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Metro 2039 reveal trailer is a grimly defiant response to the Russia-Ukraine war

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Metro 2039 reveal trailer is a grimly defiant response to the Russia-Ukraine war

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The first story trailer and gameplay footage from the sequel to Metro Exodus reveals a game literally forged in war, by Ukrainian developer 4A Games.

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The tragedy of the Russian invasion of Ukraine is so serious that we always feel nervous about discussing it in the context of video games. But the fact is that Ukraine has a very active development community – one of the most significant in Eastern Europe – and since the invasion began we’ve spoken to both indie developers and S.T.A.L.K.E.R. creator GSC Game World, who have all carried on working during the war.

As such, it’s sadly obvious why there’s been a seven year gap since Metro Exodus. But developer 4A Games is back and have unveiled Metro 2039 today, via an Xbox event that we were allowed to see in advance.

Based on a series of novels by Russian author Dmitry Glukhovsky, who assists with the games but has been exiled from Russia for speaking out against the war, they’re set in a post-apocalyptic Moscow and portray the world in a way that, to paraphrase co-creative director Pavel Ulmer, makes Fallout seem like a ‘theme park ride.’

We strongly encourage you to watch the video below, which is 15 minutes long and split between the pre-rendered reveal trailer (which is also the video above), commentary from the developers, and a minute or so of in-game footage.

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Introducing itself as ‘proudly made in Ukraine’ the reveal trailer portrays a series of nightmare visions of what is presumably the main character – known only as The Stranger but fully voiced in the game.

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He seems to be searching for his daughter, with post-apocalyptic scenes reminiscent of the bomb dropping in Terminator 2 and then images of him being literally held back by chains as a Nazi-like figure, who has apparently united all the different human factions, indoctrinating children and issuing propaganda.

It’s all very disturbing and while it’s not exactly subtle in its message, the world as a whole seems to have moved past subtlety a long time ago.

According to creative director Andriy ‘mLs’ Shevchenko, the Metro series has always been anti-war but, as he says, ‘Now war is our reality and our message has shifted to be about the consequences.’

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He ruminates on ‘The cost of silence, the horrors of tyranny, and the price of freedom,’ in what is clearly going to be a very heavy game. In fact, it’s specifically said that it will be much darker in tone than the previous games, which weren’t exactly Barbie Horse Adventures themselves.

As the impossibly gravelly-voiced Pavel Ulmer (co-creative director and lead audio designer) says, they’re not ‘romanticising the post-apocalypse’ and are instead taking a more tragic view of humanity than most similar games.

4A Games admits that their plans for the new Metro completely changed after the Russia invasion, so this game is heavily influenced by the ramifications of that, as you can already tell from the trailer and the promise of a ‘uniquely Ukrainian perspective.’

In terms of the gameplay, only a little was shown but the graphics looked fantastic (enabled by 4A Games’ own propriety game engine) and showed off a typically terrifying fight with a mutated monster.

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The Metro games are part first person shooter and part survival horror, but the series’ storytelling is also very important to the experience, with engaging characters and a lack of moralising.

Metro 2039 will be out ‘this winter’ on Xbox Series X/S, PlayStation 5, and PC. Interestingly, the PlayStation 5 version was mentioned, despite this technically being a Microsoft showcase.

Metro 2039is not going to be a happy tale (Deep Silver)

Email gamecentral@metro.co.uk, leave a comment below, follow us on Twitter.

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Power vacuum at Cambridge City Council amid discussions to form new leadership

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Cambridgeshire Live

The Liberal Democrats said they were “sorry not to have expanded into other parts of the city”

The Liberal Democrats say they will “work constructively” with other parties after last week’s election’s shake-up left Cambridge City Council without a leader. Cameron Holloway lost his seat, meaning both the council and local Labour Party must find a replacement.

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Cambridge Labour will decide on a new leader at this Sunday’s AGM as discussions continue about what the next council administration may look like.

Labour remains the largest party on the council with 17 councillors, though after losing their majority no single party has the required 22 seats. The Green Party is now the second largest with 12 seats, picking up six from Labour, and the Liberal Democrats are third with 11.

Councils with no overall majority can be governed in a few different ways. Some have a minority administration, with one party in control despite not having more than half of all councillors. This usually happens where they have the most councillors or close to a majority.

