Southeast Asia is quietly emerging as one of the most dynamic frontiers in RNA interference (RNAi) biotechnology, as governments, academic institutions, and pharmaceutical companies converge on a technology once confined to Western research labs

Key takeaways

• Southeast Asia’s RNAi technology market, valued at USD 80.20 million in 2024, is set to grow at a striking 16.25% CAGR through 2033, driven by rising government support and expanding pharmaceutical R&D investment across the region.
• Singapore dominates the regional landscape, cementing its position as Asia’s premier precision medicine hub through landmark collaborations with global pharma giants including Alnylam, Bayer, Boehringer Ingelheim, and Novo Nordisk.
• siRNA leads all RNAi modalities as the most commercially mature technology, with breakthrough research, such as NUS Medicine’s lipid nanoparticle therapy for liver disease, underscoring its growing clinical and commercial relevance across Southeast Asia.

 A new industry analysis covering the period through 2033 paints a striking picture of accelerating momentum, and the numbers are hard to ignore.

According to a comprehensive market report published by UnivDatos Market Insights, the Southeast Asia RNAi Technology Market was valued at approximately USD 80.20 million in 2024 and is projected to expand at a compound annual growth rate (CAGR) of roughly 16.25% through 2033. That trajectory, driven by a confluence of government policy, academic-industry collaboration, and surging demand for precision medicine, would place the region firmly on the global map for RNA-based therapeutics and research services.

What Is RNAi, and Why Does It Matter?

RNA interference is a gene-silencing mechanism that enables scientists to selectively suppress the activity of specific genes using short interfering molecules. In practical terms, it offers researchers a molecular scalpel: the ability to turn off disease-causing genes with extraordinary precision. Since its discovery earned a Nobel Prize in 2006, RNAi has moved steadily from the laboratory bench toward clinical application, finding use in drug discovery, rare disease treatment, oncology, and metabolic disorder research.

In Southeast Asia, the technology is gaining traction precisely because it shortens drug development timelines, reduces the cost of target validation, and integrates well with the outsourcing models increasingly favored by pharmaceutical companies seeking efficiency in a competitive global market.

siRNA Dominates the Market Landscape

Among the various RNAi modalities, which include short hairpin RNA (shRNA) and microRNA (miRNA), short interfering RNA, or siRNA, commands the largest share of the regional market. Its dominance reflects a straightforward reality: siRNA is the most clinically validated and commercially mature format, supported by established delivery systems and a proven track record in rare diseases, oncology, and metabolic conditions.

A noteworthy example of siRNA’s real-world potential emerged from Singapore in late 2025, when researchers at NUS Medicine announced a novel RNA-based therapy for metabolic dysfunction-associated steatohepatitis (MASH), a liver condition affecting approximately 25% of people globally and up to 40% of adults in Singapore. The team used lipid nanoparticles to deliver siRNA directly into liver cells, where it silenced a gene called SPTLC2 that drives the accumulation of ceramides, fat-like molecules linked to liver inflammation and fibrosis. The breakthrough illustrated exactly the kind of translational research driving long-term commercial demand for siRNA tools across the region.

Pharma and Biotech Companies Lead Adoption

On the end-user side, pharmaceutical and biotechnology companies represent the dominant segment. Their strategy is clear: use RNAi technology to de-risk drug targets before committing to expensive clinical investment, thereby improving development efficiency and pipeline diversity. Southeast Asia’s pharma companies are increasingly outsourcing RNAi-based discovery efforts, a trend that is catalyzing the growth of specialized service providers and contract development and manufacturing organizations (CDMOs) throughout the region.

A notable example of this dynamic came in April 2025, when GenScript Biotech Corporation, a global leader in biotechnology research services, announced a strategic partnership with NSG Bio, Singapore’s premier biotech incubator. Under the agreement, GenScript committed to offering preferential rates and expert technical guidance across its full range of biotech services to incubator residents, a direct investment in the kind of early-stage ecosystem that feeds long-term RNAi adoption.

Singapore: The Undisputed Regional Hub

If there is one country that defines Southeast Asia’s RNAi ambitions, it is Singapore. The city-state’s combination of world-class intellectual property protections, a proactive government, deep life-science infrastructure, and proximity to global pharmaceutical leaders has made it the region’s dominant commercialization hub for RNA technologies.

The most striking signal of Singapore’s position came in December 2025, when Precision Health Research, Singapore (PRECISE) announced a landmark collaboration with four global pharmaceutical giants, Alnylam, Bayer, Boehringer Ingelheim, and Novo Nordisk, under Phase II of Singapore’s National Precision Medicine (NPM) programme. The initiative marked Singapore as the first country in Asia to establish a pre-competitive collaboration with leading pharmaceutical companies, effectively setting the blueprint for how precision medicine ecosystems should be built in the region.

