Business
Moderna, Merck report cancer vaccine breakthrough in melanoma trial
Moderna CEO Stéphane Bancel discusses positive cancer vaccine trial results and the impact GLP-1 drugs on ‘Mornings with Maria.’
A breakthrough personalized mRNA cancer vaccine that trains the immune system to target patients’ unique tumor mutations is showing promising results.
Five-year trial data show the risk of recurrence or death in melanoma patients was cut by about half when combined with Merck’s Keytruda, Moderna CEO Stéphane Bancel told FOX Business Wednesday.
“The results are really exciting,” Bancel told FOX Business’ “Mornings with Maria.”
“We saw a recurrence-free survival, meaning people [are] not dying from the disease or getting the disease coming back. At five years, we saw 50% improvement versus people getting Keytruda [alone], Merck’s blockbuster medicine, which has saved so many lives.
COMMON VITAMIN SHOWN TO SLASH SKIN CANCER RISK IN SOME GROUPS, STUDY SUGGESTS

An assistant conducts cancer vaccine research in the lab at the Moderna Inc. headquarters in Cambridge, Mass., on Tuesday, Mar. 26, 2024. (Adam Glanzman/Bloomberg via Getty Images)
“As you see, this is very meaningful for patients, and we are very excited because this year we should get the Phase 3 study result for that medicine and, hopefully, if it’s positive, we should be able to file very quickly with the FDA to get this to the American people to save them from their disease.”
Melanoma is considered the deadliest form of skin cancer. The American Cancer Society estimates about 8,500 Americans will die from the disease in 2026.
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Keytruda is a prescription medicine used to treat a type of skin cancer called melanoma. (Merck )
Bancel said the individualized approach of intismeran autogene (formerly known as mRNA-4157) allows Moderna to design a custom treatment for each patient based on their specific tumor mutations, enabling the immune system to more precisely target cancer cells.
“If you and I were diagnosed the same day by the same doctor with skin cancer, Moderna would make a different medicine for your cancer and a different medicine for mine,” he told anchor Maria Bartiromo, adding the personalized vaccine can be manufactured in roughly 30 days.
Bancel said the treatment showed no added safety risks or side effects compared with Keytruda alone.
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FOX Business’ Geri Willis and ‘The Big Money Show’ panel discuss the application of artificial intelligence in the medical field and people flocking to the technology for health information.
“You see a huge benefit for the patients and the families with no downside of side effects, so that’s why it’s also so exciting,” he said.
Beyond melanoma, Moderna’s collaboration with Merck is expanding, with nine ongoing studies examining the personalized mRNA therapy in cancers such as kidney, bladder and gastric cancer, among others.
Business
How small businesses could save thousands on fuel as gas prices rise: expert
President Donald Trump sits down with FOX Business’ Maria Bartiromo to discuss escalating Middle East tensions, his warning to Iran on nuclear weapons and why he believes gas prices will drop ahead of the midterms.
High gas prices continue to squeeze small businesses across the U.S., but cutting one costly habit could help owners save significantly.
New data from Ford Pro, the commercial vehicle division of Ford Motor Company, shows that unnecessary idling — leaving a car running while parked — can cost fleet operators thousands of dollars each year, cutting directly into margins at a time when fuel prices remain high.
According to the U.S. Department of Energy, the average fleet vehicle idles between one and two hours per day, burning up to two gallons of fuel daily per vehicle. With gas prices rising, those costs can add up quickly.
As of Sunday, the national average price for unleaded gas stood at $4.04, up from $3.88 just a month ago, according to AAA.
BESSENT WARNS GAS STATIONS THAT TREASURY DEPT WILL KEEP THEM ‘HONEST’ AFTER SPIKE IN PRICES

Ford Motor Co. F-150 pickup trucks are displayed at a car dealership in Orland Park, Illinois, on Sept. 27, 2019. (Daniel Acker/Bloomberg via Getty Images / Getty Images)
“You can burn up one to two gallons of gas just doing that,” Matt Krukin, who leads software and digital growth for Ford Pro, told FOX Business. “So if that happens per day… that’s $8 a day that’s idling.”
