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Iovance Biotherapeutics (IOVA) Stock Rallies on Analyst Upgrades, Amtagvi Momentum

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Iovance Biotherapeutics Inc

SAN CARLOS, Calif. — Shares of **Iovance Biotherapeutics Inc.** (NASDAQ: IOVA) climbed sharply in early March 2026 trading, fueled by renewed analyst optimism and ongoing commercial progress for its flagship tumor-infiltrating lymphocyte (TIL) therapy, **Amtagvi** (lifileucel). The biotech company’s stock, which has hovered in the low single digits for much of the year, gained traction after multiple price target increases and positive commentary on its revenue trajectory.

Iovance Biotherapeutics Inc
Iovance Biotherapeutics Inc

As of March 7, 2026, IOVA closed at approximately $5.13, up from recent lows around $4.58, with intraday highs reaching $5.16 in heavy volume sessions. The stock has seen notable volatility, trading in a 52-week range from $1.64 to $5.16, reflecting broader biotech sector pressures but also bursts of enthusiasm tied to clinical and commercial milestones.

The latest catalyst came from UBS, which raised its price target on IOVA from $2 to $4, citing strong fourth-quarter revenue growth for Amtagvi despite a challenging market environment. Other firms followed suit: Baird increased its target to $4 from $3, Barclays to $11 from $10, and Citizens upgraded the stock to Outperform from Market Perform. These adjustments highlight growing confidence in Iovance’s ability to scale its pioneering TIL platform beyond advanced melanoma.

Amtagvi, the first FDA-approved TIL therapy, received accelerated approval in February 2024 for adult patients with unresectable or metastatic melanoma previously treated with other therapies. The personalized cell therapy, manufactured from a patient’s own tumor tissue, has driven rapid revenue ramp-up in its first full commercial year.

Iovance reported preliminary full-year 2025 product revenue of approximately $264 million, within its guided range of $250 million to $300 million. This marked a 61% increase from 2024’s $164.1 million, largely propelled by Amtagvi’s U.S. sales of about $220 million and global Proleukin (aldesleukin) contributions of roughly $44 million. Fourth-quarter product revenue hit $86.8 million, up about 30% sequentially, with gross margins improving to around 50% as manufacturing efficiencies took hold.

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Management emphasized accelerating demand through an expanding network of authorized treatment centers (ATCs), faster production turnaround times (32 days or less), and supportive real-world data demonstrating durable responses in advanced melanoma. In a February 2026 earnings update, executives described 2026 as poised for “remarkable” revenue growth, with detailed U.S. product guidance forthcoming soon. Long-term goals include gross margins approaching 70% through full internalization of lifileucel manufacturing.

Pipeline advancements further bolster the bullish case. On February 24, 2026, Iovance announced positive early results from the first clinical trial of lifileucel in soft tissue sarcomas, specifically undifferentiated pleomorphic sarcoma (UPS) and dedifferentiated liposarcoma (DDLPS). The study showed a 50% confirmed objective response rate, prompting plans for a registrational trial. The data, presented at scientific meetings, sparked a 25%+ single-day stock surge earlier in the year.

In non-small cell lung cancer (NSCLC), lifileucel earned FDA Fast Track designation for second-line advanced non-squamous NSCLC, supported by interim data showing a 26% objective response rate and durable benefit compared to standard docetaxel. Management targets a supplemental biologics license application (sBLA) and potential accelerated approval/launch in the second half of 2027, eyeing a multibillion-dollar U.S. peak sales opportunity in lung cancer—potentially seven times larger than melanoma.

Additional trials explore frontline melanoma combinations (TILVANCE-301), second-line NSCLC (IOV-LUN-202), endometrial cancer (IOV-END-201), and next-generation engineered TIL therapies like IOV-5001, with an IND submission planned for the first half of 2026. International regulatory progress includes priority reviews in Australia and recommendations in Switzerland, with decisions expected in early 2026.

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Financially, Iovance ended 2025 with about $303 million in cash, providing runway into the third quarter of 2027. Full-year costs and expenses totaled around $667 million, resulting in a net loss of $391 million, or $1.09 per share—improvements over prior periods but underscoring the cash-intensive nature of commercial-scale cell therapy.

