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Pfizer (PFE) earnings Q4 2025

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Pfizer (PFE) earnings Q4 2025
Pfizer beats quarterly estimates despite Covid product decline, reaffirms modest outlook

Pfizer on Tuesday reported fourth-quarter results that topped estimates even amid dwindling demand for its Covid products, while reaffirming its modest 2026 guidance that rattled investors in December.

The pharmaceutical giant is looking to longer-term investments in its pipeline, including its $10 billion acquisition of the obesity biotech Metsera, to counter waning Covid product sales and declines from older drugs. Pfizer moved to show the promise of that investment Tuesday, when it also reported mid-stage data showing that an obesity injection from Metsera can be taken once a month and drive solid weight loss.

In addition, Pfizer is on track to cut costs by about $7.7 billion by the end of 2027 as part of two separate initiatives.

Here’s what the company reported for the fourth quarter compared with what Wall Street was expecting, based on a survey of analysts by LSEG: 

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  • Earnings per share: 66 cents adjusted vs. 57 cents expected
  • Revenue: $17.56 billion vs. $16.95 billion expected

Pfizer reported revenue of $17.56 billion for the fourth quarter, down around 1% from the same period a year ago. That is largely because of lower demand for its Covid vaccine and Paxlovid, an antiviral pill for the virus.

The company booked a net loss of $1.65 billion, or 29 cents per share. That compares with net income of $410 million, or 7 cents per share, during the same period a year ago.

Excluding certain items, including restructuring charges and costs associated with intangible assets, the company posted earnings per share of 66 cents for the quarter.

Pfizer expects 2026 adjusted profit to come in between $2.80 and $3 per share, and revenue to total $59.5 billion to $62.5 billion. Those sales would largely be flat compared with 2025 revenue.

Pfizer previously said the lackluster revenue outlook comes in part from declining sales of its Covid vaccine and antiviral pill Paxlovid, which it expects to fall by about $1.5 billion year over year to $5 billion. 

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The company also pointed to another roughly $1.5 billion year-over-year expected drop in sales due to certain products losing their market exclusivity. Some blockbuster drugs, such as the company’s pneumonia vaccine Prevnar, are facing more competition from rivals.

More CNBC health coverage

In December, Pfizer CFO Dave Denton told investors there is also “price compression and margin compression baked into” the company’s 2026 guidance as it plans to provide “deeper discounts” in its Medicaid business as part of a landmark drug pricing deal struck with President Donald Trump

Under that agreement, Pfizer agreed to sell its existing drugs to Medicaid patients at the lowest price offered in other developed countries and guarantee the same “most-favored-nation” pricing on its new drugs for Medicare, Medicaid and commercial payers. In return, the company will get a three-year exemption from tariffs. 

Pfizer’s Xeljanz and Xeljanz XR, treatments for rheumatoid arthritis and other inflammatory conditions, were selected in January for the third round of Medicare drug price negotiations. New negotiated prices will come into effect in 2028. 

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Perdaman progresses 50MW solar farm near Karratha

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Perdaman progresses 50MW solar farm near Karratha

A Perdaman-backed solar farm looks set to become the foundation tenant of a traditional owner-backed green energy park near Karratha.

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Vacant Perth lot earmarked for office, dwellings in $10m plan

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Vacant Perth lot earmarked for office, dwellings in $10m plan

A vacant strip of land in Northbridge has been earmarked for an eight-storey office and apartment building.

Skypacts Property Resources has submitted a $10 million plan to build a mixed-use development on 441 William Street.

The 508-square metre lot, currently an unoccupied infill site, sits next to the Perth Mosque and is bound by William Street and Brisbane Place.

According to Skypacts’ application filed with the City of Vincent, the proposed development comprises offices and associated parking from the first to the fourth floor, and nine apartments across the upper levels.

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Lateral Planning, on behalf of Skypacts, said the project would be a high-quality development on an underutilised infill site.

“Overall, the proposed development will not detract from the amenity of the area rather, it will significantly enhance it,” the application said. 

“It represents a positive, forward-looking contribution to the locality, by supporting strategic planning goals, and promoting sustainable urban growth.”

RP data shows Skypacts bought the site for about $2.5 million in 2022.

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Skypacts Property Resources is owned by Kian Kiong Lee and has a registered address in Nedlands, according to an Australian Securities and Investments Commission document.

About 600 metres away, another vacant Northbridge lot was flagged for development.

A 480-square metre site at 195 Beaufort Street, next to the Ellington Jazz Club, has been vacant for about 20 years.

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In May 2024, a development assessment panel approved a $2.4 million proposal to build a four-storey apartment and retail project on the site.

However, the site, with the attached development application approval, was recently listed on the market.

