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UCLA Study Links Common Pesticide Chlorpyrifos to More Than Double the Risk of Getting Parkinson’s Disease
LOS ANGELES — A widely used agricultural pesticide may pose a far greater threat to brain health than previously understood, according to new research from UCLA Health that links long-term exposure to the chemical chlorpyrifos with a sharply elevated risk of developing Parkinson’s disease, while also identifying a specific biological mechanism that may explain why.
The study, published in the journal Molecular Neurodegeneration, found that people with long-term residential exposure to chlorpyrifos had more than 2.5 times the risk of developing Parkinson’s disease compared with those who were not exposed. The research combined human population data with laboratory experiments in mice and zebrafish, providing both an epidemiological link and biological evidence to support it.
Researchers analyzed data from 829 people diagnosed with Parkinson’s disease and 824 individuals without the condition, all enrolled in UCLA’s long-running Parkinson’s Environment and Genes study. The cohort was drawn from three agricultural counties in central California — Kern, Fresno and Tulare — with participants recruited in two waves, one from 2000 to 2007 and a second from 2009 to 2015. To estimate each participant’s cumulative exposure to chlorpyrifos, the research team combined California’s Pesticide Use Report database, which has tracked agricultural chemical use in the state since 1972, with detailed residential and workplace address histories spanning decades.
Dr. Jeff Bronstein, a professor of Neurology at UCLA Health and the study’s senior author, said the findings move beyond general associations between pesticides and Parkinson’s to implicate one chemical specifically.
“This study establishes chlorpyrifos as a specific environmental risk factor for Parkinson’s disease,” Bronstein said, adding that the work does not simply lump pesticides together as a broad category but isolates this compound’s distinct contribution to disease risk.
To understand how chlorpyrifos might cause that damage, researchers turned to laboratory experiments. Mice were exposed to aerosolized chlorpyrifos through inhalation for 11 weeks, a method designed to mirror how people in agricultural communities are most commonly exposed to the chemical in real-world settings. The exposed mice developed movement problems and lost dopamine-producing neurons, the same population of brain cells that gradually dies off in people with Parkinson’s disease. The animals also showed signs of brain inflammation and an abnormal buildup of alpha-synuclein, a protein that clumps together in the brains of Parkinson’s patients and is considered a hallmark of the disease.
Additional experiments in zebrafish helped researchers pinpoint the underlying mechanism. The team found that chlorpyrifos disrupts autophagy, the cellular process responsible for clearing out damaged proteins and cellular debris before they can accumulate and cause harm. When autophagy was disrupted, neurons became significantly more vulnerable to injury. Critically, when researchers either restored the autophagy process or eliminated the synuclein protein in the affected cells, the neurons were protected from the pesticide’s damaging effects, pointing to a specific, targetable pathway rather than a vague or nonspecific form of toxicity.
Outside experts who reviewed the findings said the combination of human and laboratory evidence strengthens the case that chlorpyrifos plays a direct, causal role in some cases of Parkinson’s disease, rather than simply correlating with it. Dr. Michael Okun, a neurologist at the University of Florida and co-author of the book “Ending Parkinson’s Disease,” told The Associated Press that the results help explain the disease’s origins. The findings, he said, provide compelling evidence that this specific pesticide can initiate the biological cascade leading to Parkinson’s.
Nathan Donley, environmental health science director at the Center for Biological Diversity, framed the discovery within a broader pattern of research implicating the chemical in neurological harm, noting that chlorpyrifos has been linked to just about anything that can go wrong in the brain.
Chlorpyrifos is an organophosphate insecticide originally developed by Dow Chemical and introduced in 1965. It has been used for decades on a wide range of crops, including almonds, citrus and cotton. Residential use of the chemical was banned in the United States in 2001, and the U.S. Environmental Protection Agency further restricted its agricultural applications in 2021, but it remains approved for use on close to a dozen crops domestically and continues to be widely used in agriculture in many other countries around the world.
