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Turning Cancer Research Into Real Therapies
A Scientist Focused on What Helps Patients
Dr. Flavia Pichiorri has spent much of her career asking one core question: how can discoveries in the lab help patients faster?
Based in Los Angeles, she works at the intersection of translational science and clinical research, focusing on blood cancers such as multiple myeloma and acute leukemia. Her work explores therapeutic targets like CD38 and CD84, as well as radiation-based treatment strategies designed to improve patient outcomes.
But her path into cancer research did not start in a hospital or a lab. It began in the Roman countryside.
“I grew up riding horses every morning before school,” she recalls. “That environment taught me discipline and focus very early in life.”
Those lessons would later shape the way she approaches science.
Growing Up in Rome: Discipline and Curiosity
Pichiorri was born in Rome in 1974 and grew up in a family deeply connected to analytical fields. Her mother worked in statistics and organizational science. Her father was a mechanical engineer who worked on large industrial projects across Europe and the Middle East.
The home environment valued structure and problem solving. But her childhood also included long hours outdoors.
She spent years living near the historic Appia Antica, an ancient Roman road lined with archaeological ruins. Before school, she often rode horses through the surrounding countryside. She also competed in show jumping for nearly twenty years.
“That experience taught me resilience,” she says. “In science, just like in riding, you have to stay focused and keep moving forward even when things don’t go as planned.”
From Classical Studies to Molecular Biology
Pichiorri’s academic path began with classical literature. In high school she studied Latin and Greek, which sharpened her analytical thinking.
Later, she shifted toward science at the University of Rome Tor Vergata, where she studied molecular biology and biochemistry. She earned a master’s degree in Biochemistry and Enzymology in 1999, graduating with top honors.
Her early research focused on enzyme polymorphisms and protein interactions. She trained on advanced biochemical techniques such as circular dichroism spectroscopy, FPLC, and HPLC.
Soon after graduating, she joined the Italian National Research Council, where she began studying growth factors that influence the growth of multiple myeloma cells.
That work introduced her to the disease that would define much of her scientific career.
“At the time, patients with multiple myeloma often survived only a short period after diagnosis,” she explains. “There was a huge need to understand the biology of the disease.”
Moving to the United States for Cancer Research
In the early 2000s, Pichiorri joined research teams in the United States. She worked at Thomas Jefferson University in Philadelphia and later at The Ohio State University, where she completed doctoral research on tumor suppressor genes and cancer biology.
Her studies explored fragile site genes and the molecular mechanisms involved in tumor development.
During this period she helped develop a diagnostic assay based on Clusterin, a circulating biomarker for colon cancer detection.
The project led to a patented screening method and early clinical applications.
But the turning point in her career came during her postdoctoral research.
A Breakthrough in Multiple Myeloma Research
After finishing her PhD, Pichiorri focused on understanding how multiple myeloma cells evolve and survive.
Her research revealed that the disease is influenced not only by genetic mutations but also by epigenetic changes driven by oncogenic pathways such as c-Myc.
The findings were published in the journal Proceedings of the National Academy of Sciences. The paper quickly became one of the most cited publications in its field.
“It showed that plasma cell degeneration is not just about genetic mutations,” she says. “Epigenetic regulation also plays a major role.”
The discovery helped open new paths for therapeutic research.
Building Translational Research Programs
In 2011, Pichiorri launched her independent research career as an assistant professor in internal medicine. She received several major grants and began leading translational programs focused on new therapies for blood cancers.
Her work helped advance clinical development of AR-42 (REC-2282), an HDAC inhibitor studied for hematologic malignancies.
She also contributed to research on oncolytic viral therapy, including Pelareorep, designed to target cancer cells while sparing healthy tissue.
“In translational research, the goal is always the same,” she says. “You move ideas from the laboratory to the clinic, and then back again to refine them.”
Advancing CD38 and CD84 Targeted Therapies
In 2016, Pichiorri joined City of Hope, where she expanded her research programs and secured multiple federal grants.
Her team developed new antibody-based therapies targeting CD38, a protein widely expressed on myeloma cells. Some of these therapies combine antibodies with radioactive isotopes to deliver targeted treatment directly to cancer cells.
