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Preparing for the impact of GLP-1s

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Preparing for the impact of GLP-1s
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Monex Group, Inc. 2026 Q4 – Results – Earnings Call Presentation (OTCMKTS:MNXBF) 2026-05-12

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OneWater Marine Inc. (ONEW) Q1 2026 Earnings Call Transcript

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Seeking Alpha’s transcripts team is responsible for the development of all of our transcript-related projects. We currently publish thousands of quarterly earnings calls per quarter on our site and are continuing to grow and expand our coverage. The purpose of this profile is to allow us to share with our readers new transcript-related developments. Thanks, SA Transcripts Team

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Tennessee Democrats stripped of House committee seats over redistricting protests

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Tennessee Democrats stripped of House committee seats over redistricting protests


Tennessee Democrats stripped of House committee seats over redistricting protests

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Cal-Maine acquires frozen food business

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Cal-Maine acquires frozen food business

Van’s Foods is a manufacturer of frozen breakfast foods. 

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Air India crisis deepens ahead of final Ahmedabad crash report

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Air India crisis deepens ahead of final Ahmedabad crash report

Air India faces a leadership vacuum and mounting financial losses as it struggles to recover from the crash.

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Vir Biotechnology, Inc. (VIR) Presents at Bank of America Global Healthcare Conference 2026 Transcript

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OneWater Marine Inc. (ONEW) Q1 2026 Earnings Call Transcript

Q1: 2026-05-06 Earnings Summary

EPS of -$0.85 misses by $1.33

 | Revenue of -$29.00K (-100.96% Y/Y) misses by $109.31M

Vir Biotechnology, Inc. (VIR) Bank of America Global Healthcare Conference 2026 May 12, 2026 7:20 PM EDT

Company Participants

Marianne De Backer – President, CEO & Director

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Conference Call Participants

Alec Stranahan – BofA Securities, Research Division

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Presentation

Alec Stranahan
BofA Securities, Research Division

Thanks for joining the session with Vir Biotechnology. My name is Alec Stranahan. I cover SMID-cap biotech at Bank of America, and I’m the covering analyst for Vir. And it’s my pleasure to introduce Marianne De Backer, Chief Executive Officer of Vir. Marianne, thanks for being here.

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Marianne De Backer
President, CEO & Director

Yes, my pleasure. Thank you.

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Question-and-Answer Session

Alec Stranahan
BofA Securities, Research Division

Looking forward to the discussion. I guess just jumping right into it, you’ve effectively built a 2-engine value story for Vir. You’ve got the near-term potential from HDV, which we can talk about and the longer-term oncology platform using the PRO-XTEN technology. I guess when you look at how the market is valuing the company today, where do you see the biggest opportunity for re-rating? Is it on HDV approval and launch? Is it on the VIR-5500 progress to registrational studies? Or is it maybe the broader platform as the TCE data matures?

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Marianne De Backer
President, CEO & Director

Sure. Yes. Thank you. And thank you, Alec, for hosting us and Bank of America for hosting Vir Biotechnology. So we are very fortunate that at Vir Biotechnology, we have multiple pathways to value creation, as you point out. Obviously, our most advanced program is our delta program, already in registrational trial, initial data are going to read out starting fourth quarter of this year. So obviously, that’s an important route to value creation near term.

And then as you mentioned, we have a portfolio of 3 clinical assets, 3 clinical

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Surviving When Predictive Models Break

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Surviving When Predictive Models Break

Yesterday’s chaotic nine-goal thriller between Paris Saint-Germain and Bayern Munich completely shattered every conservative forecasting model on the market.

By examining the massive collapse of predictive algorithms during that specific match, business leaders can learn brutal, necessary lessons about surviving sudden operational chaos.

Corporate executives love to boast about making “calculated, data-driven decisions,” totally ignoring the fact that most financial forecasts are incredibly fragile. You can hire the most expensive analysts, build a massive spreadsheet and present a flawless quarterly projection to the board, but the reality of business is inherently volatile. When a massive supply chain failure or a sudden regulatory change hits your sector, the historical data is basically useless. To truly understand how quickly a supposedly perfect model can disintegrate, corporate leaders need to look outside the boardroom and study the aggressive, heavily scrutinized world of sports analytics. Yesterday’s Champions League clash is the absolute perfect case study.

No sane predictive model anticipated a 5-4 result between two European heavyweights. Examining the pre-match analytics on platforms like ThePuntersPage provides a brilliant corporate baseline, showing exactly what the smartest algorithms in the world expected to happen. They expected a tight, heavily defensive chess match. Instead, they got absolute pandemonium. Watching how the market reacted to that unexpected chaos offers a masterclass in modern risk management for any scaling enterprise.

The Illusion of the Safe Corporate Bet

Before the referee even blew the whistle in Paris, the financial narrative was already fully settled. Every major syndicate and data analyst backed the under on total goals. The logic was completely sound: semi-finals are notoriously tense, both squads possess world-class defensive structures and the stakes were simply too high for either manager to risk playing an open, attacking style. It was the textbook definition of a “safe bet.”

