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The quarter’s escalating tensions with Iran contributed to higher energy prices, pressuring headline inflation through rising gasoline costs. Core inflation also moved higher, reflecting secondary effects from

Researchers at Boston Children’s Hospital have found that fecal microbiome transplantation, delivered orally through capsules sometimes referred to informally as “poop pills,” increased peanut tolerance in some adults with severe peanut allergies, offering an early but notable signal for a potential new approach to treating one of the most dangerous common food allergies.

The research, published August 5 in the journal Science Translational Medicine, examined whether transplanting gut bacteria from healthy, non-allergic donors into people with peanut allergies could reduce the severity of their allergic response. The Phase 1 trial was led by Dr. Rima Rachid, director of the Food Allergy Program and the Allergen Immunotherapy Program at Boston Children’s Hospital, alongside Dr. Talal Chatila, director of translational immunology at the hospital and a professor at Harvard Medical School.

Researchers enrolled 15 adults between the ages of 18 and 33, all with highly sensitive peanut allergies who reacted to 100 milligrams of peanut protein or less during an initial food challenge, an amount smaller than what is found in half of a typical peanut. Participants swallowed 36 frozen, odorless capsules containing carefully screened stool-derived microbes from healthy donors, consumed over the course of a few hours across one or two days.

The trial unfolded in two stages. In the first stage, 10 participants received the fecal transplant alone. Four months later, three of those 10 showed increased peanut tolerance, with two able to tolerate two to four peanuts before reacting and one able to tolerate more than four peanuts without any reaction. In the second stage, five additional participants took antibiotics before receiving the transplant, intended to clear space in the gut for the donated microbes to take hold more effectively. Three of those five participants showed increased tolerance, bringing the overall total to six of 15 participants, or 40%, who responded to the treatment.

Rachid described the significance of the findings in a statement. “This landmark study was the first to demonstrate that a microbiome-based therapy may improve food allergy in people,” Rachid said, noting that the research also revealed how gut bacteria, their metabolites and the immune system interact to influence how well individual patients respond to the treatment.

Among participants who experienced increased tolerance, researchers found elevated levels of immune cells called RORγt+ regulatory T cells, which help regulate immune system activity. When researchers subsequently transplanted stool samples from those responsive participants into mice, the mice were similarly protected against peanut allergic reactions, reinforcing the connection between the transplanted bacteria and the observed protective effect.

The protective effect was linked to increased bile acid metabolites in both the human participants and the mice studied. When researchers removed bile salt hydrolase, an enzyme involved in bile acid metabolism, from Bacteroides bacteria in mice, the increased peanut tolerance disappeared, suggesting that enzyme plays a specific role in the mechanism, though that particular portion of the research was conducted only in mice and not confirmed in humans.

Chatila said the underlying mechanism observed in the mouse studies suggests the approach could extend beyond peanut allergies specifically. Because the mouse experiments tested a different allergen than peanut, “the faecal transplant treatment is likely to work for more than just peanut allergies,” Chatila said, pointing to potential broader applications for other food allergies down the line.

Researchers emphasized that safety was the trial’s primary focus, given its early Phase 1 design. Rachid told Healthline that none of the participants experienced serious adverse events during the trial, and that the encouraging tolerance data emerged as a secondary finding building on earlier promising results observed in mouse studies.

Outside experts urged caution about over-interpreting the results given the trial’s small size. Dr. Mohammad Bakhtiar, a general practitioner and clinical lead at Medical Express Clinic who was not involved in the research, said the underlying biological premise makes sense given the gut microbiome‘s broad influence on the body. “The gut microbiome already has a major effect on many parts of human physiology,” Bakhtiar told Healthline, while cautioning that a 15-person, open-label study cannot demonstrate how the treatment would perform across a broader population, given that nine of the 15 participants did not respond to the treatment.

Current treatments for peanut allergy include oral immunotherapy and biologic medications, and many patients still need to carry an epinephrine auto-injector in case of a severe reaction or anaphylaxis. Researchers stressed that fecal microbiome transplantation is not yet ready to be recommended as an allergy treatment based on these preliminary findings alone.