The work has already led to clinical trials in multiple myeloma and acute leukemia.
Her group also identified CD84 as a therapeutic target in acute myeloid leukemia, leading to the development of an antibody later licensed to a biotechnology company.
Another project involves a single-chain CD38-directed T-cell engager, a therapeutic approach designed to help immune cells recognize and destroy leukemia stem cells.
A Philosophy Centered on Scientific Rigor
Despite a long list of grants, publications, and clinical programs, Pichiorri measures success in a different way.
“I rarely dwell on success,” she says. “In science it can be fleeting.”
Instead, she focuses on the durability of scientific findings.
“True scientific value comes when results stand the test of time,” she explains. “It takes patience and careful validation.”
She believes meaningful progress often requires challenging established thinking.
“Scientific progress relies on questioning assumptions,” she says. “That is how new knowledge is created.”
Looking Ahead
Today, Pichiorri continues working on translational therapies targeting CD38, CD84, and radiation-based treatments for blood cancers.
Her research spans laboratory experiments, animal models, and early-phase clinical trials. The goal remains the same: bring new treatments to patients who need them.
Outside the lab, she finds balance in hiking, gardening, horseback riding, and writing about science.
During demanding periods, she keeps her priorities simple.
“During times of change, I focus on what I value most,” she says. “Writing science and being present with my family.”
For Pichiorri, curiosity remains the driving force.
“Each day brings new questions,” she says. “Staying engaged with those questions is what keeps science moving forward.”
Thailand has launched a sweeping energy-saving campaign targeting government operations and public behavior, prompted by global energy market disruptions linked to Middle East tensions.
The initiative includes measures such as reducing electricity consumption in government buildings, promoting the use of public transportation, and encouraging citizens to adopt energy-efficient practices in their daily lives. Authorities are also exploring renewable energy alternatives to reduce dependency on imported fuels, aiming to enhance the nation’s energy security amidst uncertain global conditions.
Key Details:
- Civil servants are ordered to use stairs instead of elevators, work from home, and suspend non-essential overseas trips.
- Air conditioning in government offices must be set to 26–27°C, and formal attire has been replaced with short-sleeved shirts to reduce cooling demand.
- The government is halting energy exports to all countries except Laos and Myanmar, while urging the public to carpool and conserve energy.
- A tariff reduction to 3.88 baht per unit for January–April 2026 has been approved to ease household costs, based on falling LNG prices.
Why It Matters:
These coordinated measures aim to stabilize energy supply, reduce national consumption by up to 20%, and shield citizens from rising costs while ensuring critical infrastructure and military operations remain unaffected.
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“The key driver for introducing a new banknote series is always to increase counterfeit resilience, but it also provides an opportunity to celebrate different aspects of the UK,” said the Bank’s chief cashier, Victoria Cleland, whose signature appears on notes.
Meta’s advisers say its methods for policing AI videos are inadequate, especially at times of crisis.
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Benchmark U.S. crude skyrocketed by as much as 31% after futures markets opened Sunday night, surpassing $118 a barrel. But a fast-stabilizing market Monday morning pushed down prices to around $96 a barrel.
Front-month West Texas Intermediate crude remains more than 60% higher than the start of the year.
Disneyland’s Tomorrowland area cleared after a chemical reaction in a backstage zone hospitalized five employees, prompting a hazmat response team Tuesday. (SKY FOX)
It wasn’t pixie dust in the air Tuesday when a backstage chemical reaction at Disneyland sent five cast members to hospitals.
The incident happened Tuesday afternoon when materials being used by a contractor produced a reaction in a backstage area of the Anaheim, California, theme park, a Disneyland spokesperson confirmed to Fox News Digital.
According to the Anaheim Fire Department, firefighters responded to a report of an unknown odor in the backstage area near the Star Tours attraction in Tomorrowland around 12:30 p.m.
The area was evaluated by first responders in hazmat suites. Aerial video from Sky Fox captured authorities responding to the theme park incident.
