Follow Daily Mail Sport’s live coverage of the latest updates as the two favourites France and Spain go head-to-head in Dallas for a spot in the World Cup final.
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France vs Spain – World Cup semi-final LIVE: European rivals reignite rivalry in bid to reach final
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AOC calls out Susan Collins’ claims about ICE after deadly Maine shooting of innocent man: ‘Wrote the blank check’
Rep. Alexandria Ocasio-Cortez (D-N.Y.) pushed back on claims by Sen. Susan Collins (R-Maine) that she included safeguards for Immigration and Customs Enforcement after ICE shot and killed a man in Biddeford on Monday.
She was speaking after ICE shot and killed Joan Sebastian Guerrero shortly after 7 a.m in Biddeford. Guerrero was authorized to work in the United States. Witnesses to the shooting said that a distressed family yelled “you took her dad” alongside a child who “couldn’t have been older than three” still in her Bluey pajamas, the Portland Press Herald reported on Monday.
The shooting comes as Collins faces a difficult re-election in Maine, a state that voted for Kamala Harris. Many of the Democrats who are running in the mini-primary to replace scandal-plagued Graham Platner excoriated Collins, who is chairwoman of the Senate Appropriations Committee and therefore writes the budget for ICE.
“Senator Collins wrote the blank check to allow these officers to conduct themselves in the way that they have in Maine in the first place, and she’s the one who’s poured resources into it,” Ocasio-Cortez told The Independent. “And just because now that there’s live footage of the atrocities that she has enabled, doesn’t make it better than preventing them from happening in the first place.”
Specifically, Democrats criticized her for voting to give ICE and Customs and Border Protection $70 billion earlier this year.
Collins did so on a party-line vote after a months-long shutdown of the Department of Homeland Security. Democrats and Republicans voted for a bill to fund all of Homeland Security except for ICE and CBP. Republicans then voted on a separate party-line bill to fund ICE and CBP. This came after an ICE official shot and killed Renee Good and CBP officials shot and killed another protester, Alex Pretti, in Minneapolis.
In response, ICE reportedly said it would temporarily halt traffic stops of vehicles, according to an email obtained by The Atlantic.
“I discussed that possibility with the Secretary of Homeland Security and urged him to proceed with a halt in non-emergency vehicle stops,” Collins told The Independent when asked about it.
But Ocasio-Cortez criticized the fact that it took another killing for this to happen.
“I mean, they’re just trying to cover for the fact that what they are doing shouldn’t be allowable in the first place,” she told The Independent. “And the fact that they’re pausing it is to distract from the fact that in many of these instances they shouldn’t be allowed to do it in the first place.”
Collins said that ICE remained a necessity to investigate human trafficking, child exploitation, drug smuggling, weapons smuggling and international financial crimes, but there needed to be safeguards.
“So, I am also very eager to get the body-worn cameras out to all ICE officials, it should be mandatory,” she said. Collins then pointed out that she brokered a deal with Democratic Vice Chairwoman Patty Murray (D-Wash.) to include $20 million for body cameras for ICE, funneling $12.8 million to oversee money spent for President Donald Trump’s “One Big, Beautiful Bill” legislation and $20 million for independent oversight of ICE detention facilities.
Those provisions came in a stopgap spending bill after the killing of Good. But Democrats largely came out against funding the Department of Homeland Security after CBP officials killed Pretti.
Collins also lamented the shooting when The Independent asked what her message would be to the family of Guerrero.
“It appears to have been a horrible tragedy,” she said. “We don’t have all the facts yet, and that’s why the investigation, which is being conducted by the state attorney general’s office, by the FBI, and by the independent office of Inspector General out of Boston is so important, but it’s always a tragedy when someone is killed.”
Democrats and some Republicans criticized the fact that the federal government has not done a comprehensive probe into the killings of Pretti and Good. That ultimately led to the shutdown and the eventual resolution.
