Will Texas avenge last season’s loss to Ohio State? Can Michigan bounce back against Oklahoma after a shocking and controversial near-upset? Which teams will prove that their Week 1 performance wasn’t a fluke, but a trend to rely on? 

The college football season rolls on, and Week 2’s lineup is looking strong with some big cross-conference games, from Texas-Ohio State to Michigan-Oklahoma to Illinois-Duke and so many more.

So before Week 2 kicks off, we’ve got some picks of the week, along with answers to those questions and more. We’re breaking down our straight-up picks for Week 2 and which matchups to keep a close eye on this weekend.

Let’s get into it. 

Austin Simmons threw for 252 yards and four touchdowns in his debut for Missouri in Week 1. (Photo by Scott Winters/Icon Sportswire via Getty Images)

When: Friday, 8 p.m. ET (FOX)
Where: David Booth Kansas Memorial Stadium, Lawrence, Kansas
Line: Missouri -5.5

RJ Young: Missouri
The Tigers have the better quarterback, and their run game is still rather awesome even without Ahmad Hardy in the backfield.

Laken Litman: Missouri
Mizzou takes down Kansas in an old rivalry game as former Ole Miss quarterback Austin Simmons lights up the Jayhawks with another multi-touchdown performance.

Michael Cohen: Missouri
As a new face in a new place, Missouri quarterback Austin Simmons gave the Tigers plenty to be excited about in Week 1 with four touchdowns and only two incompletions. He keeps it rolling against the Jayhawks. 

Ben Portnoy: Missouri
I’m in on Austin Simmons being a difference maker for the Tigers, even with a depleted run game. Head coach Eli Drinkwitz has largely handled business as a favorite during his tenure, and I think he does it again this week.

John Mateer (10) and Oklahoma defeated Michigan 24-13 in 2025. (Photo by Stacy Revere/Getty Images)

When: Saturday, noon ET (FOX)
Where: Michigan Stadium, Ann Arbor, Michigan
Line: Oklahoma -5.5

Young: Oklahoma 
The Sooners have the edge at quarterback, wide receiver and defensive line. This could get ugly for Michigan if Bryce Underwood doesn’t show a tremendous leap in development.

Litman: Oklahoma
The biggest question for me is how Michigan quarterback Bryce Underwood will look after last week’s near disaster against Western Michigan. You know Oklahoma head coach Brent Venables will put together a defensive game plan that makes it as hard as possible for the young signal-caller to succeed. 

Cohen: Oklahoma
Maybe the Wolverines will bounce back a bit following last week’s controversial win over Western Michigan. But the safer bet is that Oklahoma’s terrific defense can cause even more problems for Bryce Underwood, whose time as the starter feels like it’s dwindling.

Portnoy: Oklahoma
Recency bias has me incredibly down on the Wolverines, but there’s nothing I saw in Saturday’s win (?) over Western Michigan that makes me think they can beat a team of Oklahoma’s caliber. I think the Sooners are a legit dark horse to win the SEC this year, and I love what a healthy John Mateer brings. Give me the Sooners, big.

Dante Moore and Oregon beat Oklahoma State 69-3 in 2025. (Photo by Robin Alam/ISI Photos/ISI Photos via Getty Images)

When: Saturday, noon ET (ESPN)
Where: Boone Pickens Stadium, Stillwater, Oklahoma
Line: Oregon -22.5

Young: Oregon
Oregon is coming off of an embarrassing win, still has one of the best rosters in the sport and is about to play an Oklahoma State team that got beat by Tulsa, the smallest FBS school in the country. Name the number, Ducks.

Litman: Oregon
The Ducks had their “wake-up call” last week vs. Boise State, who could end up being the Group of Six College Football Playoff representative. While Stillwater is a tough place to play, Dan Lanning will have his team ready to go, while the Cowboys are in a transition year.

