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Acadia Pharmaceuticals: Another Bite At The Alzheimer’s Apple (NASDAQ:ACAD)

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Acadia Pharmaceuticals: Another Bite At The Alzheimer's Apple (NASDAQ:ACAD)

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Retired history instructor. Alzheimer’s disease researcher for the past two decades.My goal is to give investors solid advice based on the mechanisms of action of Alzheimer’s drugs. This advice is informed by a background in biology (conservation, ecology, evolution, environmental science, and biochemistry) and twenty years of a very in depth review of the research on Alzheimer’s disease. I have come to the conclusion that Alzheimer’s disease is caused by oxidation and nitration. Many treatments for Alzheimer’s disease address factors that can contribute to oxidation and nitration such as misfolded amyloid and tau proteins and neuroinflammation, but very few direct scavenge compounds (such as hydrogen peroxide and peroxynitrite) that cause oxidation and nitration nor do they reverse any of the damage already present. Thus, most treatments for Alzheimer’s disease only slow down the early progression of the disease for awhile. Certain natural products such as panax ginseng and various essential oils via aromatherapy inhibit oxidation and nitration, scavenge agents that cause oxidative and nitrostative stress, and reverse part of their damage. Such treatments have the potential to stabilize Alzheimer’s disease.

Analyst’s Disclosure: I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Seeking Alpha’s Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.

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Records across the board for Duratec

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Records across the board for Duratec

Yes. Corporate subscriptions are available for teams and organisations, with discounted rates as user numbers increase. Pricing starts from $1,625 + GST per user.
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Why Tesla has been caught up in a massive car recall in China

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A composite image of the front pages of the Daily Star and the Guardian on 26 August 2026

Hidden door handles are widely used in modern cars in China, with around 60% of the top 100 best-selling new energy vehicles, including EVs and hybrids, having them.

The minimalist design gives vehicles a “sleek look and reduces wind drag” but can be confusing to use, car industry analyst Stephen Dyer from consultancy AlixPartners told the BBC.

“Even I often find it difficult to locate the switch to open the door from the inside of an unfamiliar vehicle,” said Dyer, who is based in Shanghai.

But beyond their usability, the handles have been blamed for endangering the lives of drivers and passengers.

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Electronically powered door handles became an industry trend, but raised “real safety concerns” when doors failed to open promptly, delaying rescue efforts after accidents, said Nanyang Technological University associate professor Lyu Chen.

“A door handle may seem simple, but it becomes safety-critical in the seconds after a crash,” Chen said.

Chinese carmaker Xiaomi faced intense scrutiny following two fatal crashes in 2025 involving its SU7 model, when suspected electrical failures allegedly trapped occupants.

One of the incidents took place on a highway in Tongling city, eastern China, killing three people, according to regional news coverage cited by state-controlled media Global Times.

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Relatives of the victims said the passengers were stuck in the car as the vehicle’s doors could not be unlocked after the collision, the outlet said.

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HMC Capital Limited 2026 Q4 – Results – Earnings Call Presentation (OTCMKTS:HMCLF) 2026-08-25

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OneWater Marine Inc. (ONEW) Q1 2026 Earnings Call Transcript

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Seeking Alpha’s transcripts team is responsible for the development of all of our transcript-related projects. We currently publish thousands of quarterly earnings calls per quarter on our site and are continuing to grow and expand our coverage. The purpose of this profile is to allow us to share with our readers new transcript-related developments. Thanks, SA Transcripts Team

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Back to school: How to save on uniform costs

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A composite image of the front pages of the Daily Star and the Guardian on 26 August 2026

Parents can cheaply stock up on frequent-wear items with supermarket bundle deals, while the charity Family Action suggested they team up to bulk buy items that would otherwise take them over budget.

According to research from the bank Nationwide, a third of parents said they buy uniform from supermarkets, a third shop around for the best value and 23% purchase larger sizes so items last longer.

Kate Steere, parent and consumer editor at the comparison site Finder, said sports kit costs can be “brutal”.

“I always encourage parents to tap into their club’s community. Families with older kids are usually eager to pass down gear,” she said.

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“My boys’ football team runs a summer sale for second-hand kit, and apps like Vinted or Facebook Marketplace are goldmines.”

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Inflation result puts rate rise on the table

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Inflation result puts rate rise on the table

Despite headline inflation falling to 3.5 per cent – the lowest level since November – an above-expectations result adds to the case for more rate hikes.

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Sale of SeaLink Rottnest ferry service scrapped

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Sale of SeaLink Rottnest ferry service scrapped

The planned $15 million sale of the SeaLink Rottnest ferry service to the owner of the competing Rottnest Express service has been cancelled after coming under ACCC scrutiny.