NewsBeat
Taco Bell under investigation over outbreak of ‘explosive diarrhea’ parasite
Health officials are investigating whether Taco Bell may be connected to an outbreak of a parasite that causes ‘explosive diarrhea’, according to a new report.
The fast-food chain has removed several fresh ingredients from some of its restaurants in the US following a possible connection to cyclosporiasis.
Thousands of cases of the intestinal illness have been reported in the US, as officials try to identify the source of the outbreak.
According to The Washington Post, state and federal investigators are examining Taco Bell after some people who became ill recently ate at the restaurant.
Last week, the Taco Bell locations in Michigan warned customers that lettuce, cilantro, onions, pico de gallo and guacamole were temporarily unavailable because of a nationwide recall.
A Taco Bell spokesperson said: ‘The health and safety of our guests is our top priority.
‘Public health officials have not confirmed a link to Taco Bell or any specific ingredient, supplier, restaurant or retailer.
‘While authorities continue their broader review, Taco Bell has voluntarily and temporarily removed limited ingredients at select restaurants as a precautionary measure.’
As the investigation continues, officials have explained that the outbreak is not believed to be confined to Taco Bell.
The illness, which is caused by the parasite Cyclospora, is believed to spread through food or water contaminated with human waste.
Symptoms can include watery diarrhoea, severe or ‘explosive’ bowel movements, stomach cramps, bloating, nausea, vomiting, fatigue and a low-grade fever.
So far, the US Centers for Disease Control and Prevention (CDC) has confirmed that there have been 843 cases across 31 states since May.
From this number, 86 people have been hospitalised with the real number of infections expected to be much higher.
In Michigan in particular, 3,309 cases have been reported compared to around 50 in a typical year.
Meanwhile, cases in Illinois, Virginia, Ohio and New York have also started to increase.
Dr Natasha Bagdasarian, the department’s chief medical executive, said in a statement: ‘Although we do not have a definite product identified as the source of the outbreak, we want to let Michiganders know what we have learned so far so they can take steps to protect their families.
‘Early information has shown lettuce as a common product that regularly comes up during the investigation.’
Officials are advising people to buy whole heads of lettuce instead of pre-packaged salad.
Most healthy people will recover from cyclosporiasis without treatment, although the illness can be prolonged and last several days or even more than a month
MORE: Thousands of UK women had ‘two periods in June’ — this is why
MORE: Government wasted £10,000,000,000 on PPE during Covid pandemic
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Teenagers to face overnight social media curfew and infinite scrolling shut-down
Andy Lulham, chief operating officer at online safety provider Verifymy, said the default setting for the overnight limit for 16 and 17-year-olds “will ask the most of platforms technically, since they’ll now need to identify and apply different rules to three distinct groups – the under-16s being banned from next spring, older adolescents, and adults with full, open access”.
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Pictured: Man, 34, whose body was found in a suitcase – after it was discovered in woods ‘by family taking part in teddy bear hunt’
A man whose body was found inside a suitcase by families taking part in a teddy bear hunt has been pictured for the first time.
Dale Mundell, 34, from Islington, was discovered inside the case that was reportedly covered in ‘hundreds of flies’ and left at Borstal Recreation Ground in Rochester, Kent.
Police had been alerted to a potential murder at an address on Kingfisher Court, off Queensmere Road, in Wimbledon at 10.55pm on Thursday.
Officers found nobody inside the property during the search but believed someone had been hurt at the scene and launched a murder investigation.
They later arrested Joshua Miller, 32, and Jamie Cooper, 27, who have since been charged.
Miller, 32, appeared via videolink to Medway Magistrates’ Court on Monday charged with the murder of Mr Mundell on July 8, and preventing a lawful burial on July 9.
He appeared alongside co-defendant Cooper, of the same address, who is charged with preventing a lawful burial on July 9.
The victim and the two suspects were known to each other, police previously said.