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This exact same mentality traps small and medium-sized enterprises every single day. Founders look at historical revenue charts and assume that because a specific product line or vendor relationship has been stable for three years, it will automatically remain stable for the fourth. They confuse historical consistency with future security. But relying entirely on past performance creates a massive operational blind spot. When you assume a market is safe, you stop aggressively monitoring the perimeter for threats. Just like the oddsmakers who totally failed to account for a sudden, aggressive tactical change in the first ten minutes of the match, companies that cling to their comfortable, safe bets are usually the first ones to get wiped out when the industry suddenly pivots.

Navigating the Black Swan Event

In financial terminology, a Black Swan is an unpredictable, incredibly rare event that carries severe consequences. Five goals being scored before the halftime whistle in a Champions League semi-final is the sporting equivalent of a Black Swan. It completely destroys the mathematical framework. When an event like this occurs, staring at your outdated dashboard and wondering why the numbers look wrong is a massive waste of time.

Corporate leaders constantly make the mistake of trusting the data even after the foundational reality has changed. According to a recent January 2026 financial analysison streamlining disconnected risk data, banks and massive corporations consistently fail to react to macroeconomic shocks because their internal reporting systems are too slow to process sudden, violent changes in the market. The algorithm cannot save you if the algorithm was built for a reality that no longer exists. When the match suddenly turns chaotic, or when a major competitor unexpectedly drops their pricing by forty percent, executives need to immediately abandon their rigid pre-planned models. Survival requires aggressive, real-time adaptation, totally disregarding the beautiful quarterly forecast that took three months to build.

Damage Control and the Art of Hedging

Perhaps the most valuable lesson from yesterday’s match is not how the models failed, but how Bayern Munich handled a catastrophic situation. Down 5-2 away from home, the German side was staring at total tournament elimination. An amateur manager would have panicked, thrown every single player forward and likely conceded three more goals on the counter-attack, completely bankrupting their chances for the second leg.

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Instead, they executed perfect damage control. They tightened their structure, absorbed the pressure and managed to claw back two late goals to make it 5-4, entirely saving the aggregate tie. This is exactly how ruthless founders manage a terrible financial quarter. If a new product launch is failing miserably, you do not double down and burn the rest of your venture capital trying to force it to work. You cut your losses, hedge your remaining assets and mitigate the damage so the company lives to fight another day. Reviewing strategies on mastering risk management as a trader directly translates to this executive mindset. It is about understanding that sometimes, the goal is not to win the quarter. No, the goal is simply to stop the bleeding before the damage becomes terminal.

Building an Agile Operational Framework

Business culture heavily romanticizes the maverick CEO who stubbornly sticks to their initial vision regardless of what the market dictates. In 2026, operating with that level of stubborn pride is borderline negligence. The market does not care about your initial vision, and it certainly does not care about your perfectly formatted Excel spreadsheets.

To survive in an increasingly volatile commercial environment, small and medium enterprises must transition away from rigid, multi-year plans and build highly agile frameworks. You train your management team to view corporate metrics with the same ruthless, emotionally detached objectivity found in the live sports forecasting industry. You learn to read the room, identify the exact moment the historical data becomes useless and pivot your resources without hesitation. Stop treating your business forecasts like an absolute guarantee. Treat them like a pre-match probability that can, and inevitably will, get blown to pieces the second the reality of the market kicks in.

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Ultragenyx Pharmaceutical Inc. (RARE) Presents at Bank of America Global Healthcare Conference 2026 Transcript

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OneWater Marine Inc. (ONEW) Q1 2026 Earnings Call Transcript

Q1: 2026-05-05 Earnings Summary

EPS of -$1.54 misses by $0.08

 | Revenue of $136.00M (-2.36% Y/Y) misses by $22.41M

Ultragenyx Pharmaceutical Inc. (RARE) Bank of America Global Healthcare Conference 2026 May 12, 2026 5:20 PM EDT

Company Participants

Howard Horn – Executive VP of Corporate Strategy & CFO
Joshua Higa – Director of Investor Relations & Corporate Communications

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Presentation

Unknown Analyst

I’m one of the biotech analysts here at BofA. Our next presenting company is Ultragenyx. And here with me are Howard Horn, Chief Financial Officer; and Josh Higa, Head of IR. Thank you for joining us, guys.

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Question-and-Answer Session

Unknown Analyst

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So I think there’s a lot going on at the company. I think most people are familiar with it, but maybe we can start with a quick overview of the company, kind of your commercial products, and you have a very busy second half of the year. So maybe you can highlight some of the key catalysts coming up.

Howard Horn
Executive VP of Corporate Strategy & CFO

Sure. Glad to, and thank you for having us. So Ultragenyx is a next-generation rare disease company on a pathway to profitability in 2027. We have 4 commercialized products, and we are estimating between $730 million and $760 million in revenue this year. We are hopeful to have 2 approvals and launches of 2 gene therapy programs this year. And the other data event people are waiting for is our Phase III data in Angelman that we talked about coming out in the second half of the year. So yes, it’s a very busy year.

