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Opera Callas Diva Special Edition Loudspeakers at AXPONA 2026: Understated Italian Design That Doesn’t Care If You Notice

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Italian loudspeakers tend to follow their own playbook, and the Opera Callas Diva Special Edition distributed in the U.S. by Fidelity Imports, leans into that identity without apology. Priced at $13,999, this is a reflex, floor-standing design with a rear-firing radiation system (dipole), built around the kind of materials and construction choices that set Italian brands apart: hand-crafted wood cabinetry, leather-clad baffles, and tank-like assembly that feels more atelier than assembly line.

Whether the leather actually changes the sound is still a matter of debate, but as with most things Italian, it’s as much about feel and intent as measurable outcome.

There’s also a clear voicing philosophy here. Like most offerings from Sonus faber and Opera, the goal isn’t clinical neutrality; it’s a more romantic, expressive presentation that leans into tone and texture. That doesn’t mean these speakers lack drama; if anything, they just deliver it with better timing and less shouting over Sunday gravy at Nonna’s house. Think Sophia Loren, not a reality TV meltdown—controlled, confident, and fully aware of the effect… the kind of presence that makes a room go quiet when she crosses her legs, looks your way, and lets you wonder if you’re worth the match.

Fidelity Imports is pushing Opera hard in the U.S. right now, and it’s not difficult to understand why. Paired with electronics from Unison Research, the system synergy is obvious—cohesive, deliberate, and unmistakably Italian. Bellissima, but not in a way that begs for attention. It just assumes you’re paying attention already.

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Italian Engineering in a Tailored Suit, Not a Tracksuit

The Opera Callas Diva Special Edition is a reflex loaded, floor standing loudspeaker that combines a traditional forward firing driver array with a rear firing dipole tweeter system. It’s a hybrid approach that aims to balance direct sound with controlled rear radiation, adding spatial cues without turning the room into an echo chamber.

Up front, the speaker uses a single 8-inch long throw woofer paired with a 7-inch midrange driver featuring a re cooked polypropylene cone and phase plug. High frequencies are handled by a 1-inch Scan Speak 9700 tweeter, notably run without ferrofluid and incorporating a double decompression chamber, choices that typically favor openness and low mechanical damping over sheer robustness.

Around back, Opera adds two 1-inch tweeters in what it describes as a “natural dipole” configuration. This rear array expands the soundstage by introducing ambient high frequency energy, effectively making the system a 3-way plus rear dipole design rather than a conventional forward only speaker.

The crossover network is relatively straightforward, using 12 dB per octave slopes across all drivers, woofer, midrange, front tweeter, and rear tweeters, with crossover points centered approximately at 200 Hz and 2,000 Hz. This suggests a focus on phase coherence and smoother driver integration rather than aggressive filtering.

Frequency response is rated at 30 Hz to 25 kHz, covering full range playback without immediate reliance on a subwoofer. Sensitivity is specified at 90 dB (2.83V at 1 meter), making the speaker reasonably amplifier friendly, though the 4 ohm nominal impedance with a minimum above 3.2 ohms means it will benefit from stable current delivery.

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Power handling is listed at 240 watts without clipping, and placement guidelines recommend at least 10 cm, about 4 inches, from the rear wall, which is modest considering the inclusion of rear firing drivers.

Physically, the Callas Diva Special Edition is substantial: 116 x 37 x 53.5 cm (H x W x D), approximately 45.7 x 14.6 x 21.1 inches, and each speaker weighs 65 kg, about 143 pounds, including its metal base. This is not a lightweight cabinet, so think carefully about which relative still has the energy to help you move it after sausage and peppers. And don’t forget the cannoli. Marone!

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Italian Soul, British Precision, No Passport Required

Fidelity Imports had a lot of rooms at AXPONA. Enough that you start making choices. I only had time for a few. This one, and the Ruark Audio room were the ones that actually made me stop, close my eyes and listen, and silently wish that I didn’t have 30 more rooms to cover on the next two floors.