Thermo Fisher Scientific’s parallel investment reinforced the picture. In December 2025, the company announced an expansion of its bioprocessing capabilities across Asia, including a broadening of its existing Bioprocess Design Center in Singapore, offering bench-to-pilot scale bioprocessing, expert-led training, and technical collaboration to help companies scale early-stage processes toward sustainable biomanufacturing.

Vietnam: The Fastest-Growing Market to Watch

While Singapore commands today’s market, the report identifies Vietnam as the country expected to record the highest growth rate over the forecast period. Vietnam’s emergence reflects a broader pattern: as the biotech ecosystems of Indonesia, Thailand, the Philippines, and Malaysia continue to mature, RNAi adoption is spreading beyond the region’s established innovation hubs into markets characterized by rapidly improving lab infrastructure, growing research talent pipelines, and expanding government commitment to life sciences.

The Competitive Landscape

The Southeast Asia RNAi technology space features a mix of global giants and regional specialists. Key players operating in the market include GenScript, Integrated DNA Technologies (a Danaher Corporation subsidiary), Thermo Fisher Scientific, Merck KGaA, QIAGEN, Revvity, ABT Biomedical Solutions, and Bio Basic Asia Pacific. Their growth strategies span partnerships, new product launches, geographic expansions, and licensing agreements.

One example: in August 2025, Hongene Biotech Corporation, a CDMO focused on nucleic acid therapeutics, secured a non-exclusive licensing agreement with UMass Chan Medical School to produce and supply extended nucleic acid (exNA) monomers and modified oligonucleotides for research use. The deal expanded access to innovative oligonucleotide technologies for both academic and biopharmaceutical researchers working on RNAi, antisense oligonucleotides, CRISPR guides, and related modalities.

Challenges Ahead

The road to full regional maturity is not without obstacles. The report identifies limited local RNAi manufacturing capacity, the high cost of advanced tools, a shortage of specialists trained in RNA technologies, and uneven regulatory frameworks across countries as the principal headwinds. Regulatory complexity for RNA-based therapeutics remains particularly challenging: each Southeast Asian market brings its own approval pathways, complicating the commercialization strategies of companies seeking regional scale.

Uneven adoption is perhaps the most structural challenge. While Singapore and, increasingly, Malaysia and Vietnam are building the institutional and industrial scaffolding for serious RNAi development, other markets in the region are earlier in that journey. Bridging that gap will require sustained policy commitment, cross-border talent development, and deeper integration between academic research and commercial application.

The Bigger Picture

What the Southeast Asia RNAi market ultimately represents is a test of whether the region can convert scientific ambition into durable biotechnology competitiveness. The ingredients are increasingly in place: government support is growing, global companies are expanding their regional footprint, and breakthrough research, from Singapore’s liver disease therapy to the continent-wide precision medicine collaborations, is generating the kind of proof points that attract further investment.

At a 16.25% annual growth rate, the sector is expanding nearly twice as fast as the broader global healthcare market. For investors, researchers, and policymakers with a view toward the next decade of biomedical innovation, Southeast Asia’s RNAi story has only just begun

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Shares of Mukesh Ambani-led Reliance Industries declined over a per cent to their day’s low of Rs 1,311 on the NSE on Monday after it reported a 13% year-on-year decline in consolidated net profit at Rs 16,971 crore for the fourth quarter of FY26, compared with Rs 19,407 crore in the same period last year.

Revenue from operations during the quarter rose 13% YoY to Rs 2.98 lakh crore. On a sequential basis, profit slipped 8% from Rs 18,645 crore reported in the December quarter. Operating performance remained largely flat, with EBITDA easing 0.3% YoY to Rs 48,588 crore. EBITDA margin declined 200 basis points from the year-ago period to 14.9%.

Jio Platforms delivered a strong quarter, with operating revenue rising 13% YoY to Rs 44,928 crore. Reliance Retail posted a marginal increase in profitability for the March quarter. Net profit rose 0.5% YoY to Rs 3,563 crore, while revenue from operations climbed 11% to Rs 87,344 crore.

The O2C business reported mixed trends in Q4. Revenue increased 12% YoY to Rs 1.84 lakh crore, while EBITDA fell 4% to Rs 14,520 crore. The oil and gas segment had a weaker quarter, with revenue declining 9% YoY to Rs 5,867 crore. EBITDA dropped 18% to Rs 4,195 crore. JioStar reported strong performance, with revenue of Rs 9,784 crore and EBITDA, including other income, of Rs 827 crore.