Analysts maintain a mixed but increasingly positive consensus, with average price targets around $9–$10 implying substantial upside from current levels. High-risk elements persist: competition in solid tumors, manufacturing complexities, and the need for consistent revenue scaling amid biotech funding challenges. Yet, Iovance’s leadership in TIL therapy positions it as a potential platform player if label expansions materialize.

Upcoming investor visibility includes presentations at the TD Cowen 46th Annual Healthcare Conference on March 2 and the Barclays 28th Annual Global Healthcare Conference on March 11, where leadership will likely discuss growth drivers and 2026 guidance.

As Iovance transitions from launch-year execution to multi-indication expansion, the stock’s performance hinges on Amtagvi’s sustained momentum and pipeline catalysts. Investors watch closely for first-quarter 2026 results, expected in May, which could provide clearer visibility into the year’s trajectory.

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With its innovative approach to solid tumor immunotherapy and accelerating commercial story, Iovance Biotherapeutics remains a high-conviction name in the biotech space amid 2026’s evolving oncology landscape.

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Market Brief: Is Bitcoin Approaching A Cycle Transition?

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Market Brief: Is Bitcoin Approaching A Cycle Transition?

BloFin Research focuses on crypto research and analysis, dedicated to providing institutional-grade insights into the digital asset market. Our work covers major crypto assets, market trends from a macroeconomic perspective, and industry-wide studies on key developments shaping the digital asset ecosystem.

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(VIDEO) Selena Gomez Praises Taylor Swift’s Songwriting in Heartfelt Instagram Tribute

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Selena Gomez and Taylor Swift

Selena Gomez paid glowing tribute to Taylor Swift’s songwriting prowess in a new Instagram Story video posted late Thursday, highlighting the enduring bond between the two longtime friends and their shared history in the spotlight.

Selena Gomez and Taylor Swift

In the clip, Gomez lip-synced enthusiastically to Swift’s unreleased track “Father Figure,” a song that has circulated among fans in bootleg form and gained renewed attention recently. Overlaid text on the video read a simple but pointed message: “The songwriting… unmatched,” with heart emojis emphasizing her admiration. The post appeared on Gomez’s “Secret Friends” Story list — a private feature she’s used this week to share exclusive content, including never-before-seen photos with Swift.

The tribute arrives just days after Gomez opened up in depth about Swift’s songwriting during an appearance on the “Friends Keep Secrets” web series, hosted by her husband Benny Blanco alongside rapper Lil Dicky. In the March 3 episode, Gomez confirmed long-standing fan theories that Swift’s 2020 “Evermore” track “Dorothea” was written about her, praising how eloquently Swift captured their nearly two-decade friendship.

“Well, ‘Dorothea’ is about me, one of her songs,” Gomez said on the podcast. “I feel like a lot of huge moments that were self-defining, from relationships to family to love to hate, all of it in between — we were figuring it out because I was 15 and she was 18, and we didn’t really know what was going on. And so we’ve never seen each other any differently. So when I listen to it, I’m so impressed how it’s eloquently put.”

Gomez, 33, described connecting with Swift’s music “a million percent” on a different level, attributing it to their parallel journeys from teenage stars to accomplished women navigating Hollywood’s highs and lows. She also revealed that Swift penned an unreleased song titled “Family” more than a decade ago about their bond, with lyrics imagining their dreams of stardom — “you have these amazing dreams. You want to be in a movie, in every crowd I see you.”

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The Instagram video tribute amplified that sentiment, with fans quickly screenshotting and sharing the clip across social platforms. “The way Selena just casually reminds us Taylor’s pen game is elite,” one commenter wrote on X. Others noted the timing, coming amid Swift’s ongoing personal milestones, including preparations for her rumored wedding to Travis Kelce, speculated for June 13 at Ocean House in Rhode Island.

Gomez and Swift’s friendship dates back to 2008, when they met as rising Disney talents — Gomez on “Wizards of Waverly Place” and Swift climbing the country-to-pop charts. They’ve supported each other through breakups, career pivots, health challenges and public scrutiny. Swift attended Gomez’s September 2025 wedding to Blanco in California, where she reportedly gave a heartfelt speech. In return, Gomez has been a fixture at Swift’s events, including Eras Tour stops and award shows.