Part of it was the system; Opera speakers, Unison Research electronics, and the new Michell Gyro Turntable spinning records like it knew that a certain American competitor was MIA and that this was its moment to make everyone take notice.

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But it was also the reaction. People didn’t just walk in and walk out. They slowed down. Took a step closer. Leaned in to look at the front baffle, then drifted over to the turntable like it might tell them something if they got close enough. Weird that. Especially because it happened more than a few times.

Nobody rushed. Nobody talked too loud. That’s usually a sign. People stood along the back of the room and listened.

I wasn’t the only one who noticed. And in a show full of rooms fighting for attention, this one didn’t have to. Steve Jain needs to make this set-up a permanent hi-fi show experience.

Michell Gryo Turntable with Unison Research Unico PRE V2 and Unico DM V2 power amplifier at AXPONA 2026
Michell Gryo Turntable with Unison Research Unico PRE V2 and Unico DM V2 power amplifier at AXPONA 2026

The room was driven by the Unison Research Unico PRE V2 and Unico DM V2 power amplifier. Together, they retail for $18,498 USD. That’s not inexpensive, but in the context of AXPONA, it sits well below many of the larger systems on display.

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The Unico DM V2 is a high power, dual mono hybrid design using Unison Research’s A.S.H.A. Class A-AB output stage. The emphasis is on current delivery and stability into more demanding loudspeaker loads rather than chasing extreme specifications.

The Unico PRE V2 is a fully balanced preamplifier with a tube based input stage. It includes a well equipped MM/MC phono stage with selectable gain and loading, making it a viable option for vinyl playback without requiring an external phono stage.

There is no built in streaming platform or Bluetooth support. That appears to be a deliberate choice, leaving digital source selection to external components.

The PRE V2 does include an internal DAC based on the Sabre ES9018K2M converter. It uses a balanced output stage designed to integrate with the tube input section, with the goal of maintaining consistent tonal balance between digital and analog inputs.

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Digital connectivity includes USB-B, two S/PDIF, and two optical inputs. USB supports PCM up to 384 kHz and native DSD up to 256, along with DoP up to 128. S/PDIF and optical inputs support resolutions up to 192 kHz.

The Unico DM V2 is rated at 220 watts into 8 ohms and 340 watts into 4 ohms in stereo operation, with stability down to 2 ohms. In bridged mono configuration, it delivers 650 watts into both 8 ohm and 4 ohm loads.

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My biggest takeaway from this room? Synergy matters. A lot.

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Having spent time with and reviewed some of Unison Research’s tube amplifiers, the new pairing has a lot more palle, but it doesn’t trade away the qualities that made those designs stand out. The tonal balance, clarity, and sense of flow are still intact. It just brings more control and authority when the music asks for it.

Unison deserves your attention. So do these Opera loudspeakers. They’re expressive without being aggressive. They don’t grab your Members Only jacket and threaten you with brute force. They take a different approach and pull you in, keep you there, and let the music do the work.

There’s something to that. Not everything needs to hit you over the head to make its point.

More info at: operaloudspeakers.com | unisonresearch.com | michellaudio.com

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US Senate Candidate Caught Insider Trading on Kalshi Says He Did It on Purpose

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Kalshi announced Wednesday that it had taken action against three US politicians for violating the prediction market platform’s rules on insider trading. One of the candidates, Mark Moran, a former investment banker and contestant on the reality dating show FBoy Island, is running a long-shot campaign for US Senate in Virginia against incumbent Mark Warner. According to Moran, getting caught was actually his plan all along: “I bet $100 on myself, not denying that, I did do it,” he tells WIRED. “I wanted to see if they would enforce it.”

Moran claims he was inspired to pull off the stunt after observing what he believed was market manipulation on Polymarket related to the New York mayoral race in 2025. The intended goal, he says, was to raise awareness about how prediction markets are “contributing to the further devolvement of our society.” Describing his decision, Moran framed it as a kind of avant-garde campaign tactic that tested the limits of the “all press is good press” credo. “I’ve been waiting for months for attention to come,” Moran says. “Because in politics, money buys attention, but I know how to get it organically. It only cost $100 to get you on the phone, right?”

