Connect with us

Business

BridgeBio set for promotion to the Russell 1000

Published

on

Choosing the right packaging is definitely one of the biggest challenges for a cosmetic brand; the packaging is a statement, a message from the brand to the end user, and brands must get it done perfectly if they want to last in time.

At the June 26 reconstitution of the Russell US indexes, California biopharmaceutical firm BridgeBio is expected to graduate to the Russell 1000.

Analysts at Mizuho have emphasized that the move would be long-term positive for BridgeBio’s stock price, and Nasdaq studies show that index inclusion almost always brings new long-term investors into a company’s shareholder base.

The annual Russell Index reconstitution is a once-a-year process in which FTSE Russell reviews the US equity market and reshuffles companies across its indexes, based largely on market capitalisation.

Historically, the Russell 2000 index has served as a launchpad for future large-cap leaders, with high-profile stocks such as Nvidia, Amazon, Costco, Netflix, Adobe, Etsy and Intuit joining the Russell 2000 before later graduating to the Russell 1000.

What would graduating to the Russell 1000 mean for BridgeBio?

Overall, the expected graduation to the Russell 1000 reflects BridgeBio’s sustained growth since its founding in 2015 and suggests the market is increasingly recognizing the scale and maturity of its pipeline and commercial outlook.

Advertisement

BridgeBio currently stands out in the R2000 index with a market cap of over $13 billion, roughly 12 times the index median, making it one of the largest companies in the index.

The expected graduation to the R1000 is a long-term positive for the stock, as it expands BridgeBio’s investor base. BridgeBio‘s expected move to the Russell 1000 could create some short-term selling pressure at reconstitution. This is because some funds explicitly follow the R2000, and when companies leave the index, they are obliged to sell.

Analysts at Mizuho explained that this would only cause short-term volatility and emphasized that it is a technical dynamic rather than a reflection of BridgeBio’s fundamentals. The analysts highlighted that any volatility would be a good entry point for investors.

Overall, BridgeBio has strong fundamentals, and its expected graduation to the Russell 1000 on June 26 reflects its continued growth, reinforcing Mizuho’s Outperform rating on the stock.

Advertisement

What is BridgeBio?

BridgeBio is a commercial-stage biopharmaceutical company founded in 2015 and headquartered in Palo Alto, California. It was co-founded in 2015 by Neil Kumar, Ph.D., Frank McCormick, Ph.D., and Andrew Lo, Ph.D., among others, with the aim of delivering transformative medicines for patients with genetic diseases.

BridgeBio operates an integrated model that spans target identification, preclinical research, clinical development and commercialization, aiming to streamline the process from bench to bedside.

BridgeBio has won three FDA approvals to date, though Attruby is the only one it still markets. Nulibry (Fosdenopterin) received FDA approval in February 2021 and has been shown to improve survival in children with molybdenum cofactor deficiency (MoCD). The treatment has also been shown to reduce levels of SSC, one of the compounds that builds up and is thought to cause seizures and severe brain abnormalities in patients with MoCD Type A. BridgeBio sold Nulibry to Sentynl Therapeutics in March 2022.

BridgeBio’s approved drug, Attruby (Acoramidis), is used to treat adults with cardiomyopathy caused by wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM). In a 30-month clinical study, people treated with Attruby did significantly better than those who did not receive it, reducing the risk of death and hospitalization.

Advertisement

In May this year, BridgeBio also presented late-stage data which showed patients taking Attruby had a 34% lower rate of cardiovascular hospitalizations than those on tafamidis, the ATTR-CM treatment manufactured by Pfizer and sold under the name Vyndamax. These figures come from an indirect, matched comparison. According to the study, all-cause mortality risk was 28% lower, although that result was not statistically significant.

Attruby generated $362.4 million in its first full year on the market. Jefferies analysts forecast peak annual sales for the drug of more than $3 billion. The ATTR-CM treatment market is projected to reach $16.5 billion by 2030.

Acoramidis is also sold in Germany by Bayer and marketed as Beyonttra. Germany was the first European country where BridgeBio’s ATTR-CM treatment was launched. Speaking at the 2026 Leerink Partners Global Healthcare Conference, Chinmay Shukla, BridgeBio’s SVP of Strategic Finance, said Bayer has reported “north of 50% treatment-naive share” there, which he contrasted with the US environment, citing Germany’s single-payer system and fewer access hurdles.

Shukla added that the next European launch of Acoramidis is expected to be Denmark, followed by other markets including Spain, Italy, and France. He noted it has been disclosed that Bayer “won the bid in Denmark.”