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Unknown Analyst

All right. Great. Maybe we can start with a quick question on the commercial side. So you recently reported earnings. I think there was a slight miss in the quarter, but you reaffirmed your guidance for the year. Maybe you can talk to us a little bit about 1Q dynamics and kind of what gives you

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Sebi may relax norms for select agri commodity F&O contracts

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Sebi may relax norms for select agri commodity F&O contracts
Mumbai: The Securities and Exchange Board of India (Sebi) on Tuesday proposed to allow select agricultural commodity derivatives contracts to begin trading as cash settled instruments before transitioning to mandatory physical settlement.

The regulator said exchanges may be allowed on a pilot basis, to launch or revive delivery-based agricultural contracts that initially operate as financially settled products and later shift to compulsory physical settlement once predefined thresholds such as average daily traded volume, open interest levels, or a two-year period are met. “Liquidity formation in several agricultural contracts remains constrained, especially at the launch or relaunch stage. Low volumes and limited open interest can reduce market confidence, creating a feedback loop that further suppresses participation,” Sebi said in a discussion paper.

“Although accredited warehouses and assaying mechanisms have expanded, their utilisation in certain commodities remains limited.”

Sebi suggested that on a pilot basis, a couple of commodities could be considered under the proposed framework such as maize, groundnut and chilli.

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In a separate development, Sebi has also proposed doubling the client-level open position limits across all categories of agri commodities.


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Dalal Street sees sharp selloff as rising oil and dollar rush hurt sentiment

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Dalal Street sees sharp selloff as rising oil and dollar rush hurt sentiment
Mumbai: The rupee slumped to a record low for the second day running and key equity indices slumped nearly 2% on Tuesday, their biggest single-day fall in six weeks, after uncertainty over the outcome of the US-Iran peace talks sent oil prices higher.

US President Donald Trump said the ceasefire with Iran was on “life support” after Tehran’s cold response to an American proposal to end the war, which, combined with Prime Minister Narendra Modi’s austerity call, has eroded market confidence.

The Indian currency came under renewed pressure, closing at a record of 95.62 per dollar after touching an intraday low of 95.75. Traders attributed the latest bout of weakness to elevated oil prices and mounting concerns over the fiscal deficit outlook. The PM’s appeal to the public also triggered a rush for dollars, traders said. The currency had previously settled at 95.31 to the dollar and remains highly sensitive to movement in crude oil prices.

The Nifty fell 436.3 points or 1.8% to close at 23,379.55. The Sensex declined 1,456.04 points or 1.9% to end at 74,559.24. On Monday, both indices had slipped 1.5-1.7%. The fall over the past two days has wiped off ₹16.8 lakh crore in BSE’s market capitalisation. “Expectations of an early end to the war have also been reassessed after recent events,” said Rakesh Vyas of Quest Investment.

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Screenshot 2026-05-13 062225Agencies

Hopes Fading

“Higher crude, combined with record rupee weakness, elevated gold imports and capital outflows, has soured sentiment in the markets,” he said. Vyas, who is CIO and portfolio manager at Quest Investment Managers, said index heavyweight IT stocks also corrected on Tuesday due to renewed concerns over AI disruption and a weak demand outlook, sharpening the fall.
Crude prices inched up by over 3% on Tuesday to cross $107, while the Nifty IT index dropped 3.7%.
In the forex market, the Reserve Bank of India likely intervened at around the 95.50 and 95.75 per dollar levels through state-run banks to curb excessive rupee depreciation, traders said. Market participants added that sustained support for the currency will ultimately depend on attracting fresh dollar inflows into the country.
“Following the PM’s comments, gold traders have grown increasingly anxious about the possibility of policy changes, maybe a potential increase in import duty rates,” said Anil Bhansali, head of treasury at Finrex Treasury Advisors. “That uncertainty has triggered heavy dollar buying from the bullion traders over the past two sessions.” He expects the rupee to trade between 95.25 and 96 per dollar on Wednesday. “Everyone is already aware of the situation around Hormuz and the blockade,” said a trader at a private sector bank. “But when the PM comes out and asks the public to reduce consumption, it signals that there may be something more to worry about. Market participants are now bracing for possible policy changes, and that is triggering panic dollar buying.”

The India Volatility Index (VIX), known as the fear gauge of the market, jumped 3.9% to 19.28 levels on Tuesday, indicating rising caution among traders.

Broader market indices underperformed the benchmark, as the Nifty Midcap 150 dropped 2.5% and Nifty Small-cap 250 fell 3%. Out of the total 4,410 stocks traded on the BSE, 782 advanced and 3,500 declined on Tuesday.

The trend remains “sell-on-rise,” said Bhavya Shah, technical research analyst at Stoxbox.

“Traders should avoid catching falling knives, utilising temporary retracements to execute hedged shorts until a definitive base forms,” he said. However, the 23,140-23,210 zone remains a strong support area for the Nifty, offering a tactical opportunity to build small long positions with defined risk, said Shah.

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Mama’s Creations adds to prepared meal offerings

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Mama’s Creations adds to prepared meal offerings

Three new prepared meals are rolling out at Walmart stores. 

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