Cohen: Oregon
There will certainly be a response from Oregon’s defense after the highly-touted unit was gashed by Boise State in a surprisingly close opener. The Ducks should roll against an Oklahoma State team that looked quite rough in an upset loss to Tulsa. 

Portnoy: Oregon
Oregon got a scare from Boise State last week, but there’s no way that’s happening two weeks in a row. Oklahoma State looked atrocious last week in Eric Morris’ debut at Tulsa. I’d be shocked if the Ducks don’t roll in this one.

Bear Bachmeier and BYU beat Arizona 33-27 in overtime in 2025.  (Photo by Christian Petersen/Getty Images)

When: Saturday, 3:30 p.m. ET (FOX)
Where: LaVell Edwards Stadium, Provo, Utah
Line: BYU -7.5

Young: BYU
I trust the BYU defense more than I trust quarterback Noah Fifita and the Arizona offense.

Litman: BYU
Quarterback Bear Bachmeier and the Cougars have to win their first Big 12 game to keep pace with the likes of Texas Tech and Houston, and will take care of business against Arizona. 

Cohen: BYU
This is an important early-season mile marker for BYU in its quest to supplant Texas Tech in the Big 12 hierarchy. A controlled win over Arizona should give the Cougars plenty of confidence at the start of conference play.

Portnoy: BYU
If BYU is really going to challenge for the Big 12 title, this is the kind of game the Cougars need to win. Arizona was much improved last year and Noah Fifita is back, but I think BYU’s talent advantage outweighs that.

Nate Sheppard (20) rushed for 227 yards and two touchdowns as Duke defeated Tulane 17-3 in Week 1. (Photo by Alex Halloway/Getty Images)

When: Saturday, 3:30 p.m. ET (FS1)
Where: Gies Memorial Stadium, Champaign, Illinois
Line: Illinois -5.5

Young: Duke
The defending ACC champs — Duke! — have a bona fide star at running back in Nate Sheppard and the Illinois defense gave up 24 first downs and 194 rushing yards to UAB in its opener.

Litman: Illinois
Quarterback Katin Houser builds on his four-TD performance against UAB in Week 1 against the Darian Mensah-less Duke Blue Devils.

Cohen: Illinois
How popular is Illinois football right now? Illinois sold out Memorial Stadium for this week’s non-conference tilt against Duke. A crowd like that should push head coach Bret Bielema’s squad to a win. 

Portnoy: Illinois
Katin Houser put up huge numbers at East Carolina and his Big Ten return is off to a nice start. I like what Bret Bielema and this staff did with Luke Altmyer and Houser feels like a nice replacement. Duke has some talent, but Illinois is the better team here. 

Jaron-Keawe Sagapolutele threw for 271 yards, two touchdowns and two interceptions in Cal’s Week 1 loss to UCLA. (Photo by Ezra Shaw/Getty Images)

When: Saturday, 3:30 p.m. ET (USA Net)
Where: JMA Wireless Dome, Syracuse, New York
Line: Syracuse -3.5

Young: Syracuse
Head coach Fran Brown has his quarterback in Steve Angeli, and his quarterback is healthy. Angeli can be as good as Kyle McCord was at ‘Cuse if he stays healthy, and I like this matchup for a veteran head coach against a rookie one, in Cal’s Tosh Lupoi, coming off a loss and traveling across three time zones.

Litman: Syracuse
An early season classic ACC matchup! Orange quarterback Steve Angeli keeps up momentum from a strong Week 1 performance as Cal falls to 0-2 in the Tosh Lupoi era.

Cohen: Cal
Fool me once (as the Bears did last week), shame on you. Fool me twice (as I back the Bears again this week), shame on me. They should bounce back with a win.

Portnoy: Cal
Tosh Lupoi’s team didn’t exactly help my case for the Golden Bears as potential ACC contenders with their loss to UCLA last week, but I’m riding with the “Calgorithm” again. Fran Brown’s team should be much improved with Steve Angeli, but I think Lupoi’s bunch bounce back after a tough opener.