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Contractor materials caused a chemical reaction at Disneyland Tuesday, hospitalizing five cast members with dizziness and shortness of breath in a backstage area near the Star Tours attraction. (Sky Fox / Fox News)
Several cast members were treated on site by paramedics and released, according to the park. Five others who experienced dizziness and shortness of breath were taken to nearby hospitals for further evaluation.
Their conditions were not immediately known.
The Sleeping Beauty Castle at Disneyland in Anaheim, California. (Jeff Gritchen, Orange County Register/SCNG via Getty Images / Getty Images)
Out of an abundance of caution, adjacent onstage areas were temporarily cleared of guests, the spokesperson said. Those areas were expected to reopen soon.
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Disneyland did not specify what materials were involved or the nature of the reaction. It was also unclear how many employees were in the area at the time.
Disneyland evacuated guests from Tomorrowland Tuesday after a chemical reaction in the backstage area hospitalized five cast members, according to fire officials. (Sky Fox / Fox News)
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The park remained open during the response.
Fire and emergency crews responded. The situation was contained to the backstage area, and no guests were reported to be injured, the park said.
Business
Alphabet Shares Climb Modestly in Midday Trading, Hovering Near $308 as AI Investments Fuel Optimism
Alphabet Inc. shares advanced modestly in midday trading on March 11, 2026, reflecting continued investor confidence in the tech giant’s aggressive push into artificial intelligence, even as concerns linger over soaring capital expenditures and ongoing regulatory scrutiny.
Alphabet Class A (NASDAQ: GOOGL) opened around $306.84 and traded in a range from a low of $305.57 to a high of $309.51, with shares changing hands near $307.95 to $308.76 in recent updates, up roughly 0.5% to 0.8% from the previous close of $306.36. Volume exceeded 6 million shares by early afternoon, aligning with average levels and underscoring sustained interest in the parent company of Google.
The uptick followed a strong prior session close on March 9 at $306.36, marking a 2.63% gain that outperformed broader market benchmarks. Alphabet’s performance has shown resilience in early 2026, recovering from softer periods amid macroeconomic pressures while benefiting from robust cloud growth and AI advancements. The stock’s 52-week range spans $140.53 to $349.00, with the current price positioned solidly in the upper half after peaking near $349 in early February.
A key driver remains Alphabet’s massive commitment to AI infrastructure. Management guided 2026 capital expenditures between $175 billion and $185 billion, primarily earmarked for data centers, servers and advanced computing to support Gemini models and Google Cloud expansion. The figure represents a significant escalation from prior years, positioning Alphabet at the forefront of the AI race alongside rivals like Microsoft and Amazon. Analysts note that while front-loaded spending raises short-term margin pressure concerns, long-term payoffs in cloud dominance and AI monetization could justify the outlay.
Google Cloud continues to shine as a growth engine. Recent quarterly results showed the segment’s revenue surging 48% year-over-year to $17.7 billion, with operating income more than doubling to $5.3 billion and margins improving to 30.1%. This momentum has bolstered sentiment, as enterprises increasingly adopt Google’s AI tools for productivity and development. YouTube and search advertising also delivered steady contributions, underpinning overall revenue strength.
Alphabet recently initiated a quarterly dividend of $0.21 per share, with an ex-date of March 9 and payment scheduled for March 16. The move, representing an annualized yield around 0.3%, signals confidence in cash flow generation despite elevated investments. The payout ratio remains modest at approximately 7.8%, leaving ample room for reinvestment.
Regulatory headlines persist as a backdrop. The U.S. Department of Justice and states appealed aspects of the 2024 search antitrust ruling, seeking stricter remedies after a judge found monopoly violations but rejected breakup proposals. Alphabet has defended its practices while complying with data-sharing mandates for competitors. In Europe, publishers filed complaints over AI Overviews, alleging unfair content usage, adding to ongoing EU probes. Despite these challenges, markets have largely shrugged off immediate risks, viewing Alphabet’s scale and innovation as protective moats.
Analyst consensus remains constructive. Price targets average around $377 to $385, implying notable upside from current levels, with highs reaching $443 in optimistic scenarios. Firms highlight AI leadership, Waymo’s autonomous driving progress and diversified revenue streams as tailwinds. Some forecasts project 2026 earnings per share near $8.89 and revenue approaching $407 billion, reflecting 18-19% top-line growth.