Dale Mundell, 34, from Islington, was discovered inside the case that was reportedly covered in ‘hundreds of flies’ and left in Borstal Recreation Ground in Rochester, Kent
Police are pictured at the scene on Friday following the discovery of the case that was reportedly covered in ‘hundreds of flies’
One resident, who wished to remain anonymous, was at the park attending a teddy bear hunt organised as a fundraiser for a local nursery when the suitcase was discovered.
She told KentOnline: ‘I saw the luggage before the police. I was with my niece and nephew, so I was busy keeping them from seeing it.
‘What I saw was the suitcase covered in hundreds of flies. I actually heard the buzzing from them first.
‘I noticed that it was a large suitcase and had a snow sledge next to it.’
Mr Mundell’s family are being supported by specialist officers.
Miller will next appear at Maidstone Crown Court on July 15.
Miller and Cooper will then both appear at the same court on August 10 for a plea hearing.
Detective Inspector Ben Dalloway, who is leading the investigation, previously said: ‘Our thoughts remain with the victim’s family who are understandably distraught at their loss.
‘We will continue to offer them every support.
‘This has been a fast-moving investigation and we are working tirelessly to establish the exact circumstances of the incident.
‘Although we have made two arrests and do not believe there is any wider risk to the public, we would ask that anyone with information comes forward to police as soon as possible by calling 101 with CAD 9504/9JUL.’
NewsBeat
Exhibition showing horrors of October 7 attacks on Israel is ‘the bucket of cold water people need over their heads’, says Boris Johnson
Boris Johnson has said an exhibition showing the horrors of the October 7 attacks is ‘the bucket of cold water people need’ – as he reiterated his support for Israel.
The former prime minister visited the Nova Exhibition on Tuesday, a memorial set up in Shoreditch to the 413 people killed by Hamas terrorists at the festival in 2023.
He called for people to visit the display as a ‘dose of reality’ and to understand what ‘really happened’ on October 7.
Mr Johnson also criticised Andy Burnham‘s pledge to impose sanctions on those ‘involved in the violence on Gaza’ and to implement ‘measures to ban trade in goods with illegal settlements’.
Speaking to the Daily Mail at the exhibition, Mr Johnson also paid tribute to Ann Widdecombe following her alleged murder last week at her home in Devon.
He said that the former prisons minister was a ‘great platform speaker’ who had ‘Tory audiences in the absolute palm of her hand’.
The October 7 attacks by Hamas-led militants killed nearly 1,200 people in Israel and saw 251 others taken hostage.
Boris Johnson has said an exhibition showing the horrors of the October 7 attacks is ‘the bucket of cold water people need’ – as he reiterated his support for Israel
The former prime minister visited the Nova Exhibition on Tuesday, a memorial set up in Shoreditch to the 413 people killed by Hamas terrorists at the festival in 2023
One of the exhibits is a burnt out car from the festival in 2023
Israel’s attacks have since killed more than 73,000 Palestinians, half of which are women and children, according to the Gaza health ministry.
Specifically, the Nova Exhibition – which has travelled around the world – is set up to commemorate Nova Festival goers who were killed in the October 7 attack.
Mr Johnson told the Mail: ‘People need to understand that the people who committed these massacres were motivated by an absolutely nihilistic ideology, that hates equality between sexes and hates the idea of people having fun at a music festival.
‘Hamas are Islamists – how can we support that?
‘How can nice, clever, sensible, young students in Britain, let alone the dons effectively support this ideology by backing them against Israel.’
He added: ‘What’s so odious about what Hamas did was that they knew by committing these atrocities, on that scale, being quite so barbarous.
‘The cruelty they elicited was enormous. They knew that by doing that they could trigger a violent response as well.
‘And then they could ratchet up their claim to martyrdom and the rest of it.’
The former prime minister criticised students joining pro-Palestine demonstrations and chanting ‘from the river to the sea’.
He said: ‘All these students out on the streets, saying from the river to the sea. Then what are they doing in the evening?