Other councils are run by coalitions of parties. In some, the largest party is unable to rule as a minority because a coalition of smaller parties has banded together.

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The Liberal Democrats have pledged to “work constructively” with other parties after the results which saw them hold three seats, but fail to gain more.

Cllr Tim Bick, Cambridge leader of the party, said they were “sorry not to have expanded into other parts of the city” but “missed out by very narrow margins”. He said they held their seats with “increased majorities”.

He described this as a “resounding vote of confidence in how Liberal Democrats serve and champion our local residents”, particularly given the party won every seat in South Cambridgeshire bar two.

He said Cambridge faces “two vital years” before the council is replaced with a new unitary authority with “major decisions on housing, the local plan and local services to be made”.

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Cllr Bick said: “This calls for the political parties to find the right formula to work together to hand over to the new unitary council in a way that benefits the city for the long term. For our part, in this more open political environment, we Liberal Democrats are ready to work with others to try and achieve the priorities we have campaigned on.

“We will work constructively with other parties who are open themselves to do that: willing to share in responsibility and respond positively to last week’s election result. People voted for a change last week and they must see that in the way their council is run over the next two years.”

Parties are currently discussing political agreements to allow a new administration to be formed, such as what the political make-up of a new cabinet would look like. Councillors will vote on a new leader and appointments to committees at an annual meeting on Thursday, May 21.

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Hamilton Community Growth Area plans approved

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Daily Record

The application sought for approval to vary existing planning conditions attached to the wider Hamilton Community Growth Area masterplan.

Plans linked to the long-running Hamilton Community Growth Area development have been approved despite public objections.

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Councillors on today’s planning committee (May 12), approved proposals which relate to land south and west of the town near Strathaven Road, Meikle Earnock Road and Highstonehall Road.

The application sought for approval to vary existing planning conditions attached to the wider Hamilton Community Growth Area masterplan.

This now means that developers have greater flexibility to submit future applications covering matters such as housing layouts, housing types and numbers, positioning of buildings, infrastructure and landscape details.

The wider Community Growth Area spans around 171 hectares and already benefits from planning permission in principle granted in 2017.

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Planning officers say the changes are intended to “future proof” the development and make it easier for underdeveloped parts of the site to come forward over time.

A report prepared for the Planning Committee states the principle of residential development on the site is already established under the South Lanarkshire Local Development Plan.

Council officials also stated that the proposal supports national housing policies aimed at delivering “high quality, affordable and sustainable homes”.

READ MORE: South Lanarkshire Council reveals new support for care-experienced young people

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And it was established that the site is in a sustainable location and would support the creation of “20 minute neighbourhoods”.

But, the proposal did generate 42 objections during the consultation process.

Residents raised concerns including continued large-scale housebuilding in the area, loss of greenspace and wildlife habitat, increased traffic and congestion, pressure on local infrastructure, drainage and flooding concerns, impacts on woodland and protected species and claims of inadequate public consultation.

The report presented to councillors notes that future submissions will still need approval on issues including flood risk, biodiversity, roads and transport, landscaping, public transport provision, play areas, drainage and sewage disposal, archaeology and pollution control.

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Cambridgeshire kebab vans named among the best in the UK

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Cambridgeshire Live

Four Cambridgeshire kebab vans are in the running to be named ‘Van of the Year’

Four Cambridgeshire kebab vans have been shortlisted for an award at this year’s Turkish Restaurant and Takeaway Awards (TURTA). Diamond Kebab in Cambridge, Gourmet kebab kitchen in Caxton, HsK Kebab Van in Cambridge, and Haddenham Kebab And Burger Van are all in the running to be named ‘Van of the Year’.

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The awards help to promote the importance and popularity of Turkish cuisines. TURTA states: “The Turkish Restaurant and Takeaway Awards (TURTA) stand as a celebration of excellence, heritage, and innovation within one of the UK’s most vibrant culinary communities.

“Bringing together chefs, restaurateurs, entrepreneurs, and food lovers, the awards recognise the outstanding contributions of Turkish, Kurdish, and Turkish Cypriot businesses that have helped shape the nation’s dining landscape.”