The new findings add to a growing body of research connecting chlorpyrifos exposure to neurological harm across different stages of life. Earlier research has linked the pesticide to impaired brain development and reduced motor function in children exposed during pregnancy or early childhood, building on a string of prior studies examining the chemical’s effects on developing brains. The new UCLA research is among only a handful of studies to specifically investigate chlorpyrifos’s potential role in causing Parkinson’s disease in adults, an area that had previously relied mostly on animal studies showing that the chemical can induce cell death and alter or eliminate neurons, both recognized markers of the disease.
The research arrives amid a broader wave of scientific and legal scrutiny of pesticides and their potential links to Parkinson’s disease. A separate chemical, the herbicide paraquat, has drawn significant attention in recent years after internal corporate documents revealed that Syngenta, the company that manufactures and markets the product, was aware of research linking paraquat to brain disease decades ago. Syngenta now faces thousands of lawsuits from individuals who allege that paraquat exposure caused them to develop Parkinson’s disease, a separate legal and scientific track from the chlorpyrifos findings but part of the same broader push to understand how environmental chemicals may contribute to the disease.
Parkinson’s disease affects nearly 1 million Americans and is characterized by the gradual loss of dopamine-producing neurons in the brain, a process that leads to symptoms including tremors, muscle stiffness, slowed movement and difficulty with balance and coordination. While certain genetic factors are known to raise risk, researchers have increasingly turned their attention to environmental exposures, including pesticides, as important contributors to the disease’s development. There is currently no cure for Parkinson’s, though treatments such as the medication levodopa, along with rehabilitation therapies and, in some cases, surgery, can help manage symptoms and improve quality of life.
The UCLA researchers say their discovery that autophagy dysfunction drives much of the neurotoxicity observed in their experiments points toward a promising new therapeutic target, raising the possibility that future treatments could focus on restoring or boosting the brain’s natural cellular cleanup processes to protect vulnerable neurons. The team also said people with known historical exposure to chlorpyrifos, particularly those who lived or worked near treated agricultural fields for extended periods, might benefit from closer neurological monitoring going forward. Researchers noted that while chlorpyrifos use has declined in the United States in recent years, many people were exposed before current restrictions took effect, and similar organophosphate pesticides remain in widespread use around the world, suggesting the public health relevance of the findings extends well beyond U.S. borders.
Part of three-year pilot program with OFI.
International clients will continue to receive BSE Market Data Products from BSE starting January 1, 2027, with no interruption in service, the exchange said in a statement.
BSE and Deutsche Borse AG are working together to ensure a smooth transition throughout the migration process. There will be no change for clients based out of India, who will continue to access market data products directly from BSE.
In October 2013, BSE and Deutsche Borse AG entered into a market data service agreement for licensing BSE market data products to all international clients. Under this agreement, Deutsche Borse AG was responsible for sales and marketing of all BSE market data products to customers outside of India, while BSE serves all the domestic clients directly.
Most B2B marketing now pushes buyers towards self-service. Chatbots, automated email sequences and gated content do the heavy lifting, and a salesperson only appears at the very end, if at all. And for a lot of the journey, that’s exactly what buyers want. But watch what happens at the decision point, and the picture shifts.
When the stakes are high, buyers reach for a person. We’ll walk you through why that conversation still matters and what businesses lose when they remove it.
What Buyers Are Really Looking For in That Call
By the time a B2B buyer picks up the phone, they’ve usually done their homework. They’ve read your site, compared you against two or three competitors and formed a rough opinion. What they can’t get from any of that is reassurance, and that’s the thing they’re after when they ask to speak to someone.
They want their specific questions answered. Not the generic ones a FAQ page covers, but the awkward ones tied to their own setup, their budget and the people they’ll have to convince internally. A chatbot script can’t handle that. A real conversation can.
There’s also a quieter test happening. The buyer is working out whether you actually understand their problem or whether you’re just reading from a deck. A good agent picks up on that and adjusts, reading the room in a way a script can’t. It’s the kind of judgement a knowledgeable B2B telemarketing agency is built around, and it’s often what keeps a deal moving when automation has taken it as far as it can.
The Gap Most Businesses Aren’t Filling
Plenty of companies have poured money into content and automation to handle the research stage, and they’ve done it well. The problem is what happens next. When the buyer is finally ready to talk, there’s nobody picking up the phone.