Mr Johnson speaks to people at the exhibition in Shoreditch on Tuesday
Rows upon rows of discarded shoes, trainers and sandals meanwhile are reminiscent of a scene from Auschwitz
‘They’re going off to discos exactly like the Nova Festival. They’re taking their clothes off.
‘They’re having fun. They’re expressing themselves in a way that Hamas finds repulsive, right?’
He also called anti-Semitism a ‘virus’ which hides ‘beneath the floorboards’ and is currently out in the open.
Singer Boy George and actor Martin Freeman were also looking around the Nova exhibition on Tuesday afternoon.
The display has run for six weeks in Shoreditch and visitors can experience the timeline of terror that took place at Nova.
Burned out cars, toilet cubicles riddled with bullet holes and abandoned camping gear are among the personal possessions, hairbrushes and half-eaten food items left behind by those who fled for their lives – and those that never returned.
Rows upon rows of discarded shoes, trainers and sandals meanwhile are reminiscent of a scene from Auschwitz inside a room filled with memorial candles and photographs of the young lives taken that day.
More than 40,000 people have visited the exhibition, including Mayor of London Sadiq Khan and senior government figures including Wes Streeting, David Lammy, and Angela Rayner.
NewsBeat
Sara Cox Vernon Kay and Clive Myrie among BBC’s highest-paid list
Horwich-born Vernon Kay, Bolton-born Clive Myrie and Little Lever’s Sara Cox all feature in the top 20 of the list of BBC stars who earned more than £178,000 during the financial year ending March 31, 2026.
Vernon Kay (Image: BBC)
Vernon Kay is the highest-paid of the trio, ranking joint fourth on the list with earnings of £405,000 to £409,999.
His salary increased from £390,000 to £394,999 the previous year.
The former Radio 1 presenter now hosts the mid-morning programme on BBC Radio 2 after taking over the slot previously held by Ken Bruce.
Clive Myrie
News presenter and Mastermind host Clive Myrie is listed in the £320,000 to £324,999 pay band, placing him joint 17th.
His earnings were down slightly from £335,000 to £339,999 in 2024/25.
Sara Cox, who grew up in Little Lever, also appears in the £320,000 to £324,999 pay band alongside Myrie.
The Radio 2 Drivetime presenter received a pay rise from £310,000 to £314,999 in the previous year.
Sara Cox (Image: Ian West/PA Wire)
The BBC publishes the salaries of presenters earning more than £178,000 each year as part of its annual report.
The figures cover staff paid directly by the corporation and do not include presenters employed through BBC Studios or independent production companies.
Former Radio 2 Breakfast Show presenter Scott Mills topped this year’s list with earnings of £745,000 to £749,999, followed by Radio 1’s Greg James and BBC Radio Ulster presenter Stephen Nolan.
Other familiar names in the top 20 include Laura Kuenssberg, Alan Shearer, Naga Munchetty, Fiona Bruce, Gary Lineker and Sophie Raworth.
Speaking ahead of the annual report’s release, deputy director-general Rhodri Talfan Davies said he felt there had been “remarkable progress” on salaries, claiming that talent above the £500,000 threshold had been reduced by 50% across the past seven years.
He said: “If you look at all our on-air presenter costs over the last seven years, they’ve come down by about £20 million pounds, so we have been focused on it, there is always a balancing act.
“We want to be a broadcaster that can attract the best talent, but we’re also very mindful of the financial pressures that we’re facing.
“But I think we’re striking that balance very, very carefully, and I think you’ll see that downward trend continuing in the months to come.”
The full list:
Here is a full list of BBC on-air pay above £178,000 for 2025/26, as published in the corporation’s annual report.
The list is ranked by pay band, starting with the highest.
The equivalent pay band for 2024/25 is shown in brackets, with a description of the year-on-year change.
The list does not include people who are paid through independent production companies or the BBC’s commercial arm BBC Studios.