The latest gestures underscore how their relationship has evolved into one of mutual artistic respect. Gomez, who has released albums like “Rare” and built the billion-dollar beauty brand Rare Beauty, has increasingly spoken about Swift’s influence. During the podcast, she marveled at both finding stable partners after past heartbreaks — Swift with Kelce and Gomez with Blanco — calling it unbelievable luck.

Swift’s songwriting has long been celebrated for its personal storytelling, earning her multiple Grammys, including Album of the Year wins for “Folklore” and “Midnights.” Tracks like “Dorothea,” with its nostalgic reflection on a small-town friend chasing fame, exemplify her ability to weave real-life inspirations into universal anthems. Fans have long speculated about Gomez references in Swift’s catalog, from “Evermore” to earlier songs, but Gomez’s recent confirmations provide rare firsthand insight.

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The “Father Figure” lip-sync adds another layer, as the track — believed to date from Swift’s earlier catalog sessions — touches on themes of guidance and admiration, which Gomez appeared to mirror in her praise. While neither artist has commented further publicly, the moment has sparked widespread fan appreciation for their supportive dynamic in an often competitive industry.

Gomez’s post caps a week of nostalgia for the pair. Earlier, she shared throwback images via her Secret Friends list, including unseen photos from Swift’s wedding preparations and past hangouts. The gestures come as both navigate busy careers: Gomez continues starring in “Only Murders in the Building” and expanding Rare Beauty, while Swift remains one of music’s top earners with ongoing projects post-Eras Tour.

Industry observers see these public affirmations as a refreshing contrast to celebrity feuds that dominate headlines. “In an era of manufactured drama, Selena and Taylor’s genuine friendship stands out,” said one entertainment analyst. “It’s a reminder of how powerful long-term support can be.”

As clips of the tribute circulated Friday morning, hashtags like #SelenaPraisesTaylor and #SwiftSongwriting trended on social media. Fans expressed hope for future collaborations, though both have focused on solo endeavors in recent years.

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Gomez’s tribute reinforces Swift’s reputation as one of the era’s most gifted lyricists, while highlighting the depth of their bond. In a business built on fleeting alliances, their nearly 18-year friendship — immortalized in songs and now celebrated anew — remains a rare and enduring highlight.

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What’s Driving The Gold Price? … And Other Important Questions

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What’s Driving The Gold Price? ... And Other Important Questions

Invesco is an independent investment management firm dedicated to delivering an investment experience that helps people get more out of life.Be the first to know! Sign up for Invesco US Blog and get expert investment views as they post.Disclosure for all Invesco US articles: Before investing, carefully read the prospectus and/or summary prospectus and carefully consider the investment objectives, risks, charges and expenses. The information provided is for educational purposes only and does not constitute a recommendation of the suitability of any investment strategy for a particular investor. Invesco does not provide tax advice. The tax information contained herein is general and is not exhaustive by nature. Federal and state tax laws are complex and constantly changing. Investors should always consult their own legal or tax professional for information concerning their individual situation. The opinions expressed are those of the authors, are based on current market conditions and are subject to change without notice. These opinions may differ from those of other Invesco investment professionals. NOT FDIC INSURED MAY LOSE VALUE NO BANK GUARANTEE All data provided by Invesco unless otherwise noted. Invesco Distributors, Inc. is the US distributor for Invesco Ltd.’s retail products and collective trust funds. Invesco Advisers, Inc. and other affiliated investment advisers mentioned provide investment advisory services and do not sell securities. Invesco Unit Investment Trusts are distributed by the sponsor, Invesco Capital Markets, Inc., and broker-dealers including Invesco Distributors, Inc. PowerShares® is a registered trademark of Invesco PowerShares Capital Management LLC (Invesco PowerShares). Each entity is an indirect, wholly owned subsidiary of Invesco Ltd. ©2015 Invesco Ltd. All rights reserved.

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Form 4 German American Bancorp Inc For: 7 March

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Form 4 German American Bancorp Inc For: 7 March

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Concurrent Losers: 10 BSE-200 stocks decline for 5 consecutive sessions

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The Economic Times

Over the last five trading sessions ending March 6, the BSE Sensex benchmark tumbled 4.05%, or 3,330 points, to close at 78,918. The index recorded losses in four of those five sessions. During this period, around 10 stocks within the BSE 200 posted consistent declines across all five sessions. (Data source: ACE Equity)

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Coforge, Persistent Systems among 10 stocks that have fallen most in 2026. Do you own any?