In a notice of disciplinary action against Moran that the company sent to the Commodity Futures Trading Commission, Kalshi claimed that the politician had purchased event contracts in markets related to his own candidacy and promoted them on social media. Kalshi noted that it had fined Moran $6,229.30 and banned him from the platform for five years after he “refused to resolve the matter via settlement.”

Moran claims that he stopped speaking to Kalshi because he objected to the company’s settlement terms. “They wanted me to make a public statement,” he says. That was the thing that I pushed back on, that’s a violation of my First Amendment rights, to compel my speech.” (Public statements are often included in the terms of legal settlements.) Kalshi declined to comment.

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The other two enforcement actions Kalshi announced today, against candidates in congressional races in the Minnesota Democratic Primary and the Texas Republican Primary, were settled after the accused paid smaller fines. In another batch of cases announced in February, Kalshi revealed that it had fined far-right Republican politician and former California gubernatorial candidate Kyle Langford for market manipulation. In an interview with WIRED, Langford described his trades as a “campaign gimmick.”

Moran says that if he is elected, he plans to work on legislation to strengthen guardrails around prediction markets. A nationwide political battle is currently underway over what rules the industry should be required to follow. A number of states have filed lawsuits against leading companies in the space, alleging that they are running unlicensed gambling operations.

There is also growing concern over insider trading on political markets. New York governor Kathy Hochul signed an executive order on Wednesday banning state government employees from insider trading, following similar orders in California and Illinois.

Although he switched his affiliation from Democrat to Independent at the beginning of the month, Moran is still listed as a candidate on Kalshi’s market for the Virginia Democratic Primary. His odds are currently at 1 percent.

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Loewe Acquires Cabasse to Build Integrated Premium A/V Ecosystem and Preserve Iconic French Audio Brand

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Loewe has acquired Cabasse following the French audio brand’s recent move into receivership and it’s not happening in a vacuum. It’s the latest move in a wave of consolidation that is reshaping the A/V industry at a pace we haven’t seen before.

Over the past 18 months, strategic partnerships and acquisitions have started to redraw the competitive map. TCL’s partnership with Sony signaled a shift in how major TV brands are thinking about scale and control, while Barco’s acquisition of VerVent Audio Holding brought Focal and Naim Audio into a broader ecosystem play that ties premium audio directly into professional and consumer video solutions.

Loewe stepping in to take control of Cabasse fits that pattern almost too well. A heritage European TV brand with ambitions beyond displays acquires a respected but financially vulnerable French loudspeaker manufacturer. It’s a practical move, not a sentimental one, and another clear indication that standing still in this industry is no longer an option.

Cabasse Logo Since 1950

It is being reported that Loewe has acquired Cabasse for €400,000; a figure that feels low for a brand with that kind of history, but one that reflects the reality of Cabasse’s recent move into receivership. The deal keeps the lights on and most of the team intact, with 24 of 26 employees retained. Not perfect, but in this market, it’s better than the alternative.

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Loewe says Cabasse will continue to operate independently, which is the right move on paper. The French brand keeps its identity, its engineering DNA, and hopefully its voice, while Loewe gets a foothold in high-end audio that it didn’t have before.

The strategy is straightforward. Loewe is betting it can extract value by applying its operational structure and commercial reach to a brand that struggled on its own. The goal is to accelerate international distribution of higher-margin products and strengthen its position as a more serious player in the premium video and audio space.

Cabasse Speakers
Cabasse Loudspeaker range

What Cabasse Brings to the Table

Cabasse was founded in Brittany, France, in 1950. Over the decades, they have established themselves as experts in designing and making coaxial speakers. Building on this foundation, Cabasse has created attention-getting products such as the Sphere Evo. and Pearl Theater

In addition, Cabasse has made sound systems for French cinemas and large venues, and has also made loudspeakers for studios and broadcast environments. Cabasse introduced active loudspeakers as early as the late 1950s and continued to refine coaxial and multi-driver technologies through the 1970s, 1980s, and 1990s.