That gap costs deals. Most buyers do prefer to research on their own first, and Gartner found in early 2026 that 67% would rather buy without a rep at all. But that’s not the whole picture. Buyers who go fully self-service are 1.65 times more likely to regret the purchase, and Gartner expects that by 2030, 75% of buyers will prefer sales experiences that put human interaction ahead of AI. The demand for a real conversation is there at the moments that matter. The supply, on the buyer’s terms, often isn’t.
The fix doesn’t mean scrapping your automation. It means having experienced people ready to step in at the point where the buyer wants a proper discussion. Some businesses build that capacity in-house, while others bring in outside help to put trained agents on the phone who can hold a consultative conversation instead of a scripted one.
Why Complex Deals Make the Human Even More Important
The bigger the decision, the stronger the pull towards a human. A few things tend to be true of high-value B2B purchases:
- The contract value is significant, so the buyer wants to reduce their risk
- Several stakeholders are involved, each with their own concerns
- The product is complex enough that a written answer leaves too much room for doubt
Gartner puts the typical B2B buying group at six to ten people, each weighing the decision differently. The more voices in the room, the harder it is for static content alone to bring them to a shared yes.
In those situations, a conversation does work that no email can. It lets the buyer think out loud, push back and get straight answers in real time. It also lets the supplier qualify properly, so both sides know early whether there’s a genuine fit.
This is the part automation will probably never replace. Software is brilliant at scale and consistency, but it can’t read hesitation in someone’s voice or sense when a prospect needs more time. A skilled agent can, and that’s often what tips a careful buyer into saying yes.
A Quick Recap
If you’ve leaned hard into digital-first marketing, it’s worth checking whether you’ve accidentally removed the human from the moment buyers most want one. The research stage runs well on automation. The decision stage rarely does.
Keep the content and the email sequences doing what they’re good at. Just make sure that when a prospect is ready to talk, there’s someone capable on the other end of the line. That combination, smart automation early and a real conversation when it counts, is what tends to close the better deals.
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Discover how ROHA’s micronized natural colors elevate clean-label, high-performance food innovation.
Ford’s limited-edition Super Duty Proud to Honor package features patriotic styling, with a portion of proceeds supporting Blue Star Families. (Credit: Ford Motor Company)
Ford has rehired experienced human engineers to help address the shortcomings of artificial intelligence (AI) tools meant to tackle quality issues in the automaker’s production processes.
The hiring push helped Ford top the JD Power 2026 U.S. Initial Quality Study (IQS) for the first time since 2010 amid improvements in the quality of its new vehicles, and follows some hard-learned lessons about the ability of AI to replace human knowledge in production processes.
“Artificial intelligence is a fantastic tool, but it’s only as good as the information you use to train it,” Charles Poon, Ford’s vice president of vehicle hardware engineering, said on a press call Wednesday, according to a report by Bloomberg.
“Over prior years, we didn’t pay as much attention as we should have to the experience of our most knowledgeable engineers that have been with us through many product cycles,” he said.
FORD TEAMS UP WITH OUTDOOR OUTFITTER FILSON TO LAUNCH NEW BRONCO SUV
Ford rehired veteran engineers to help guide AI systems that weren’t sufficient to improve production quality on their own. (Jim Young/AFP via Getty Images)
“Mistakenly, we thought that by just introducing artificial intelligence and ingesting the design requirements that we had, that would produce a high quality product,” Poon said.
He also noted that the AI tools lacked the training and expertise that veteran technicians have, and many of the company’s veteran technicians left Ford before their knowledge could be used to improve the performance of the AI tools.
“We recognized that for us to enhance some of our automation and machine learning and artificial intelligence tools, we needed to ensure that they were trained by the most experienced individuals,” Poon said.
FORD CEO SAYS ‘CUSTOMER HAS SPOKEN’ AFTER EV SHIFT DRIVES MAJOR QUARTERLY LOSS
| Ticker | Security | Last | Change | Change % |
|---|---|---|---|---|
| F | FORD MOTOR CO. | 14.13 | +0.02 | +0.14% |
The Detroit giant said that it has hired about 300 veteran engineers to work in its vehicle engineering division in the last few years.