Advertisement

BridgeBio’s current pipeline is extensive and spans investigational drugs which aim to treat the following conditions: Canavan disease, Hypochondroplasia, achondroplasia, Chronic Hypoparathyroidism-NIH IIR, Autosomal Dominant Hypocalcemia Type 1, Limb-Girdle Muscular Dystrophy Type 2I/R9, and Early-Stage Variant Transthyretin Amyloidosis. Three of these programs have reported positive Phase 3 results and are now at or near FDA submission: BridgeBio has filed NDAs for BBP-418 in limb-girdle muscular dystrophy type 2I/R9 (which was granted Priority Review) and encaleret in ADH1, and plans to submit oral infigratinib in achondroplasia in the second half of 2026.

The company currently has a market cap of over $13 billion, and reported $502.1 million in full year revenue in 2025.

Advertisement
Continue Reading
Click to comment

You must be logged in to post a comment Login

Leave a Reply

Business

Nintendo Shares Fall Nearly 6% as Surging Global Memory Chip Prices Threaten Switch 2 Profit Margins

Published

on

Nintendo is broadening its reach in theme parks to win non-gamer fans

Shares of Nintendo fell 5.72% on Friday, dropping 466 yen to close at 7,679 yen in Tokyo trading, even as the broader Nikkei 225 index surged more than 4% during the same session, underscoring how directly the ongoing global memory chip shortage continues to weigh on the video game maker’s stock even amid a broader market rally.

Friday’s decline stood out against the backdrop of a powerful rebound across Asian technology stocks, driven by blowout earnings from Microsoft, Amazon and Meta Platforms that sent chipmakers surging worldwide. But that same rally in memory chip prices, driven by tight global supply and surging demand tied to artificial intelligence infrastructure, has become an increasingly acute problem for Nintendo specifically, since the company relies heavily on memory components to manufacture its Switch 2 console.

Nintendo has repeatedly flagged rising memory chip costs as a direct threat to its profitability throughout 2026. When the company reported earnings in February, its stock slid as much as 11% in Tokyo trading after Nintendo missed market estimates for quarterly revenue and flagged mounting headwinds from what it described as an unprecedented shortage of memory chips, even as profit growth for the nine-month period remained strong. The company’s shares fell again in May, dropping between 7% and 8.4% after Nintendo confirmed it would raise the retail price of the Switch 2 in European, U.S. and Japanese markets by 7% to 20% later in the year specifically because of higher component costs, with memory chips cited as the primary driver.

The company’s most recent full-year results, reported in May, showed operating profit for the fiscal year ending March 31 climbing nearly 28% to 360 billion yen, or roughly $2.29 billion, aided by a near-doubling of net sales. Despite that strong headline growth, the profit figure still fell short of market expectations. Nintendo’s forecast for the current fiscal year proved considerably more cautious, with the company projecting operating profit of just 370 billion yen, well below market forecasts of 480 billion yen, and forecasting a sales decline of 11.4% year-on-year to 2.05 trillion yen. Nintendo specifically guided for weaker Switch 2 sales in the current fiscal year, citing the planned price increases tied to component cost pressure, with the company forecasting fiscal 2027 Switch 2 unit sales of 16.5 million, down from 19.86 million units sold in the prior year.

Advertisement

Not every analyst has viewed Nintendo’s recent stock weakness as fully justified by the underlying fundamentals of the business. Speaking following the company’s May guidance, Morningstar analyst Ito described Nintendo’s shares as undervalued relative to the company’s longer-term prospects. “We view Nintendo’s shares as undervalued,” Ito said. “The market appears overly focused on near-term headwinds and conservative guidance, while underappreciating the long-term earnings growth from over 100 million Switch users migrating to the new platform and increasing game purchases.”

Nintendo’s stock has continued to face pressure from sources beyond memory chip costs alone throughout the year. Shares fell more than 7% in June after the company’s latest Nintendo Direct presentation disappointed investors by failing to unveil a new mainline entry in the Super Mario franchise, with the showcase instead centered on a remake of “The Legend of Zelda: Ocarina of Time” and other previously established titles. Reports had separately indicated that the next major Mario title would not arrive until 2027 rather than during Nintendo’s ongoing 40th anniversary celebrations for the franchise this year.

Nintendo’s next detailed quarterly earnings release is scheduled for August 6, according to the company’s investor relations disclosures, giving the market its next formal opportunity to assess how the combination of rising memory chip costs, planned price increases and the broader software release pipeline are affecting the company’s financial trajectory heading into the back half of the fiscal year.

The stock’s 52-week trading range spans from a low of 6,544 yen to a high of 14,795 yen, according to recent trading data, illustrating the scale of the decline Nintendo shares have experienced over the past year even as the underlying Switch 2 console has continued to post strong unit sales figures relative to Nintendo’s own historical hardware launches. Nintendo’s current price-to-earnings ratio stands at approximately 21.07, with the stock currently offering a dividend yield of roughly 2.85%.