This year’s semi-finalists have been selected following a nationwide nomination process in categories including Fine Dining Restaurant, Best Value Restaurant, and Best Regional Takeaway. The awards now enter a voting phase giving the public an opportunity to support their favourites.

A ceremony is due to be held at JW Marriott Grosvenor House in London on June 22. It will mark the fourth year of the awards taking place.

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Diamond Kebab in Cambridge on Arbury Road is a popular hotspot among locals. It is described by customers as “hands down the best kebab in Cambridge” and a must-try for visitors. The menu offers a large variety of kebab options alongside burgers and sides.

Gourmet kebab Kitchen in Caxton offer a range of items including kebabs, burgers, salads, and sides. The van is described by customers as “fresh, tasty, and cooked perfectly” where “you can really tell the guys put their passion into it”.

HsK Kebab Van is located on Histon Road in Arbury. This top-notch van offers a similar style menu with a range of kebabs, burgers, and gyros. It seems to be in popular demand with some previous diners claiming they were “really impressed”.

Haddenham Kebab And Burger Van can be found on Chewells Lane. Reviews have said this van offers the “best quality” service and “huge” portions all while serving “flavourful” food.

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Council house painter hit woman after drinking vodka

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Whitby sex offender given suspended prison sentence

After an argument with the woman and others, painter decorator Stephen Lee Wood, 51, went to his van, drank a “vast amount of vodka” and returned, said Judge Simon Hickey,

In a bid to “punish (her) son or maybe in revenge,” the drinker tried to hit the son and hit the woman instead.

Jordan Parkinson, prosecuting, said the woman suffered bruises on her arm, soreness to the right of her face, swelling to her mouth and a headache.

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Wood had gone to the council house in west York to paint its exterior and had announced his arrival by knocking on its window.

But after he had climbed a ladder to start work, the woman inside the house claimed he was working in an unsafe manner and the argument started.

After he went to his van and returned, CCTV footage showed him being asked to leave, but not doing so, and people pushing and shoving each other.  It also showed violence towards Wood.

Wood was working for a company sub-contracted by City of York Council to do painting work.

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Wood was on a suspended prison sentence at the time for hitting a paramedic in the face three times, kicking them in the leg and other offences and has 44 convictions.

“You lost your temper, turned to drink again and very foolishly went back to the house. That is why you are here,” Judge Hickey told Wood. 

After reading a letter handed in by Wood’s lawyers from a Leed-based alcohol rehabilitation organisation about his efforts to deal with his drinking, the judge said the painter appeared to be starting to turn his life round.

He gave him a six-month prison sentence suspended for 18 months and ordered him to do 20 days’ rehabilitative activities and wear an alcohol abstinence tag for 60 days.

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The earlier suspended prison sentence remains in force.

Wood, 51, of no fixed address but based in Leeds, pleaded guilty to affray and breaching the earlier suspended prison sentence.

Thomas Doyle, for Wood, said: “He is a man absolutely ravaged by alcoholism and poor mental health which have acted co-ordinately with disastrous results. He has relapsed into alcoholism and fallen into a dark pit of despair.”

He had lost his job, his home and his relationship and last autumn had been suicidal.

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But he had been sober since December and was now taking medication that was helping him.

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Doctor warns common condition may flare in summer and easy steps to combat

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As temperatures across the UK begin to rise, a doctor has warned that a common condition one in three Brits suffer from may starts to worsen as the weather warms up.

As the mercury rises across Britain and summer approaches, certain health conditions may see their symptoms become more pronounced during the warmer months. With varicose veins affecting one in three people in the UK, a doctor has issued advice to those living with the condition and explained how to properly manage its symptoms as temperatures increase.

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Varicose veins occur when veins become enlarged and twisted, often appearing as bulging, bluish lines visible under the skin’s surface. They’re primarily caused by underlying problems, usually weakened vein walls and faulty valves, although factors including genetics, age, lifestyle choices, and pregnancy can all contribute to their formation.

While varicose veins pose challenges year-round, symptoms often worsen and become more noticeable when the weather gets hotter, reports the Express.

Dr Mark Bratby, Consultant Interventional Radiologist at VeinCentre, explains: “Warmer temperatures cause your veins to dilate more, meaning as your veins get larger, the valves struggle even more to deal with blood flow.

