were unveiled in October 2023 by The Royal Mint.

The tails side of every newly-minted coin from the 1p to the £2 now features the country’s flora and fauna – from bees to an oak tree leaf.

Coins in circulation in the UK carrying the portrait of King Charles have so far been limited to the 5p, 50p and £1.

Old coins with the image of the late Queen Elizabeth II can still be used, so the new coins are only struck in response to demand.

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That is why, with 1.4 billion 10p coins in circulation, there has been no need for the new 10p to be released until now by The Royal Mint.

Now. 600,000 of these coins, dated 2023, and 6.5 million dated 2026 have been released to banks and post offices nationwide.

However, King Charles III coins still only represent about 1% of the 24.1 billion coins in circulation across the UK, making any new ones highly sought after by seasoned numismatists and new coin collectors.

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Tyro Payments Limited (TYPMF) Q4 2026 Earnings Call Transcript

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OneWater Marine Inc. (ONEW) Q1 2026 Earnings Call Transcript