For businesses operating multiple vehicles, the impact can be substantial. A 20-vehicle fleet idling for two hours a day could waste more than $160 in fuel every day, according to Ford Pro.
Excessive idling is particularly common in North America, where about 29% of fleet vehicles idle unnecessarily, compared to just 10% in Europe, Krukin noted.
To help address the issue, Ford Pro is investing in software and data-driven tools.
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A person pumps gas into a car. (Sean Gallup/Getty Images / Getty Images)
Its newly launched artificial intelligence (AI) assistant allows fleet managers to monitor vehicle behavior in real time, identify inefficiencies and coach drivers to adopt more fuel-efficient habits.
Ford Pro says customers using these tools have seen measurable improvements, including a 52% reduction in idling.
While reducing idling is one of the simplest ways to cut costs, other driving behaviors — such as aggressive acceleration, rapid braking, and speeding — can also increase fuel consumption and wear on vehicles, according to Krukin.
The system can even limit acceleration, while in-cab alerts provide real-time feedback.
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Cars are seen driving on the highway. (Jonas Walzberg/picture alliance via Getty Images / Getty Images)
“It’s like the fleet manager’s right next to them to coach them along the way,” Krukin said.
Users have also seen a 25% drop in speeding, a 16% decrease in hard braking and an 11% reduction in harsh acceleration, according to Ford Pro.
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“We’re not just recommending solutions for the heck of it,” Krukin said. “… At the end of the day, it’s really about bringing it all together, so that these fleets actually get a pleasurable experience with the tools and technology coming together.”
Business
BOJ’s hawkish hints keep rate hike on the cards

BOJ’s hawkish hints keep rate hike on the cards
Business
Eli Lilly in advanced talks to acquire Kelonia Therapeutics for over $2 billion, WSJ says

Eli Lilly in advanced talks to acquire Kelonia Therapeutics for over $2 billion, WSJ says
Business
World Bank Highlights AI Boom as a Bright Spot Amid Slowing Growth in East Asia and the Pacific
Growth across East Asia and the Pacific is losing momentum this year, weighed down by an energy shock, rising trade barriers, and persistent domestic vulnerabilities, but a surge in artificial intelligence-related trade and investment is offering a rare point of optimism, according to the World Bank’s latest regional economic report.
Key takeaways
- AI-related exports and investment surged across East Asia and the Pacific in 2025, with Malaysia, Thailand, and Viet Nam leading the way.
- Regional growth is forecast to slow to 4.2% in 2026, pressured by the Middle East energy shock, trade barriers, and weak domestic demand.
- Closing gaps in connectivity and skills is essential for the region to fully capture the productivity benefits of AI.
Regional growth is projected to slow to 4.2% in 2026, down from 5.0% in 2025, as the energy shock stemming from the Middle East conflict compounds the adverse impact of elevated trade barriers, global policy uncertainty, and domestic economic difficulties.
China, the region’s largest economy, is expected to decelerate from 5.0% growth in 2025 to 4.2% in 2026 and 4.3% in 2027, as weak domestic demand and property sector challenges persist and the global slowdown weighs on exports. The rest of the region is forecast to slow to 4.1% in 2026 before rebounding to 5.0% in 2027 as geopolitical tensions ease.
Against that difficult backdrop, the World Bank’s East Asia and Pacific Economic Update: Industrial Policy in the Digital Age identifies AI as a meaningful bright spot. The report highlights surging AI-related exports and investment in 2025, particularly in Malaysia, Thailand, and Viet Nam, as a notable positive development for the region.
Yet the Bank cautions that the full benefits of AI remain out of reach for much of the region. Adoption is constrained by gaps in connectivity and skills, with only 13 to 17% of multinational subsidiaries in China and Thailand currently using AI, roughly one third of the proportion seen in industrialised countries.