Reliance Industries share: Should you buy, sell or hold?

Morgan Stanley has maintained its Overweight rating on Reliance Industries with an unchanged target price of Rs 1,803, implying an upside potential of 35%. The brokerage said earnings were largely in line, though EBITDA was slightly below expectations due to higher upstream costs. It highlighted strong retail growth led by quick commerce and FMCG, while O2C margins remained weaker than peers but were improving due to better crude sourcing trends. Morgan Stanley added that chemicals and fuel markets are showing early signs of recovery.

The brokerage noted that capex remains elevated with a focus on new energy. It said any rerating in the stock would depend on margin improvement across segments and continues to view Reliance as a top pick, with recovery in the energy and retail businesses seen as key triggers.
Goldman Sachs has maintained its Buy rating on Reliance Industries with an unchanged target price of Rs 1,910. The brokerage said Q4 EBITDA missed estimates mainly due to weaker O2C margin capture, as high crude premiums and elevated logistics costs offset the benefit of strong product cracks. It noted that the petrochemical business delivered mixed performance, with pressure continuing in the naphtha chain. However, Goldman Sachs expects sequential margin recovery in the coming quarters.The brokerage added that retail growth remained strong, although margins were impacted by quick commerce. It believes Reliance’s integrated business model is well placed to benefit from a tightening downstream environment, with earnings recovery likely to be driven by normalisation in refining and chemicals.

Motilal Oswal Financial Services has maintained its Buy rating on Reliance Industries while reducing the target price to Rs 1,655, implying a potential upside of 25%. The brokerage has cut its FY27E EBITDA and PAT estimates by 3-4% due to challenges in the energy business and delays in tariff hikes at Jio. It expects Jio to remain the company’s biggest growth driver, with digital expected to contribute around 80% of Reliance’s incremental EBITDA. EBITDA is projected to grow at an 18% CAGR over FY26-28E, supported by an expected wireless tariff hike of around 15% in 2Q, market share gains in wireless, and continued expansion of Homes and Enterprise offerings.

It also expects Reliance Retail to deliver around 12% revenue CAGR over FY26-28E, driven by store additions, better productivity, and the scale-up of hyper-local offerings. However, it noted that faster growth in lower-margin businesses could weigh on blended EBITDA margins.

Elara Capital has upgraded Reliance Industries to Buy while revising its target price downward to Rs 1,619. The brokerage said weak O2C margin capture weighed on performance despite strong product cracks. It noted that the digital and retail businesses continue to provide steady growth support, though retail margins remain under pressure due to ongoing investments. At the same time, the oil and gas and O2C segments continued to drag overall performance.

Elara Capital has cut its EPS estimates because of a weaker outlook for petrochemicals and retail. However, it believes the recent correction in the stock price has already factored in near-term headwinds. The brokerage sees upside potential led by normalisation in GRMs and sustained growth in the digital business.

(Disclaimer: Recommendations, suggestions, views and opinions given by the experts are their own. These do not represent the views of The Economic Times.)

Officers note ‘adverse landscape impacts’ but say project would help authority meet housing targets

Cheshire East planners are recommending approval for up to 85 homes in the open countryside at Nantwich despite acknowledging ‘the proposed development on this site would cause harm’.

Barratt David Wilson Homes has applied for outline permission for the dwellings, including 30 per cent affordable, together with landscaping, children’s play area and sustainable urban drainage on 6.39 hectares of agricultural land at London Road.

Cheshire East doesn’t have a five-year housing land supply, a significant material consideration which weighs in favour of permitting the development.

A report from a council planning officer to next week’s meeting of the strategic planning board, states: “The proposed development on this site would cause harm.

“There would be adverse landscape impacts on the character and appearance of the area due to the urbanising effect of the housing within the open countryside.

“There would also be a minor reduction in the Willaston, Wistaston, Nantwich, Crewe strategic green gap.

“However, these impacts could be appropriately managed and limited by securing appropriate details at the reserved matters stage.”

It adds: “Development of the site would result in the loss of ‘best and most versatile’ agricultural land.

“This does weigh in against the proposal but needs to be balanced against the prevalence of agricultural land in Cheshire East.”

Stapeley Parish Council has objected to the proposal citing several reasons why it should be refused.

These include the impact on highways and the loss of agricultural land and natural habitats.

Ward councillor John Priest has also raised concerns about highways.

Thirteen residents have objected for varying reasons including loss of open countryside, loss of strategic green gap and landscape, and visual impacts.

The planning officer’s report says there are a range of benefits that weigh in favour of the scheme.

It states: “The NPPF (national planning policy framework) attaches great importance to housing delivery that meets the needs which the proposal would help address.