Maddux Madsen threw for three touchdowns as Boise State nearly upset Oregon in Week 1. (Photo by Ali Gradischer/Getty Images)

When: Saturday, 6 p.m. ET (USA Network)
Where: Albertsons Stadium, Boise, Idaho
Line: Boise State -8.5

Young: Boise State
I saw enough from the Broncos to believe they’re one of the two best teams in the Group of Six. Sadly, Memphis is not one of those two teams.

Litman: Boise State
Coming off an impressive performance from Week 1 where they almost knocked off then-No. 2 Oregon in Eugene, the Broncos get into the win column.

Cohen: Boise State
The Broncos played incredibly on the road at Oregon last week to establish themselves as legitimate CFP contenders from the Group of Six. Memphis wants to be viewed in that same category after knocking off UNLV in its season opener. Boise State is a cut above. 

Portnoy: Boise State
I’m rolling with the Broncos until proven otherwise. This team is as experienced as any in the Group of Six, and they looked the part last week at Oregon. Could there be a letdown? Sure, but I think Boise State will be able to run the ball more effectively against Memphis, and that gives the Broncos the edge.

Jeremiah Smith and Ohio State beat Texas 14-7 in 2025. (Photo by Jason Mowry/Getty Images)

When: Saturday, 7:30 p.m. ET (FOX)
Where: DKR-Texas Memorial Stadium, Austin, Texas
Line: Texas -1.5

Young: Ohio State
The Buckeyes’ weakness is on the offensive line. However, the cheat code exists. Quarterback Julian Sayin doesn’t have to punch up the “Konami code.” Just press four. Jeremiah Smith will beat the game.

Litman: Texas
Arch Manning and the Texas defense aren’t about to let Ohio State beat them a third straight time in less than two years.

Cohen: Ohio State
A year ago, new defensive coordinator Matt Patricia put the clamps on Texas’ offense. This time, new Ohio State offensive coordinator Arthur Smith will unleash a few wrinkles the Longhorns aren’t ready for. The Buckeyes get it done. 

Portnoy: Texas
If not now, when? That’s how I feel about Texas and its national title aspirations. Saturday’s game is a chance to cement the Longhorns as the top team in the country. I’m still skeptical of Arch Manning, but I think the talent drain on Ohio State’s defense shows up in Austin, and the home team gets a major résumé boost.

The Michigan Wolverines, fresh off an improbable and controversial win over Western Michigan, face a stiff challenge at home on Saturday night when they host the Oklahoma Sooners in a marquee showdown for Week 2 of the college football season. The Wolverines escaped with a 13-12 Hail Mary win in Week 1, while the Sooner pounded UTEP 51-0. This matchup should offer a better glimpse of what to expect once Big Ten and SEC play begins for each side. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:

Kickoff is at noon ET from Michigan Stadium in Ann Arbor, Mich. The Sooners are 5-point favorites in the latest Oklahoma vs. Michigan odds, while the over/under is 43.5 points. Before making any Oklahoma vs. Michigan picks, check out the Oklahoma vs. Michigan predictions from the SportsLine Projection Model. 

The model simulates every FBS game 10,000 times. It is on a 33-20 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal. Anybody following its college football betting picks could have seen strong returns.  

Now, the model has set its sights on Oklahoma vs. Michigan. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Michigan vs. Oklahoma:

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Top Oklahoma vs. Michigan predictions

After simulating Oklahoma vs. Michigan 10,000 times, SportsLine’s model is going Under (43.5 points) at the best betting apps. The Under hit in Oklahoma’s game vs. UTEP because the Sooners didn’t allow a single point, even in garbage time (51.5 in a 51-0 victory). 

Those that watched Michigan’s controversial win over Western Michigan saw a defense that was tough to move the ball on, plus and offense that had issues doing the same. It culminated in just 25 total points in 60 minutes — give or take a second. 