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“This leads to more accumulation of blood inside your veins, resulting in swelling, bigger bulges, and ultimately greater discomfort.”

In addition to the uncomfortable symptoms that can trigger restlessness and frustration, many people with varicose veins also experience heightened self-consciousness during warmer weather, as they shed layers of clothing to keep cool.

Dr Bratby says: “For those who don’t have varicose veins, it’s easy to think that the impact is simply physical, but often weighs heavily on patients’ mental health.

“It can be a dent in people’s confidence levels, as the veins become more visible when they expand, making some feel apprehensive about wearing clothes that expose their legs and feet.”

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However, there are numerous approaches to managing varicose veins when the weather gets warmer, from simple changes to your everyday habits right through to pursuing medical intervention.

Keep cool and stay hydrated

The most straightforward solution for dealing with overheating is to try and lower your body temperature. Avoid direct sunlight where you can to stop your veins from becoming overly dilated, and make sure you’re drinking enough water to stay well hydrated.

Dr Bratby adds: “If you’re on holiday in a warm country, try and get in the pool or paddle in the sea to lower your body temperature.”

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Keep active

While exercising might be the last thing on your mind when it’s hot, it can actually be remarkably helpful for people dealing with varicose veins.

Dr Bratby shares: “Staying active can be beneficial for your veins, as it gets your heart pumping and encourages better blood flow, which will help your circulatory system to clear some of the blood that accumulates in your varicose veins.”

Raise your legs

This is a simpler change than some of the previously mentioned suggestions, and can be easily worked into your everyday routine.

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Dr Bratby advises: “Elevating your legs when you’re sitting or lying down will give your veins a helping hand getting your blood back to your heart.

“It’s also beneficial to avoid standing up for prolonged periods, so make sure you have multiple breaks if you are out and about during the warmer weather.”

Seek treatment

For numerous sufferers, the discomfort – not just during the summer months but all year round – can become intolerable, especially as symptoms are only likely to worsen over time.

Fortunately, a range of effective and minimally invasive treatment options are on offer.

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Dr Bratby says: “You can put the discomfort of varicose veins behind you and begin feeling more comfortable and confident by getting treatment.

“The best treatment for your varicose veins depends on their severity and your individual needs, but by booking a consultation with an experienced Vascular Consultant, you can take the first step to healthier looking skin.”

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Under-fire Welsh coach gets public backing and URC club launch review after major backlash

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Wales Online

Here are your rugby morning headlines for Wednesday, May 13.

Under-fire Welsh boss gets public backing

Wales scrum-half Keira Bevan has publicly backed under-pressure head coach Sean Lynn ahead of this weekend’s crunch Women’s Six Nations clash with Italy.

Wales head into Sunday’s showdown at Cardiff Arms Park desperate to avoid a third consecutive Wooden Spoon after slipping to a ninth straight defeat in the competition following last weekend’s loss to Ireland.

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Lynn only took charge at the start of last year’s Six Nations campaign after winning three successive Premiership Women’s Rugby titles with Gloucester-Hartpury, but pressure has intensified after a disappointing World Cup campaign and another difficult Six Nations.

Despite the scrutiny, Bevan insists the squad remain fully behind the coach and his staff.

“Yeah, 100%,” she said when asked if the players still backed Lynn. “And the help he has in the background, it’s massive.

“(Defence coach) Tyrone Holmes has been incredible for us. That’s probably one of the shining lights of this campaign, how good we’ve been defensively.

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“And obviously Ash [Ashley Beck] has got such a way of attacking rugby and he wants you to express yourself. We’ve got the right people in the right place, it’s just about us being able to execute what they’re asking.”

Wales have dropped to 12th in the world rankings and criticism has mounted after another winless campaign appeared on the horizon.

Bevan admitted the players understand the frustration among supporters, but urged patience as the squad continues to rebuild.

“Nobody is more frustrated and disappointed than us,” she said. “Yes, we probably haven’t had the wins we want, but we are performing and getting better every game.

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“It’s such a cliché, but stick with it because it’s going to come and hopefully soon.”

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The scrum-half also acknowledged Wales are currently operating without specialist kicking and breakdown coaches, additions she admitted would help strengthen the backroom team.