The report also examines how rising energy costs could deepen hardship for ordinary households. A sustained 50% increase in fuel prices could result in a 3 to 4% loss in income for households across the region, with the poor and small and medium enterprises identified as the most vulnerable.
On a longer-term strategy, the update argues that industrial policy, if carefully designed, can help unlock productivity gains. Targeted support for specific industries in the Republic of Korea, Malaysia, and, more recently, Viet Nam proved effective in part because those countries had strengthened their economic foundations, including infrastructure, education, and regulatory institutions, and had liberalised trade and investment. The Bank warns that similar efforts elsewhere have delivered weaker results where those foundations remain fragile.
World Bank Vice President for East Asia and the Pacific Carlos Felipe Jaramillo noted that while the region continues to outperform much of the world, sustaining growth will require confronting structural challenges and seizing the opportunities of the digital age to increase productivity and create more jobs.
World Bank Group Director of Research Aaditya Mattoo cautioned that present difficulties could increase economic distress and inhibit productivity growth, adding that measured support for people and firms could preserve jobs today while reviving stalled structural reforms could unleash growth tomorrow.
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S&P 500: I Sold Too Early, What Now? (Technical Analysis) (SP500)
Andrew McElroy is Chief Analyst at Matrixtrade, author of the ebook ‘Fractal Market Mastery’ and producer of the ‘Daily Edge.’ The ‘Daily Edge’ is emailed before each US session and outlines actionable ideas, directional bias, and important levels in the S&P500. It also looks at ‘What’s Hot,’ on any particular day, whether it is commodities, stocks, crypto, or forex. Andrew has developed a top-down proprietary system that starts with his weekend Seeking Alpha article focusing on the higher timeframes. Fractals, Elliott Wave, and Demark exhaustion signals are all incorporated, as are macro drivers and analysis of the market narrative. It is much more than just a few lines on a chart – it is a system developed over 15 years and proven to deliver a consistent edge. An independent trader since 2009, Andrew manages a family portfolio of stocks and ETFs with his wife and fellow Seeking Alpha contributor Macrogirl.
Analyst’s Disclosure: I/we have a beneficial long position in the shares of VOO either through stock ownership, options, or other derivatives. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.
Seeking Alpha’s Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.
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ServiceNow Q1 Preview: Earnings Growth It Needs Is Too High To Justify A Buy (NYSE:NOW)
I aim to provide alpha-generating investment ideas. I am an independent investor managing my family’s portfolio, primarily via a Self Managed Super Fund. My articles deliver 5-Minute Pitches focused on the core fundamental and technical drivers of the security.I have a generalist approach as I explore, analyze and invest in any sector so long there is perceived alpha potential vs the S&P500. The typical holding period ranges between a few months to multiple years.I am very much focused on adding value via alpha generation. I always start with a Performance Assessment section for each follow-up article. I publish unusually detailed analytics on my long-only, zero-leverage global equity portfolio performance on my Hunting Alphas website every month. At Hunting Alphas, you can also access the models to all the tickers I publish on.A bit about how I approach research and coverage of a stock:I build and maintain spreadsheets showing historical data on the financials, key metric disclosures, data on the guidance and surprise trends vs consensus estimates, time-series values of the valuations vs peers, data on key coincident or leading indicators of performance and other monitorables. In addition to the company’s filings, I also keep tabs on relevant industry news and reports plus other people’s coverage of the stock. In some cases, such as during times of a CEO change, I will do a deep dive on a key leader’s background and his/her past performance record.I very rarely build DCFs and project financials many years out into the future as I don’t think it adds much value. Instead, I find it more useful to assess how a company has delivered and the broad outlook on the 5 key drivers of a DCF valuation: revenues, costs and margins, cash flow conversion, capex and investments and the interest rates (which affect the discount rate/opportunity cost of capital). In some cases, especially for companies trading at very high multiples on a TTM or 1-yr fwd basis, I do a reverse DCF to make sense of the implied growth CAGR implications.Note: Hunting Alphas is related to VishValue Research on Seeking Alpha.
Analyst’s Disclosure: I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.
Seeking Alpha’s Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.
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