With both teams showcasing dominant defenses in Week 1, SportsLine’s model is projecting 42 combined points, making the Under the value pick hitting 51% of the time. See the model’s spread and money-line picks at SportsLine.

How to make Oklahoma vs. Michigan picks

In addition to going Under on the total, the model also says one side of the spread hits well over 60% of the time. You can only get the pick at SportsLine. 

So who wins Michigan vs. Oklahoma, and which side of the spread hits well over 60% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that’s on a 33-20 run on top-rated CFB money-line picks, and find out.

Jake and Logan Paul are set to bring their combat sports careers to television with a new unscripted fight competition series for Hulu and ESPN. Produced by Most Valuable Promotions and Wheelhouse, the upcoming show will feature the Paul brothers coaching rival teams of fighters as they compete in a combination of combat and survival challenges.

The project was officially announced on September 10, 2026, with the current official title being “Untitled Paul Brothers Fight Competition Series.” However, the show’s casting website is branded as “Fight Game.” Casting is now open, while production is scheduled to begin in 2027.

Jake recently spoke about the project while revealing that he had been rehired by Disney. He said:

“Yep, you heard the news. I got rehired by Disney. We’re back. It’s cool. ESPN, Logan, and me. We got picked up. We got a show, baby. Greenlit. Greenlit.”

The Paul brothers then explained that the show will combine fighting with survival challenges in the wild.

“Those people are gonna be fighting. It’s gonna be violent. Not only are they fighting, but they’re also doing survival in the woods, jungle-style, every week, like Naked and Afraid, for example, but imagine they have to fight to survive.”

The casting announcement is aimed at fighters from different combat sports backgrounds. Jake Paul and Logan Paul said:

“We need MMA fighters, boxers, anyone who has survival skills. You’re gonna be on ESPN and Hulu. Click the link to sign up for the cast. We’re casting. We’re looking for people who literally want to fight to survive.”

The brothers also emphasized the demanding nature of the competition, saying:

“You have to be made of absolute steel. This is gonna be the hardest and most rewarding game show of your entire lives.”

How will Jake and Logan Paul’s Fight Game work, and who can apply?

The competition will be split into two rival teams, with Jake and Logan Paul coaching one team each. The fighters will live and train together in the wild, while also facing different survival and combat challenges.

Unlike traditional reality competitions where contestants are eliminated through votes, the new series will have fighters choose their opponents, with eliminations being decided through fights. According to MVP, Jake and Logan will send the losing fighters home until one man and one woman are left standing.

Most Valuable Promotions described the concept in a post on X:

“Jake vs. Logan. Two rival teams. One man and one woman left standing. MVP and Wheelhouse are bringing a new unscripted fight competition series to Hulu and ESPN, where fighters choose their matchups and eliminations are settled by a fight—not a vote.”

The official announcement confirms that casting is currently open and interested applicants can apply through the show’s casting website. The site lists the following eligibility requirements, and the applying participant would have to meet the following conditions:

• At least eighteen (18) years of age.
• A legal resident of the United States.
• Not an employee of Producer, Network, any of their respective parent, subsidiary, related or affiliated entities, or any other person or entity directly involved in the development, production or exhibition of the Program;
• No member of my immediate family (i.e., spouse, parents, children, siblings or “step” relatives) nor anyone living in my household (whether related to me or not) is, nor has been within the past one (1) year, an employee, officer or director (excluding interns or other short-term independent contractors) of Producer or Network;
• Not been convicted of a felony in the past ten (10) years (unless expunged); and
• Not a candidate for public office and, if selected for the Program, agree not to become a candidate until one (1) year after the initial exhibition of the Program).

In other news, Jake Paul claims he paid $40 million in cash for a 6,000-acre Georgia ranch, containing 81 miles of property, a racetrack, a shooting range, and more.