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Illinois vs. Houston prediction, odds, spread, time: 2026 NCAA Tournament picks from proven model

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The third-seeded Illinois Fighting Illini take on the second-seeded Houston Cougars in a 2026 NCAA Tournament South Region Sweet 16 matchup on Thursday. Illinois is coming off a 76-55-88 last-second victory over VCU on Saturday in the second round, while Houston defeated Texas A&M 88-57 on Saturday. The Illini (26-8), who finished in second place in a three-way tie in the Big 10 Conference, have won four of the last five games. The Cougars (30-6), who came in second in the Big 12, have also won four of five games. 

Tipoff from Toyota Center in Houston is set for 10:05 p.m. ET. The all-time series is split 3-3 as the programs meet for the first time since 2022. The Cougars are 2.5-point favorites in the latest Illinois vs. Houston odds, while the over/under for total points scored is 139.5. The Coogs are at -141 on the money line (risk $141 to win $100). Before making any Houston vs. Illinois picks, check out the Illinois vs Houston predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 Sweet 16 on a sizzling 11-1 run on its top-rated over/under college basketball picks dating back to last season, and is on a 28-22 run on top-rated CBB side picks.

Now, the model has simulated Illinois vs. Houston 10,000 times and just revealed its college basketball picks and predictions. You can head to SportsLine now to see the model’s picks. Here are several college basketball odds and college basketball lines for Illinois vs. Houston:

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Illinois vs. Houston spread:    

Houston -2.5

Illinois vs. Houston over/under:    

139.5 points

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Illinois vs. Houston money line:    

Houston -141, Illinois +118

Illinois vs. Houston picks:    

See picks at SportsLine

Illinois vs. Houston TV:

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Top Illinois vs. Houston predictions

After 10,000 simulations of Illinois vs. Houston, SportsLine’s model is going Over on the total (139.5 points). The total has gone Over in three of Illinois last four games. Houston’s last game also came in Over the total. The Illini are 10-2 straight up in their last 12 games played on a Thursday.

The model projects the Illini to have four players score 12 points or more, including Keaton Wagler, who is projected to score 15.7 points. The Cougars are projected to have three players score 12 points or more, led by Emanuel Sharp, who is projected to score 16.2 points. The model is projecting 149 combined points as the Over clears in 74.3% of simulations. You can get the spread pick at SportsLine.

How to make Illinois vs. Houston picks

Now, the model simulated every possession of Illinois vs. Houston 10,000 times and says one side of the spread hits in over 50% of simulations. You can only see that pick at SportsLine.

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So who wins Illinois vs. Houston, and which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the Illinois vs. Houston spread to back, all from the advanced model that just simulated this game 10,000 times, and find out.

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MJF to face 2-time WWE World Champion after huge meltdown on social media

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One of AEW’s top stars, MJF, took aim at a former WWE World Champion on social media recently after the latter critiqued his performance on Dynamite. Now, the self-proclaimed generational talent is officially scheduled to face off with the talent in question, Nic Nemeth (fka Dolph Ziggler).

For some time now, seeds were being planted for a potential showdown between Maxwell Jacob Friedman and Nic Nemeth, especially after The Wolf of Wrestling issued a public challenge to the “Most Wanted Man” to lock horns with him in an AEW World Title match this past January. Following on the heels of Wednesday Night Dynamite this week, the erstwhile Dolph Ziggler offered some words of criticism to Friedman while appearing on Busted Open. This prompted MJF to explosively lash out at the ex-WWE superstar, going so far as to call the latter an “overhyped” mid-carder.

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It appears that a showdown between the AEW Men’s World Champion and the former WWE World Heavyweight Champion is finally set to take place. The matchup will go down at Create A Pro Monumental Moment on May 1, at Melville, New York.

“. @Myers_Wrestling just hit me up and said this clowns down to throw hands. See ya there Nicky.” – posted MJF on X/Twitter.

This will seemingly be the first-ever in-ring singles encounter between MJF and the “Show-Off”.

MJF has a massive AEW title match scheduled for next month

Maxwell Jacob Friedman survived one of the biggest threats to his current World Title reign earlier this month at Revolution 2026, where he managed to retain his belt against Hangman Page in a Texas Death Match, and managed to lock him out of the World Championship picture as per the challenger’s own stipulation.

As he was celebrating his victory over The Cowboy this week on AEW Dynamite, The Salt of The Earth was interrupted and confronted by Kenny Omega, who earlier that night had become the new #1 contender for the “Triple B” by beating Swerve Strickland. The two stars exchanged words, leading to a World Title match between them being scheduled for Dynasty 2026.

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Match graphic for Maxwell Jacob Friedman vs Kenny Omega at Dynasty (Image via X @WrestlePurists)Match graphic for Maxwell Jacob Friedman vs Kenny Omega at Dynasty (Image via X @WrestlePurists)
Match graphic for Maxwell Jacob Friedman vs Kenny Omega at Dynasty (Image via X @WrestlePurists)

It remains to be seen whether the so-called “God of Pro-Wrestling” will be able to dethrone The Devil this coming month.