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The Economic Times

Several stocks on the BSE 200 index have seen sharp declines at the start of CY2026 as volatility grips markets. Technology and new-age companies dominate the list of laggards. Coforge, LTIMindtree and Persistent Systems lead the fall, reflecting pressure on IT stocks amid global uncertainty and concerns around rapid advances in artificial intelligence.

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What is the fastest growing thing in finance? SIPs? SIFs? Credit cards? Radhika Gupta answers

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What is the fastest growing thing in finance? SIPs? SIFs? Credit cards? Radhika Gupta answers
India’s financial landscape has been undergoing a rapid transformation as more people begin participating in investments, banking and digital payments. One of the most notable changes in recent years is the rising participation of women across multiple financial segments, including mutual funds, insurance, stock market investing, cryptocurrency and digital payments.

Highlighting this trend, Radhika Gupta, Managing Director and CEO of Edelweiss Mutual Fund, said that women are currently the fastest-growing segment in finance.

Also Read | Women crypto investors grow 116.8% in India, hold 4 different digital assets: CoinDCX

In a recent video shared on social media platform X, Gupta posed a question about what has been the fastest-growing development in the financial sector lately. While one might assume the answer to be mutual fund SIPs, the newly launched product by SEBI, SIFs, or credit cards, Gupta explained that the real answer is the rise of women in finance.
Speaking in the video, Gupta highlighted several rising trends that show how women are increasingly shaping India’s financial ecosystem. According to her, women have recorded nearly 140% growth in mutual fund folios, reflecting a sharp rise in their participation in market-linked investments.


The trend is not limited to mutual funds. Gupta noted that women’s presence has been expanding across a range of financial products. In the insurance sector, she pointed out that one in three life insurance policies in India is now held by women, indicating a growing focus on financial security and long-term planning.
Women are also becoming more active in the stock market. Gupta said their participation in equities has grown by more than 300%, demonstrating a strong shift from traditional saving habits towards investment-oriented financial planning.Beyond investments, women are increasingly using formal financial services. Gupta highlighted that bank account coverage among women has reached around 89%, reflecting the progress made in expanding financial inclusion. At the same time, their participation in credit markets has also risen.

Women have also played a major role in the growth of digital payments in the country. The surge in transactions through Unified Payments Interface (UPI), which has transformed the way Indians transact, has been partly driven by the growing number of women using digital financial platforms.

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Also Read | Share of equity mutual funds in portfolio of women investor surge to 32% in 5 years : Report

Summing up the trend, Gupta said that while the financial industry often focuses on products, platforms and technology, the most important shift is the growing financial participation of women themselves.

“The fastest-growing thing in finance today is women,” Gupta said, underscoring how their rising presence is reshaping the country’s financial landscape.

(Disclaimer: Recommendations, suggestions, views and opinions given by the experts are their own. These do not represent the views of The Economic Times)

If you have any mutual fund queries, message ET Mutual Funds on Facebook or Twitter. We will get them answered by our panel of experts. Do share your questions at ETMFqueries@timesinternet.in along with your age, risk profile and Twitter handle.

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Top 10 mutual funds to invest through SIP with investment horizon of 3 years. Check details

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The Economic Times

Several mutual funds have delivered strong SIP returns over the past three years, led by gold funds and multi-asset allocation schemes. Data from Value Research shows that a monthly SIP of Rs 10,000 in some of these funds would have grown significantly, highlighting the potential of disciplined long-term investing.

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Enphase: The ‘Sneaky AI Thesis’ Played Out, Now It’s Time To Step Aside (NASDAQ:ENPH)

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Enphase: The ‘Sneaky AI Thesis’ Played Out, Now It’s Time To Step Aside (NASDAQ:ENPH)

This article was written by

Julian Lin is a financial analyst. He finds undervalued companies with secular growth that appreciate over time. His approach is to look for companies with strong balance sheets and management teams in sectors with long growth runways.
Julian is the leader of the investing group Best Of Breed Growth Stocks where he only shares positions in stocks which have a large probability of delivering large alpha relative to the S&P 500. He also combines growth-oriented principles with strict valuation hurdles to add an additional layer to the conventional margin of safety. Features include: exclusive access to Julian’s highest conviction picks, full stock research reports, real-time trade alerts, macro market analysis, individual industry reports, a filtered watchlist, and community chat with access to Julian 24/7. Learn more.