While there had been positives in earlier defeats to Scotland, France and England, Bevan conceded the performance in Belfast against Ireland felt like “a backwards step”.

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Attention now turns to Italy, who travel to Cardiff full of confidence after impressive displays against Scotland and England.

“We’re under no illusions of what Italy can do,” she said. “It wasn’t a one-off last year because we’ve seen glimpses in this campaign of how physical and dominant they can be, so for us we’ve got to be on it.

“To get the win would be massive. It would set us up nicely heading into pre-season and then obviously the new WXV tournament as well, but we know we’re going to have to work for it.”

URC club launch review after major backlash

Munster Rugby have commissioned an independent governance and organisational review following the backlash surrounding the proposed appointment of New Zealander Roger Randle as attack coach.

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Randle’s arrival was announced on April 15, but controversy quickly followed after a 1997 rape allegation resurfaced. The alleged incident took place in Durban, South Africa, during his time playing for Super Rugby side Hurricanes. The charge was later dropped by the complainant and Randle has always denied the allegation.

The fallout led to a series of resignations within the province. Former players Billy Holland, Killian Keane and Mick O’Driscoll stepped down as independent nominees on Munster’s Professional Game Committee, while members of the club’s voluntary Commercial Advisory Group also resigned.

On April 30, Munster confirmed that Randle would no longer be joining the province, describing the outcome as a “mutual agreement”.

General manager Ian Costello admitted at the time that it had been “a difficult conclusion”, but said it became clear ending the arrangement was “the best course of action for Roger, his family and Munster Rugby”.

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Munster announced on Tuesday that an external review will now “assess the organisation’s governance, leadership, culture and communications structures and provide recommendations back to the board”.

The process will be carried out by The Governance Company, an independent consultancy specialising in corporate governance, and overseen by an independent chairperson who is expected to be appointed in the coming days.

Chief executive Ian Flanagan said: “It is clear that the past number of weeks have been difficult for staff, players, coaches, supporters, and everyone who cares about Munster Rugby.

“We recognise the impact that recent events and decisions have had on our stakeholders. This independent review is an important step in ensuring we can learn from past events and strengthen how we can positively operate going forward.

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“We look forward to working fully with The Governance Company and independent chair to support an effective review process. The primary and clear objective of this important exercise is the overall wellbeing of Munster Rugby.”

Munster are currently sixth in the United Rugby Championship standings ahead of their final regular-season match against Lions on Saturday, May 16.

Lions star accuses South Africa of ‘getting personal’

Mack Hansen has opened up on the fierce rivalry between Ireland and South Africa, admitting clashes with the Springboks become “personal” and leave players feeling like they “hate their guts”.

The British and Irish Lions tourist was discussing Ireland’s growing rivalries on the For the Love of Rugby podcast when he gave a candid insight into the mentality inside the camp before facing the world champions.

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Relations between Ireland and South Africa have intensified in recent years, particularly around the 2023 Rugby World Cup, when Andy Farrell’s side beat the Springboks in the pool stages before later being knocked out by New Zealand in the quarter-finals.

Hansen admitted the animosity ramps up significantly in the build-up to those huge Test matches.

“It does then become so personal leading up to the weeks when we’re playing South Africa or New Zealand,” he said.

“Again, you talk to them off the field and they’re like anyone in rugby — good fellas, you get on with them, they’re great blokes — but leading up to that week you despise them.

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“You’re like: ‘These are some of the worst people in the world at this moment.’

“There’s a lot going on in the world and you’re like: ‘I honestly hate their guts.’ Then once it’s finished, it’s done.”

The full-back insisted that edge is ultimately good for the sport and helps bring the best out of players.

“But I think that’s what’s good about it,” he added.

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“A bit of passion and intensity adds to the game. When you know there are two teams that genuinely dislike each other, you give it your everything.”

The Connacht wing also revealed Ireland’s Six Nations rivalry with Scotland has become increasingly heated in recent seasons.

“Another one in the Six Nations for us is probably Scotland,” Hansen said.

“There’s a bit of a thing going on there. We’ve maybe got the better of them recently, but whenever we’re playing them they’re normally on a bit of a roll, we’re locked into it, we dislike them and we want to beat them.

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“We don’t want them to get one over on us. That’s a testament to them. It adds a lot to you as a person when you have those rivalries going into a game.”