Looking ahead, Rachid said the research team hopes to test a more purified version of the treatment, called microbiota transplantation therapy, which contains less than 1% nonmicrobial fecal material and can be stored in a standard home refrigerator. She said future studies would examine whether prolonged administration allows patients to tolerate higher peanut doses with more durable effects, and said that with adequate research funding, clinical applications could potentially emerge within 10 to 15 years if the approach continues to prove effective in larger trials. Bakhtiar agreed that a roughly decade-long timeline was plausible if larger follow-up studies confirm the initial results, though he said patients should continue following current medical guidance, including strict peanut avoidance and specialist allergy care, in the meantime.

Constipation affects roughly 20% of people in North America, according to health researchers, and while the condition is usually manageable, doctors and registered dietitians say certain foods can play a meaningful role in relieving symptoms, particularly when paired with adequate hydration and physical activity.

Constipation is generally defined as having fewer than three bowel movements per week, often accompanied by hard stools, straining, or a persistent feeling of incomplete relief. Grace Derocha, a registered dietitian and spokesperson for the Academy of Nutrition and Dietetics, said the condition can stem from a range of underlying causes, including irritable bowel syndrome, hypothyroidism and certain types of diabetes, as well as psychological factors like stress and anxiety. She said identifying and addressing the specific cause behind a person’s constipation is essential for finding effective, lasting relief rather than relying on dietary changes alone.

Fiber remains the most consistently recommended dietary tool for relieving constipation. According to Johns Hopkins Medicine, fiber adds bulk to stool while also supporting the gut microbiome and helping coordinate the muscle contractions that move food through the intestines, a process known as gut motility.

Prunes rank among the most well-studied foods for constipation relief. Beyond containing roughly 2 grams of fiber per ounce, prunes are rich in sorbitol, a sugar alcohol the body does not easily digest, which helps draw water into the intestines and stimulate bowel movements. A review examining multiple clinical studies found that prunes consistently helped soften stool, improve its consistency, and increase how frequently people had bowel movements.

Apples offer a similar benefit through a specific type of soluble fiber called pectin, known for its laxative effect. A small apple contains about 4 grams of fiber, and in one clinical study, participants who took pectin supplements for four weeks saw meaningfully faster movement of waste through the colon, along with an increase in beneficial gut bacteria.

Leafy greens such as spinach also rank highly among dietitian recommendations. Registered dietitian Keri Cording described the combination of fiber and magnesium found in leafy greens as particularly effective, calling magnesium “nature’s muscle relaxer” for its role in easing intestinal muscle activity. She recommended incorporating greens through a spinach salad or blending them into a smoothie for easier daily inclusion.

Artichokes, meanwhile, offer a less commonly recognized fiber source. Cording noted that artichokes are surprisingly high in a type of soluble fiber called inulin, which she said can help stimulate digestion while also supporting healthy gut bacteria balance.

Brussels sprouts made the list as well, despite their reputation for causing gas. Bianca Tamburello, a registered dietitian nutritionist with Nourish, recommended loading up on high-fiber Brussels sprouts, noting that when seasoned well, they can be an easy way to add meaningful fiber to a meal while also supporting regular bowel movements.

Legumes, including black beans, chickpeas and lentils, offer some of the most concentrated fiber content of any commonly eaten food group. Tamburello pointed out that a single cup of black beans contains roughly 15 grams of fiber, meaning a modest addition to a soup or salad can make a substantial difference toward daily fiber goals. Legumes also contain resistant starch, which digests more slowly than simple starches like white rice or potatoes and functions similarly to fiber in supporting digestion.

Whole grains, including oats, brown rice, quinoa and whole-wheat products, retain the bran, germ and endosperm of the grain kernel, unlike refined grains, which have the bran and germ removed along with most of their fiber content. Because of that structural difference, whole grains provide significantly more fiber than their refined counterparts and are widely recommended as a foundational part of a constipation-friendly diet.

Coffee has also been shown to support bowel regularity, according to nutritionists. Coffee triggers several digestive responses, including contracting the muscles of the colon and stimulating the release of gastrin, a hormone that speeds the movement of food through the digestive tract. However, experts caution that excessive coffee and caffeine consumption can increase the risk of dehydration, which can worsen constipation rather than relieve it, making moderation and adequate water intake important alongside any coffee consumption.

Adequate hydration ranks as a foundational recommendation across virtually every source on constipation relief. The Centers for Disease Control and Prevention recommends drinking water or other fluids whenever thirsty, and specifically suggests drinking fluids alongside meals, since dehydration is a well-established risk factor for constipation.