1 Scott Mills £745,000-£749,999 (up from £355,000-£359,999)
2 Greg James £440,000-£444,999 (up from £425,000-£429,999)
3 Stephen Nolan £425,000-£429,999 (up from £405,000-£409,999)
4= Vernon Kay £405,000-£409,999 (up from £390,000-£394,999)
4= Laura Kuenssberg £405,000-£409,999 (up from £395,000-£399,999)
6 Alan Shearer £390,000-£394,999 (down from £440,000-£444,999)
7 Justin Webb £375,000-£379,999 (up from £365,000-£369,999)
8 Naga Munchetty £360,000-£364,999 (up from £355,000-£359,999)
9 Fiona Bruce £345,000-£349,999 (down from £410,000-£414,999)
10 Sophie Raworth £340,000-£344,999 (down from £350,000-£354,999)
11= Mark Chapman £335,000-£339,999 (up from £325,000-£329,999)
11= Nick Grimshaw £335,000-£339,999 (not listed in 2024/25)
13= Trevor Nelson £330,000-£334,999 (up from £245,000-£249,999)
13= Nick Robinson £330,000-£334,999 (down from £410,000-£414,999)
15= Reeta Chakrabarti £325,000-£329,999 (up from £300,000-£304,999)
15= Gary Lineker £325,000-£329,999 (down from £1,350,000-£1,354,999)
17= Sara Cox £320,000-£324,999 (up from £310,000-£314,999)
17= Clive Myrie £320,000-£324,999 (down from £335,000-£339,999)
17= Amol Rajan £320,000-£324,999 (up from £315,000-£319,999)
20 Anna Foster £315,000-£319,999 (not listed in 2024/25)
21= Emma Barnett £305,000-£309,999 (up from £285,000-£289,999)
21= Evan Davis £305,000-£309,999 (up from £300,000-£304,999)
23= Ros Atkins £300,000-£304,999 (up from £295,000-£299,999)
23= Tina Daheley £300,000-£304,999 (up from £295,000-£299,999)
25 Nicky Campbell £295,000-£299,999 (down from £300,000-£304,999)
26= Gabby Logan £290,000-£294,999 (not listed in 2024/25)
26= Jason Mohammad £290,000-£294,999 (up from £230,000-£234,999)
28 Chris Mason £275,000-£279,999 (up from £270,000-£274,999)
29= Victoria Derbyshire £270,000-£274,999 (down from £275,000-£279,999)
29= Jeremy Bowen £270,000-£274,999 (up from £260,000-£264,999)
29= Simon Jack £270,000-£274,999 (up from £225,000-£229,999)
32 Jeremy Vine £265,000-£269,999 (down from £310,000-£314,999)
33 Sarah Montague £255,000-£259,999 (up from £250,000-£254,999)
34 Jo Whiley £250,000-£254,999 (up from £230,000-£234,999)
35= Katya Adler £245,000-£249,999 (up from £240,000 -£244,999)
35= Sarah Smith £245,000-£249,999 (up from £230,000-£234,999)
37 Fergal Keane £240,000-£244,999 (up from £235,000-£239,999)
38= Faisal Islam £235,000-£239,999 (no change)
38= Lauren Laverne £235,000-£239,999 (not listed in 2024/25)
40= Matt Chorley £230,000-£234,999 (not listed in 2024/25)
40= Lyse Doucet £230,000-£234,999 (up from £205,000-£209,999)
40= Rick Edwards £230,000-£234,999 (down from £235,000-£239,999)
43= Jon Kay £225,000-£229,999 (down from £240,000-£244,999)
43= Johnathan Joseph £225,000-£229,999 (not listed in 2024/25)
45 Orla Guerin £220,000-£224,999 (up from £210,000-£214,999)
46= Rachel Burden £215,000-£219,999 (down from £220,000-£224,999)
46= Kelly Cates £215,000-£219,999 (not listed in 2024/25)
46= Katie Razzall £215,000-£219,999 (down from £220,000-£224,999)
49= Matthew Amroliwala £210,000-£214,999 (up from £200,000-£204,999
49= Ben Brown £210,000-£214,999 (up from £200,000-£204,999)
49= Paddy O’Connell £210,000-£214,999 (not listed in 2024/25)
49= Jonny Dymond £210,000-£214,999 (up from £205,000-£209,999)
53= Owain Wyn Evans £205,000-£209,999 (up from £195,000-£199,999)
53= Lucy Hockings £205,000-£209,999 (up from £200,000-£204,999)
53= Caitriona Perry £205,000-£209,999 (up from £185,000-£189,999)
53= John Simpson £205,000-£209,999 (up from £190,000-£194,999)