Advertisement

Friday’s decline adds to what has already been a volatile year for Nintendo’s stock, with shares having fallen nearly 45% over the trailing 12-month period at various points during 2026, according to recent market analysis, even as the company’s Switch 2 console continued setting new sales records relative to prior Nintendo hardware generations. With global memory chip prices continuing to climb amid what rival Samsung Electronics has separately warned could be a supply shortage persisting through 2028, investors are likely to keep close watch on how Nintendo’s profit margins hold up in the coming quarters, particularly given the company’s heavy reliance on memory components across its flagship gaming hardware.

Continue Reading

Business

Snapchat joins other platforms in the fight against ‘AI slop’

Published

on

A closeup of Snapchat's logo, a white cartoon ghost with a bright yellow background, held over a laptop conputer keyboard.

As Chris Best, the co-founder and chief executive of Substack put it last week: “It’s getting harder to tell what’s real on the internet.”

Announcing a new tool, external designed to let readers on the newsletter platform detect AI-generated writing, Best cited other research that has found up to 40% of writing on social media is now fake or AI-generated.

“Platforms that reward fakeness will create a race to the bottom,” Best said.

LinkedIn, a social media platform focused on work, introduced a button on its platform this week that allows any user to report if a post or a comment appears to be AI-generated.

Advertisement

“AI slop is a top priority for all of us,” LinkedIn’s chief product officer Hari Srinivasan wrote on the platform.

In just the last couple of months, he said the platform had “blocked billions” of attempts to post AI-generated comments.

“Every day we are now catching hundreds of thousands of automated comment attempts,” Srinivasan said.

Like Snap, LinkedIn said it is not rejecting the use of AI entirely and users that use AI tools to “refine” their posts should not get caught up in efforts to combat AI slop.

Advertisement

Nonetheless, LinkedIn is removing an automated prompt that would show up for users writing a post offering to “enhance” it through the use of AI. It will go back to a simple proofreading tool.

YouTube, the video platform owned by Google, also this month updated its policies, external around what kind of content can be monetised by creators.

Research from last year found scores of channels on YouTube that were solely AI-generated content, external, many of which had millions of subscribers and some of which made millions of dollars in revenue.

In an effort to discourage YouTube from filling up with what the platform calls “inauthentic content”, earlier this month the site broke down into three categories the kind of videos that will not be allowed to make money through it: generic, repetitive, or template-based.

Advertisement

Those styles of content are much easier to make, and quickly, with the use of generative AI tools.

YouTube’s trust and safety chief Matt Halprin said in an interview, external on the updated rules that, while AI tools can help people with their content, they are more frequently being used to create fake and low-quality videos.

“The same technology really enables great stuff,” Halprin said.

“But it also enables stuff that’s kind of content farming, and that’s the stuff that we don’t want to have.”

Advertisement
Continue Reading

Business

Life Time Group Holdings, Inc. (LTH) Q2 2026 Earnings Call Transcript

Published

on

OneWater Marine Inc. (ONEW) Q1 2026 Earnings Call Transcript

Conference Call Participants

Arpine Kocharyan – UBS Investment Bank, Research Division
John Heinbockel – Guggenheim Securities, LLC, Research Division
Randal Konik – Jefferies LLC, Research Division
Molly Baum – Morgan Stanley, Research Division
Anthony Bonadio – Wells Fargo Securities, LLC, Research Division
Benjamin Chaiken – Mizuho Securities USA LLC, Research Division
Weili Chen – Mizuho Securities USA LLC, Research Division
Eric Des Lauriers – Craig-Hallum Capital Group LLC, Research Division
Chris Woronka – Deutsche Bank AG, Research Division
Owen Rickert – Northland Capital Markets, Research Division
Logan Reich – RBC Capital Markets, Research Division
Andrew Chasanoff – Oppenheimer & Co. Inc., Research Division

Presentation

Advertisement

Operator

Greetings, and welcome to the Life Time Group Holdings Inc. Q2 2026 Earnings Conference Call. [Operator Instructions] As a reminder, this conference is being recorded. [Operator Instructions] It’s now my pleasure to turn the call over to Connor Wienberg, Vice President, Capital Markets and Investor Relations. Connor, please go ahead.

Connor Wienberg
Senior Vice President of Treasury & Investor Relations

Advertisement

Good morning. Thank you for joining us for the Second Quarter 2026 Life Time Group Holdings Earnings Conference Call. With me today are Bahram Akradi, Founder, Chairman and CEO; and Erik Weaver, Executive Vice President and CFO. During the call, we will make forward-looking statements, which involve a number of risks and uncertainties that may cause actual results to differ materially from those forward-looking statements made today.