“Free from daily production schedules, these engineers now act as internal auditors, running mandatory weekly design reviews to hunt for and eliminate potential failure points before blueprints ever reach the factory floor,” Ford said in a release.
Ford Chief Operating Officer Kumar Galhotra said that the experienced engineers and technical specialists were “at the heart” of the company’s efforts to improve production quality by addressing process issues before they’re incorporated into workflows.
FORD RECALLS MORE THAN 255,000 FOCUS VEHICLES OVER ENGINE STALL RISK
Ford CEO Jim Farley said the quality improvements are helping Ford’s bottom line. (Nic Antaya/Getty Images)
Ford CEO Jim Farley told Bloomberg TV that the shift is helping improve the company’s financial performance, with spending on warranty coverage and recalls coming down, which in turn is boosting the automaker through cost reductions.
JD Power’s 2026 IQS not only placed Ford at the top of the list for the first time in 16 years, but it also ranked the Ford F-150, Ford Mustang and Ford Super Duty at the top of their respective segments for the second straight year.
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Additionally, the Ford Escape, Ford Explorer, Ford Expedition and Ford Maverick also ranked among the top three in their segments – which meant that seven of the company’s top 10 models ranked in the top three of their categories.
FOX Business reached out to Ford for comment.
The construction industry has always been built on hard work, skilled teams, and careful planning. Today, technology is changing how projects are managed, tracked, and completed. Few people understand that shift better than Ryan Basnaw.
As the CEO of Axsus Civil Development Company, Basnaw has spent years working at the intersection of construction and technology. His experience in engineering, project management, and business operations has shaped the way he approaches both challenges and opportunities.
His journey began long before he entered the construction industry. Growing up in northeastern Washington, Basnaw developed a strong appreciation for discipline, problem-solving, and the outdoors. He spent much of his free time riding dirt bikes, snowmobiling, skiing, and playing music. Those experiences helped build the mindset that would later define his career.
Today, he is focused on helping construction companies improve the way they operate through technology and better systems.
How Ryan Basnaw’s Engineering Background Shaped His Career
Basnaw attended Newport High School before earning an Associate of Engineering degree from Spokane Falls Community College in 2014. He later completed a Bachelor’s degree in Petroleum Engineering in 2017.
Engineering taught him to think systematically. Instead of focusing only on the problem in front of him, he learned to examine the process behind it.
That mindset became valuable as he entered the construction industry.
Over time, Basnaw recognized that many contractors faced similar operational challenges. Tracking labor, equipment, schedules, inspections, materials, and project costs often required multiple systems and significant manual effort.
Rather than accepting those inefficiencies, he began looking for ways to improve them.
“Never be too proud to admit you don’t know something,” Basnaw says. “That’s how you learn and improve.”
That willingness to keep learning became one of the driving forces behind his leadership style.
Lessons Learned From Real Construction Challenges
Like many business leaders, Basnaw’s biggest lessons came from difficult situations.
He openly discusses challenges involving cash flow issues, lawsuits, and team members who misrepresented their qualifications or abilities. Instead of viewing those experiences as setbacks, he treated them as opportunities to strengthen his business systems.
One lesson stands out.
On a past project, significant rework became necessary because an inspector failed to properly document completed work. The disagreement created costly complications that could have been avoided with better records.
The experience changed how Basnaw approaches project documentation.
“A project required significant rework due to an inspector not documenting our work correctly,” he recalls. “Now we document everything so inspectors can never claim they didn’t know something when it happened.”
The lesson reinforced a principle that remains central to his leadership philosophy: details matter.
Why Documentation and Consistency Matter in Construction
Ask Basnaw what contributes most to long-term success and his answer is simple.
“Consistency and attention to detail.”
While many people search for shortcuts, he believes strong systems and daily execution create lasting results.
That philosophy can be seen throughout his work. Whether managing construction operations or developing software tools, he focuses on creating processes that help teams stay organized, accountable, and efficient.
The approach reflects another one of his guiding beliefs.
“Show up and do the work.”
It is a straightforward message, but one that has become increasingly important in industries where project complexity continues to grow.