53= Sumi Somaskanda £205,000-£209,999 (up from £185,000-£189,999)
58= Maryam Moshiri £200,000-£204,999 (up from £195,000-£199,999)
58= Sally Nugent £200,000-£204,999 (no change)
60= Sally Bundock £195,000-£199,999 (up from £190,000-£194,999)
60= Christian Fraser £195,000-£199,999 (down from £205,000-£209,999)
60= Jane Hill £195,000-£199,999 (down from £200,000-£204,999)
60= Annita McVeigh £195,000-£199,999 (up from £190,000-£194,999)
60= Alex Scott £195,000-£199,999 (down from £205,000-£209,999)
65= Craig Charles £190,000-£194,999 (no change)
65= Steve Rosenberg £190,000-£194,999 (not listed in 2024/25)
65= Charlie Stayt £190,000-£194,999 (no change)
68= Adrian Chiles £185,000-£189,999 (not listed in 2024/25)
68= Michael Vaughan £185,000-£189,999 (not listed in 2024/25)
70 Steven Lai £178,000-£184,999 (no change)
NewsBeat
Wildfire breaks out in Mumbles as smoke seen for miles around
A large-scale emergency services response has been seen in the area on Tuesday evening
A huge fire has taken hold in Mumbles on Tuesday evening, prompting a large-scale emergency services response. Billowing smoke has been seen in the popular seaside area and from miles away this evening, as the fire service deals with the blaze.
South Wales Police confirmed it was a wildfire, which originated near Mumbles Cricket Club. Never miss a Swansea story by signing up to our newsletter here.
It said in a statement that there is currently no threat to the public, but advised the public to avoid the area.
A spokesman said: “At this moment the fire is not being treated as suspicious.”
County councillors for Mumbles, Angela O’Connor, Will Thomas and Hannah Williams thanked the emergency services for their efforts to bring the fire under control.
They said in a joint statement: “A huge thank you to our incredible firefighters and emergency services who responded so quickly to the fire along the cliff path this evening.
“Thankfully, it appears no one has been injured, and the fire is now almost completely out.
“Early indications suggest it was caused by natural factors.
“We are incredibly fortunate to have such dedicated crews who work tirelessly, often in difficult conditions, to keep our communities and our beautiful coastline safe. Thank you for everything you do.
“Please continue to avoid the affected area until it is declared safe by the emergency services.”
The fire service has been contacted for comment.
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NewsBeat
26 Teesworks jobs up for grabs – here’s how to apply
Teesworks, the vast industrial site on the former Redcar steelworks, is the UK’s largest freeport and industrial zone, sitting on 4,500 acres on the south bank of the River Tees.
The multibillion-pound regeneration project is turning Europe’s largest brownfield site into a hub for clean energy, advanced manufacturing, and low-carbon industry, with thousands of roles expected as more firms move in.
The latest 26 vacancies have been posted on the Teesworks jobs portal and span a wide range of careers in engineering, construction, project management, commercial, administration, finance, health and safety, and port operations.
Roles include junior site cost controller, junior structural engineer, work package engineer, civil and structural superintendent, welding repair specialist, assistant accountant, QA systems lead, and cost accountant, alongside site design coordinator, port operations supervisor, and materials controller.