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Strictly fans spot ‘confirmation’ of another major hosting change ahead of 2026 series

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Manchester Evening News

Fans think they’ve spotted another change to the show’s hosting line-up, as they await news from the BBC on who has landed the main hosting gig

Strictly Come Dancing fans think they have spotted ‘confirmation’ of another change to the show’s hosting line-up as they await news from the BBC as to who has landed the main hosting gig.

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The broadcaster recently said that further plans for the next series of the BBC One dance show, including who will be the new hosts following the exits of both Tess Daly and Claudia Winkleman, would be announced in due course.

It came as it was confirmed that Craig Revel Horwood, Shirley Ballas, Motsi Mabuse and Anton Du Beke would be returning as judges for the 24th run of the popular competition programme, set to kick off in the autumn, alongside the line-up of professional dancers.

Returning from 2025’s series are Alexis Warr, Amy Dowden, Aljaz Skorjanec, Dianne Buswell, Johannes Radebe, Jowita Przystal, Julian Caillon, Kai Widdrington, Katya Jones, Lauren Oakley, Nancy Xu, Neil Jones, Nikita Kuzmin, Vito Coppola, and Carlos Gu, who won last year’s series with former England footballer Karen Carney.

The BBC also confirmed new professionals would be recruited and announced closer to the dancing show’s return in autumn to replace Gorka Marquez, Michelle Tsiakkas, Karen Hauer, Nadiya Bychkova and Luba Mushtuk, who have all left Strictly.

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But there have also been reports that changes are ahead of Strictly’s spin-off show, It Takes Two, which airs every weeknight on BBC Two, bringing fans extra interviews with the show’s stars as well as behind-the-scenes insight. It is currently hosted by Fleur East and Janette Manrara.

However, it was recently reported that the show, launched in 2004 with Claudia originally helming it, will be no more when Strictly returns for its 2026 run, with a suggestion that the entertainment programme will follow the vodcast route used by The Traitors and The Apprentice.

Now, eagle-eyed Strictly fans have claimed to have spotted a major move from both Janette and Fleur that reveals their future, despite it not being confirmed by the two stars themselves or the BBC.

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@superTV247 said: “Fleur East & Janette Manrara have removed ‘#Strictly It Takes Two’ from their Instagram profiles following rumours that the show’s format will be changing, seemingly confirming that it will have new hosts too. But could Fleur or Janette be joining Emma Willis on the main show?” @RyanSoapKing25 also noted: “UPDATE: Janette Manrara & Fleur East have now BOTH removed #ItTakesTwo from their Instagram bios. Does this mean #Strictly #StrictlyComeDancing It Takes Two is really getting scrapped for a “Visualised Podcast” this year? What do we think of this move?”

@PhilipCarm96996 replied: “I hope not as it’s part of our Strictly experience watching ITT. Hopefully it’s staying but with different hosts which if so is a shame as they’d made it their own.” @AMG_Review added: “Makes zero sense for a VISUAL first show about dancing to prioritise podcast format for its spin off Yes have a podcast if you want but ITT works so well in its own format.”

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Emergency services called to incident in Whitley Bridge

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Emergency services called to incident in Whitley Bridge

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easyJet warning as ‘lunatic’ plan would see flight prices jump up

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easyJet boss has hit out at a new rule expected to come into force

Passengers flying within Europe could soon see a significant shift in baggage rules, and travellers are being put on notice.

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At present, those travelling on basic fares with easyJet, as well as with Ryanair, are restricted to one small personal item, with any extra luggage attracting additional fees. Following changes to EU regulations, Ryanair was required to enlarge the maximum dimensions of its personal bags last year. The revised rules permit passengers to carry hand luggage measuring up to 40 x 30 x 20cm, a 20% boost from the former 40 x 20 x 25cm restriction.

easyJet’s personal bag specifications already complied with these requirements, meaning no adjustment was necessary. And now further EU regulatory shifts could enable travellers to bring both a cabin bag measuring up to 100cm and a personal bag without incurring additional charges.

In February, the European Parliament voted overwhelmingly to grant all passengers the entitlement to carry a small case in addition to the complimentary under-seat bags currently allowed. The Parliament’s proposal would give passengers the right to bring on board, at no extra charge, one personal item (such as a handbag, rucksack or laptop) and one small piece of hand luggage with maximum combined dimensions of 100cm (length, width and height) and weighing up to seven kilos.

