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‘Poop Pills’ Show Early Promise For Treating Severe Peanut Allergy, Boston Researchers
Researchers at Boston Children’s Hospital have found that fecal microbiome transplantation, delivered orally through capsules sometimes referred to informally as “poop pills,” increased peanut tolerance in some adults with severe peanut allergies, offering an early but notable signal for a potential new approach to treating one of the most dangerous common food allergies.
The research, published August 5 in the journal Science Translational Medicine, examined whether transplanting gut bacteria from healthy, non-allergic donors into people with peanut allergies could reduce the severity of their allergic response. The Phase 1 trial was led by Dr. Rima Rachid, director of the Food Allergy Program and the Allergen Immunotherapy Program at Boston Children’s Hospital, alongside Dr. Talal Chatila, director of translational immunology at the hospital and a professor at Harvard Medical School.
Researchers enrolled 15 adults between the ages of 18 and 33, all with highly sensitive peanut allergies who reacted to 100 milligrams of peanut protein or less during an initial food challenge, an amount smaller than what is found in half of a typical peanut. Participants swallowed 36 frozen, odorless capsules containing carefully screened stool-derived microbes from healthy donors, consumed over the course of a few hours across one or two days.
The trial unfolded in two stages. In the first stage, 10 participants received the fecal transplant alone. Four months later, three of those 10 showed increased peanut tolerance, with two able to tolerate two to four peanuts before reacting and one able to tolerate more than four peanuts without any reaction. In the second stage, five additional participants took antibiotics before receiving the transplant, intended to clear space in the gut for the donated microbes to take hold more effectively. Three of those five participants showed increased tolerance, bringing the overall total to six of 15 participants, or 40%, who responded to the treatment.
Rachid described the significance of the findings in a statement. “This landmark study was the first to demonstrate that a microbiome-based therapy may improve food allergy in people,” Rachid said, noting that the research also revealed how gut bacteria, their metabolites and the immune system interact to influence how well individual patients respond to the treatment.
Among participants who experienced increased tolerance, researchers found elevated levels of immune cells called RORγt+ regulatory T cells, which help regulate immune system activity. When researchers subsequently transplanted stool samples from those responsive participants into mice, the mice were similarly protected against peanut allergic reactions, reinforcing the connection between the transplanted bacteria and the observed protective effect.
The protective effect was linked to increased bile acid metabolites in both the human participants and the mice studied. When researchers removed bile salt hydrolase, an enzyme involved in bile acid metabolism, from Bacteroides bacteria in mice, the increased peanut tolerance disappeared, suggesting that enzyme plays a specific role in the mechanism, though that particular portion of the research was conducted only in mice and not confirmed in humans.
Chatila said the underlying mechanism observed in the mouse studies suggests the approach could extend beyond peanut allergies specifically. Because the mouse experiments tested a different allergen than peanut, “the faecal transplant treatment is likely to work for more than just peanut allergies,” Chatila said, pointing to potential broader applications for other food allergies down the line.
Researchers emphasized that safety was the trial’s primary focus, given its early Phase 1 design. Rachid told Healthline that none of the participants experienced serious adverse events during the trial, and that the encouraging tolerance data emerged as a secondary finding building on earlier promising results observed in mouse studies.
Outside experts urged caution about over-interpreting the results given the trial’s small size. Dr. Mohammad Bakhtiar, a general practitioner and clinical lead at Medical Express Clinic who was not involved in the research, said the underlying biological premise makes sense given the gut microbiome‘s broad influence on the body. “The gut microbiome already has a major effect on many parts of human physiology,” Bakhtiar told Healthline, while cautioning that a 15-person, open-label study cannot demonstrate how the treatment would perform across a broader population, given that nine of the 15 participants did not respond to the treatment.
Current treatments for peanut allergy include oral immunotherapy and biologic medications, and many patients still need to carry an epinephrine auto-injector in case of a severe reaction or anaphylaxis. Researchers stressed that fecal microbiome transplantation is not yet ready to be recommended as an allergy treatment based on these preliminary findings alone.
Looking ahead, Rachid said the research team hopes to test a more purified version of the treatment, called microbiota transplantation therapy, which contains less than 1% nonmicrobial fecal material and can be stored in a standard home refrigerator. She said future studies would examine whether prolonged administration allows patients to tolerate higher peanut doses with more durable effects, and said that with adequate research funding, clinical applications could potentially emerge within 10 to 15 years if the approach continues to prove effective in larger trials. Bakhtiar agreed that a roughly decade-long timeline was plausible if larger follow-up studies confirm the initial results, though he said patients should continue following current medical guidance, including strict peanut avoidance and specialist allergy care, in the meantime.
Foreign investment options in the Philippines include domestic corporations, One Person Corporations, or branch offices, each affecting legal, governance, liability, and future growth opportunities.
Business Formation Options in the Philippines
Foreign investors exploring entry options in the Philippines typically consider establishing a domestic corporation, forming a One Person Corporation (OPC), or registering a branch office of an existing foreign entity. Each choice provides a legal framework for operation but impacts various factors such as regulatory compliance, governance structure, liability, and future growth prospects. The decision influences whether the investment complies with local laws, how the business is managed, and the company’s capacity to attract capital or partners.