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By bringing Cabasse on board, Loewe gains access to established audio technologies, a portfolio of patents, and deep acoustic expertise, all of which can be leveraged to expand its reach in the premium A/V market.

Cabasse represents the very essence of acoustic excellence,” declares Aslan Khabliev, CEO of Loewe Technology. “By integrating their exceptional expertise into the Loewe universe, we are taking our audio capabilities to a completely new level.

Joining Loewe marks a new chapter in our history. We will continue to innovate from Brest, true to our heritage, while benefiting from a powerful international platform to accelerate our development,” adds Arnaud Hendoux, Deputy Managing Director of Cabasse.

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Who Is Loewe?

Loewe has been around long enough to see the entire arc of consumer electronics play out in real time. Founded in 1923 in Berlin, the company was an early innovator in radio technology and one of the first to experiment with integrated electronic systems. By the postwar period, Loewe had established itself as a premium European manufacturer, leaning heavily into design and engineering at a time when most brands were chasing scale.

Through the latter half of the 20th century, Loewe built its reputation on high quality television sets, including early stereo TV implementations and later advancements in integrated AV systems. It was also among the first manufacturers to push smart TV concepts in Europe and became the first company to secure Dolby Vision certification for OLED TVs, reinforcing its position as a design forward, technically capable brand operating at the higher end of the market.

The transition from CRT to flat panel displays, however, didn’t do Loewe any favors. As production shifted toward Asia and price competition intensified, the company struggled to maintain relevance in markets like the United States. That pressure eventually led to bankruptcy and insolvency proceedings, effectively pulling Loewe out of the U.S. market and putting its future in doubt.

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The turnaround began in 2019, when new investment and ownership gave the brand another shot. Loewe restructured its operations, reopened manufacturing in Germany, and rebuilt its product portfolio with a focus on premium positioning rather than volume. The current strategy is less about competing with mass market TV brands and more about carving out space in the luxury segment, where design, materials, and system integration still matter.

That shift became clearer last year when Loewe announced plans to return to the U.S. market with a refreshed lineup of luxury televisions and personal audio products, including headphones. It’s a more focused, more realistic version of the company, but one that still carries nearly a century of engineering DNA into a market that looks nothing like the one it left behind.

loewe-stellar-77-tv
77″ Loewe Stellar TV at AXPONA 2026

The Bottom Line 

Loewe’s acquisition of Cabasse makes sense on paper, and more importantly, it fills a gap that Loewe could not address on its own. Loewe knows displays, industrial design, and system integration. Cabasse brings decades of loudspeaker engineering, acoustic research, and a patent base that gives Loewe something it has lacked credibility in until now. That combination opens the door to fully integrated premium A/V systems that actually feel cohesive rather than stitched together from third party parts.

What should we expect? Start with tighter ecosystem plays. Think high-end TVs paired with purpose built wireless or active speaker systems that are designed from the ground up to work together. Better control over voicing. More consistent performance across video and audio. Possibly more aggressive moves into luxury all-in-one solutions where aesthetics matter just as much as performance. If Loewe is serious, Cabasse will not just remain a standalone speaker brand. It will become part of a broader platform.

There is some real upside here. We saw Loewe’s top OLED TV at both CES and AXPONA 2026 and it was one of the more impressive displays at the shows from both a design and picture quality standpoint. On the personal audio side, their Leo wireless headphones left a strong impression on our Headphone Editor Will Jennings. The pieces are already in place. This deal gives them more control over how those pieces fit together.

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But none of this guarantees success. The premium A/V market is crowded and unforgiving. Brands like Sony have already figured out that scale and partnerships matter, which is why its alignment with TCL is worth watching. Loewe now has the tools to compete more seriously with a deeper bench of wireless audio technology.

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New Mac malware goes straight for developer keys

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Two newly discovered macOS threats are designed to harvest developer credentials and cloud access as attackers focus on long-term persistence and avoid fast, visible attacks.