For people managing constipation through diet, Johns Hopkins Medicine also points to the BRAT diet, bananas, rice, applesauce and toast, as an option some dietitians recommend for a range of digestive issues, noting it can help with both constipation and diarrhea depending on an individual’s specific symptoms and needs.

While dietary changes can meaningfully help many people manage occasional or mild constipation, doctors emphasize that severe, persistent or worsening constipation warrants medical evaluation rather than relying solely on food-based remedies. This article discusses general nutrition information related to constipation and is not a substitute for personalized medical advice; anyone experiencing severe or ongoing constipation, especially if accompanied by significant pain, bleeding or unexplained weight loss, should consult a doctor to rule out an underlying medical condition and determine the most appropriate treatment approach.

A machete- and pickaxe-wielding man was arrested after allegedly smashing into a jewelry display at a South Carolina Costco before customers and employees helped detain him, according to local reports.

Greenville police responded Thursday to the Costco on Woodruff Road after receiving reports of an armed robbery in progress, WSPA 7News reported, citing the Greenville Police Department.

Police identified the suspect as 24-year-old Jose Alejandro Giraldo, who allegedly entered the store and broke into display cases at the jewelry counter.

Giraldo was equipped with a machete and pickaxe and allegedly indicated that he had a gun when confronted, according to WSPA.

POPULAR RESTAURANT AT DISNEY SHOPPING AREA ROBBED BY SUSPECT IN SCUBA GEAR

A Costco storefront and suspect Jose Giraldo.  (Gary Hershorn/Getty Images; Greenville County Detention Center)

FOX Carolina similarly reported, citing police, that callers initially described the weapon used to break the display cases as appearing to be a hammer. Police later confirmed Giraldo had a machete and pickaxe, the outlet reported.

Costco shoppers scramble for a free sample of Phillips Foods Lobster Meat during the grand opening of a new store in North Port, Florida. (Mike Lang/Sarasota Herald-Tribune/USA Today Network via Imagn Images)

Customers detained Giraldo inside the warehouse store until officers arrived, according to FOX Carolina.

Store employees also reportedly helped restrain the suspect.

One customer was injured while helping subdue Giraldo, prompting a response from emergency medical personnel, according to WSPA. The outlet did not immediately report the extent of the customer’s injuries.

A Costco store in Vallejo, California, on May 29, 2025. (David Paul Morris/Bloomberg)

Giraldo was charged with armed robbery and third-degree assault and battery, according to both outlets.

A mugshot of Giraldo was subsequently released by the Greenville County Detention Center.

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FOX Business has reached out to the Greenville Police Department for comment and additional details about the incident.

Au Vodka is in talks with US drinks giant Sazerec

One of Wales leading brands is set to be acquired in a deal worth hundreds of millions of pounds.

Swansea-based Au Vodka, the premium vodka brand known for its iconic gold bottles, is in advanced talks with Kentucky-based drinks giant Sazarec whose brands include BuzzBallz and Southern Comfort.

According to the Sunday Times based on future performance the deal could be worth around £500m. Au Vodka was set up Charlie Morgan and Jackson Quinn. thirties. If a deal is finalised the founders, both still in their early thirties, could each receive a windfall of more than £100m.

DJ Charlie Sloth acquired a 20% stake in the company after being contacted by Morgan and Quinn.

In 2023, Au Vodka also sold a minority stake to private equity firm Metric Capital.

Au Vodka, underpinned by excellent marketing, use of social media, and celebrity product endorsement, has enjoyed huge international expansion.

Its bottles are sold in 40 countries, from Spain to Australia. It has experienced huge growth in the lucrative US market, where it has had a presence since 2022.

It has also diversified into the canned vodka market, which has supported its continued and impressive revenue growth.

Last year it opened a new £3m headquarters in at Crucible Park in Llansamlet.

Latest published audited accounts for the year to end of April, 2025, show that the business grew revenues by 27.3% to £82.7m with a pre-tax profit of £6.7m compared to £5.13m a year earlier. It has net assets of more than £33m.

Au Vodka, whose parent company is Aurous Topco, has workforce of around 80.

Au Vodka and Sazerac declined to comment.