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Motorcycle Holdings FY2026 slides: profit surges 43%, margin expansion

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Motorcycle Holdings FY2026 slides: profit surges 43%, margin expansion

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Dolly Parton’s remarkable legacy of giving extends far beyond music

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Dolly Parton’s remarkable legacy of giving extends far beyond music

Country music icon Dolly Parton, who died Tuesday in Nashville, spent decades turning her success into support for children, medical research and communities recovering from disasters.

One of Parton’s best-known philanthropic efforts, Dolly Parton’s Imagination Library, has distributed more than 332 million free books since its founding, according to the organization’s website.

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The program mails free books each month to children from birth to age 5. It launched in Sevier County, Tennessee – where Parton was raised – in 1995, expanded nationally in 2000 and later reached several other countries.

“The seeds of these dreams are often found in books and the seeds you help plant in your community can grow across the world,” Parton said, according to the organization’s website.

DOLLY PARTON $650 MILLION EMPIRE: FROM HUMBLE ROOTS TO QUEEN OF COUNTRY MUSIC, MOVIES AND NOW MAKEUP

Dolly Parton

Dolly Parton’s free book gifting program has distributed more than 332 million free books since its founding. (Jason Kempin/Getty Images)

The Imagination Library is the signature program of the Dollywood Foundation, which Parton established in 1988 to improve educational outcomes in Sevier County. 

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The foundation initially focused on reducing the local high school dropout rate before expanding its mission to promote childhood literacy.

Parton’s giving extended well beyond education.

After wildfires destroyed the homes of more than 1,000 Sevier County families in 2016, Parton asked the foundation to create the My People Fund.

The fund provided affected families with $1,000 per month for six months. By May 2017, it had raised and distributed more than $12 million. Additional money funded one-time scholarships for high school seniors who lost their homes, according to the Imagination Library.

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CITY HARVEST FEEDS 1.5M NEW YORKERS AS CELEBRITIES, CHEFS RALLY FOR HUNGER RELIEF

Dolly Parton's Mountain Magic Christmas

Dolly Parton established the Dollywood Foundation in 1988 to improve educational outcomes in her childhood home of Sevier County, Tennessee. (Katherine Bomboy/NBC via Getty Images)

Parton also contributed millions of dollars to medical research.

In 2020, she donated $1 million to Vanderbilt University Medical Center in Nashville to support COVID-19 research, according to BBC News

In 2022, she contributed another $1 million for pediatric infectious disease research at Vanderbilt University Medical Center, according to the Vanderbilt Health website. That same year, Parton received the Carnegie Medal of Philanthropy.

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In the aftermath of Hurricane Helene in 2024, Parton donated $1 million to the Mountain Ways Foundation to help flood victims. Several of her East Tennessee businesses and the Dollywood Foundation pledged to match her gift with another $1 million, according to an announcement at the time from the Mountain Ways Foundation.

` FINANCIER MICHAEL MILKEN REVEALS THE TRUE ESSENCE OF AMERICAN DREAM ISN’T MATERIAL WEALTH

Dollywood

Parton received the Carnegie Medal of Philanthropy in 2022 for her decades of charitable work. (Ron Davis/Getty Images)

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“We believe that her many philanthropic achievements embody the values of our founder, who, with us, would surely greet Parton with ‘affection, gratitude, and admiration,’” the nonprofit stated at the time.

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Parton died in Nashville, Tennessee on Tuesday, according to a press release obtained by Fox News Digital. 

Her nephew revealed the news in an Aug. 25 Instagram video. The news comes after Parton spent months battling an unknown health issue.

Fox News Digital’s Christina Dugan Ramirez contributed to this report.

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Disney offers early retirement to executives ahead of restructuring

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Disney offers early retirement to executives ahead of restructuring

Disney is moving forward with a program allowing longtime employees in certain roles the opportunity to accept an early retirement package ahead of anticipated restructuring.

The entertainment giant outlined the voluntary early retirement offer (VERO) available to tenured executives who meet eligibility criteria in an internal email sent by Disney Chief People Officer Sonia Coleman, which was reviewed by FOX Business. The early retirement program was first reported by Deadline.

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Coleman’s note said that the voluntary early retirement packages are time-limited and are one of several actions Disney is taking to restructure the organization, including involuntary staff reductions that are underway in some parts of the company and are expected to continue into next year.

Disney’s memo said the eligibility criteria for executives and indicated that they will receive separate, personalized communications from the company that specify details of the offer, the election process, important dates and other resources that will be available to them as they weigh their decision.

DISNEY REPORTEDLY LAYS OFF HUNDREDS OF EMPLOYEES, PIXAR HIT HARD DESPITE BLOCKBUSTER SUCCESS

Disney headquarters

Disney is offering certain executives with at least 10 years of service the opportunity to take a voluntary early retirement package amid restructuring. (AaronP/Bauer-Griffin/GC Images)

To be eligible for the voluntary early retirement package, employees must be based in the U.S. in roles ranging from director to executive vice president in Disney Entertainment, ESPN and the corporate divisions. They must also have 65 points – calculated based on their age plus years of service – with a minimum age of 50 and at least 10 years of service.

