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Astros vs Cardinals: Odds, Predictions, Betting Tips & Starting lineups

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The Houston Astros (8-12) broke out of an eight-game win streak, winning their first two games in Colorado before the Rockies took the series finale on Thursday. The Astros are rock bottom in the AL West standings, 2.5 games behind the leaders, the Texas Rangers, tied on record with the Athletics.

The St. Louis Cardinals recorded two wins against the Cleveland Guardians in their latest series. They come to Houston with a 3-3 record on the road and third in the NL Central with a 10-8 record.

Astros vs Cardinals Game 1: Projected Lineups and Starters

Starting Lineups

Astros

  1. 2B Jose Altuve R
  2. DH Y. Alvarez L
  3. 3B I. Paredes R
  4. 1B C. Walker R
  5. SS C. Correa R
  6. RF Cam Smith R
  7. LF J. Loperfido L
  8. C Yainer Diaz R
  9. CF T. Trammell L

Cardinals

  1. 2B J. Wetherholt L
  2. DH Ivan Herrera R
  3. 1B A. Burleson L
  4. RF J. Walker R
  5. 3B Nolan Gorman L
  6. SS Masyn Winn R
  7. LF T. Saggese R
  8. C Pedro Pages R
  9. CF Victor Scott L

Starting Pitchers

Astros: Peter Lambert, first start of 2026

Cardinals: Kyle Leahy, 1-2 record, 5.14 ERA, 7 Ks, 1.71 WHIP

Astros vs Cardinals Game 1: Preview

Both lineups are fifth in their respective leagues in home run totals. The Astros have hit 21 bombs while the Cardinals have 20 homers. Yordan Alvarez has hit one-third of Houston’s home runs and also paces them with a .328 average while having an MLB-best 18 RBIs. Similarly, Jordan Walker leads the Cardinals in all three batting metrics (8 home runs, 15 RBIs, .319 average).

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The Cardinals’ pitching staff has recorded a 4.75 ERA in their last ten games. The Astros are worse with a 6.61 ERA in the same stretch of games. St. Louis will start with Kyle Leahy, who earned two runs in his previous loss to the Boston Red Sox on April 12. Houston called up Peter Lambert who will get his first MLB start since 2024.

Astros vs Cardinals Game 1: Projected Odds, Tips and Prediction

Odds as per DraftKings Sportsbook

Moneyline: Astros -143, Cardinals +119

Total: Over 9 (+102), Under 9 (-122)

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Run Line: Astros -1.5 (+153), Cardinals +1.5 (-186)

The Cardinals have a 5-4 record in evening starts, while the Astros have a 5-7 record. But the oddsmakers are trusting the Astros’ home field advantage.

Prediction: Astros 5, Cardinals 3