Institutional activity supports the bullish case. Recent filings showed Capital World Investors increasing its stake, while insider transactions — including CEO Sundar Pichai’s sales — drew attention but align with routine planning. Broader tech sentiment has improved, with megacap peers rebounding from earlier weakness tied to interest rate expectations and geopolitical factors.
Alphabet’s market capitalization hovers near $3.7 trillion, cementing its status among the world’s most valuable companies. The trailing price-to-earnings ratio stands around 28, considered reasonable given growth prospects in cloud and AI compared to historical averages.
As trading progresses, investors monitor upcoming catalysts, including potential AI product updates and quarterly earnings in late April. Alphabet’s ability to translate heavy investments into accelerated revenue and profitability will shape near-term performance. Executives express optimism about the “agentic AI era,” positioning the company to capture a significant share of a projected multi-trillion-dollar opportunity.
Monday’s activity reflects balanced sentiment: enthusiasm for technological edges tempered by awareness of execution risks in a capital-intensive environment. Alphabet’s diversified portfolio — encompassing search, YouTube, Android, cloud and emerging bets like Waymo — provides resilience amid industry shifts.
The company’s trajectory underscores broader themes in tech: massive AI spending as a prerequisite for leadership, balanced against regulatory and competitive pressures. For now, shares trade with measured gains, buoyed by fundamentals that continue to outpace many peers.
Indoor air quality used to be considered mostly a residential concern. Today, it has become an important topic for businesses, property developers, and building owners.
Offices, rental properties, hotels, and commercial spaces all depend on healthy indoor environments to attract tenants and maintain long-term property value.
One of the key issues affecting indoor environments is moisture. Poor ventilation often leads to high humidity indoors in the UK, especially in modern airtight buildings. When humidity levels rise too much, buildings can develop condensation problems, mould growth, and unpleasant indoor air conditions. These issues affect occupant comfort and can also lead to higher maintenance costs and reputational risks for property owners.
Because of this, building developers and asset managers are increasingly focusing on ventilation solutions that provide both energy efficiency and stable air quality.
The growing need for MVHR systems
MVHR (Mechanical Ventilation with Heat Recovery) systems
are designed to continuously replace stale indoor air with fresh outdoor air while recovering heat that would otherwise be lost.
In commercial and residential buildings, this technology provides several important advantages. First, it allows buildings to remain energy efficient without sacrificing airflow. As modern construction standards require tighter insulation and sealed building envelopes, natural airflow becomes limited. MVHR systems solve this by creating controlled and balanced ventilation.
Second, MVHR helps maintain stable humidity levels. In the United Kingdom, where the humidity indoors can fluctuate due to weather conditions and building design, proper ventilation is essential. When ventilation systems operate effectively, excess moisture from activities like cooking, cleaning, and daily occupancy is removed before it becomes a structural problem.
This reduces the risk of condensation on windows, damp walls, and mould growth, all of which can become expensive issues for property owners.
Ventilation matters for property investors
The conversation around building technology is no longer limited to engineers or architects. Increasingly, financial stakeholders are paying attention as well. For an investment company focused on property or infrastructure, indoor air quality can have a direct impact on asset performance.
Buildings that maintain comfortable indoor environments tend to have higher occupancy rates and lower tenant turnover. Poor ventilation, on the other hand, can lead to complaints, repair costs, and potential regulatory issues. As awareness grows around indoor air quality and health, tenants are becoming more selective about the spaces they occupy.
From an investment perspective, technologies like MVHR can help protect long-term building value. By improving air circulation, maintaining stable temperatures, and controlling humidity levels, these systems contribute to more durable and attractive properties.
For an investment company evaluating real estate portfolios, energy-efficient ventilation is increasingly viewed as part of responsible asset management.
Ventilation in sustainable buildings
Across Europe and the UK, building standards continue to evolve toward higher energy efficiency and healthier indoor environments. Regulations are gradually encouraging developers to adopt ventilation technologies that support both goals at the same time.