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Ford and Geely in talks for manufacturing, technology partnership, sources say

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Ford and Geely in talks for manufacturing, technology partnership, sources say


Ford and Geely in talks for manufacturing, technology partnership, sources say

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Analysis: Fiscal realities rein in US’s aggressive Nordic ambitions

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Analysis: Fiscal realities rein in US’s aggressive Nordic ambitions

ANALYSIS: The negative response of financial markets dissuaded the US president from pursuing his designs on Greenland.

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Pinterest sacks engineers for tracking layoffs

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Pinterest sacks engineers for tracking layoffs

The social media platform announced last week that it was laying off around 15% of its workforce.

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Brokerages May Start Charging ETF Issuers Distribution Fees, Says J.P. Morgan

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Brokerages May Start Charging ETF Issuers Distribution Fees, Says J.P. Morgan

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Analysis-Ultra-low bond spread unity still out of reach for euro area

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Analysis-Ultra-low bond spread unity still out of reach for euro area


Analysis-Ultra-low bond spread unity still out of reach for euro area

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Opinion: Net downside in fishing bans

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Opinion: Net downside in fishing bans

OPINION: The state government may have hooked itself with what looked like an easy political decision.

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Airbnb: Hotel Expansion Is Promising, But The Valuation Leaves Little Room For Error

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Airbnb: Hotel Expansion Is Promising, But The Valuation Leaves Little Room For Error

Airbnb: Hotel Expansion Is Promising, But The Valuation Leaves Little Room For Error

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Voters concerned about affordability of homeownership, new poll shows

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Voters concerned about affordability of homeownership, new poll shows

American voters are concerned about being able to afford homeownership amid high housing costs as the electorate prepares to cast ballots in this fall’s midterm elections, a new poll shows.

A poll conducted for the National Association of Realtors by Public Opinion Strategies and Hart Research showed that over half of voters (52%) say that the affordability of housing is a very important voting issue to them.

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Sentiment around the housing market remains at a historically low level, as the poll shows that just 17% of voters think now is a good time to buy a home – down from 69% in 2013.

Despite the headwinds affecting housing affordability, homeownership remains a key part of what voters view as the American dream, with 85% calling it an essential part of the American dream, an increase from 79% in 2013 with strong support across political groups.

EFFORTS TO REIN IN WALL STREET LANDLORDS COULD PUSH US HOME PRICES UP, INVESTORS SAY

A California home is up for sale.

Homeownership remains a key part of how voters view the American dream, the NAR poll showed. (Loren Elliott/Bloomberg via Getty Images)

Renters and other non-homeowners expressed concerns about never being able to afford homeownership, with 76% of that group expressing the belief that they will never be able to afford buying a home and 59% saying they want to buy but lack affordable options in their community.

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In contrast, just 27% of all voters were concerned about never being able to afford to buy a home and only 21% cited a lack of affordable options in their community as a barrier.

Homeowners in the survey were asked about reasons that are keeping them from moving, with 35% saying their current mortgage rate is low, and they can’t afford a higher rate. 

Additionally, 30% said they would like to buy another home but lack affordable options in their community, while 16% said they would like to sell but can’t afford the taxes from the profit on the sale.

TRUMP SAYS HE’S ‘NOT A HUGE FAN’ OF 401(K) WITHDRAWAL PLAN FOR HOMEBUYERS’ DOWN PAYMENTS

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Home with a "for sale" sign

Voters cited a lack of affordable homes as a key barrier to homeownership. (iStock/Getty Images Plus)

Voters across political groups generally said that federal government policies make it harder to buy a home, with majorities of Democrats (56%) and Independents (53%) along with a plurality of Republicans (41%) expressing that sentiment.

The NAR poll also gauged respondents’ views of several congressional proposals aimed at improving housing affordability.

More than four-fifths of all voters, 84%, expressed support for letting prospective home buyers save money tax-free that can be used to buy a home, with over 80% of all political groups.

Over three-fourths of voters, 76%, backed a proposal to provide a one-time option to sell your home without paying taxes on the profit. That idea was most strongly backed by Republicans (87%) and saw some skepticism among Democrats (65%).

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HOUSING EXPERT WARNS PRE-PANDEMIC AFFORDABILITY LEVELS MAY NEVER RETURN IN AMERICA

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NAR’s poll asked voters about proposals aimed at making housing more affordable. (Mandel Ngan/AFP via Getty Images)

A similar proposal that would increase the amount of profit that sellers can take before having to pay taxes was backed by two-thirds (67%) of voters, with Republicans (78%) and Independents (66%) viewing the idea more favorably than Democrats (58%).

Providing tax incentives requiring building developers to provide affordable rentals for low-income households was backed by 71% of voters, with Democrats more bullish on the idea (90% support) than Republicans (53%).

Incentivizing home rental investors to sell homes to first-time home buyers was backed by 71% of voters, with similar levels of support across political groups. 

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NAR and its polling firm partners then asked voters whether Congress passing those proposals would make it easier to buy or sell a home, and 64% of respondents said that it would, compared to the 9% who think current federal policies make it easier to buy or sell a home.

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