“The construction of up to 85 homes, including 26 affordable units, is provided substantial weight.

“The application site is also adjacent to the settlement boundary of Nantwich, which is a key service centre, and will be accessible to all the various services in the area.”

It says the development would produce some economic benefits in terms of employment opportunities during the construction phase and direct and indirect benefits associated with additional household expenditure within the local economy.

The strategic planning board meeting takes place at 10.30am on Wednesday, April 29, at Macclesfield Town Hall.

To find all the planning applications, traffic diversions, road layout changes, alcohol licence applications and more in your community, visit the Public Notices Portal.

LOS ANGELES — Luka Doncic remains sidelined with a Grade 2 left hamstring strain but is progressing in his recovery, with Lakers insiders projecting a potential return in Game 1 or Game 2 of the Western Conference semifinals if the team advances past the Houston Rockets, according to multiple reports on Monday.

The Slovenian superstar has been out since suffering the injury on April 2 against the Oklahoma City Thunder. He has not played in the Lakers’ first-round playoff series, which stands at 3-0 in Los Angeles’ favor entering Game 4 on Sunday. Coach JJ Redick and team officials continue to describe Doncic’s status as “out indefinitely,” emphasizing caution with the partial muscle tear.

Medical experts note that Grade 2 hamstring strains typically require four to six weeks of recovery, sometimes longer for athletes with prior hamstring issues. At roughly 25 days since the injury as of April 27, Doncic has begun light on-court work and is ramping up his return-to-play progression, but no firm timeline has been set.

Injury Details and Recovery Progress

Doncic initially felt discomfort late in the first half against Oklahoma City and was removed after grabbing his leg. An MRI confirmed the Grade 2 strain, sidelining him for the remainder of the regular season and the early playoffs. He traveled to Europe for specialized regenerative treatments before returning to Los Angeles to continue rehab.

Recent updates show encouraging signs. Redick revealed Doncic is preparing to increase on-court activity soon, though the team is managing expectations. Lakers insider Jovan Buha and others suggest the goal is to have him ready for the second round against a likely opponent like Oklahoma City, giving him additional rest while the supporting cast closes out Houston.

Austin Reaves, dealing with his own oblique strain, is further along and listed as questionable for recent games, providing a clearer path for his return. Doncic’s situation requires more patience due to the hamstring’s vulnerability to re-injury.

Impact on Lakers’ Playoff Run

The Lakers have shown impressive depth without their star acquisition. LeBron James continues to lead the way with vintage performances, while role players have stepped up in a balanced attack. A 3-0 series lead against Houston demonstrates resilience, but coaches acknowledge the ceiling rises significantly with Doncic available.

A return in early May would align with a potential Game 1 or 2 of the next round. This timeline allows for proper healing while minimizing risk of setback. Rushing back too soon could sideline him longer, a lesson learned from past hamstring cases across the league.

Expert Opinions and Medical Outlook

Physical therapists and analysts caution against aggressive timelines for Grade 2 strains. The injury involves partial tearing of muscle fibers, requiring careful loading to avoid aggravation. Doncic’s history with lower-body issues adds extra precaution. Reports indicate he has looked strong in recent light sessions, but full basketball activity remains the next major step.

League insiders emphasize that the Lakers’ conservative approach prioritizes long-term health over short-term gains, especially with a potential deep playoff run ahead. If Los Angeles advances quickly, Doncic could gain valuable extra recovery time.

Fan and League Reaction

Supporters have mixed feelings — excitement over the team’s strong start without Doncic tempered by eagerness for his return. Social media buzzes with debates over optimal timing, with many urging patience to ensure he’s fully healthy for tougher matchups.

League-wide, the case highlights ongoing discussions about star availability in the playoffs and load management. Doncic’s acquisition represented a major shift for the Lakers’ championship aspirations, making his recovery a focal point of the postseason narrative.

What’s Next for Doncic and the Lakers

As the first-round series progresses, updates will come through official injury reports and coach comments. Game 4 offers another chance for the supporting cast to shine, potentially setting up a favorable second-round scenario. Doncic continues individualized work, with re-evaluations guiding the next phase of his progression.

The 27-year-old, acquired in a blockbuster move, averaged elite numbers before the injury. His playmaking, scoring and vision elevate the offense, making his return a game-changer regardless of when it occurs. For now, the focus remains on smart rehab and team momentum.

Doncic’s exact return date stays fluid, but the consensus points toward early May if the Lakers advance. Fans and analysts will monitor every update closely as the postseason unfolds. The organization’s measured approach suggests confidence in a strong comeback rather than a rushed one, positioning the Lakers for sustained success with their star back on the court.