For Basnaw, success is rarely about a single breakthrough. It comes from repeated actions performed well over time.
How Technology Is Changing Construction Management
As construction projects become more complex, technology is playing a larger role in daily operations.
Basnaw has been heavily involved in developing systems designed to help contractors manage their businesses more effectively. These tools support areas such as time tracking, fleet management, inspections, scheduling, material management, and cost tracking.
His interest in technology stems from a practical goal: helping companies gain better visibility into their operations.
The construction industry generates enormous amounts of information every day. Without proper systems, important details can easily be lost.
Basnaw believes technology should simplify decision-making rather than complicate it.
By improving visibility and accountability, companies can better understand what is happening across projects and respond more effectively when issues arise.
What Success Means to Ryan Basnaw
Many people define success by revenue, titles, or growth.
Basnaw views it differently.
“Your level of success is measured by the freedom to do what you want with your time.”
That perspective influences both his personal and professional goals. He believes people should pursue success in a way that creates long-term flexibility and fulfillment.
At the same time, he recognizes that professional achievement cannot exist in isolation.
“Personal and professional success have to be focused on together.”
It is a balanced view that reflects years of experience managing businesses, projects, and teams.
Looking Ahead
Ryan Basnaw’s career has been shaped by engineering, construction, technology, and a commitment to continuous improvement.
From growing up in northeastern Washington to leading a construction company and helping develop modern management tools, his path has been built on practical experience and lessons learned in the field.
Through challenges, successes, and industry changes, one principle has remained constant.
Pay attention to the details. Keep learning. Show up every day and do the work.
For Basnaw, those simple ideas continue to guide both his leadership and his vision for the future of construction.
Fabrício Blois
Group CEO & Executive Director
Hello, partners. Welcome to our results day. I’m Fabricio, I’m CEO of Prosus. Today morning, we released our results. I’m very excited about what we are delivering, and I hope you’ll enjoy our results call today.
Today is a special call. I’m not going only to show you the numbers, but we are going — we have 2 special guests, yes. Last time, you asked me to talk more about the ecosystem and food delivery. And today, we have the CEO of iFood and the CEO of Just Eat here with me to tell you much more details about what’s happening at Prosus.
I’m very excited about the results. I’m going to make an introduction to you about our ecosystem, and I hope you’ll enjoy what we are going to see today. So to start, first, I’m very happy on how Prosus is delivering. We are now much more focused. We are focused in delivery. We are focused in finance. We are focused in experience, and all our business are growing and doing well. And I’m going to open to you today much more info about how we are operating.
We are also focused in
The proposed IPO comprises a fresh issue of equity shares worth up to Rs 500 crore and an offer-for-sale (OFS) of up to 1.32 crore equity shares by promoters and another selling shareholder, according to the draft red herring prospectus (DRHP) filed on Sunday.
The promoters offloading shares through the OFS are C Bharanikumar, Pradeep Chandrasekaran, Prasath Chandrasekaran, Sabarinathan Anbalagan, Hari Sudhan A, Nithin Arumugam, P Anbalagan and P Arumugam, while Palaniappan Ramalingam is the other selling shareholder.
The Coimbatore-based company may also consider a pre-IPO placement of up to Rs 100 crore in consultation with the book-running lead managers. If such a placement is completed, the size of the fresh issue will be reduced accordingly.
As per market sources, the IPO size is pegged at Rs 1,100 crore to Rs 1,300 crore.
Proceeds from the fresh issue will include Rs 150 crore to part-finance capital expenditure towards the Phase-II expansion of its manufacturing facility at Mundra in Gujarat, Rs 250 crore for payment of debt, with the remaining funds to be used for general corporate purposes, the draft papers showed.
Incorporated in 1987, Eswari Global Metal Industries is an integrated multi-metal and waste recycling and value-added manufacturing company engaged in recycling non-ferrous metals, plastics and e-waste.It manufactures value-added products including pure lead and lead alloys, aluminium alloys, copper ingots, tin products and plastic granules catering to industries such as battery manufacturing, automotive and industrial sectors.