Four overlapping Apple MacBook lids in different colors, including silver, space gray, dark blue, and black, arranged in a fan shape on a light background
Some Mac computers have two security threats to worry about

The Mosyle security research team unveiled their discovery of “Phoenix Worm” and “ShadeStager” on April 22. These two are previously unknown malware that went undetected by antivirus engines at the time of their discovery.
While the lack of detection sounds concerning, it’s important to remember that new malware often begins with limited or no antivirus coverage before signatures catch up. Together, Phoenix Worm and ShadeStager outline a full attack path that moves from initial system access to deep credential harvesting.
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Google confirms context-aware Siri built from Gemini will debut in 2026

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Search giant Google has publicly confirmed that Apple’s updated Siri, complete with its long-promised personalized responses, will finally be coming out at some point in 2026.

Man in a gray suit stands on a dark, curved stage under a large glowing Apple logo, delivering a presentation in a dramatic, spotlighted auditorium setting
Google Cloud CEO Thomas Kurian talking about Apple at Google Cloud Next 26 – Image Credit: Google/YouTube

In January, Apple confirmed that it had entered into a multi-year deal with Google to use the Gemini model to create Apple’s Foundation Models. Google now says that the fruits of Apple’s AI labor will be on display before the end of 2026.
Speaking at the Google Cloud Next 26 opening keynote, Google Cloud CEO Thomas Kurian talked about Apple as a key customer of the company. Standing in front of the Apple Logo in the auditorium, he enthused about how Apple was using its technology.
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Leak hints at Canon EOS R8 II launch with a retro design

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Canon might be about to lean into nostalgia with its next full-frame mirrorless camera.

According to a fresh leak, the EOS R8 II is in the works. It could arrive with a retro-inspired design to mark 50 years since the iconic AE-1.

The report, via CanonRumors, suggests the upcoming model will act as a direct successor to the EOS R8, which is now over three years old.

But instead of a routine refresh, Canon is said to be rethinking the design entirely. Specifically, Canon may draw inspiration from the Canon AE-1, one of its most successful cameras ever. Over five million AE-1 units have sold since its 1976 debut.

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That could mean a more angular body, a smaller grip, and potentially a different control layout compared to Canon’s current mirrorless lineup. While details are still thin, the shift hints at something closer to the growing trend of retro-styled digital cameras. In other words, Canon might blend modern internals with classic aesthetics.

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Outside of the design, there’s little confirmed about the EOS R8 II so far. Specs, pricing, and an exact launch date remain under wraps, though the leak claims the camera could arrive “soon.” Whether Canon will pair it with matching retro-style lenses is also unclear at this stage.

Interestingly, the EOS R8 II might not be launching alone. The same source suggests Canon is also preparing an EOS R6 V, reportedly aimed at video-focused users with upgraded filming features. However, specifics haven’t surfaced yet.

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For now, the retro angle is the standout. If accurate, the EOS R8 II could signal a rare stylistic shift for Canon, which has largely stuck to modern, functional designs in its mirrorless range.

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Sam Altman’s Orb Company Promoted a Bruno Mars Partnership That Doesn’t Exist

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Sam Altman’s eyeball-scanning startup, Tools for Humanity, announced last week that a new product called Concert Kit—designed to give verified humans a way to purchase concert tickets—would first roll out on Bruno Mars’ world tour of his latest studio album, The Romantic.

However, Bruno Mars Management and Live Nation, the producer for the Romantic Tour, told WIRED in a joint statement on Tuesday that the partnership “does not exist,” and that Tools for Humanity never even approached them about working together.

The confusion stemmed from a Tools for Humanity event April 17 in San Francisco, where chief product officer Tiago Sada said the company would be joining the Romantic Tour to not just provide access to tickets but also “VIP experiences for verified humans.”

The statement was reiterated in a blog post published by the company, which read: “Concert Kit launches today and will roll out during the Bruno Mars World Tour featuring DJ Pee .Wee (aka Anderson .Paak), where verified humans will have exclusive access to VIP suite experiences at select stops.”

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A video of the event, and the company’s blog post, have since been edited and reshared by Tools for Humanity. They now say that Concert Kit will roll out on the 2027 European tour for Jared Leto’s band, Thirty Seconds to Mars.