There are also openings for construction and engineering leads, section engineers, sub-agents, welding engineers, package managers, assistant quantity surveyors, commissioning engineers, painting and insulation superintendents, completions leads, and other specialist posts linked to major projects on the site.
Many of the jobs are permanent, full-time positions based across Darlington, Hartlepool, Middlesbrough, Redcar and Cleveland, and Stockton, with competitive salaries and benefits highlighted in their job adverts.
Mayor Houchen said: “More investment means more opportunities for local people.
Mayor Ben Houchen at Teesworks (Image: SARAH CALDECOTT)
“There are currently 26 live vacancies advertised through Teesworks, with roles across engineering, construction, project management, commercial, administration, health and safety and more.
“Every new business that chooses to invest here creates more opportunities for local people to build a career close to home – and we’re seeing that happen right across the site.
“If you’re looking for your next role, or know someone who is, it’s well worth taking a look.
“More jobs. More investment. More opportunities for local people.”
You can have a look at teesworks.co.uk/jobs/jobs-careers
The mayor has repeatedly argued that the site will ultimately support tens of thousands of jobs across the region as more businesses choose to base themselves there.
Jobseekers are being encouraged to visit the Teesworks Jobs and Careers website to view the current vacancies.
You can also register with the Teesworks Skills Academy to receive alerts about new roles and training as they go live.
NewsBeat
‘Game-changer’ self-injectable drug that can slow Alzheimer’s progression by up to eight years is approved in US – and could soon be available on NHS
A self-injectable drug that slows Alzheimer’s progression by up to eight years has been approved in the US and could soon be available on the NHS.
The ‘game-changer’ jab is taken once a week and can be administered at home in just 15 seconds, sparing users the need to visit a hospital.
It was previously given via intravenous drip, which took an hour to infuse and placed a heavy burden on patients, medical staff and beds.
The drip version is available privately in the UK but drugs watchdog NICE ruled it should not be offered on the NHS as it did not offer value for money.
This was largely due to the resource-intensive delivery method, which could be hundreds of pounds a time, excluding the cost of the drug itself.
The US Food and Drug Administration today approved the use of the injectable version of lecanemab for the treatment of early Alzheimer’s disease, saying patients could go straight to jabs without needing to start on infusions.
It will be available to purchase in the US from next month.
Charities tonight said the development raises hopes that the drug would pass NICE’s affordability tests, paving the way for it to be offered on the NHS.
The US Food and Drug Administration today approved the use of the injectable version of lecanemab for the treatment of early Alzheimer’s disease.
Hilary Evans-Newton, chief executive of Alzheimer’s Research UK, said: ‘An injectable version of lecanemab from the start of treatment would be a game-changer in terms of convenience for people and affordability of administration for health services.
‘The UK is at risk of falling further behind as we continue to wrangle on the licensed treatments which are not currently available on the NHS.
‘The cost of IV infusions has been identified as one of the key barriers to cost effectiveness.
‘UK patients and their families are waiting for these advances to be available and the government needs to fulfil its manifesto commitment to put Britain at the forefront of transforming treatment for dementia.’
The UK regulator, the Medicines and Healthcare products Regulatory Agency (MHRA), is expected to follow the FDA’s ruling when they consider an application from Japanese drug maker Eisai.
A trial presented at an Alzheimer’s conference in December showed lecanemab could delay disease progression from mild cognitive impairment to moderate Alzheimer’s disease by 8.3 years among patients with low levels of amyloid protein in the brain and who started treatment at an early stage.
Mild cognitive impairment due to AD is the earliest symptomatic stage of Alzheimer’s disease and can appear with subtle symptoms such as forgetfulness, confusion, or feeling at a loss for words.
Announcing the FDA approval, Eisai said the weekly jab is expected to be as effective as the intravenous treatment and have a similar safety profile, while placing less of a ‘burden’ on healthcare systems.
Hilary Evans-Newton, chief executive of Alzheimer’s Research UK, said an injectable version of lecanemab from the start of treatment would be a ‘game-changer’.