The proposed reforms, which must receive approval from the European Council before becoming law, would apply to all travellers flying to or from an EU airport on an EU-based airline. This directly affects the overwhelming majority of short-haul flights departing from the UK.

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While this may seem like a positive development for passengers, easyJet has slammed the proposals to enforce free additional baggage as a “lunatic idea”. Chief executive Kenton Jarvis insisted that granting all passengers the right to extra free carry-on luggage would be “crazy” and “terrible for the consumer”.

The easyJet boss described it as “politicians completely not understanding their subject and getting involved with things they shouldn’t”, adding: “There just isn’t the space in the cabin, so that’s another lunatic idea. We would go back to the days of having to offload cabin bags and put them in the hold – it was one of the number one causes of delayed boarding in the old days.”

Baggage fees accounted for a significant portion of easyJet’s more than £2.5bn in annual income from extras, or ancillary revenue, “and that would have to be passed on” through increased fares for all passengers, he warned.

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Small study hints CAR-T cell therapy might help fight HIV

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Small study hints CAR-T cell therapy might help fight HIV

WASHINGTON (AP) — Scientists are tweaking a powerful cancer therapy in hopes it could fight HIV instead, by supercharging patients’ own immune cells.

On Tuesday, researchers said a single dose of those revved-up cells strongly suppressed HIV in two people — one for nearly a year and the other for nearly two years — without requiring their usual medicines.

Larger and longer studies are needed to prove if what’s called CAR-T cell therapy might really offer long-lasting help for HIV, cautioned Dr. Steven Deeks of the University of California, San Francisco, who led the research.

“We find the fact that two people have had such a really sustained response provocative,” he said. “There is a real need for a one-and-done, safe and scalable cure … and this is one of the strategies that we’re pursuing.”

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The data is being presented at a meeting of the American Society of Gene and Cell Therapy in Boston.

There are nearly 40 million people living with HIV around the world. Today’s medicines have turned the virus that causes AIDS from a fast killer into a manageable chronic disease, often keeping the virus at undetectable levels, but only if people can afford the drugs and stick with them. The virus hides out in reservoirs in the body and rebounds fast if people stop treatment.

Researchers have long hunted an elusive cure, pursuing such clues as a rare gene mutation that makes some people naturally resistant to HIV or how a handful of HIV patients who also had certain cancers were declared cured or in long-term remission after receiving a stem cell transplant, something too risky for most people.

CAR-T therapy involves taking immune soldiers called T cells out of a person’s blood, genetically engineering them into “living drugs” and infusing them back into the patient. They’re widely used to cure certain types of cancer and are being studied for other diseases.

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For HIV, scientists at the nonprofit drug developer Caring Cross created CAR-T cells with dual features. They’re programmed to better find and kill HIV-infected cells — and engineered with protection against infection by the very virus they’re supposed to fight.

With that added armor, they should be able to reproduce enough to keep HIV in check, said Caring Cross executive director Boro Dropulić.

Deeks’ early-stage experiment tested different dosing strategies in people who stopped their HIV medicine the day they received their CAR-T cells. There were no serious side effects. The first three recipients showed no response and resumed their usual medicines.

Six others received a small amount of chemotherapy to make space for the new T cells. Those two strong responders saw their HIV drop to undetectable levels, inching up only occasionally when the CAR-T cells presumably got to work again. A third patient had a temporary response and resumed regular HIV treatment.

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Those three patients all had started their original HIV treatment soon after they’d been infected, Deeks said. That makes sense because people treated early tend to have less HIV hiding in the body and a healthier immune system.

“This is certainly very fascinating that they’ve had this positive response,” said Dr. Hans-Peter Kiem, a gene therapy expert at Seattle’s Fred Hutchinson Cancer Center who wasn’t part of the new study. He cautioned that it will take additional research to prove if CAR-T really works.

But the strategy is exciting because it’s “boosting what our body, our immune system, can already do,” said Andrea Gramatica, vice president for research at amfAR, The Foundation for AIDS Research, which is funding some work to create easier-to-use versions.

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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

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