“To be clear, we were never approached by TFH, nor were we in any discussions regarding a partnership or tour access,” said Bruno Mars’ Management and Live Nation in a joint statement to WIRED. “We first learned that our tour was being used to promote their project after their keynote made those initial claims.” (WIRED had referenced the Bruno Mars partnership in its original story about the event; the story has since been updated to include this new information.)

A spokesperson for Tools for Humanity confirmed to WIRED in a statement Wednesday that the startup “does not have any agreement with Bruno Mars to test or feature Concert Kit, and there is no association or affiliation with the artist or his tour.” Tools for Humanity declined to explain why they announced Mars as a partner for the project in the first place.

Tools for Humanity was cofounded in 2019 by OpenAI CEO Sam Altman and German entrepreneur Alex Blania, with the aim of using blockchain technology to verify people in online environments where scams are prevalent. In 2023, the company launched a physical, iris-scanning orb that works in conjunction with a mobile app.

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While Live Nation and Bruno Mars Management say they “have no opinions for or against their products,” it’s possible that Live Nation is feeling prickly about Tools for Humanity for other reasons. The startup is proposing that Concert Kit will help thwart the bot problem that plagues sites like Ticketmaster—which is owned by Live Nation.

In September, Bloomberg reported that the US Federal Trade Commission was investigating Ticketmaster over whether it had done enough to keep bots off its platform. Anderson .Paak made a cameo at the Tools for Humanity event to vouch for this approach, saying to the crowd, “I fucking hate bots … they make everything really shitty. Especially for the fans.” (Anderson .Paak, for what it’s worth, will soon be touring with Bruno Mars under his moniker DJ Pee .Wee. The plot thickens.)

Tools for Humanity also took a jab at Ticketmaster in its press release for last week’s event, saying that “diehard Swifties will never forget the Eras Tour presale, where Ticketmaster faced 3.5 billion system requests in a single day, locking out millions of fans.”

The partnership with Mars was one of many announced at Tools for Humanity’s Lift Off event, which aimed to legitimize the startup’s identity-verifying technology by working with major brands. Executives from Tinder, Zoom, and Docusign said they’d be expanding their work with Tools for Humanity at the event. In the past, Tools for Humanity has struggled to get governments around the world on board with its technology as a safe, privacy-protecting way to identify real humans.

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Amazon names AWS exec Prasad Kalyanaraman to S-team, promotes Dave Brown to SVP

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Prasad Kalyanaraman, VP of AWS Infrastructure Services, has been named to Amazon’s senior leadership team. (Amazon Photo)

Amazon added a new member to its senior leadership team Wednesday, naming AWS infrastructure chief Prasad Kalyanaraman to the group known as the S-team or “steam,” while also promoting cloud computing and AI services leader Dave Brown to senior vice president.

CEO Andy Jassy announced the changes internally, according to a memo viewed by GeekWire, and the company updated its public list of S-team members to reflect the changes.

Kalyanaraman oversees AWS infrastructure, including data centers, networking, and supply chain. He has been with the company for more than 20 years, starting in Amazon’s fulfillment and supply chain operations before moving to the cloud division in 2012.

Jassy’s memo praised his “customer obsession, high standards, ability to be right often, delivery, and missionary approach (always focusing on what’s best for customers — and the company as a whole vs. just his own area),” alluding in part to Amazon’s leadership principles

Dave Brown, newly promoted to senior vice president at Amazon, leads AWS EC2 and AI services including Bedrock and SageMaker. (Amazon Photo)

Brown leads AWS compute services (EC2) along with fast-growing AI services including Bedrock and SageMaker. He has been on the S-team since 2023, previously as a vice president.

“There are several reasons for his promotion, but chief among them are his outstanding delivery, propensity to look around corners and deliver services customers want, being right a lot, obsessing about customers, and continuing to develop strong teams,” Jassy wrote.

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The addition of Kalyanaraman brings the S-team back up to 28 members. That’s still down from more than 30 when the last big round of additions was made in September 2023. 