It added that the new formulation was ‘highly preferred by patients’, with 97 per cent saying they were satisfied with it.
Users loved its speed, convenience and less painful administration, along with the ability to travel away from home and not be near a hospital.
Lecanemab represents a huge step forward in research because it targets a known cause of the disease, rather than just treating symptoms.
It binds to amyloid, a protein which builds up in the brains of people living with Alzheimer’s disease.
By binding to amyloid, the drugs are designed to help clear the build-up and slow down cognitive decline.
Dr Richard Oakley, associate director of research and innovation at Alzheimer’s Society, said people living with dementia are ‘desperate’ for new treatments that offer them more time before symptoms worsen.
But he cautioned: ‘The reality is that even if lecanemab was made available on the NHS tomorrow, our healthcare system isn’t ready to deliver it.
‘A third of people with dementia in the UK do not have a diagnosis, and services aren’t equipped with the staff and tools needed to diagnose more people at pace and monitor people on new treatments were they available.
‘We need to see urgent investment in preparing health systems for delivering new treatments, coupled with clear national targets on early and on accurate diagnosis to ensure the right people can access the right treatments at the time when they’re most effective.’
The list price for the subcutaneous treatment in the US is £288 per auto injector, which equates to an induction treatment cost of £29,900 per patient per year.
The induction IV treatment list price in the US is £19,800 a year for a patient weighing 70 kg, excluding the cost of delivering the drug.
Both treatments can be reduced to a less frequent ‘maintenance’ regime after 18 months, which will cost less per year.
NICE’s appraisal committee met earlier this month to consider new evidence after its decision to reject the use of intravenous lecanemab and a similar drug on the NHS was appealed. It is expected to deliver its finding next month.
A Department of Health and Social Care spokesperson said the government is delivering the ‘biggest expansion of NHS diagnostics in a generation’.
They added: ‘We will continue to invest in the latest technology and expanding the workforce so patients can get the care they need quickly.’
NewsBeat
Police probe social media post ‘celebrating’ Ann Widdecombe death
The post, allegedly made by a University of Aberdeen employee, claimed the former MP’s killing was “good news” and hoped it was an “extremely painful death”.
Police are looking into reports of a social media post that apparently celebrated the death of Ann Widdecombe. The post, allegedly made by a University of Aberdeen employee, claimed the former MP’s killing was “good news” and hoped it was an “extremely painful death”.
Former MEP Miss Widdecombe, 78, was found dead at her home in Haytor on Dartmoor, Devon, last Thursday. It has since emerged terror cops believe she was killed in a “targeted attack”.
On Tuesday, a Police Scotland spokesperson said the force was looking into the incident. They added: “We received reports on Saturday, July 11 relating to a post made online. Following further assessment, additional enquiries are being carried out.”
It comes as Heather Herbert, a former Scottish Green election candidate who works at the university as a web developer, reportedly wrote on Bluesky that the Reform UK member’s death was “some good news for once” before adding: “And I hope she was handcuffed to the bed as she screamed in agony.”
University rector Iona Fyfe condemned the posts saying complaints would be dealt with through the appropriate procedures. In a statement on X, she wrote: “I have been made aware of criticism regarding comments made by a member of the university staff.
“I have received a significant volume of emails regarding this to my Rector email. Please note, as Rector, it is not my responsibility to oversee complaints regarding the behaviour of staff.
“This will go through correct and proper complaints procedure. The university is aware of the comments being referred to online and are looking into the matter.
“There is no further comment right now, only that in my personal capacity, I’d like to condemn any comments which glorifies violence of any sort, against anyone.”
A spokesperson for the university previously said: “The comments that have been shared are entirely the individual’s own and do not represent the views of the University of Aberdeen. We do not condone violence or hateful behaviour in any form.
“We are cooperating with Police Scotland as they carry out their enquiries and cannot comment further.”
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