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Disney’s offer includes separation pay, continued vesting of equity awards, healthcare support at active employee rates, as well as continued Silver Pass access.

Eligible executives will be given a defined election window followed by a confirmation period so they have an opportunity to consider whether accepting the VERO is the right decision for them. Participation is voluntary and eligible executives aren’t required to opt in to the early retirement plan.

DISNEY SPOTLIGHTS AMERICAN BUSINESSES POWERING ITS MAGIC IN NATION’S 250TH YEAR

Ticker Security Last Change Change %
DIS THE WALT DISNEY CO. 111.25 +0.64 +0.58%

The company’s intent with the voluntary retirement program is to give eligible employees a chance to make a decision on their own terms before Disney proceeds with finalizing broader organizational decisions.

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The voluntary early retirement offer is time-limited, and once it closes, the company will continue moving forward with addressing organizational needs through its standard reduction-in-force process that will be on a separate timeline.

DISNEY CEO UNVEILS ENTERTAINMENT GIANT’S NEW 3-PILLAR GROWTH PLAN

Josh D'Amaro speaks on stage during South by Southwest.

Disney CEO Josh D’Amaro previewed workforce reductions in a shareholder letter earlier this month. (Adam Kissick/SXSW Conference & Festivals via Getty Images)

Earlier this month, Disney CEO Josh D’Amaro and CFO Hugh Johnston said in a letter to shareholders that they “remain highly focused on reducing costs across the enterprise to create incremental capacity for growth and are evaluating a variety of levers, including reductions in labor and SG&A.”

They added at the time that they were “mid-stream in this work” and would provide future updates.

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Chrysler recalls nearly 75K Dodge Durango SUVs over loose spoilers

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Chrysler recalls nearly 75K Dodge Durango SUVs over loose spoilers

Chrysler has recalled nearly 75,000 SUVs over a manufacturing defect that could cause certain parts to break loose while driving, creating unexpected road hazards and significantly increasing the risk of a crash, according to federal regulators. 

Nearly 74,578 Dodge Durango vehicles from the 2021-2023 model years are affected by the recall, which was submitted to regulators on Aug. 13, the National Highway Traffic Safety Administration (NHTSA) said.

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According to the recall notice, the vehicles may have rear spoilers that were improperly aligned during installation, causing the spoiler to strike the vehicle’s roof whenever the liftgate opens and closes. Over time, the impact can weaken the spoiler’s structural integrity and cause it to detach while the vehicle is in motion.

“Rear spoilers which detach from a vehicle may create road debris and increase the risk of a vehicle crash,” the notice said. 

TESLA FILES PLANS FOR PROPOSED $10.1B TEXAS SOLAR MANUFACTURING PLANT

spoiler on brown suv

A brown Dodge Durango SUV is shown with a rear spoiler attached to its liftgate. (AFP PHOTO/Stan HONDA / Getty Images)

Regulators said the safety defect was previously addressed under two recall campaigns filed in 2021 and 2023 but warned that owners must return for additional repairs due to persistent issues.

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The affected vehicles were manufactured between July 13, 2020, and March 28, 2023. 

Approximately 0.8% of the recalled vehicles are estimated to contain the defect. No crashes or injuries have been reported. 

MORE THAN 20,000 OFF-ROAD MOTORCYCLES RECALLED OVER DANGEROUS BRAKE DEFECT THAT COULD LEAD TO DEATH

Chrysler, Dodge, Jeep, and Ram showroom

Cars are parked outside a Chrysler, Dodge, Jeep, and Ram showroom in New York. (Deb Cohn-Orbach/UCG/Universal Images Group / Getty Images)

As of July 29, 2026, Chrysler reportedly identified 116 warranty claims, eight customer assistance records and 37 other service reports related to post-remedy failures. 

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The final, permanent technical repair is currently under development by Chrysler, according to officials.

Ticker Security Last Change Change %
STLA STELLANTIS NV 5.26 +0.04 +0.77%

Dealers were formally notified on Aug. 20, and searchable vehicle identification numbers became available on NHTSA.gov the same day, officials said.

Owner notification letters are scheduled to begin mailing on Sept. 10, 2026.

chrysler dealership

The Chrysler logo is displayed on the service department at a Chrysler Jeep and Dodge dealership on May 2, 2011, in Vallejo, California. (Justin Sullivan / Getty Images)

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Owners can contact Chrysler customer service at 1-800-853-1403 or the NHTSA Vehicle Safety Hotline at 1-888-327-4236. 

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