The company operates nine manufacturing facilities across Karnataka and Tamil Nadu through itself and its subsidiaries, with a total installed production capacity of 165,106 metric tonnes per annum (MTPA) as of December 31, 2025.
For the nine months ended December 2025, the company reported a revenue of Rs 1,401.5 crore and a net profit of Rs 83.9 crore.
DAM Capital Advisors, ICICI Securities and Motilal Oswal Investment Advisors are the book-running lead managers to the issue, while KFin Technologies is the registrar.
Jack Ross
CEO & Chairman
Welcome to the 2026 Annual Meeting of the Stockholders of Synergy CHC Corp. It is now 10:00 a.m., and the meeting will please come to order. My name is Jack Ross, and I’m the Chief Executive Officer, and I will provide over the — preside over the meeting. Also present are Jamie Fickett, our Chief Financial Officer; Jon Smith from Vstock Transfer, who will act as our Inspector of Elections for this meeting; and Mike Bradshaw from Nelson Mullins Riley & Scarborough LLP, the company’s outside counsel.
We have adopted an agenda for our program this morning. In accordance with the agenda, we will proceed as follows: I will conduct official business of the 2026 Annual Meeting during this portion of the meeting. All discussions will be limited to official business at hand and participation will be limited to the stockholders of record and their proxies. If you wish to participate in this meeting, please use the Q&A button on your screen.
We will now proceed to the business portion of this meeting. We have an affidavit from Vstock Transfer LLC, certifying that on or about April 30, 2026, the company furnished notice of the annual meeting and made proxy materials available to the stockholders in accordance with the applicable SEC rules, including by mailing a notice of intent, availability proxy materials and stockholders entitled to vote at the meeting. A list of the stockholders entitled to vote at this morning’s meeting has been available at the company’s headquarters for the past 10 days for inspection of any of the stockholders entitled to vote.
Vstock Transfer has examined the
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Organic moringa supplements sold through major online retailers including Amazon, Walmart, Target and TikTok Shop are being recalled nationwide after a supplier identified a potential salmonella contamination risk.
New York-based Total Nutrition Inc. voluntarily recalled two TNVitamins organic moringa products after its supplier recalled the raw organic moringa ingredient because of possible salmonella contamination. The company said no illnesses have been reported in connection with the recall.
The recalled products include TNVitamins 100% Organic Moringa 1,200 mg Capsules (Product No. AB9917, Lot 2800, expiration date February 2028) and TNVitamins 100% Organic Moringa Powder (Product No. AB9904, Lot 2782, expiration date May 2028).
Split image showing TNVitamins organic moringa capsules and moringa powder, two products recalled nationwide over possible salmonella contamination. (TNVitamins)
The supplements were distributed nationwide through Amazon, Walmart, Target, TikTok Shop and the company’s website.
The back label of a TNVitamins organic moringa supplement bottle displays the product’s ingredients and supplement facts. (TNVitamins)
COSTCO-BRAND COLD AND FLU MEDICATION RECALLED BY FDA: ‘NOT EFFECTIVE’
Salmonella can cause serious and sometimes fatal infections in young children, older adults and people with weakened immune systems. Healthy people infected with the bacteria often experience symptoms including fever, diarrhea, nausea, vomiting and abdominal pain. In rare cases, the infection can spread to the bloodstream and lead to more severe illnesses.
Consumers who purchased the affected products should not consume them and should dispose of them immediately. Products with lot numbers that do not match the recalled lots are not affected.
NEARLY 6,000 POUNDS OF FROZEN MEATLOAF RECALLED OVER UNDECLARED SOY, USDA SAYS
Consumers who purchased the affected products should not consume them and should dispose of them immediately. (Jeffrey Greenberg/Universal Images Group via Getty Images)
The recalled moringa capsules come in a white bottle containing 90 clear capsules filled with green organic moringa powder, while the moringa powder is sold in a white HDPE jar containing 96 grams of green organic moringa powder.
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Customers seeking additional information can visit TNVitamins’ recall page or contact the company via email.
World Acceptance director Charles Way sells $174,930 in stock
BNY Expands Institutional Crypto Custody with USDC Minting and Redemption
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