As a result, MVHR systems are becoming more common not only in residential homes but also in office developments, rental housing, and mixed-use buildings.
For businesses involved in property development, construction, or long-term real estate management, ventilation is no longer just a technical detail. It has become part of a broader strategy to create buildings that are efficient, comfortable, and resilient for the future.
The brand’s products will now be formulated with avocado oil.
Kenneth Walker III, the explosive running back who propelled the Seattle Seahawks to a Super Bowl victory and earned MVP honors, has agreed to a landmark free-agent contract with the Kansas City Chiefs. The three-year deal, worth up to $45 million, marks the richest free-agent contract for a running back in NFL history and signals a major shift for the 25-year-old standout.
Walker’s journey from a small-town Tennessee talent to one of the league’s premier backs has been marked by record-breaking college performances, consistent NFL production and a breakthrough 2025 season capped by postseason heroics. Here are 10 essential things to know about Kenneth Walker III as he prepares to join Patrick Mahomes and the Chiefs for the 2026 campaign.
- Hometown Roots and Early Rise Born Oct. 20, 2000, in Arlington, Tennessee—a suburb of Memphis—Walker grew up in a football-loving family. His father, Kenneth Walker Jr., and mother, Shaunteshia Brown, supported his athletic pursuits. At Arlington High School, he emerged as a star running back, showcasing the speed and power that would define his career. This Tennessee background made his Super Bowl LX MVP win historic: He became the first player from the state to claim the award.
- College Dominance at Michigan State After starting his collegiate career at Wake Forest, Walker transferred to Michigan State in 2021. He exploded onto the national scene, rushing for 1,636 yards and 18 touchdowns in 12 games. His performance earned him the Doak Walker Award as the nation’s top running back and the Walter Camp Player of the Year—becoming the first Michigan State player to win both. Walker’s 2021 season included eight 100-yard rushing games and cemented his status as a top NFL prospect.
- NFL Draft Selection by Seattle The Seahawks selected Walker in the second round (41st overall) of the 2022 NFL Draft. Despite a loaded running back class that year, Seattle viewed him as a dynamic complement to their offense. He quickly became the team’s lead back, rushing for over 1,000 yards in multiple seasons despite injury setbacks early in his career.
- Consistent Production in Seattle Across four seasons with the Seahawks (2022-2025), Walker amassed 3,555 rushing yards and 29 touchdowns on 821 carries. His career yards per carry average stands at 4.3. In 2025, he played all 17 regular-season games for the first time, rushing for 1,027 yards and five touchdowns on 221 carries while adding 31 receptions for 282 yards. His durability and explosiveness made him a cornerstone of Seattle’s run-heavy attack.
- Breakout Postseason and Super Bowl Heroics Walker’s 2025 playoffs were legendary. He rushed for 313 yards and four touchdowns across three games, including 135 yards on 27 carries in Super Bowl LX against the New England Patriots. The Seahawks won 29-13, and Walker earned MVP honors—the first running back to win the award in nearly three decades. His performance included a dominant ground game that controlled the clock and wore down the Patriots’ defense.
- Nickname and Playing Style Known as “K9” for his relentless, dogged running style, Walker combines elite speed, vision and contact balance. At 5-foot-9 and 211 pounds, he excels in both inside zone runs and explosive outside plays. His receiving skills add versatility, making him a three-down threat. Analysts praise his ability to create big plays, as evidenced by his long runs and tackle-breaking ability.
- Injury History Overcome Early in his NFL tenure, Walker dealt with injuries that limited him to 12-15 games per season. But 2025 marked a turning point—he stayed healthy through the full regular season and playoffs, proving his resilience and conditioning. This durability boosted his free-agent value significantly.
- Historic Free-Agent Move to Kansas City With the Seahawks declining the franchise tag, Walker hit the open market as one of the top available backs. The Chiefs, seeking to bolster their running game after previous inconsistencies, signed him to a three-year deal worth up to $45 million. The contract includes significant upside incentives and positions Walker as a workhorse in Andy Reid’s offense alongside quarterback Patrick Mahomes. Experts call it a perfect fit, solving Kansas City’s need for explosive plays on the ground.