In the meantime, the group has seen departures including Adam Selipsky as AWS CEO (replaced by Matt Garman); longtime devices chief Dave Limp, (succeeded by former Microsoft executive Panos Panay); artificial intelligence leader Rohit Prasad; grocery head Tony Hoggett; and device software leader Rob Williams. 

Here’s the full list as it stands now.

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‘Simply by doing their daily work’: Meta tracks staff activity to teach AI how to replace them

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  • Meta is recording employee clicks, keystrokes, and screen activity to train AI agents on real work behavior
  • The program is part of a broader push to build AI systems that can perform everyday tasks with minimal human input
  • The move comes just ahead of reports of layoffs at the company

Meta has begun collecting everything its employees do as they go about their normal work to train its AI models, as first reported by Reuters. The Model Capability Initiative records mouse movements and clicks, keyboard keystrokes, and even occasional screenshots from computers used by Meta employees in the U.S. The company wants to observe how people actually use software, then feed that behavior into AI models so they can learn to do the same things.

Meta essentially wants to make its systems more reliable for the small actions that define a workday. That means everything from navigating a menu and moving between windows to parsing different website formats. These aren’t easily solved with text data alone.

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How Gut Bacteria May Affect The Outcome Of Cancer Immunotherapy

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In the ongoing development of cancer immunotherapy, as well as our still developing understanding of the human immune system, there’s always been a bit of massive elephant in the room. The thing about human bodies is that they’re not just human cells, but also consist of trillions of bacteria that mostly live in the intestines. What effect these bacteria have on the immune system’s functioning and from there on immunotherapies was recently investigated by [Tariq A. Najar] et al., with an article published in Nature.

The relevant topic here is that of antigenic mimicry, involving microbial antigens that resemble self-antigens. Since these self-antigens are a crucial aspect of both autoimmune diseases and cancer immunotherapy there is considerable room for interaction with their microbial mimics. Correspondingly these mimics can have considerable negative as well as positive implications, ranging from potentially triggering an autoimmune condition to hindering or boosting cancer immunotherapy.

In this study mice were used to investigate the effect of such microbial interference, in particular focusing on immune checkpoint blockade (ICB), which refers to negative feedback responses within the immune system that some cancers use to protect themselves. In some immunotherapy patients ICB inhibiting using e.g. anti programmed cell death protein (anti-PD-1) treatment does not provoke a response for some reason.

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For the study mice had tumors implanted and the effect of a particular microbe (segmented filamentous bacteria, SFB) on it studied, with the presence of it markedly improving the response to anti-PD-1 treatment due to anti-gens expressed by SFB despite the large gut-skin distance. Whether in humans similar mechanisms play a similarly strong role remains to be investigated, but it offers renewed hope that cancer immunotherapies like CAR T-cell immunotherapy will one day make cancer an easily curable condition.

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Complete will combine remasters and a sequel into one package

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Last year, Ecco the Dolphin creator Ed Annunizata teased plans to remaster the first two games in the series and create an entirely new sequel. Ecco the Dolphin: Complete, announced by Annunziata’s studio A&R Atelier, appears to be the result of that work. The game doesn’t have a release date yet, but A&R Atelier says it combines the planned remasters and third title into “the complete, definitive Ecco the Dolphin experience, created by the people who made the originals.”

Complete includes “all versions of Ecco the Dolphin and Ecco: The Tides of Time,” according to the developer, alongside “a brand-new contemporary Ecco game.” Besides graphical improvements, A&E Atelier says the game will introduce “built-in speedrunning support, achievements and leaderboards,” and things like the ability to create custom courses from existing levels. And while A&R Atelier’s announcement doesn’t include footage of the new game or the platforms it’ll release on, the official Ecco the Dolphin website has a countdown clock that could point to when more information will be released.

Annunziata sued Sega to try and win the rights to the Ecco the Dolphin IP in 2013, the same year he failed to get The Big Blue, a spiritual sequel to Ecco the Dolphin, fully funded on Kickstarter. Sega and Annunziata ultimately settled their lawsuit in 2016, which may have laid the groundwork for Ecco the Dolphin: Complete to happen.

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