There’s a comprehensive discussion of risk factors in the company’s SEC filings, which you are encouraged to review. The company will also discuss certain non-GAAP financial measures, including adjusted net income, adjusted EBITDA, adjusted diluted EPS, net debt to adjusted EBITDA or what

Advertisement
Continue Reading

Business

The 100 Best Annuities. How to Avoid Common Mistakes and Pick the Right One.

Published

on

The 100 Best Annuities. How to Avoid Common Mistakes and Pick the Right One.

The 100 Best Annuities. How to Avoid Common Mistakes and Pick the Right One.

Continue Reading

Business

Eurobank S.A. (ERBKY) Q2 2026 Earnings Call Transcript

Published

on

OneWater Marine Inc. (ONEW) Q1 2026 Earnings Call Transcript

Operator

Ladies and gentlemen, thank you for standing by. I’m Constantinos, your Chorus Call operator. Welcome, and thank you for joining the Eurobank conference call to present and discuss the second quarter 2026 financial results. At this time, I would like to turn the conference over to Mr. Fokion Karavias, CEO. Mr. Karavias, you may now proceed.

Fokion Karavias
CEO, Member of Executive Board & Executive Director

Advertisement

Ladies and gentlemen, good afternoon, and welcome to the Eurobank First Half 2026 Results Presentation. Together with me is our CFO, Harris Kokologiannis, and the Investor Relations team. We will start with some key recent developments, then present our results and answer your questions.

The global environment remains agile and challenging with geopolitical developments weighing on market sentiment and adding to inflation. Inflationary pressures will push euro rates higher even as the European economy remains subdued despite a better-than-expected second quarter performance. Nevertheless, the economies in the regions where we operate have so far demonstrated remarkable resilience, supported by a number of factors. First, investment activity remains robust. In Greece, in particular, the government recently unveiled a EUR 23 billion national development program for the period 2026 to 2030, focused on infrastructure, climate resilience and regional economic convergence. Second, the tourism sector continues to demonstrate resilience. In both Greece and Cyprus, tourist arrivals rebounded swiftly and current trends point to a season broadly in line with last year’s strong performance.

Advertisement
Continue Reading

Business

FIFA has scrapped $20 billion World Cup sell-off plan, New York Post reports

Published

on


FIFA has scrapped $20 billion World Cup sell-off plan, New York Post reports

Continue Reading

Business

Narendra Modi has his eyes set on boosting business: Joao Cravinho, EU Ambassador

Published

on

ET Logo
While the world’s democratic superpower was maintaining armslength from Narendra Modi (then Gujarat Chief Minister in 2012-13), Europe led by an European Union delegation in India was quietly engaging with the BJP leader nearly two years before the Lok Sabha elections. In fact, Ambassador Joao Cravinho, head of the EU delegation, led Ambassadors of various European countries to a quiet lunch with Modi at the capital last year. And in the runup to the polls, he even travelled across India to get a sense of the probable outcome and interacted with all players cutting across the political spectrum, something foreign envoys seldom do. In an interview with ET, Ambassador Cravinho described India’s new Prime Minister as a man with clarity of thought who has a clear vision for India and governance. The Ambassador feels that EU member states have the potential to drive Modi’s economic diplomacy and help boost India’s economic health.

How do you view this victory of Narendra Modi and the BJP? And how will it impact the Indian economy?

We want India to do well. This election has ensured that there’s political stability for the next five years. A decisive leadership would mean tougher decisions, and no good governance is possible without tough decisions. The BJP-led NDA has a clear mandate to take bold and innovative decisions. International politics is not about zero-sum game and while India would economically engage other powers, EU has the potential to drive growth in India. EU is already the single biggest trading partner as a bloc, and is the single largest source of FDI for India as a bloc. We are ready to meet India’s needs in the fields of technology and funds.

You have interacted with Modi when he was the Gujarat Chief Minister. How do you rate him as a leader of modern India?

Advertisement

As a former Secretary of State for Foreign Affairs and Cooperation of Portugal, I had interacted with various leaders worldwide and I can say that Mr Modi is among the best. He has clarity of thought and clear vision of governance and that’s what India requires. He also has a very clear understanding of the challenges before the country. He is a good listener as well as a good talker and can engage in enriching discussions. No Prime Minister would like to have communal strife on his record, and I am certain that he would not allow any communal tensions in India. His priority is to boost the economy and he has his eyes set on that.

Where do India-EU relations go from here? What are the priority areas for India-EU and what’s the future of Free Trade Agreement that’s being negotiated for many years now?