- Fantasy Football Impact and Expectations Walker has long been a high-upside fantasy option, and his move to the Chiefs has sparked massive excitement for 2026 drafts. Analysts predict a “massive season” in Kansas City, where he could thrive in a high-powered offense. His 2025 stats (1,027 rushing yards, five touchdowns) were solid, but a healthier supporting cast and creative play-calling could push him toward career highs in yards and scores.
- Legacy and Future Potential At just 25, Walker has already achieved what many running backs chase over entire careers: a Super Bowl ring and MVP trophy. His transition to the Chiefs offers a chance to contend for more titles in one of the league’s premier organizations. As free agency unfolds, Walker’s signing reshapes the 2026 landscape—potentially influencing draft strategies and rival backfields. From Michigan State standout to Super Bowl hero to Chiefs newcomer, Kenneth Walker III’s story continues to captivate NFL fans.
Joby Aviation founder and CEO JoeBen Bevirt details the launch of the Uber Air taxi service, powered by Joby eVTOLs, starting in Dubai on ‘The Claman Countdown.’
The Federal Aviation Administration (FAA) announced Monday that it selected eight proposals for a new pilot program testing new advanced air mobility and electric vertical takeoff and landing (eVTOL) aircraft in 26 states.
Transportation Secretary Sean Duffy and the FAA unveiled the pilot program, known as the Advanced Air Mobility and eVTOL Integration Pilot Program (e-IPP), which will center on eight projects in 26 states.
The futuristic aircraft can run on electric or hybrid engines and may carry people or cargo, taking off and landing in relatively confined spaces. They’re often referred to as “air taxis” or “flying cars” since they represent an alternative to traditional means of transportation.
Under the pilot program, several operational concepts will be tested, including urban air taxi services and regional passenger transportation, including with short takeoff and landing aircraft.
THE FLYING TAXI: A LOOK AT THE FUTURE OF TRAVEL
Joby Aviation tests its full-scale prototype eVTOL aircraft in New York City in 2023. (Joby Aviation )
Additional concepts include cargo and logistics networks, emergency medical response operations, autonomous flight technologies and offshore and energy-sector transportation.
Among the projects selected for participation in the pilot program was one involving the Port Authority of New York and New Jersey, which will have four industry partners participate in testing 12 operational concepts across New England.
The Texas Department of Transportation will be involved with four industry partners in supporting regional flights connecting Dallas, Austin, San Antonio and eventually Houston with air taxi networks expanding from each city.
ARCHER AVIATION TEAMS UP WITH UNITED AIRLINES TO MAKE AIR TAXIS A REALITY
The Archer Aviation Midnight eVTOL aircraft in flight. (Courtesy of Archer Aviation / Fox News)
Four states spanning the Pacific Northwest, the Rocky Mountains and the Plains of Oklahoma will test a range of next-generation aircraft and operational concepts under the leadership of the Utah Department of Transportation.
Florida’s Department of Transportation will work with industry partners to test three phases of operations focused on cargo delivery, passenger transportation, automation and medical response with public and private investment.
Louisiana will host operations to test cargo and personnel transportation capabilities to enable flights over the high seas into the Gulf of America and energy industry locations in Louisiana, Texas and Mississippi.
A NEW WAY OF COMMUTING IS CLOSER TO TAKING OFF IN THE US
Joby Aviation tests its full-scale prototype eVTOL aircraft in New York City in 2023. (Joby Aviation )
Other projects detailed in the announcement include those led by the transportation departments of North Carolina and Pennsylvania, as well as the City of Albuquerque.
The program was created under an “Unleashing Drone Dominance” executive order signed by President Donald Trump.
“Thanks to President Trump, the future of aviation is here, and it’s going to dramatically improve how people and products move,” Duffy said. “Congratulations to the great American innovators behind each of these exciting pilot programs.
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“Working together, we will ensure America leads the way in safely leveraging next-gen aircraft to radically redefine personal travel, regional transportation, cargo logistics, emergency medicine and so much more.”
Companies named as participants in the pilot program include Archer, BETA, Electra, Joby, Wisk, Ampaire, Elroy Air, Reliable Robotics and others.
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