Business
Moderna, Merck report cancer vaccine breakthrough in melanoma trial
Moderna CEO Stéphane Bancel discusses positive cancer vaccine trial results and the impact GLP-1 drugs on ‘Mornings with Maria.’
A breakthrough personalized mRNA cancer vaccine that trains the immune system to target patients’ unique tumor mutations is showing promising results.
Five-year trial data show the risk of recurrence or death in melanoma patients was cut by about half when combined with Merck’s Keytruda, Moderna CEO Stéphane Bancel told FOX Business Wednesday.
“The results are really exciting,” Bancel told FOX Business’ “Mornings with Maria.”
“We saw a recurrence-free survival, meaning people [are] not dying from the disease or getting the disease coming back. At five years, we saw 50% improvement versus people getting Keytruda [alone], Merck’s blockbuster medicine, which has saved so many lives.
COMMON VITAMIN SHOWN TO SLASH SKIN CANCER RISK IN SOME GROUPS, STUDY SUGGESTS
An assistant conducts cancer vaccine research in the lab at the Moderna Inc. headquarters in Cambridge, Mass., on Tuesday, Mar. 26, 2024. (Adam Glanzman/Bloomberg via Getty Images)
“As you see, this is very meaningful for patients, and we are very excited because this year we should get the Phase 3 study result for that medicine and, hopefully, if it’s positive, we should be able to file very quickly with the FDA to get this to the American people to save them from their disease.”
Melanoma is considered the deadliest form of skin cancer. The American Cancer Society estimates about 8,500 Americans will die from the disease in 2026.
NUCLEAR WASTE BEING TRANSFORMED INTO PROMISING CANCER TREATMENT AT FORMER MANHATTAN PROJECT SITE
Keytruda is a prescription medicine used to treat a type of skin cancer called melanoma. (Merck )
Bancel said the individualized approach of intismeran autogene (formerly known as mRNA-4157) allows Moderna to design a custom treatment for each patient based on their specific tumor mutations, enabling the immune system to more precisely target cancer cells.
“If you and I were diagnosed the same day by the same doctor with skin cancer, Moderna would make a different medicine for your cancer and a different medicine for mine,” he told anchor Maria Bartiromo, adding the personalized vaccine can be manufactured in roughly 30 days.
Bancel said the treatment showed no added safety risks or side effects compared with Keytruda alone.
GET FOX BUSINESS ON THE GO BY CLICKING HERE
FOX Business’ Geri Willis and ‘The Big Money Show’ panel discuss the application of artificial intelligence in the medical field and people flocking to the technology for health information.
“You see a huge benefit for the patients and the families with no downside of side effects, so that’s why it’s also so exciting,” he said.
Beyond melanoma, Moderna’s collaboration with Merck is expanding, with nine ongoing studies examining the personalized mRNA therapy in cancers such as kidney, bladder and gastric cancer, among others.