Analyst’s Disclosure: I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Seeking Alpha’s Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.

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5 best practices for new-age traders to follow in commodity derivatives

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5 best practices for new-age traders to follow in commodity derivatives
Commodity derivatives have become one of India’s most dynamic trading segments, especially on exchanges like MCX. It’s important to understand commodity derivatives and the right way to trade in them.

Commodity derivatives are financial contracts linked to the price of physical commodities such as gold, crude oil, natural gas, silver, copper, and agricultural products. One doesn’t need to buy the actual gold bar or a barrel of oil, instead, they can trade futures contracts, where one agrees to buy or sell a commodity at a future date and price. These instruments help traders benefit from price movements without handling the physical commodity, making them popular for hedging and short-term trading.

In today’s fast, technology-led markets, a new-age trader must be informed, disciplined, and process-driven. Here are the five best practices every modern commodity trader should follow.

1. Understand What Moves Commodity Prices

Commodity markets react quickly to global and domestic triggers. A new-age trader must know the key factors that influence prices:

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  • Global cues: Movement of the US dollar, geopolitical tensions, and inflation trends can make commodities like gold or crude oil rise or fall. For example: A rising dollar often pushes gold prices down, making it important for traders to track the currency.
  • Domestic factors: Import/export numbers, monsoon forecasts, and government policy changes can move agri-commodities significantly. For example: A poor monsoon forecast may lift prices of crops like cotton or soybean.
  • Exchange margin updates: During high volatility, exchanges may increase margins. Traders who are unaware may face forced square-off.

Understanding these fundamentals helps traders avoid panic reactions and make informed decisions based on data and not emotions.

2. Trade with a Defined System

Random trading is the fastest way to lose money. A new-age trader follows a well-defined trading system that includes:

  • Clear entry signals (like a breakout, trend change, or fundamental cue)
  • A pre-decided stop-loss to limit damage
  • A realistic target based on volatility
  • Position sizing rules to protect capital

Back-testing strategies on historical MCX charts helps understand how the system might perform in real markets.

3. Put Risk Management Before Profit Chasing

In commodity trading, staying in the game matters more than making a quick profit. Prices in markets like crude oil, natural gas, and metals can swing wildly, and one bad trade can drain your capital if you’re not careful.

A disciplined trader:

  • Risks only a small fraction of their total capital on each trade
  • Keeps a margin buffer to avoid forced RMS square-offs during sudden volatility
  • Steers clear of over-leveraging, no matter how tempting the opportunity looks

Example:

If you have ₹1,00,000 in your trading account, putting ₹20,000 at risk on a single gold futures trade is extremely risky. A smart new-age trader limits risk to just 1–2% of capital (₹1,000–₹2,000). This approach protects your account during bad phases and ensures you can continue trading for the long run.

4. Use Technology to Stay Ahead

Modern traders use technology to remove emotional errors and improve precision.

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  • Real-time data dashboards help track price movements instantly.
  • Automated alerts notify you of breakouts, margin changes, or global news.
  • Algo or semi-auto systems help execute trades faster and more consistently.

Example: Setting an automated alert for crude oil at a key support level saves you from staring at the screen all day and allows faster reaction when the price hits your level.

5. Stay Updated on Contracts and Regulations

Commodity traders must know the rules of the game:

  • Lot sizes, contract specifications, and expiry dates
  • Position limits for traders and clients
  • Intraday square-off timings, especially for MIS/BO/CO orders
  • Margin changes announced by MCX during volatility

Lack of awareness can lead to penalties, forced exits, or unintended losses.

Example: If you forget that a contract is nearing expiry, you may be forced to roll over at a poor price or risk physical delivery obligations.

Conclusion

A successful new-age commodity derivatives trader combines market knowledge, rule-based trading, strict risk control, smart use of technology, and strong regulatory awareness. In a market where price swings are sharp and margins change frequently, discipline and capital preservation are the real competitive edge. By following these five practices, traders can navigate volatility confidently and build long-term success in commodity markets.

(The author is Head of Commodities Retail Business, Kotak Securities Ltd.)

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