Legal and Sectoral Restrictions on Foreign Investment
Unlike some countries with more liberalized foreign investment policies, the Philippines imposes restrictions based on constitutional, statutory, and sector-specific laws, especially in industries deemed sensitive or strategic. Restrictions extend beyond ownership caps and include limitations on land acquisition, natural resources, mass media, utilities, and certain educational sectors. These regulations determine the permissible levels of foreign ownership and viable establishment structures for different industries.
Choosing the Right Structure for Your Investment
A domestic corporation offers maximum flexibility for evolving Philippine businesses, supporting multiple shareholders, joint ventures, and future capital raises. Conversely, an OPC caters to sole investors wanting full control without additional shareholders, suitable for wholly owned subsidiaries expected to maintain concentrated ownership. Understanding these options helps optimize legal compliance and business growth potential within the Philippines’ regulatory environment.
Read the original article : Choosing Between a Domestic Corporation, OPC, or Branch Office in the Philippines
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Agriculture Secretary Brooke Rollins says Americans should see more grocery price relief as egg prices fall, beef costs ease and the Trump administration pushes to lower food prices.
Granola marketed to breastfeeding mothers and sold nationwide is being recalled over concerns that it may be contaminated with salmonella.
The Hampton Grocer, Inc., a New York-based company, is recalling certain 8-ounce packages of its Lacnola Lactation Granola after an ingredient used in the product was linked to a positive salmonella test, according to a company announcement posted Aug. 14 by the U.S. Food and Drug Administration (FDA).
The granola was sold nationwide through The Hampton Grocer’s website, Amazon and other online retailers between Oct. 21, 2025, and Aug. 12, 2026.
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The granola was sold nationwide through The Hampton Grocer’s website, Amazon and other online retailers. (iStock)
“The Hampton Grocers, Inc. of Montauk, NY is recalling Lacnola Lactation Granola, 8oz, because it has the potential to be contaminated with Salmonella, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems,” the announcement noted.
The recalled product comes in a pink stand-up pouch with UPC 850035324554.
Consumers should check their packages for either of the following lot codes and expiration dates:
- HGLC-102125, expiration date Oct. 21, 2026
- HGLC-021326, expiration date Feb. 13, 2027
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The recalled product is packaged in a pink stand-up pouch and carries UPC 850035324554 (U.S. Food and Drug Administration )
The lot code and expiration date are printed in black ink on the upper-left side of the back of the package.
No illnesses have been reported in connection with the recall, according to the notice.
The potential contamination was discovered after a supplier said one of its products tested positive for salmonella. The granola contains the same organic moringa powder used in that product.
TOYOTA RECALLS 655K CAMRYS GLOBALLY OVER DISPLAY DEFECT THAT CAN KNOCK OUT SAFETY INDICATORS
No illnesses have been reported in connection with the recall. (U.S. Food and Drug Administration )
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Production has been halted while the company and FDA investigate.
Consumers who purchased the recalled 8-ounce packages are being urged to throw them away and contact the place of purchase for a full refund.
The Hampton Grocer could not immediately be reached by FOX Business for comment.
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Nate Rempe, Omaha Steaks President and CEO, explains that soaring beef prices, up 13%, are due to a 72-year low in domestic cattle herds. He predicts meaningful herd building and price recovery won’t happen until 2028 or 2029.
Relief from high beef prices may depend on something that can’t be fixed overnight: rebuilding America’s shrinking cattle herd.
America’s ranchers are facing their smallest cattle herd in 75 years, a shortage now rippling from pastures to some of the nation’s largest meatpackers.
Tyson Foods announced last week that it will close beef facilities in Illinois and Utah and pursue the sale of another in Washington as it reshapes its beef business amid what the company called one of the most historic cattle shortages the country has ever experienced. Tyson said recent USDA data suggest supply constraints are likely to persist.
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USDA data shows the U.S. entered 2026 with about 86.2 million cattle and calves, the smallest herd since the early 1950s. That’s down from roughly 94.7 million cattle and calves in 2019, a decline of more than 8 million animals.
Rebuilding that lost supply will take time, particularly after years of conditions that pushed ranchers to shrink their herds.
Chief among them is persistent drought.
“The biggest thing has been drought,” Eric Belasco, head of the agricultural economics department at Montana State University, previously told Fox News Digital.
He said years of dry weather have depleted grasslands across the West and Plains, leaving ranchers without enough feed or water to sustain their herds. Many have been forced to sell cattle early, including cows needed to produce the next generation of calves, making the road to recovery even longer.
The effects are reaching beyond ranches and into grocery stores, where consumers are paying more for beef.
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According to USDA data, the retail value of Choice beef rose from about $8.51 per pound in August 2024 to $10.49 per pound in July 2026, an increase of roughly 23%.
Behind that price pressure is a cattle supply crunch that experts say has been years in the making.
“The biggest thing has been drought,” Eric Belasco, head of the agricultural economics department at Montana State University, previously told Fox News Digital.
BEEF PRICES ARE CLOSE TO RECORD HIGHS — BUT AMERICANS AREN’T CUTTING BACK
The U.S. cattle herd has fallen to its smallest level in 75 years. (Jonne Roriz/Bloomberg/Getty Images / Getty Images)
He said years of dry weather have depleted grasslands across the West and Plains, leaving ranchers without enough feed or water to sustain their herds.
Many have been forced to sell cattle early, including cows needed to produce the next generation of calves, making the road to recovery even longer.
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For consumers waiting for cheaper beef, the path to relief starts with rebuilding America’s cattle herds, a process that could take years.
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